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Toxic thyroid adenoma

MedGen UID:
549890
•Concept ID:
C0302840
•
Disease or Syndrome
Synonym: Hyperfunctioning follicular adenoma of thyroid gland
SNOMED CT: Hyperfunctioning follicular adenoma of thyroid gland (449097000); Toxic thyroid adenoma (449097000)

Professional guidelines

PubMed

The Role of Nuclear Medicine in the Clinical Management of Benign Thyroid Disorders, Part 1: Hyperthyroidism.
Mariani G, Tonacchera M, Grosso M, Orsolini F, Vitti P, Strauss HW
J Nucl Med 2021 Mar;62(3):304-312. Epub 2020 Oct 2 doi: 10.2967/jnumed.120.243170. PMID: 33008929
TREATMENT OF TOXIC THYROID ADENOMA BY THE ETHANOL DESTRUCTION METHOD.
Espenbetova M, Zhumanbayeva Z, Krykpayeva A, Amrenova K, Glushkova N
Georgian Med News 2018 Mar;(276):81-86. PMID: 29697387
Radiometabolic treatment of hyperthyroidism with a calculated dose of 131-iodine: results of one-year follow-up.
Regalbuto C, Marturano I, Condorelli A, Latina A, Pezzino V
J Endocrinol Invest 2009 Feb;32(2):134-8. doi: 10.1007/BF03345702. PMID: 19411811

Recent clinical studies

Etiology

The Role of Nuclear Medicine in the Clinical Management of Benign Thyroid Disorders, Part 1: Hyperthyroidism.
Mariani G, Tonacchera M, Grosso M, Orsolini F, Vitti P, Strauss HW
J Nucl Med 2021 Mar;62(3):304-312. Epub 2020 Oct 2 doi: 10.2967/jnumed.120.243170. PMID: 33008929
TREATMENT OF TOXIC THYROID ADENOMA BY THE ETHANOL DESTRUCTION METHOD.
Espenbetova M, Zhumanbayeva Z, Krykpayeva A, Amrenova K, Glushkova N
Georgian Med News 2018 Mar;(276):81-86. PMID: 29697387
Eosinophilic fasciitis and toxic thyroid adenoma--a novel association.
Khalifa M, Slim I, Ghannouchi N, Kaabia N, Sriha B, Letaief A, Bahri F
Acta Clin Belg 2008 May-Jun;63(3):197-9. doi: 10.1179/acb.2008.032. PMID: 18714852
Postpartum thyroid dysfunction and postpartum depression: are they two linked disorders?
Lucas A, Pizarro E, Granada ML, Salinas I, Sanmartí A
Clin Endocrinol (Oxf) 2001 Dec;55(6):809-14. doi: 10.1046/j.1365-2265.2001.01421.x. PMID: 11895224
Treatment of hyperfunctioning thyroid nodules with percutaneous ethanol injection: Eight years' experience.
Monzani F, Caraccio N, Goletti O, Casolaro A, Lippolis PV, Cavina E, Miccoli P
Exp Clin Endocrinol Diabetes 1998;106 Suppl 4:S54-8. doi: 10.1055/s-0029-1212058. PMID: 9867198

Diagnosis

The Role of Nuclear Medicine in the Clinical Management of Benign Thyroid Disorders, Part 1: Hyperthyroidism.
Mariani G, Tonacchera M, Grosso M, Orsolini F, Vitti P, Strauss HW
J Nucl Med 2021 Mar;62(3):304-312. Epub 2020 Oct 2 doi: 10.2967/jnumed.120.243170. PMID: 33008929
Parathyroid adenoma with concurrent toxic thyroid adenoma: a rare combination.
Sardiwalla II, Mokhtari A, Sardiwalla Y
S Afr J Surg 2017 Mar;55(1):41-44. PMID: 28876558
Toxic thyroid adenoma presenting as hypokalemic periodic paralysis.
Tagami T, Usui T, Shimatsu A, Naruse M
Endocr J 2007 Dec;54(5):797-803. Epub 2007 Oct 2 doi: 10.1507/endocrj.k07-126. PMID: 17917308
Radioiodine or surgery for toxic thyroid adenoma: dissecting an important decision. A cost-effectiveness analysis.
Vidal-Trecan GM, Stahl JE, Eckman MH
Thyroid 2004 Nov;14(11):933-45. doi: 10.1089/thy.2004.14.933. PMID: 15671772
CHYLOTHORAX DUE TO TOXIC THYROID ADENOMA.
WHITE AG
Proc R Soc Med 1964 Dec;57(12):1131-2. PMID: 14244894Free PMC Article

Therapy

TREATMENT OF TOXIC THYROID ADENOMA BY THE ETHANOL DESTRUCTION METHOD.
Espenbetova M, Zhumanbayeva Z, Krykpayeva A, Amrenova K, Glushkova N
Georgian Med News 2018 Mar;(276):81-86. PMID: 29697387
Comparison of four different protocols of I-131 therapy for treating single toxic thyroid nodule.
Zakavi SR, Mousavi Z, Davachi B
Nucl Med Commun 2009 Feb;30(2):169-75. doi: 10.1097/MNM.0b013e3283169148. PMID: 19194214
Radioiodine or surgery for toxic thyroid adenoma: dissecting an important decision. A cost-effectiveness analysis.
Vidal-Trecan GM, Stahl JE, Eckman MH
Thyroid 2004 Nov;14(11):933-45. doi: 10.1089/thy.2004.14.933. PMID: 15671772
Gain of function TSH receptor mutations and iodine deficiency: implications in iodine prophylaxis.
Tonacchera M, Vitti P, De Servi M, Agretti P, De Marco G, Chiovato L, Pinchera A
J Endocrinol Invest 2003;26(2 Suppl):2-6. PMID: 12762632
Managing toxic thyroid adenoma: a cost-effectiveness analysis.
Vidal-Trecan GM, Stahl JE, Durand-Zaleski I
Eur J Endocrinol 2002 Mar;146(3):283-94. doi: 10.1530/eje.0.1460283. PMID: 11888833

Prognosis

Radioiodine or surgery for toxic thyroid adenoma: dissecting an important decision. A cost-effectiveness analysis.
Vidal-Trecan GM, Stahl JE, Eckman MH
Thyroid 2004 Nov;14(11):933-45. doi: 10.1089/thy.2004.14.933. PMID: 15671772
Gain of function TSH receptor mutations and iodine deficiency: implications in iodine prophylaxis.
Tonacchera M, Vitti P, De Servi M, Agretti P, De Marco G, Chiovato L, Pinchera A
J Endocrinol Invest 2003;26(2 Suppl):2-6. PMID: 12762632
Managing toxic thyroid adenoma: a cost-effectiveness analysis.
Vidal-Trecan GM, Stahl JE, Durand-Zaleski I
Eur J Endocrinol 2002 Mar;146(3):283-94. doi: 10.1530/eje.0.1460283. PMID: 11888833
Postpartum thyroid dysfunction and postpartum depression: are they two linked disorders?
Lucas A, Pizarro E, Granada ML, Salinas I, Sanmartí A
Clin Endocrinol (Oxf) 2001 Dec;55(6):809-14. doi: 10.1046/j.1365-2265.2001.01421.x. PMID: 11895224
Treatment of hyperfunctioning thyroid nodules with percutaneous ethanol injection: Eight years' experience.
Monzani F, Caraccio N, Goletti O, Casolaro A, Lippolis PV, Cavina E, Miccoli P
Exp Clin Endocrinol Diabetes 1998;106 Suppl 4:S54-8. doi: 10.1055/s-0029-1212058. PMID: 9867198

Clinical prediction guides

TREATMENT OF TOXIC THYROID ADENOMA BY THE ETHANOL DESTRUCTION METHOD.
Espenbetova M, Zhumanbayeva Z, Krykpayeva A, Amrenova K, Glushkova N
Georgian Med News 2018 Mar;(276):81-86. PMID: 29697387
Postpartum thyroid dysfunction and postpartum depression: are they two linked disorders?
Lucas A, Pizarro E, Granada ML, Salinas I, Sanmartí A
Clin Endocrinol (Oxf) 2001 Dec;55(6):809-14. doi: 10.1046/j.1365-2265.2001.01421.x. PMID: 11895224
Treatment of hyperfunctioning thyroid nodules with percutaneous ethanol injection: Eight years' experience.
Monzani F, Caraccio N, Goletti O, Casolaro A, Lippolis PV, Cavina E, Miccoli P
Exp Clin Endocrinol Diabetes 1998;106 Suppl 4:S54-8. doi: 10.1055/s-0029-1212058. PMID: 9867198
Constitutively activating TSH receptor mutations as the cause of toxic thyroid adenoma, multinodular toxic goiter and autosomal dominant non autoimmune hyperthyroidism.
Paschke R
Exp Clin Endocrinol Diabetes 1996;104 Suppl 4:129-32. doi: 10.1055/s-0029-1211720. PMID: 8981020
Behavior of soluble intercellular adhesion molecule-1 and endothelial-leukocyte adhesion molecule-1 concentrations in patients with Graves' disease with or without ophthalmopathy and in patients with toxic adenoma.
De Bellis A, Bizzarro A, Gattoni A, Romano C, Di Martino S, Sinisi AA, Abbadessa S, Bellastella A
J Clin Endocrinol Metab 1995 Jul;80(7):2118-21. doi: 10.1210/jcem.80.7.7541801. PMID: 7541801

Recent systematic reviews

Decision-Analytic Modeling Studies in Prevention and Treatment of Iodine Deficiency and Thyroid Disorders: A Systematic Overview.
Rochau U, Qerimi Rushaj V, Schaffner M, Schönhensch M, Stojkov I, Jahn B, Hubalewska-Dydejczyk A, Erlund I, Thuesen BH, Zimmermann M, Moreno-Reyes R, Lazarus JH, Völzke H, Siebert U
Thyroid 2020 May;30(5):746-758. Epub 2020 Feb 26 doi: 10.1089/thy.2018.0776. PMID: 31964247

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