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Thymoma type B3

MedGen UID:
124648
•Concept ID:
C0279705
•
Neoplastic Process
Synonyms: Atypical Thymoma; atypical thymoma; Epithelial Malignant Thymoma; epithelial malignant thymoma; Epithelial Thymoma; epithelial thymoma; Malignant Thymoma Type B3; malignant thymoma type B3; Squamoid Thymoma; squamoid thymoma; Thymoma Type B3; thymoma type B3; Thymoma, atypical, malignant; thymoma, epithelial; Thymoma, epithelial, malignant; Thymoma, type B3, malignant; Well differentiated thymic carcinoma; Well Differentiated Thymic Carcinoma; well differentiated thymic carcinoma; Well-Differentiated Thymic Carcinoma; well-differentiated thymic carcinoma
SNOMED CT: Well differentiated thymic carcinoma (128716004); Thymoma, epithelial, malignant (128716004); Thymoma, atypical, malignant (128716004); Thymoma, type B3, malignant (128716004)
 
Monarch Initiative: MONDO:0006458

Definition

Also known as well-differentiated thymic carcinoma, atypical thymoma, or epithelial thymoma, this type of thymoma displays morphologic characteristics of a well-differentiated carcinoma. The majority of cases occur in the anterior mediastinum as Masaoka stage II or stage III tumors. It is almost always invasive, it recurs frequently, and metastasizes in approximately 20% of the cases. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThymoma type B3

Professional guidelines

PubMed

Systemic treatment of advanced thymic malignancies.
Kelly RJ
Am Soc Clin Oncol Educ Book 2014:e367-73. doi: 10.14694/EdBook_AM.2014.34.e367. PMID: 24857125
Outcome of multimodality treatment for 188 cases of type B3 thymoma.
Gao L, Wang C, Fang W, Zhang J, Lv C, Fu S
J Thorac Oncol 2013 Oct;8(10):1329-34. doi: 10.1097/JTO.0b013e31829ceb50. PMID: 24457243
Thymoma versus thymic carcinoma: differences in biology impacting treatment.
Kelly RJ
J Natl Compr Canc Netw 2013 May 1;11(5):577-83. doi: 10.6004/jnccn.2013.0073. PMID: 23667207

Recent clinical studies

Etiology

FDG PET-CT aids in the preoperative assessment of patients with newly diagnosed thymic epithelial malignancies.
Benveniste MF, Moran CA, Mawlawi O, Fox PS, Swisher SG, Munden RF, Marom EM
J Thorac Oncol 2013 Apr;8(4):502-10. doi: 10.1097/JTO.0b013e3182835549. PMID: 23446204Free PMC Article

Diagnosis

Invasive thymoma presenting as classic superior vena cava syndrome: a case of venous spread metastasis.
Panda PK, Wig N, Kumar S, Arava S
BMJ Case Rep 2016 Oct 26;2016 doi: 10.1136/bcr-2016-217695. PMID: 27797848Free PMC Article
FDG PET-CT aids in the preoperative assessment of patients with newly diagnosed thymic epithelial malignancies.
Benveniste MF, Moran CA, Mawlawi O, Fox PS, Swisher SG, Munden RF, Marom EM
J Thorac Oncol 2013 Apr;8(4):502-10. doi: 10.1097/JTO.0b013e3182835549. PMID: 23446204Free PMC Article
Immunohistochemical differential diagnosis between thymic carcinoma and type B3 thymoma: diagnostic utility of hypoxic marker, GLUT-1, in thymic epithelial neoplasms.
Kojika M, Ishii G, Yoshida J, Nishimura M, Hishida T, Ota SJ, Murata Y, Nagai K, Ochiai A
Mod Pathol 2009 Oct;22(10):1341-50. Epub 2009 Jul 31 doi: 10.1038/modpathol.2009.105. PMID: 19648882
Refractory recurrent thymoma successfully treated with long-acting somatostatin analogue and prednisolone.
Ito J, Sekiya M, Miura K, Yoshimi K, Suzuki T, Seyama K, Izumi H, Uekusa T, Takahashi K
Intern Med 2009;48(12):1061-4. Epub 2009 Jun 15 doi: 10.2169/internalmedicine.48.1922. PMID: 19525599
Spontaneous regression of an invasive thymoma.
Yutaka Y, Omasa M, Shikuma K, Okuda M, Taki T
Gen Thorac Cardiovasc Surg 2009 May;57(5):272-4. Epub 2009 May 15 doi: 10.1007/s11748-008-0366-0. PMID: 19440828

Therapy

Refractory recurrent thymoma successfully treated with long-acting somatostatin analogue and prednisolone.
Ito J, Sekiya M, Miura K, Yoshimi K, Suzuki T, Seyama K, Izumi H, Uekusa T, Takahashi K
Intern Med 2009;48(12):1061-4. Epub 2009 Jun 15 doi: 10.2169/internalmedicine.48.1922. PMID: 19525599

Prognosis

FDG PET-CT aids in the preoperative assessment of patients with newly diagnosed thymic epithelial malignancies.
Benveniste MF, Moran CA, Mawlawi O, Fox PS, Swisher SG, Munden RF, Marom EM
J Thorac Oncol 2013 Apr;8(4):502-10. doi: 10.1097/JTO.0b013e3182835549. PMID: 23446204Free PMC Article
Immunohistochemical differential diagnosis between thymic carcinoma and type B3 thymoma: diagnostic utility of hypoxic marker, GLUT-1, in thymic epithelial neoplasms.
Kojika M, Ishii G, Yoshida J, Nishimura M, Hishida T, Ota SJ, Murata Y, Nagai K, Ochiai A
Mod Pathol 2009 Oct;22(10):1341-50. Epub 2009 Jul 31 doi: 10.1038/modpathol.2009.105. PMID: 19648882

Clinical prediction guides

FDG PET-CT aids in the preoperative assessment of patients with newly diagnosed thymic epithelial malignancies.
Benveniste MF, Moran CA, Mawlawi O, Fox PS, Swisher SG, Munden RF, Marom EM
J Thorac Oncol 2013 Apr;8(4):502-10. doi: 10.1097/JTO.0b013e3182835549. PMID: 23446204Free PMC Article
Immunohistochemical differential diagnosis between thymic carcinoma and type B3 thymoma: diagnostic utility of hypoxic marker, GLUT-1, in thymic epithelial neoplasms.
Kojika M, Ishii G, Yoshida J, Nishimura M, Hishida T, Ota SJ, Murata Y, Nagai K, Ochiai A
Mod Pathol 2009 Oct;22(10):1341-50. Epub 2009 Jul 31 doi: 10.1038/modpathol.2009.105. PMID: 19648882

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