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Erythrophagocytosis

MedGen UID:
86219
•Concept ID:
C0302486
•
Disease or Syndrome
Synonyms: Erythrocytophagy; Erythrophagia
SNOMED CT: Erythrophagocytosis (61070002); Erythrophagia (61070002)

Definition

Erythrophagocytosis; phagocytosis of erythrocytes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVErythrophagocytosis

Professional guidelines

PubMed

Signet-ring cell sinus histiocytosis: report of the clinicopathologic characteristics of 4 cases with emphasis on the differential diagnosis of signet-ring cell lesions.
Argyris PP, Koutlas IG, Wakely PE Jr
Hum Pathol 2023 Sep;139:47-54. Epub 2023 Jul 15 doi: 10.1016/j.humpath.2023.07.006. PMID: 37459900
Pathogenesis and treatment of anaemia of chronic disease.
Weiss G
Blood Rev 2002 Jun;16(2):87-96. doi: 10.1054/blre.2002.0193. PMID: 12127952
The treatment of chronic idiopathic thrombocytopenia with anti-D (Rho) immunoglobulin: its effectiveness, safety and mechanism of action.
Boughton BJ, Chakraverty R, Baglin TP, Simpson A, Galvin G, Rose P, Rohlova B
Clin Lab Haematol 1988;10(3):275-84. doi: 10.1111/j.1365-2257.1988.tb00021.x. PMID: 2846228

Recent clinical studies

Etiology

Reticulocytes in donor blood units enhance red blood cell alloimmunization.
Thomas TA, Qiu A, Kim CY, Gordy DE, Miller A, Tredicine M, Dzieciatkowska M, Dei Zotti F, Hod EA, D'Alessandro A, Zimring JC, Spitalnik SL, Hudson KE
Haematologica 2023 Oct 1;108(10):2639-2651. doi: 10.3324/haematol.2023.282815. PMID: 37078267Free PMC Article
Circulating mitochondrial DNA is associated with anemia in newly diagnosed hematologic malignancies.
Yue L, Li YH, Ma RL, Niu JW, Cui HT, Sun Y, Yun ZM, Zhuo HL, Wan LM, Li SB, Zhang X, Wu CJ, Hu LD, Tan YX
Leuk Lymphoma 2023 Jan;64(1):178-187. Epub 2022 Oct 19 doi: 10.1080/10428194.2022.2133537. PMID: 36260485
Proteomic and Functional Analysis of the Effects of Quinoxaline Derivatives on Entamoeba histolytica.
Avila-Bonilla RG, López-Sandoval Á, Soto-Sánchez J, Marchat LA, Rivera G, Medina-Contreras O, Ramírez-Moreno E
Front Cell Infect Microbiol 2022;12:887647. Epub 2022 Jun 27 doi: 10.3389/fcimb.2022.887647. PMID: 35832378Free PMC Article
Red blood cell storage duration and trauma.
Sparrow RL
Transfus Med Rev 2015 Apr;29(2):120-6. Epub 2014 Dec 18 doi: 10.1016/j.tmrv.2014.09.007. PMID: 25573415
Primary histiocytic dermatoses.
Ringel E, Moschella S
Arch Dermatol 1985 Dec;121(12):1531-41. PMID: 2998286

Diagnosis

Erythrophagocytosis is not a reproducible finding in liver biopsies, and is not associated with clinical diagnosis of hemophagocytic lymphohistiocytosis.
Desai N, Kudose S, Remotti HE, Del Portillo A, Fazlollahi L, Lee MJ, Xiong Y, Moreira RK, Salomao M, Fiel MI, Gonzalez RS, Misdraji J, Gill RM, Hart J, Kleiner DE, Drebber U, Bellizzi AM, Lagana SM
Virchows Arch 2024 Jan;484(1):61-69. Epub 2023 Nov 4 doi: 10.1007/s00428-023-03683-7. PMID: 37924345
Bone marrow haematopoiesis in patients with COVID-19.
Marques-Maggio E, Maccio U, Marx A, Galli S, Schwab N, Frank A, Hamelin B, Varga Z, Nombela-Arrieta C, Mertz KD, Theocharides AP, Koelzer VH
Histopathology 2023 Oct;83(4):582-590. Epub 2023 Jun 14 doi: 10.1111/his.14969. PMID: 37317636
Lupus Erythematosus Tumidus Associated With Hemophagocytosis.
Georgiadou N, Singh S, Singh M
Am J Dermatopathol 2022 Jul 1;44(7):519-522. Epub 2022 Apr 6 doi: 10.1097/DAD.0000000000002188. PMID: 35385850
Pigmented atypical fibroxanthoma.
Diaz-Cascajo C, Borghi S, Bonczkowitz M
Histopathology 1998 Dec;33(6):537-41. doi: 10.1046/j.1365-2559.1998.00567.x. PMID: 9870148
Primary histiocytic dermatoses.
Ringel E, Moschella S
Arch Dermatol 1985 Dec;121(12):1531-41. PMID: 2998286

Therapy

Immunity and reproduction protective effects of Chitosan Oligosaccharides in Cyclophosphamide/Busulfan-induced premature ovarian failure model mice.
Li X, Ye H, Su T, Hu C, Huang Y, Fu X, Zhong Z, Du X, Zheng Y
Front Immunol 2023;14:1185921. Epub 2023 May 9 doi: 10.3389/fimmu.2023.1185921. PMID: 37228612Free PMC Article
Augmenting hematoma-scavenging capacity of innate immune cells by CDNF reduces brain injury and promotes functional recovery after intracerebral hemorrhage.
Tseng KY, Stratoulias V, Hu WF, Wu JS, Wang V, Chen YH, Seelbach A, Huttunen HJ, Kulesskaya N, Pang CY, Chou JL, Lindahl M, Saarma M, Huang LC, Airavaara M, Liew HK
Cell Death Dis 2023 Feb 15;14(2):128. doi: 10.1038/s41419-022-05520-2. PMID: 36792604Free PMC Article
Ligufalimab, a novel anti-CD47 antibody with no hemagglutination demonstrates both monotherapy and combo antitumor activity.
Qu T, Zhong T, Pang X, Huang Z, Jin C, Wang ZM, Li B, Xia Y
J Immunother Cancer 2022 Nov;10(11) doi: 10.1136/jitc-2022-005517. PMID: 36450383Free PMC Article
Haemoglobin scavenging in intracranial bleeding: biology and clinical implications.
Bulters D, Gaastra B, Zolnourian A, Alexander S, Ren D, Blackburn SL, Borsody M, Doré S, Galea J, Iihara K, Nyquist P, Galea I
Nat Rev Neurol 2018 Jul;14(7):416-432. doi: 10.1038/s41582-018-0020-0. PMID: 29925923
Red blood cell storage duration and trauma.
Sparrow RL
Transfus Med Rev 2015 Apr;29(2):120-6. Epub 2014 Dec 18 doi: 10.1016/j.tmrv.2014.09.007. PMID: 25573415

Prognosis

Ligufalimab, a novel anti-CD47 antibody with no hemagglutination demonstrates both monotherapy and combo antitumor activity.
Qu T, Zhong T, Pang X, Huang Z, Jin C, Wang ZM, Li B, Xia Y
J Immunother Cancer 2022 Nov;10(11) doi: 10.1136/jitc-2022-005517. PMID: 36450383Free PMC Article
Erythrophagocytosis in a patient with B-cell acute lymphoblastic leukemia with t(12;21) (p13.2; q22.1); ETV6-RUNX1: Case report and review of the literature.
Sharma S, Gaur K, Srivastav S, Mandal P
Indian J Pathol Microbiol 2022 Jan-Mar;65(1):191-194. doi: 10.4103/IJPM.IJPM_1154_20. PMID: 35074994
Eryptosis in health and disease: A paradigm shift towards understanding the (patho)physiological implications of programmed cell death of erythrocytes.
Qadri SM, Bissinger R, Solh Z, Oldenborg PA
Blood Rev 2017 Nov;31(6):349-361. Epub 2017 Jun 17 doi: 10.1016/j.blre.2017.06.001. PMID: 28669393
Pathogenesis and treatment of anaemia of chronic disease.
Weiss G
Blood Rev 2002 Jun;16(2):87-96. doi: 10.1054/blre.2002.0193. PMID: 12127952
Primary histiocytic dermatoses.
Ringel E, Moschella S
Arch Dermatol 1985 Dec;121(12):1531-41. PMID: 2998286

Clinical prediction guides

Splenic filtration of red blood cells in physiology, malaria and sickle cell disease.
Sissoko A, Othmene YB, Buffet P
Curr Opin Hematol 2024 Nov 1;31(6):307-314. Epub 2024 Aug 26 doi: 10.1097/MOH.0000000000000839. PMID: 39259191
Targeting CEACAM5-positive solid tumors using NILK-2401, a novel CEACAM5xCD47 κλ bispecific antibody.
Seckinger A, Buatois V, Moine V, Daubeuf B, Richard F, Chatel L, Viandier A, Bosson N, Rousset E, Masternak K, Salgado-Pires S, Batista C, Mougin C, Juan-Bégeot F, Poitevin Y, Hose D
Front Immunol 2024;15:1378813. Epub 2024 Apr 24 doi: 10.3389/fimmu.2024.1378813. PMID: 38720892Free PMC Article
High-altitude hypoxia exposure inhibits erythrophagocytosis by inducing macrophage ferroptosis in the spleen.
Yang WP, Li MQ, Ding J, Li JY, Wu G, Liu B, Gao YQ, Wang GH, Luo QQ
Elife 2024 Apr 17;12 doi: 10.7554/eLife.87496. PMID: 38629942Free PMC Article
Bone marrow haematopoiesis in patients with COVID-19.
Marques-Maggio E, Maccio U, Marx A, Galli S, Schwab N, Frank A, Hamelin B, Varga Z, Nombela-Arrieta C, Mertz KD, Theocharides AP, Koelzer VH
Histopathology 2023 Oct;83(4):582-590. Epub 2023 Jun 14 doi: 10.1111/his.14969. PMID: 37317636
Immunity and reproduction protective effects of Chitosan Oligosaccharides in Cyclophosphamide/Busulfan-induced premature ovarian failure model mice.
Li X, Ye H, Su T, Hu C, Huang Y, Fu X, Zhong Z, Du X, Zheng Y
Front Immunol 2023;14:1185921. Epub 2023 May 9 doi: 10.3389/fimmu.2023.1185921. PMID: 37228612Free PMC Article

Recent systematic reviews

Haemophagocytic syndrome in rheumatic patients. A systematic review.
Atteritano M, David A, Bagnato G, Beninati C, Frisina A, Iaria C, Bagnato G, Cascio A
Eur Rev Med Pharmacol Sci 2012 Oct;16(10):1414-24. PMID: 23104659
Secondary hemophagocytic lymphohistiocytosis in zoonoses. A systematic review.
Cascio A, Pernice LM, Barberi G, Delfino D, Biondo C, Beninati C, Mancuso G, Rodriguez-Morales AJ, Iaria C
Eur Rev Med Pharmacol Sci 2012 Oct;16(10):1324-37. PMID: 23104648

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