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Adult Cholangiocarcinoma

MedGen UID:
128878
•Concept ID:
C0280725
•
Neoplastic Process
Synonyms: Adult Primary Cholangiocarcinoma; Adult Primary Cholangiocellular Carcinoma

Definition

A cholangiocarcinoma occurring in adults. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult Cholangiocarcinoma

Professional guidelines

PubMed

A Nationwide Study of GATA2 Deficiency in Italy Reveals Novel Symptoms and Genotype-phenotype Association.
Roncareggi S, Girardi K, Fioredda F, Pedace L, Arcuri L, Badolato R, Bonanomi S, Borlenghi E, Cirillo E, Coliva T, Consonni F, Conti F, Farruggia P, Gambineri E, Guerra F, Locatelli F, Mancuso G, Marzollo A, Masetti R, Micalizzi C, Onofrillo D, Piccini M, Pignata C, Raddi MG, Santini V, Vendemini F, Biondi A, Saettini F
J Clin Immunol 2023 Nov;43(8):2192-2207. Epub 2023 Oct 14 doi: 10.1007/s10875-023-01583-8. PMID: 37837580
Endoscopic management and clinical outcomes of obstructive jaundice.
Alatise OI, Owojuyigbe AM, Omisore AD, Ndububa DA, Aburime E, Dua KS, Asombang AW
Niger Postgrad Med J 2020 Oct-Dec;27(4):302-310. doi: 10.4103/npmj.npmj_242_20. PMID: 33154282
A Clinical Review of Primary Biliary Cholangitis.
Pullen R
Gastroenterol Nurs 2020 Mar/Apr;43(2):E48-E55. doi: 10.1097/SGA.0000000000000480. PMID: 32251226

Recent clinical studies

Etiology

Histological evaluation in biliary diseases.
Saffioti F, Vieira Motta R, Quaglia A
Curr Opin Gastroenterol 2023 Mar 1;39(2):75-82. Epub 2023 Jan 4 doi: 10.1097/MOG.0000000000000908. PMID: 36821454
Postoperative adjuvant chemotherapy for resectable cholangiocarcinoma.
Luvira V, Satitkarnmanee E, Pugkhem A, Kietpeerakool C, Lumbiganon P, Pattanittum P
Cochrane Database Syst Rev 2021 Sep 13;9(9):CD012814. doi: 10.1002/14651858.CD012814.pub2. PMID: 34515993Free PMC Article
Cholangiocarcinoma: Treatment, Outcomes, and Nutrition Overview for Oncology Nurses.
Acquisto S, Iyer R, Rosati LM, Pinheirn N, Driskill K, Musto K, Lowitzer H, Bradley E, Drapek L
Clin J Oncol Nurs 2018 Aug 1;22(4):E97-E102. doi: 10.1188/18.CJON.E97-E102. PMID: 30035775
 Intrahepatic, perihilar and distal cholangiocarcinoma: Management and outcomes.
Waseem D, Tushar P
Ann Hepatol 2017 Jan-Feb 2017;16(1):133-139. doi: 10.5604/16652681.1226927. PMID: 28051802Free PMC Article
Intrahepatic cholangiocarcinoma: new insights in pathology.
Sempoux C, Jibara G, Ward SC, Fan C, Qin L, Roayaie S, Fiel MI, Schwartz M, Thung SN
Semin Liver Dis 2011 Feb;31(1):49-60. Epub 2011 Feb 22 doi: 10.1055/s-0031-1272839. PMID: 21344350

Diagnosis

Histological evaluation in biliary diseases.
Saffioti F, Vieira Motta R, Quaglia A
Curr Opin Gastroenterol 2023 Mar 1;39(2):75-82. Epub 2023 Jan 4 doi: 10.1097/MOG.0000000000000908. PMID: 36821454
Infigratinib for cholangiocarcinoma.
Sadeghi S
Drugs Today (Barc) 2022 Jul;58(7):327-334. doi: 10.1358/dot.2022.58.7.3408813. PMID: 35851868
CircNFIB inhibits tumor growth and metastasis through suppressing MEK1/ERK signaling in intrahepatic cholangiocarcinoma.
Du J, Lan T, Liao H, Feng X, Chen X, Liao W, Hou G, Xu L, Feng Q, Xie K, Liao M, Chen X, Huang J, Yuan K, Zeng Y
Mol Cancer 2022 Jan 17;21(1):18. doi: 10.1186/s12943-021-01482-9. PMID: 35039066Free PMC Article
Diagnosis of cholangiocarcinoma in primary sclerosing cholangitis.
Taghavi SA, Eshraghian A, Niknam R, Sivandzadeh GR, Bagheri Lankarani K
Expert Rev Gastroenterol Hepatol 2018 Jun;12(6):575-584. Epub 2018 May 21 doi: 10.1080/17474124.2018.1473761. PMID: 29781738
Intrahepatic cholangiocarcinoma.
Nakano M, Ariizumi SI, Yamamoto M
Semin Diagn Pathol 2017 Mar;34(2):160-166. Epub 2017 Jan 5 doi: 10.1053/j.semdp.2016.12.012. PMID: 28094162

Therapy

Infigratinib for cholangiocarcinoma.
Sadeghi S
Drugs Today (Barc) 2022 Jul;58(7):327-334. doi: 10.1358/dot.2022.58.7.3408813. PMID: 35851868
Final Overall Survival Efficacy Results of Ivosidenib for Patients With Advanced Cholangiocarcinoma With IDH1 Mutation: The Phase 3 Randomized Clinical ClarIDHy Trial.
Zhu AX, Macarulla T, Javle MM, Kelley RK, Lubner SJ, Adeva J, Cleary JM, Catenacci DVT, Borad MJ, Bridgewater JA, Harris WP, Murphy AG, Oh DY, Whisenant JR, Lowery MA, Goyal L, Shroff RT, El-Khoueiry AB, Chamberlain CX, Aguado-Fraile E, Choe S, Wu B, Liu H, Gliser C, Pandya SS, Valle JW, Abou-Alfa GK
JAMA Oncol 2021 Nov 1;7(11):1669-1677. doi: 10.1001/jamaoncol.2021.3836. PMID: 34554208Free PMC Article
Patient-Derived Organoids of Cholangiocarcinoma.
Maier CF, Zhu L, Nanduri LK, Kühn D, Kochall S, Thepkaysone ML, William D, Grützmann K, Klink B, Betge J, Weitz J, Rahbari NN, Reißfelder C, Schölch S
Int J Mol Sci 2021 Aug 12;22(16) doi: 10.3390/ijms22168675. PMID: 34445380Free PMC Article
Ivosidenib in IDH1-mutant, chemotherapy-refractory cholangiocarcinoma (ClarIDHy): a multicentre, randomised, double-blind, placebo-controlled, phase 3 study.
Abou-Alfa GK, Macarulla T, Javle MM, Kelley RK, Lubner SJ, Adeva J, Cleary JM, Catenacci DV, Borad MJ, Bridgewater J, Harris WP, Murphy AG, Oh DY, Whisenant J, Lowery MA, Goyal L, Shroff RT, El-Khoueiry AB, Fan B, Wu B, Chamberlain CX, Jiang L, Gliser C, Pandya SS, Valle JW, Zhu AX
Lancet Oncol 2020 Jun;21(6):796-807. Epub 2020 May 13 doi: 10.1016/S1470-2045(20)30157-1. PMID: 32416072Free PMC Article
Comprehensive Molecular Profiling of Intrahepatic and Extrahepatic Cholangiocarcinomas: Potential Targets for Intervention.
Lowery MA, Ptashkin R, Jordan E, Berger MF, Zehir A, Capanu M, Kemeny NE, O'Reilly EM, El-Dika I, Jarnagin WR, Harding JJ, D'Angelica MI, Cercek A, Hechtman JF, Solit DB, Schultz N, Hyman DM, Klimstra DS, Saltz LB, Abou-Alfa GK
Clin Cancer Res 2018 Sep 1;24(17):4154-4161. Epub 2018 May 30 doi: 10.1158/1078-0432.CCR-18-0078. PMID: 29848569Free PMC Article

Prognosis

Surgery for cholangiocarcinoma.
Oliverius M, Havlůj L, Hajer J, Soumarová R, Hrudka J, Gürlich R
Cas Lek Cesk 2019 Spring;158(2):73-77. PMID: 31109167
Cholangiocarcinoma Prognosis Varies over Time Depending on Tumor Site and Pathology.
Kaneko R, Sato Y, Kobayashi Y
J Gastrointestin Liver Dis 2018 Mar;27(1):59-66. doi: 10.15403/jgld.2014.1121.271.kak. PMID: 29557416
Overall Survival and Clinical Characteristics of BRCA-Associated Cholangiocarcinoma: A Multicenter Retrospective Study.
Golan T, Raitses-Gurevich M, Kelley RK, Bocobo AG, Borgida A, Shroff RT, Holter S, Gallinger S, Ahn DH, Aderka D, Apurva J, Bekaii-Saab T, Friedman E, Javle M
Oncologist 2017 Jul;22(7):804-810. Epub 2017 May 9 doi: 10.1634/theoncologist.2016-0415. PMID: 28487467Free PMC Article
Multi-Institutional Phase II Study of High-Dose Hypofractionated Proton Beam Therapy in Patients With Localized, Unresectable Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma.
Hong TS, Wo JY, Yeap BY, Ben-Josef E, McDonnell EI, Blaszkowsky LS, Kwak EL, Allen JN, Clark JW, Goyal L, Murphy JE, Javle MM, Wolfgang JA, Drapek LC, Arellano RS, Mamon HJ, Mullen JT, Yoon SS, Tanabe KK, Ferrone CR, Ryan DP, DeLaney TF, Crane CH, Zhu AX
J Clin Oncol 2016 Feb 10;34(5):460-8. Epub 2015 Dec 14 doi: 10.1200/JCO.2015.64.2710. PMID: 26668346Free PMC Article
Intrahepatic sarcomatoid cholangiocarcinoma.
Kaibori M, Kawaguchi Y, Yokoigawa N, Yanagida H, Takai S, Kwon AH, Uemura Y, Kamiyama Y
J Gastroenterol 2003;38(11):1097-101. doi: 10.1007/s00535-003-1203-y. PMID: 14673730

Clinical prediction guides

Histological evaluation in biliary diseases.
Saffioti F, Vieira Motta R, Quaglia A
Curr Opin Gastroenterol 2023 Mar 1;39(2):75-82. Epub 2023 Jan 4 doi: 10.1097/MOG.0000000000000908. PMID: 36821454
CircNFIB inhibits tumor growth and metastasis through suppressing MEK1/ERK signaling in intrahepatic cholangiocarcinoma.
Du J, Lan T, Liao H, Feng X, Chen X, Liao W, Hou G, Xu L, Feng Q, Xie K, Liao M, Chen X, Huang J, Yuan K, Zeng Y
Mol Cancer 2022 Jan 17;21(1):18. doi: 10.1186/s12943-021-01482-9. PMID: 35039066Free PMC Article
Distribution and density of tertiary lymphoid structures predict clinical outcome in intrahepatic cholangiocarcinoma.
Ding GY, Ma JQ, Yun JP, Chen X, Ling Y, Zhang S, Shi JY, Chang YQ, Ji Y, Wang XY, Tan WM, Yuan KF, Yan B, Zhang XM, Liang F, Zhou J, Fan J, Zeng Y, Cai MY, Gao Q
J Hepatol 2022 Mar;76(3):608-618. Epub 2021 Nov 15 doi: 10.1016/j.jhep.2021.10.030. PMID: 34793865
Notch Signaling Pathway in Pancreatobiliary Tumors.
Borlak F, Reutzel-Selke A, Schirmeier A, Gogolok J, von Hoerschelmann E, Sauer IM, Pratschke J, Bahra M, Schmuck RB
Medicina (Kaunas) 2021 Jan 24;57(2) doi: 10.3390/medicina57020105. PMID: 33498866Free PMC Article
Intrahepatic Cholangiocarcinoma.
Padia SA
Tech Vasc Interv Radiol 2015 Dec;18(4):227-35. Epub 2015 Jul 15 doi: 10.1053/j.tvir.2015.07.006. PMID: 26615163

Recent systematic reviews

Systematic review of cholangiocarcinoma in Africa: epidemiology, management, and clinical outcomes.
Asombang AW, Chishinga N, Mohamed MF, Nkhoma A, Chipaila J, Nsokolo B, Manda-Mapalo M, Montiero JFG, Banda L, Dua KS
BMC Gastroenterol 2023 Mar 11;23(1):66. doi: 10.1186/s12876-023-02687-6. PMID: 36906562Free PMC Article
Postoperative adjuvant chemotherapy for resectable cholangiocarcinoma.
Luvira V, Satitkarnmanee E, Pugkhem A, Kietpeerakool C, Lumbiganon P, Pattanittum P
Cochrane Database Syst Rev 2021 Sep 13;9(9):CD012814. doi: 10.1002/14651858.CD012814.pub2. PMID: 34515993Free PMC Article
A pooled analysis of combined liver and inferior vena cava resection for hepatic malignancy.
Zhou Y, Wu L, Xu D, Wan T, Si X
HPB (Oxford) 2017 Sep;19(9):768-774. Epub 2017 Jun 20 doi: 10.1016/j.hpb.2017.05.008. PMID: 28645571
Success of photodynamic therapy in palliating patients with nonresectable cholangiocarcinoma: A systematic review and meta-analysis.
Moole H, Tathireddy H, Dharmapuri S, Moole V, Boddireddy R, Yedama P, Dharmapuri S, Uppu A, Bondalapati N, Duvvuri A
World J Gastroenterol 2017 Feb 21;23(7):1278-1288. doi: 10.3748/wjg.v23.i7.1278. PMID: 28275308Free PMC Article
Non-hepatocellular carcinoma spinal metastases.
Goodwin CR, Abu-Bonsrah N, Boone C, Ruiz-Valls A, Sankey EW, Sarabia-Estrada R, Elder BD, Kosztowski T, Sciubba DM
J Clin Neurosci 2016 May;27:22-7. Epub 2016 Jan 8 doi: 10.1016/j.jocn.2015.11.003. PMID: 26778049

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