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Esophageal squamous cell carcinoma

MedGen UID:
124635
Concept ID:
C0279626
Neoplastic Process
Synonyms: Esophageal Squamous Cell Carcinoma; Oesophageal Squamous Cell Carcinoma
SNOMED CT: Squamous cell carcinoma of esophagus (276804009); SCC - Squamous cell carcinoma of esophagus (276804009)
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
Concept ID:
C0600599
Genetic Function
Source: Orphanet
A mode of inheritance that depends on genetic determinants in more than one gene.
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0005580
Orphanet: ORPHA99977

Definition

Esophageal squamous cell carcinoma (ESCC) is a type of esophageal carcinoma (EC; see this term) that can affect any part of the esophagus, but is usually located in the upper or middle third. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Esophageal squamous cell carcinoma

Professional guidelines

PubMed

Deboever N, Jones CM, Yamashita K, Ajani JA, Hofstetter WL
BMJ 2024 Jun 3;385:e074962. doi: 10.1136/bmj-2023-074962. PMID: 38830686
Shah MA, Kennedy EB, Alarcon-Rozas AE, Alcindor T, Bartley AN, Malowany AB, Bhadkamkar NA, Deighton DC, Janjigian Y, Karippot A, Khan U, King DA, Klute K, Lacy J, Lee JJ, Mehta R, Mukherjee S, Nagarajan A, Park H, Saeed A, Semrad TJ, Shitara K, Smyth E, Uboha NV, Vincelli M, Wainberg Z, Rajdev L
J Clin Oncol 2023 Mar 1;41(7):1470-1491. Epub 2023 Jan 5 doi: 10.1200/JCO.22.02331. PMID: 36603169
Waters JK, Reznik SI
Curr Oncol Rep 2022 Mar;24(3):375-385. Epub 2022 Feb 10 doi: 10.1007/s11912-021-01153-4. PMID: 35142974

Recent clinical studies

Etiology

Chiang HC, Hughes M, Chang WL
Thorac Cancer 2023 Oct;14(28):2821-2829. Epub 2023 Sep 7 doi: 10.1111/1759-7714.15096. PMID: 37675608Free PMC Article
Puhr HC, Prager GW, Ilhan-Mutlu A
ESMO Open 2023 Feb;8(1):100789. Epub 2023 Feb 13 doi: 10.1016/j.esmoop.2023.100789. PMID: 36791637Free PMC Article
Codipilly DC, Wang KK
Gastroenterol Clin North Am 2022 Sep;51(3):457-484. Epub 2022 Aug 29 doi: 10.1016/j.gtc.2022.06.005. PMID: 36153105
Waters JK, Reznik SI
Curr Oncol Rep 2022 Mar;24(3):375-385. Epub 2022 Feb 10 doi: 10.1007/s11912-021-01153-4. PMID: 35142974
Batra R, Malhotra GK, Singh S, Are C
Surg Clin North Am 2019 Jun;99(3):529-541. Epub 2019 Mar 27 doi: 10.1016/j.suc.2019.02.006. PMID: 31047040

Diagnosis

Deboever N, Jones CM, Yamashita K, Ajani JA, Hofstetter WL
BMJ 2024 Jun 3;385:e074962. doi: 10.1136/bmj-2023-074962. PMID: 38830686
Codipilly DC, Wang KK
Gastroenterol Clin North Am 2022 Sep;51(3):457-484. Epub 2022 Aug 29 doi: 10.1016/j.gtc.2022.06.005. PMID: 36153105
Li B, Ren MY, Chen YZ, Meng YQ, Song TN, Su ZP, Yang B
J Gene Med 2022 Aug;24(8):e3441. Epub 2022 Aug 1 doi: 10.1002/jgm.3441. PMID: 35840542
Waters JK, Reznik SI
Curr Oncol Rep 2022 Mar;24(3):375-385. Epub 2022 Feb 10 doi: 10.1007/s11912-021-01153-4. PMID: 35142974
Harada K, Rogers JE, Iwatsuki M, Yamashita K, Baba H, Ajani JA
F1000Res 2020;9 Epub 2020 Oct 1 doi: 10.12688/f1000research.22926.1. PMID: 33042518Free PMC Article

Therapy

Liu Z, Zhao Y, Kong P, Liu Y, Huang J, Xu E, Wei W, Li G, Cheng X, Xue L, Li Y, Chen H, Wei S, Sun R, Cui H, Meng Y, Liu M, Li Y, Feng R, Yu X, Zhu R, Wu Y, Li L, Yang B, Ma Y, Wang J, Zhu W, Deng D, Xi Y, Wang F, Li H, Guo S, Zhuang X, Wang X, Jiao Y, Cui Y, Zhan Q
Cancer Cell 2023 Jan 9;41(1):181-195.e9. Epub 2022 Dec 29 doi: 10.1016/j.ccell.2022.12.004. PMID: 36584672
Shen L, Kato K, Kim SB, Ajani JA, Zhao K, He Z, Yu X, Shu Y, Luo Q, Wang J, Chen Z, Niu Z, Zhang L, Yi T, Sun JM, Chen J, Yu G, Lin CY, Hara H, Bi Q, Satoh T, Pazo-Cid R, Arkenau HT, Borg C, Lordick F, Li L, Ding N, Tao A, Shi J, Van Cutsem E; RATIONALE-302 Investigators
J Clin Oncol 2022 Sep 10;40(26):3065-3076. Epub 2022 Apr 20 doi: 10.1200/JCO.21.01926. PMID: 35442766Free PMC Article
Wang ZX, Cui C, Yao J, Zhang Y, Li M, Feng J, Yang S, Fan Y, Shi J, Zhang X, Shen L, Shu Y, Wang C, Dai T, Mao T, Chen L, Guo Z, Liu B, Pan H, Cang S, Jiang Y, Wang J, Ye M, Chen Z, Jiang D, Lin Q, Ren W, Wang J, Wu L, Xu Y, Miao Z, Sun M, Xie C, Liu Y, Wang Q, Zhao L, Li Q, Huang C, Jiang K, Yang K, Li D, Liu Y, Zhu Z, Chen R, Jia L, Li W, Liao W, Liu HX, Ma D, Ma J, Qin Y, Shi Z, Wei Q, Xiao K, Zhang Y, Zhang Y, Chen X, Dai G, He J, Li J, Li G, Liu Y, Liu Z, Yuan X, Zhang J, Fu Z, He Y, Ju F, Liu Z, Tang P, Wang T, Wang W, Zhang J, Luo X, Tang X, May R, Feng H, Yao S, Keegan P, Xu RH, Wang F
Cancer Cell 2022 Mar 14;40(3):277-288.e3. Epub 2022 Mar 3 doi: 10.1016/j.ccell.2022.02.007. PMID: 35245446
Doki Y, Ajani JA, Kato K, Xu J, Wyrwicz L, Motoyama S, Ogata T, Kawakami H, Hsu CH, Adenis A, El Hajbi F, Di Bartolomeo M, Braghiroli MI, Holtved E, Ostoich SA, Kim HR, Ueno M, Mansoor W, Yang WC, Liu T, Bridgewater J, Makino T, Xynos I, Liu X, Lei M, Kondo K, Patel A, Gricar J, Chau I, Kitagawa Y; CheckMate 648 Trial Investigators
N Engl J Med 2022 Feb 3;386(5):449-462. doi: 10.1056/NEJMoa2111380. PMID: 35108470
Luo H, Lu J, Bai Y, Mao T, Wang J, Fan Q, Zhang Y, Zhao K, Chen Z, Gao S, Li J, Fu Z, Gu K, Liu Z, Wu L, Zhang X, Feng J, Niu Z, Ba Y, Zhang H, Liu Y, Zhang L, Min X, Huang J, Cheng Y, Wang D, Shen Y, Yang Q, Zou J, Xu RH; ESCORT-1st Investigators
JAMA 2021 Sep 14;326(10):916-925. doi: 10.1001/jama.2021.12836. PMID: 34519801Free PMC Article

Prognosis

Morgan E, Soerjomataram I, Rumgay H, Coleman HG, Thrift AP, Vignat J, Laversanne M, Ferlay J, Arnold M
Gastroenterology 2022 Sep;163(3):649-658.e2. Epub 2022 Jun 4 doi: 10.1053/j.gastro.2022.05.054. PMID: 35671803
Hulshof MCCM, Geijsen ED, Rozema T, Oppedijk V, Buijsen J, Neelis KJ, Nuyttens JJME, van der Sangen MJC, Jeene PM, Reinders JG, van Berge Henegouwen MI, Thano A, van Hooft JE, van Laarhoven HWM, van der Gaast A
J Clin Oncol 2021 Sep 1;39(25):2816-2824. Epub 2021 Jun 8 doi: 10.1200/JCO.20.03697. PMID: 34101496
Li C, Zhao S, Zheng Y, Han Y, Chen X, Cheng Z, Wu Y, Feng X, Qi W, Chen K, Xiang J, Li J, Lerut T, Li H
Eur J Cancer 2021 Feb;144:232-241. Epub 2020 Dec 26 doi: 10.1016/j.ejca.2020.11.039. PMID: 33373868
Lam AK
Methods Mol Biol 2020;2129:1-6. doi: 10.1007/978-1-0716-0377-2_1. PMID: 32056165
Ando N, Kato H, Igaki H, Shinoda M, Ozawa S, Shimizu H, Nakamura T, Yabusaki H, Aoyama N, Kurita A, Ikeda K, Kanda T, Tsujinaka T, Nakamura K, Fukuda H
Ann Surg Oncol 2012 Jan;19(1):68-74. Epub 2011 Aug 31 doi: 10.1245/s10434-011-2049-9. PMID: 21879261

Clinical prediction guides

Chen M, Wang H, Huang Y, Guo F, Zheng W, Chen C, Zheng B
World J Surg Oncol 2023 Oct 9;21(1):315. doi: 10.1186/s12957-023-03211-6. PMID: 37814273Free PMC Article
Li H, Miao Y, Zhong L, Feng S, Xu Y, Tang L, Wu C, Zhang X, Gu L, Diao H, Wang H, Wen Z, Yang M
Front Immunol 2023;14:1162032. Epub 2023 Apr 28 doi: 10.3389/fimmu.2023.1162032. PMID: 37187751Free PMC Article
Yap DWT, Leone AG, Wong NZH, Zhao JJ, Tey JCS, Sundar R, Pietrantonio F
JAMA Oncol 2023 Feb 1;9(2):215-224. doi: 10.1001/jamaoncol.2022.5816. PMID: 36480211Free PMC Article
Matsuda S, Kitagawa Y, Takemura R, Okui J, Okamura A, Kawakubo H, Muto M, Kakeji Y, Takeuchi H, Watanabe M, Doki Y
Ann Surg 2023 Jul 1;278(1):e35-e42. Epub 2022 Jul 15 doi: 10.1097/SLA.0000000000005533. PMID: 35837977
Domper Arnal MJ, Ferrández Arenas Á, Lanas Arbeloa Á
World J Gastroenterol 2015 Jul 14;21(26):7933-43. doi: 10.3748/wjg.v21.i26.7933. PMID: 26185366Free PMC Article

Recent systematic reviews

Li H, Zhang L, Yang F, Zhao R, Li X, Li H
Front Immunol 2023;14:1218386. Epub 2023 Sep 29 doi: 10.3389/fimmu.2023.1218386. PMID: 37841249Free PMC Article
Shah MA, Kennedy EB, Alarcon-Rozas AE, Alcindor T, Bartley AN, Malowany AB, Bhadkamkar NA, Deighton DC, Janjigian Y, Karippot A, Khan U, King DA, Klute K, Lacy J, Lee JJ, Mehta R, Mukherjee S, Nagarajan A, Park H, Saeed A, Semrad TJ, Shitara K, Smyth E, Uboha NV, Vincelli M, Wainberg Z, Rajdev L
J Clin Oncol 2023 Mar 1;41(7):1470-1491. Epub 2023 Jan 5 doi: 10.1200/JCO.22.02331. PMID: 36603169
Ge F, Huo Z, Cai X, Hu Q, Chen W, Lin G, Zhong R, You Z, Wang R, Lu Y, Wang R, Huang Q, Zhang H, Song A, Li C, Wen Y, Jiang Y, Liang H, He J, Liang W, Liu J
JAMA Netw Open 2022 Nov 1;5(11):e2239778. doi: 10.1001/jamanetworkopen.2022.39778. PMID: 36322089Free PMC Article
Wong MCS, Deng Y, Huang J, Bai Y, Wang HHX, Yuan J, Zhang L, Yip HC, Chiu PWY
Gastrointest Endosc 2022 Aug;96(2):197-207.e34. Epub 2022 Apr 9 doi: 10.1016/j.gie.2022.04.005. PMID: 35413332
Wang C, Wang J, Chen Z, Gao Y, He J
Chin J Cancer 2017 Aug 17;36(1):65. doi: 10.1186/s40880-017-0232-5. PMID: 28818096Free PMC Article

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