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Nephrogenic adenoma

MedGen UID:
452429
•Concept ID:
C0334039
•
Neoplastic Process
Synonyms: Nephrogenic Adenoma; nephrogenic adenoma; Nephrogenic Metaplasia; Nephrogenic metaplasia
SNOMED CT: Nephrogenic metaplasia (78236000); Nephrogenic adenoma (78236000)
 
Monarch Initiative: MONDO:0004191

Definition

So-called nephrogenic adenoma is a distinct metaplastic lesion of the urothelium characterized by aggregates of cuboidal or hobnail cells. These cells line thin papillary fronds on the surface or form tubular structures within the lamina propria. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNephrogenic adenoma

Professional guidelines

PubMed

Nephrogenic Adenoma: Clinical Features, Management, and Diagnostic Pitfalls.
Gordetsky J, Gennaro KH, Selph JP, Rais-Bahrami S
Urology 2016 Sep;95:29-33. Epub 2016 Apr 29 doi: 10.1016/j.urology.2016.04.032. PMID: 27138263
Primary adenocarcinoma of the urinary bladder: differential diagnosis and clinical relevance.
Zhong M, Gersbach E, Rohan SM, Yang XJ
Arch Pathol Lab Med 2013 Mar;137(3):371-81. doi: 10.5858/arpa.2012-0076-RA. PMID: 23451748
Best practice in diagnostic immunohistochemistry: prostate carcinoma and its mimics in needle core biopsies.
Paner GP, Luthringer DJ, Amin MB
Arch Pathol Lab Med 2008 Sep;132(9):1388-96. doi: 10.5858/2008-132-1388-BPIDIP. PMID: 18788849

Recent clinical studies

Etiology

Fibromyxoid Nephrogenic Adenoma: A Series of 43 Cases Reassessing Predisposing Conditions, Clinical Presentation, and Morphology.
Li L, Williamson SR, Castillo RP, Delma KS, Gonzalgo ML, Epstein JI, Kryvenko ON
Am J Surg Pathol 2023 Jan 1;47(1):37-46. Epub 2022 Nov 4 doi: 10.1097/PAS.0000000000001986. PMID: 36395466
Tumour-like lesions of the urinary bladder.
Samaratunga H, Delahunt B, Yaxley J, Egevad L
Pathology 2021 Jan;53(1):44-55. Epub 2020 Oct 15 doi: 10.1016/j.pathol.2020.08.005. PMID: 33070959
Nephrogenic adenoma of the urinary tract: A 6-year single center experience.
Turcan D, Acikalin MF, Yilmaz E, Canaz F, Arik D
Pathol Res Pract 2017 Jul;213(7):831-835. Epub 2017 Mar 25 doi: 10.1016/j.prp.2017.03.001. PMID: 28554748
Nephrogenic Adenoma: Clinical Features, Management, and Diagnostic Pitfalls.
Gordetsky J, Gennaro KH, Selph JP, Rais-Bahrami S
Urology 2016 Sep;95:29-33. Epub 2016 Apr 29 doi: 10.1016/j.urology.2016.04.032. PMID: 27138263
Nephrogenic adenoma of the urinary bladder: our experience and review of the literature.
Porcaro AB, D'Amico A, Ficarra V, Balzarro M, Righetti R, Martignoni G, Cavalleri S, Malossini G
Urol Int 2001;66(3):152-5. doi: 10.1159/000056596. PMID: 11316978

Diagnosis

Nephrogenic Adenoma Intermixed With Urothelial Carcinoma.
Kryvenko ON, Wasco MJ, Williamson SR
Arch Pathol Lab Med 2022 May 1;147(5):552-558. doi: 10.5858/arpa.2021-0620-OA. PMID: 35976666
Tumour-like lesions of the urinary bladder.
Samaratunga H, Delahunt B, Yaxley J, Egevad L
Pathology 2021 Jan;53(1):44-55. Epub 2020 Oct 15 doi: 10.1016/j.pathol.2020.08.005. PMID: 33070959
Common and uncommon features of nephrogenic adenoma revisited.
Santi R, Angulo JC, Nesi G, de Petris G, Kuroda N, Hes O, López JI
Pathol Res Pract 2019 Oct;215(10):152561. Epub 2019 Jul 25 doi: 10.1016/j.prp.2019.152561. PMID: 31358481
Mimickers of urothelial neoplasia.
Kryvenko ON, Epstein JI
Ann Diagn Pathol 2019 Feb;38:11-19. Epub 2018 Sep 26 doi: 10.1016/j.anndiagpath.2018.09.012. PMID: 30380401
Nephrogenic adenoma.
Amin W, Parwani AV
Pathol Res Pract 2010 Oct 15;206(10):659-62. Epub 2010 Jul 8 doi: 10.1016/j.prp.2010.06.001. PMID: 20619548

Therapy

Nephrogenic Adenoma Complicating Renal Transplantation: A Case Report and Discussion.
North D, Jaw J, Hill P, Bateman S, Barraclough N, Langham R
Transplant Proc 2017 Dec;49(10):2381-2383. doi: 10.1016/j.transproceed.2017.09.003. PMID: 29198684
BK polyomavirus-infected nephrogenic adenoma of the urinary bladder in a renal transplant recipient: A case report.
Alexiev BA, Papadimitriou JC, Drachenberg CB
Pathol Res Pract 2015 Sep;211(9):697-701. Epub 2015 Jun 11 doi: 10.1016/j.prp.2015.06.006. PMID: 26189101
Nephrogenic adenoma in the augmented bladder.
Franke EI, Misseri R, Cain MP, Kaefer M, Meldrum KK, Fan R, Rink RC
J Urol 2011 Oct;186(4 Suppl):1586-9. doi: 10.1016/j.juro.2011.04.015. PMID: 21862049
Nephrogenic adenoma of the bladder: two case reports and literature review.
Nakatani T, Kuratsukuri K, Uchida J, Sugimura K, Kuroki Y, Morikawa Y
Hinyokika Kiyo 2002 Jul;48(7):463-6. PMID: 12229190
Nephrogenic adenoma of the bladder in renal transplant recipients: a report of 9 cases with assessment of deoxyribonucleic acid ploidy and long-term followup.
Fournier G, Menut P, Moal MC, Hardy E, Volant A, Mangin P
J Urol 1996 Jul;156(1):41-4. doi: 10.1016/s0022-5347(01)65932-9. PMID: 8648834

Prognosis

Tumour-like lesions of the urinary bladder.
Samaratunga H, Delahunt B, Yaxley J, Egevad L
Pathology 2021 Jan;53(1):44-55. Epub 2020 Oct 15 doi: 10.1016/j.pathol.2020.08.005. PMID: 33070959
Nephrogenic adenoma of the urinary tract: A 6-year single center experience.
Turcan D, Acikalin MF, Yilmaz E, Canaz F, Arik D
Pathol Res Pract 2017 Jul;213(7):831-835. Epub 2017 Mar 25 doi: 10.1016/j.prp.2017.03.001. PMID: 28554748
Clear cell adenocarcinoma of the urethra: review of the literature.
Venyo AK
Int J Surg Oncol 2015;2015:790235. Epub 2015 Jan 20 doi: 10.1155/2015/790235. PMID: 25685552Free PMC Article
Nephrogenic adenoma of the urinary tract: a review.
Alexiev BA, LeVea CM
Int J Surg Pathol 2012 Apr;20(2):123-31. Epub 2012 Mar 13 doi: 10.1177/1066896912439095. PMID: 22415059
Nephrogenic adenoma.
Amin W, Parwani AV
Pathol Res Pract 2010 Oct 15;206(10):659-62. Epub 2010 Jul 8 doi: 10.1016/j.prp.2010.06.001. PMID: 20619548

Clinical prediction guides

Fibromyxoid Nephrogenic Adenoma: A Series of 43 Cases Reassessing Predisposing Conditions, Clinical Presentation, and Morphology.
Li L, Williamson SR, Castillo RP, Delma KS, Gonzalgo ML, Epstein JI, Kryvenko ON
Am J Surg Pathol 2023 Jan 1;47(1):37-46. Epub 2022 Nov 4 doi: 10.1097/PAS.0000000000001986. PMID: 36395466
Nephrogenic adenoma of the urinary tract: A 6-year single center experience.
Turcan D, Acikalin MF, Yilmaz E, Canaz F, Arik D
Pathol Res Pract 2017 Jul;213(7):831-835. Epub 2017 Mar 25 doi: 10.1016/j.prp.2017.03.001. PMID: 28554748
Nephrogenic adenoma of the urinary tract: clinical, histological, and immunohistochemical characteristics.
López JI, Schiavo-Lena M, Corominas-Cishek A, Yagüe A, Bauleth K, Guarch R, Hes O, Tardanico R
Virchows Arch 2013 Dec;463(6):819-25. Epub 2013 Oct 19 doi: 10.1007/s00428-013-1497-y. PMID: 24142157
Nephrogenic adenoma of the urinary tract: a review.
Alexiev BA, LeVea CM
Int J Surg Pathol 2012 Apr;20(2):123-31. Epub 2012 Mar 13 doi: 10.1177/1066896912439095. PMID: 22415059
Nephrogenic adenoma.
Amin W, Parwani AV
Pathol Res Pract 2010 Oct 15;206(10):659-62. Epub 2010 Jul 8 doi: 10.1016/j.prp.2010.06.001. PMID: 20619548

Recent systematic reviews

Inverted papilloma of the bladder: a review and an analysis of the recent literature of 365 patients.
Picozzi S, Casellato S, Bozzini G, Ratti D, Macchi A, Rubino B, Pace G, Carmignani L
Urol Oncol 2013 Nov;31(8):1584-90. Epub 2012 Apr 19 doi: 10.1016/j.urolonc.2012.03.009. PMID: 22520573

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