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Nodular malignant melanoma

MedGen UID:
83144
•Concept ID:
C0334424
•
Neoplastic Process
Synonym: Nodular melanoma
SNOMED CT: NM - Nodular melanoma (2142002); Nodular melanoma of skin (254731001); NM - Nodular melanoma of skin (254731001); Nodular malignant melanoma of skin (254731001); Nodular melanoma (2142002)
 
HPO: HP:0012058
Monarch Initiative: MONDO:0000930

Definition

A type of melanoma that starts as a raised area that is usually dark blackish-blue or bluish-red but may not have any color. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNodular malignant melanoma

Professional guidelines

PubMed

Evaluation of performance of an accelerator-based BNCT facility for the treatment of different tumor targets.
Herrera MS, González SJ, Minsky DM, Kreiner AJ
Phys Med 2013 Sep;29(5):436-46. Epub 2013 Feb 23 doi: 10.1016/j.ejmp.2013.01.006. PMID: 23462279

Recent clinical studies

Etiology

Prognosis in stage II melanoma of the head and neck depends on the histological subtype.
Jasper S, Keim U, Leiter U, Amaral T, Flatz L, Forschner A
J Dtsch Dermatol Ges 2023 Oct;21(10):1137-1146. Epub 2023 Jul 23 doi: 10.1111/ddg.15164. PMID: 37485634
Epidemiological and clinical characteristics of malignant melanoma in Southeast Anatolia in Turkey.
Sula B, Uçmak F, Kaplan MA, Urakçi Z, Arica M, Isikdogan A
Pan Afr Med J 2016;24:22. Epub 2016 May 6 doi: 10.11604/pamj.2016.24.22.9254. PMID: 27583086Free PMC Article
Nodular malignant melanoma and multiple cutaneous neoplasms under immunosuppression with azathioprine.
Guenova E, Lichte V, Hoetzenecker W, Woelbing F, Moehrle M, Roecken M, Schaller M
Melanoma Res 2009 Aug;19(4):271-3. doi: 10.1097/CMR.0b013e32831bc44a. PMID: 19550360
Acral lentiginous melanoma.
Ridgeway CA, Hieken TJ, Ronan SG, Kim DK, Das Gupta TK
Arch Surg 1995 Jan;130(1):88-92. doi: 10.1001/archsurg.1995.01430010090019. PMID: 7802583
A retrosepctive histological study of 669 cases of primary cutaneous malignant melanoma in clinical stage I. 6. The relation of dermal solar elastosis to sex, age and survival of the patient and to localization, histological type and level of invasion of the tumour.
Larsen TE, Grude TH
Acta Pathol Microbiol Scand A 1979 Sep;87A(5):361-6. PMID: 525350

Diagnosis

Prognosis in stage II melanoma of the head and neck depends on the histological subtype.
Jasper S, Keim U, Leiter U, Amaral T, Flatz L, Forschner A
J Dtsch Dermatol Ges 2023 Oct;21(10):1137-1146. Epub 2023 Jul 23 doi: 10.1111/ddg.15164. PMID: 37485634
Nodular malignant melanoma in vulvar skin without pigmentation: a case report.
Nie J, Li Y, Shen X, Liu Y, Shi H, Lu Y
BMC Womens Health 2021 Aug 6;21(1):289. doi: 10.1186/s12905-021-01422-1. PMID: 34362374Free PMC Article
Giant congenital nodular melanoma in a newborn: a case report and literature review.
Zhou J, Lv MX, Duan L, Xie YC, A ZX, Wu HF, Gao Y
BMC Pediatr 2021 Mar 11;21(1):121. doi: 10.1186/s12887-021-02590-7. PMID: 33706747Free PMC Article
Epidemiological and clinical characteristics of malignant melanoma in Southeast Anatolia in Turkey.
Sula B, Uçmak F, Kaplan MA, Urakçi Z, Arica M, Isikdogan A
Pan Afr Med J 2016;24:22. Epub 2016 May 6 doi: 10.11604/pamj.2016.24.22.9254. PMID: 27583086Free PMC Article
Malignant melanoma in childhood.
Mehregan AH, Mehregan DA
Cancer 1993 Jun 15;71(12):4096-103. doi: 10.1002/1097-0142(19930615)71:12<4096::aid-cncr2820711248>3.0.co;2-z. PMID: 8508375

Therapy

Oncogene targeted therapy for metastatic primary scrotal melanoma.
Stocks B, Fuentes H, McDowell Z, Brooks M, Jones JA
Can J Urol 2021 Apr;28(2):10643-10647. PMID: 33872566
Nodular malignant melanoma and multiple cutaneous neoplasms under immunosuppression with azathioprine.
Guenova E, Lichte V, Hoetzenecker W, Woelbing F, Moehrle M, Roecken M, Schaller M
Melanoma Res 2009 Aug;19(4):271-3. doi: 10.1097/CMR.0b013e32831bc44a. PMID: 19550360
High-risk melanoma with nodal involvement in a young woman.
Khan O, Middleton M
Nat Clin Pract Oncol 2006 Sep;3(9):517-21; quiz 522. doi: 10.1038/ncponc0582. PMID: 16955090
Tattoo pigment in sentinel lymph nodes: a mimicker of metastatic malignant melanoma.
Chikkamuniyappa S, Sjuve-Scott R, Lancaster-Weiss K, Miller A, Yeh IT
Dermatol Online J 2005 Mar 1;11(1):14. PMID: 15748555
Nodular malignant melanoma and multiple squamous cell carcinomas in a patient treated by photochemotherapy for psoriasis.
Kemmett D, Reshad H, Baker H
Br Med J (Clin Res Ed) 1984 Dec 1;289(6457):1498. doi: 10.1136/bmj.289.6457.1498. PMID: 6439287Free PMC Article

Prognosis

Prognosis in stage II melanoma of the head and neck depends on the histological subtype.
Jasper S, Keim U, Leiter U, Amaral T, Flatz L, Forschner A
J Dtsch Dermatol Ges 2023 Oct;21(10):1137-1146. Epub 2023 Jul 23 doi: 10.1111/ddg.15164. PMID: 37485634
Giant congenital nodular melanoma in a newborn: a case report and literature review.
Zhou J, Lv MX, Duan L, Xie YC, A ZX, Wu HF, Gao Y
BMC Pediatr 2021 Mar 11;21(1):121. doi: 10.1186/s12887-021-02590-7. PMID: 33706747Free PMC Article
Epidemiological and clinical characteristics of malignant melanoma in Southeast Anatolia in Turkey.
Sula B, Uçmak F, Kaplan MA, Urakçi Z, Arica M, Isikdogan A
Pan Afr Med J 2016;24:22. Epub 2016 May 6 doi: 10.11604/pamj.2016.24.22.9254. PMID: 27583086Free PMC Article
Acral lentiginous melanoma.
Ridgeway CA, Hieken TJ, Ronan SG, Kim DK, Das Gupta TK
Arch Surg 1995 Jan;130(1):88-92. doi: 10.1001/archsurg.1995.01430010090019. PMID: 7802583
Malignant melanoma in childhood.
Mehregan AH, Mehregan DA
Cancer 1993 Jun 15;71(12):4096-103. doi: 10.1002/1097-0142(19930615)71:12<4096::aid-cncr2820711248>3.0.co;2-z. PMID: 8508375

Clinical prediction guides

Loss of dipeptidyl peptidase IV immunostaining discriminates malignant melanomas from deep penetrating nevi.
Roesch A, Wittschier S, Becker B, Landthaler M, Vogt T
Mod Pathol 2006 Oct;19(10):1378-85. Epub 2006 Jul 7 doi: 10.1038/modpathol.3800663. PMID: 16829852
c-MYC and nodular malignant melanoma. A case report.
Greulich KM, Utikal J, Peter RU, Krähn G
Cancer 2000 Jul 1;89(1):97-103. doi: 10.1002/1097-0142(20000701)89:1<97::aid-cncr14>3.0.co;2-0. PMID: 10897006
Independent prognostic importance of vascular invasion in nodular melanomas.
Straume O, Akslen LA
Cancer 1996 Sep 15;78(6):1211-9. doi: 10.1002/(SICI)1097-0142(19960915)78:6<1211::AID-CNCR7>3.0.CO;2-C. PMID: 8826942
Biological behavior and natural course of acral malignant melanoma. Clinical and histologic features and prognosis of palmoplantar, subungual, and other acral malignant melanomas.
Jimbow K, Takahashi H, Miura S, Ikeda S, Kukita A
Am J Dermatopathol 1984 Summer;6 Suppl:43-53. PMID: 6528942
A retrospective histological study of 669 cases of primary cutaneous malignant melanoma in clinical stage I. I. Histological classification, sex and age of the patients, localization of tumour and prognosis.
Larsen TE, Grude TH
Acta Pathol Microbiol Scand A 1978 Sep;86A(5):437-50. doi: 10.1111/j.1699-0463.1978.tb02068.x. PMID: 716905

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