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Atrophy

MedGen UID:
83084
•Concept ID:
C0333641
•
Pathologic Function
Synonym: Atrophies
SNOMED CT: Atrophic (13331008); Atrophy (13331008)

Definition

Any weakening or degeneration, especially through lack of use. [from NCI]

Professional guidelines

PubMed

AGA Clinical Practice Update on the Diagnosis and Management of Atrophic Gastritis: Expert Review.
Shah SC, Piazuelo MB, Kuipers EJ, Li D
Gastroenterology 2021 Oct;161(4):1325-1332.e7. Epub 2021 Aug 26 doi: 10.1053/j.gastro.2021.06.078. PMID: 34454714Free PMC Article
Peripheral Neuropathy: Evaluation and Differential Diagnosis.
Castelli G, Desai KM, Cantone RE
Am Fam Physician 2020 Dec 15;102(12):732-739. PMID: 33320513
Hashimoto thyroiditis: clinical and diagnostic criteria.
Caturegli P, De Remigis A, Rose NR
Autoimmun Rev 2014 Apr-May;13(4-5):391-7. Epub 2014 Jan 13 doi: 10.1016/j.autrev.2014.01.007. PMID: 24434360

Recent clinical studies

Etiology

Risdiplam: A Review in Spinal Muscular Atrophy.
Paik J
CNS Drugs 2022 Apr;36(4):401-410. Epub 2022 Mar 13 doi: 10.1007/s40263-022-00910-8. PMID: 35284988
Diagnosis and management of spinal muscular atrophy: Part 2: Pulmonary and acute care; medications, supplements and immunizations; other organ systems; and ethics.
Finkel RS, Mercuri E, Meyer OH, Simonds AK, Schroth MK, Graham RJ, Kirschner J, Iannaccone ST, Crawford TO, Woods S, Muntoni F, Wirth B, Montes J, Main M, Mazzone ES, Vitale M, Snyder B, Quijano-Roy S, Bertini E, Davis RH, Qian Y, Sejersen T; SMA Care group
Neuromuscul Disord 2018 Mar;28(3):197-207. Epub 2017 Nov 23 doi: 10.1016/j.nmd.2017.11.004. PMID: 29305137
Nusinersen for the treatment of spinal muscular atrophy.
Chiriboga CA
Expert Rev Neurother 2017 Oct;17(10):955-962. Epub 2017 Sep 8 doi: 10.1080/14737175.2017.1364159. PMID: 28884620
Spinal muscular atrophy: diagnosis and management in a new therapeutic era.
Arnold WD, Kassar D, Kissel JT
Muscle Nerve 2015 Feb;51(2):157-67. Epub 2014 Dec 16 doi: 10.1002/mus.24497. PMID: 25346245Free PMC Article
Spinal muscular atrophy.
D'Amico A, Mercuri E, Tiziano FD, Bertini E
Orphanet J Rare Dis 2011 Nov 2;6:71. doi: 10.1186/1750-1172-6-71. PMID: 22047105Free PMC Article

Diagnosis

Inflammation in multiple system atrophy.
Leńska-Mieciek M, Madetko-Alster N, Alster P, Królicki L, Fiszer U, Koziorowski D
Front Immunol 2023;14:1214677. Epub 2023 Jun 22 doi: 10.3389/fimmu.2023.1214677. PMID: 37426656Free PMC Article
Multiple system atrophy.
Goh YY, Saunders E, Pavey S, Rushton E, Quinn N, Houlden H, Chelban V
Pract Neurol 2023 Jun;23(3):208-221. Epub 2023 Mar 16 doi: 10.1136/pn-2020-002797. PMID: 36927875Free PMC Article
Spinal muscular atrophy.
Mercuri E, Sumner CJ, Muntoni F, Darras BT, Finkel RS
Nat Rev Dis Primers 2022 Aug 4;8(1):52. doi: 10.1038/s41572-022-00380-8. PMID: 35927425
Spinal Muscular Atrophy.
Nicolau S, Waldrop MA, Connolly AM, Mendell JR
Semin Pediatr Neurol 2021 Apr;37:100878. Epub 2021 Feb 11 doi: 10.1016/j.spen.2021.100878. PMID: 33892848
Multiple system atrophy.
Fanciulli A, Stankovic I, Krismer F, Seppi K, Levin J, Wenning GK
Int Rev Neurobiol 2019;149:137-192. Epub 2019 Nov 21 doi: 10.1016/bs.irn.2019.10.004. PMID: 31779811

Therapy

Advances and limitations for the treatment of spinal muscular atrophy.
Day JW, Howell K, Place A, Long K, Rossello J, Kertesz N, Nomikos G
BMC Pediatr 2022 Nov 3;22(1):632. doi: 10.1186/s12887-022-03671-x. PMID: 36329412Free PMC Article
Hormone replacement therapy after breast cancer: Yes, No or maybe?
Ugras SK, Layeequr Rahman R
Mol Cell Endocrinol 2021 Apr 5;525:111180. Epub 2021 Jan 26 doi: 10.1016/j.mce.2021.111180. PMID: 33508379
Age-related macular degeneration therapy: a review.
Ammar MJ, Hsu J, Chiang A, Ho AC, Regillo CD
Curr Opin Ophthalmol 2020 May;31(3):215-221. doi: 10.1097/ICU.0000000000000657. PMID: 32205470
Blood Flow Restriction Therapy Versus Standard Care for Reducing Quadriceps Atrophy After Anterior Cruciate Ligament Reconstruction.
Lipker LA, Persinger CR, Michalko BS, Durall CJ
J Sport Rehabil 2019 Nov 1;28(8):897-901. doi: 10.1123/jsr.2018-0062. PMID: 30300054
Accelerated rehabilitation following Achilles tendon repair after acute rupture - Development of an evidence-based treatment protocol.
Brumann M, Baumbach SF, Mutschler W, Polzer H
Injury 2014 Nov;45(11):1782-90. Epub 2014 Jul 7 doi: 10.1016/j.injury.2014.06.022. PMID: 25059505

Prognosis

Spinal Muscular Atrophy: An Evolving Scenario through New Perspectives in Diagnosis and Advances in Therapies.
Angilletta I, Ferrante R, Giansante R, Lombardi L, Babore A, Dell'Elice A, Alessandrelli E, Notarangelo S, Ranaudo M, Palmarini C, De Laurenzi V, Stuppia L, Rossi C
Int J Mol Sci 2023 Oct 3;24(19) doi: 10.3390/ijms241914873. PMID: 37834320Free PMC Article
Mid- and long-term (at least 12 months) follow-up of patients with spinal muscular atrophy (SMA) treated with nusinersen, onasemnogene abeparvovec, risdiplam or combination therapies: A systematic review of real-world study data.
Erdos J, Wild C
Eur J Paediatr Neurol 2022 Jul;39:1-10. Epub 2022 Apr 30 doi: 10.1016/j.ejpn.2022.04.006. PMID: 35533607
Mechanical Ventilation-induced Diaphragm Atrophy Strongly Impacts Clinical Outcomes.
Goligher EC, Dres M, Fan E, Rubenfeld GD, Scales DC, Herridge MS, Vorona S, Sklar MC, Rittayamai N, Lanys A, Murray A, Brace D, Urrea C, Reid WD, Tomlinson G, Slutsky AS, Kavanagh BP, Brochard LJ, Ferguson ND
Am J Respir Crit Care Med 2018 Jan 15;197(2):204-213. doi: 10.1164/rccm.201703-0536OC. PMID: 28930478
Prevalence, incidence and carrier frequency of 5q-linked spinal muscular atrophy - a literature review.
Verhaart IEC, Robertson A, Wilson IJ, Aartsma-Rus A, Cameron S, Jones CC, Cook SF, Lochmüller H
Orphanet J Rare Dis 2017 Jul 4;12(1):124. doi: 10.1186/s13023-017-0671-8. PMID: 28676062Free PMC Article
Clinical review: intensive care unit acquired weakness.
Hermans G, Van den Berghe G
Crit Care 2015 Aug 5;19(1):274. doi: 10.1186/s13054-015-0993-7. PMID: 26242743Free PMC Article

Clinical prediction guides

Risks and predictive biomarkers of sudden unexpected death in epilepsy patient.
Ryvlin P, Rheims S, Lhatoo SD
Curr Opin Neurol 2019 Apr;32(2):205-212. doi: 10.1097/WCO.0000000000000668. PMID: 30694923Free PMC Article
Right posterior hepatic notch sign.
Indiran V, Jagannathan K
Abdom Radiol (NY) 2017 Nov;42(11):2780. doi: 10.1007/s00261-017-1199-z. PMID: 28555264
Small bowel villous atrophy: celiac disease and beyond.
Elli L, Branchi F, Sidhu R, Guandalini S, Assiri A, Rinawi F, Shamir R, Das P, Makharia GK
Expert Rev Gastroenterol Hepatol 2017 Feb;11(2):125-138. Epub 2016 Dec 29 doi: 10.1080/17474124.2017.1274231. PMID: 28000520
International photographic classification and grading system for myopic maculopathy.
Ohno-Matsui K, Kawasaki R, Jonas JB, Cheung CM, Saw SM, Verhoeven VJ, Klaver CC, Moriyama M, Shinohara K, Kawasaki Y, Yamazaki M, Meuer S, Ishibashi T, Yasuda M, Yamashita H, Sugano A, Wang JJ, Mitchell P, Wong TY; META-analysis for Pathologic Myopia (META-PM) Study Group
Am J Ophthalmol 2015 May;159(5):877-83.e7. Epub 2015 Jan 26 doi: 10.1016/j.ajo.2015.01.022. PMID: 25634530
Very early diagnosis of systemic sclerosis.
Bellando-Randone S, Guiducci S, Matucci-Cerinic M
Pol Arch Med Wewn 2012;122 Suppl 1:18-23. PMID: 23222375

Recent systematic reviews

Indications for zygomatic implants: a systematic review.
Polido WD, Machado-Fernandez A, Lin WS, Aghaloo T
Int J Implant Dent 2023 Jul 1;9(1):17. doi: 10.1186/s40729-023-00480-4. PMID: 37391575Free PMC Article
The rate and assessment of muscle wasting during critical illness: a systematic review and meta-analysis.
Fazzini B, Märkl T, Costas C, Blobner M, Schaller SJ, Prowle J, Puthucheary Z, Wackerhage H
Crit Care 2023 Jan 3;27(1):2. doi: 10.1186/s13054-022-04253-0. PMID: 36597123Free PMC Article
The Movement Disorder Society Criteria for the Diagnosis of Multiple System Atrophy.
Wenning GK, Stankovic I, Vignatelli L, Fanciulli A, Calandra-Buonaura G, Seppi K, Palma JA, Meissner WG, Krismer F, Berg D, Cortelli P, Freeman R, Halliday G, Höglinger G, Lang A, Ling H, Litvan I, Low P, Miki Y, Panicker J, Pellecchia MT, Quinn N, Sakakibara R, Stamelou M, Tolosa E, Tsuji S, Warner T, Poewe W, Kaufmann H
Mov Disord 2022 Jun;37(6):1131-1148. Epub 2022 Apr 21 doi: 10.1002/mds.29005. PMID: 35445419Free PMC Article
Creatine in Health and Disease.
Kreider RB, Stout JR
Nutrients 2021 Jan 29;13(2) doi: 10.3390/nu13020447. PMID: 33572884Free PMC Article
AGE-RELATED MACULAR DEGENERATION.
Gheorghe A, Mahdi L, Musat O
Rom J Ophthalmol 2015 Apr-Jun;59(2):74-7. PMID: 26978865Free PMC Article

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