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Recurrent Anal Canal Carcinoma

MedGen UID:
82941
•Concept ID:
C0278556
•
Neoplastic Process
Synonyms: Recurrent Anal Canal Cancer; Recurrent Anal Cancer

Definition

The reemergence of anal carcinoma after a period of remission. [from NCI]

Professional guidelines

PubMed

Management of Localized and Locally Advanced Anal Cancer.
Stapler SJ, Gunnells DJ Jr, Hollis RH
Surg Oncol Clin N Am 2025 Jan;34(1):59-67. doi: 10.1016/j.soc.2024.07.009. PMID: 39547769
Anal Carcinoma, Version 2.2023, NCCN Clinical Practice Guidelines in Oncology.
Benson AB, Venook AP, Al-Hawary MM, Azad N, Chen YJ, Ciombor KK, Cohen S, Cooper HS, Deming D, Garrido-Laguna I, Grem JL, Hecht JR, Hoffe S, Hubbard J, Hunt S, Hussan H, Jeck W, Johung KL, Joseph N, Kirilcuk N, Krishnamurthi S, Maratt J, Messersmith WA, Meyerhardt J, Miller ED, Mulcahy MF, Nurkin S, Overman MJ, Parikh A, Patel H, Pedersen K, Saltz L, Schneider C, Shibata D, Skibber JM, Sofocleous CT, Stotsky-Himelfarb E, Tavakkoli A, Willett CG, Williams G, Algieri F, Gurski L, Stehman K
J Natl Compr Canc Netw 2023 Jun;21(6):653-677. doi: 10.6004/jnccn.2023.0030. PMID: 37308125
The Role of Immunotherapy in the Treatment of Anal Cancer and Future Strategies.
Jácome AA, Morris VK, Eng C
Curr Treat Options Oncol 2022 Aug;23(8):1073-1085. Epub 2022 Jun 6 doi: 10.1007/s11864-022-00939-3. PMID: 35666353

Recent clinical studies

Etiology

Management of inguinal lymph node metastases from rectal and anal canal adenocarcinoma.
Sato H, Maeda K, Kinugasa Y, Kagawa H, Tsukamoto S, Takahashi K, Nozawa H, Takii Y, Konishi T, Akagi Y, Suto T, Yamaguchi S, Ozawa H, Komori K, Ohue M, Hiro J, Shinji S, Minami K, Shimizu T, Sakamoto K, Uehara K, Takahashi H, Sugihara K
Colorectal Dis 2022 Oct;24(10):1150-1163. Epub 2022 May 26 doi: 10.1111/codi.16169. PMID: 35505622
Definitive chemoradiotherapy for anal canal cancer: single-center experience.
Tachibana I, Nishimura Y, Inada M, Fukuda K, Ishikawa K, Nishikawa T, Yokokawa M, Nakamatsu K, Kanamori S, Hida JI
Int J Clin Oncol 2018 Dec;23(6):1121-1126. Epub 2018 Jul 10 doi: 10.1007/s10147-018-1316-1. PMID: 29992389
Long-term update of US GI intergroup RTOG 98-11 phase III trial for anal carcinoma: survival, relapse, and colostomy failure with concurrent chemoradiation involving fluorouracil/mitomycin versus fluorouracil/cisplatin.
Gunderson LL, Winter KA, Ajani JA, Pedersen JE, Moughan J, Benson AB 3rd, Thomas CR Jr, Mayer RJ, Haddock MG, Rich TA, Willett CG
J Clin Oncol 2012 Dec 10;30(35):4344-51. Epub 2012 Nov 13 doi: 10.1200/JCO.2012.43.8085. PMID: 23150707Free PMC Article
Anal canal carcinoma treatment results: the experience of a single institution.
El-Haddad M, Ahmed RS, Al-Suhaibany A, Al-Hazza M, Al-Sanae N, Al-Jabbar AA, Hamoud S, Ashaary L, Bazerbashy S, Balaraj K
Ann Saudi Med 2011 Mar-Apr;31(2):158-62. doi: 10.4103/0256-4947.77488. PMID: 21403412Free PMC Article
Fluorouracil, mitomycin, and radiotherapy vs fluorouracil, cisplatin, and radiotherapy for carcinoma of the anal canal: a randomized controlled trial.
Ajani JA, Winter KA, Gunderson LL, Pedersen J, Benson AB 3rd, Thomas CR Jr, Mayer RJ, Haddock MG, Rich TA, Willett C
JAMA 2008 Apr 23;299(16):1914-21. doi: 10.1001/jama.299.16.1914. PMID: 18430910

Diagnosis

Prognostic and Predictive Markers for Patients With Anal Cancer.
Holliday EB, Peddireddy A, Morris VK
J Natl Compr Canc Netw 2023 Jun;21(6):678-684. doi: 10.6004/jnccn.2023.7031. PMID: 37308122
The Role of Immunotherapy in the Treatment of Anal Cancer and Future Strategies.
Jácome AA, Morris VK, Eng C
Curr Treat Options Oncol 2022 Aug;23(8):1073-1085. Epub 2022 Jun 6 doi: 10.1007/s11864-022-00939-3. PMID: 35666353
Management of inguinal lymph node metastases from rectal and anal canal adenocarcinoma.
Sato H, Maeda K, Kinugasa Y, Kagawa H, Tsukamoto S, Takahashi K, Nozawa H, Takii Y, Konishi T, Akagi Y, Suto T, Yamaguchi S, Ozawa H, Komori K, Ohue M, Hiro J, Shinji S, Minami K, Shimizu T, Sakamoto K, Uehara K, Takahashi H, Sugihara K
Colorectal Dis 2022 Oct;24(10):1150-1163. Epub 2022 May 26 doi: 10.1111/codi.16169. PMID: 35505622
Sentinel node mapping in anal canal cancer: systematic review and meta-analysis.
Tehranian S, Treglia G, Krag DN, Dabbagh Kakhki VR, Zakavi SR, Sadeghi R, Keshtgar M
J Gastrointestin Liver Dis 2013 Sep;22(3):321-8. PMID: 24078990
Anal canal carcinoma treatment results: the experience of a single institution.
El-Haddad M, Ahmed RS, Al-Suhaibany A, Al-Hazza M, Al-Sanae N, Al-Jabbar AA, Hamoud S, Ashaary L, Bazerbashy S, Balaraj K
Ann Saudi Med 2011 Mar-Apr;31(2):158-62. doi: 10.4103/0256-4947.77488. PMID: 21403412Free PMC Article

Therapy

The Role of Immunotherapy in the Treatment of Anal Cancer and Future Strategies.
Jácome AA, Morris VK, Eng C
Curr Treat Options Oncol 2022 Aug;23(8):1073-1085. Epub 2022 Jun 6 doi: 10.1007/s11864-022-00939-3. PMID: 35666353
Definitive chemoradiotherapy for anal canal cancer: single-center experience.
Tachibana I, Nishimura Y, Inada M, Fukuda K, Ishikawa K, Nishikawa T, Yokokawa M, Nakamatsu K, Kanamori S, Hida JI
Int J Clin Oncol 2018 Dec;23(6):1121-1126. Epub 2018 Jul 10 doi: 10.1007/s10147-018-1316-1. PMID: 29992389
Association of Interim FDG-PET Imaging During Chemoradiation for Squamous Anal Canal Carcinoma With Recurrence.
Hong JC, Cui Y, Patel BN, Rushing CN, Faught AM, Eng JS, Higgins K, Yin FF, Das S, Czito BG, Willett CG, Palta M
Int J Radiat Oncol Biol Phys 2018 Nov 15;102(4):1046-1051. Epub 2018 May 4 doi: 10.1016/j.ijrobp.2018.04.062. PMID: 29891206
Long-term update of US GI intergroup RTOG 98-11 phase III trial for anal carcinoma: survival, relapse, and colostomy failure with concurrent chemoradiation involving fluorouracil/mitomycin versus fluorouracil/cisplatin.
Gunderson LL, Winter KA, Ajani JA, Pedersen JE, Moughan J, Benson AB 3rd, Thomas CR Jr, Mayer RJ, Haddock MG, Rich TA, Willett CG
J Clin Oncol 2012 Dec 10;30(35):4344-51. Epub 2012 Nov 13 doi: 10.1200/JCO.2012.43.8085. PMID: 23150707Free PMC Article
Fluorouracil, mitomycin, and radiotherapy vs fluorouracil, cisplatin, and radiotherapy for carcinoma of the anal canal: a randomized controlled trial.
Ajani JA, Winter KA, Gunderson LL, Pedersen J, Benson AB 3rd, Thomas CR Jr, Mayer RJ, Haddock MG, Rich TA, Willett C
JAMA 2008 Apr 23;299(16):1914-21. doi: 10.1001/jama.299.16.1914. PMID: 18430910

Prognosis

Prognostic and Predictive Markers for Patients With Anal Cancer.
Holliday EB, Peddireddy A, Morris VK
J Natl Compr Canc Netw 2023 Jun;21(6):678-684. doi: 10.6004/jnccn.2023.7031. PMID: 37308122
The Role of Immunotherapy in the Treatment of Anal Cancer and Future Strategies.
Jácome AA, Morris VK, Eng C
Curr Treat Options Oncol 2022 Aug;23(8):1073-1085. Epub 2022 Jun 6 doi: 10.1007/s11864-022-00939-3. PMID: 35666353
Management of inguinal lymph node metastases from rectal and anal canal adenocarcinoma.
Sato H, Maeda K, Kinugasa Y, Kagawa H, Tsukamoto S, Takahashi K, Nozawa H, Takii Y, Konishi T, Akagi Y, Suto T, Yamaguchi S, Ozawa H, Komori K, Ohue M, Hiro J, Shinji S, Minami K, Shimizu T, Sakamoto K, Uehara K, Takahashi H, Sugihara K
Colorectal Dis 2022 Oct;24(10):1150-1163. Epub 2022 May 26 doi: 10.1111/codi.16169. PMID: 35505622
Sentinel node mapping in anal canal cancer: systematic review and meta-analysis.
Tehranian S, Treglia G, Krag DN, Dabbagh Kakhki VR, Zakavi SR, Sadeghi R, Keshtgar M
J Gastrointestin Liver Dis 2013 Sep;22(3):321-8. PMID: 24078990
Long-term update of US GI intergroup RTOG 98-11 phase III trial for anal carcinoma: survival, relapse, and colostomy failure with concurrent chemoradiation involving fluorouracil/mitomycin versus fluorouracil/cisplatin.
Gunderson LL, Winter KA, Ajani JA, Pedersen JE, Moughan J, Benson AB 3rd, Thomas CR Jr, Mayer RJ, Haddock MG, Rich TA, Willett CG
J Clin Oncol 2012 Dec 10;30(35):4344-51. Epub 2012 Nov 13 doi: 10.1200/JCO.2012.43.8085. PMID: 23150707Free PMC Article

Clinical prediction guides

Prognostic and Predictive Markers for Patients With Anal Cancer.
Holliday EB, Peddireddy A, Morris VK
J Natl Compr Canc Netw 2023 Jun;21(6):678-684. doi: 10.6004/jnccn.2023.7031. PMID: 37308122
The Role of Immunotherapy in the Treatment of Anal Cancer and Future Strategies.
Jácome AA, Morris VK, Eng C
Curr Treat Options Oncol 2022 Aug;23(8):1073-1085. Epub 2022 Jun 6 doi: 10.1007/s11864-022-00939-3. PMID: 35666353
Management of inguinal lymph node metastases from rectal and anal canal adenocarcinoma.
Sato H, Maeda K, Kinugasa Y, Kagawa H, Tsukamoto S, Takahashi K, Nozawa H, Takii Y, Konishi T, Akagi Y, Suto T, Yamaguchi S, Ozawa H, Komori K, Ohue M, Hiro J, Shinji S, Minami K, Shimizu T, Sakamoto K, Uehara K, Takahashi H, Sugihara K
Colorectal Dis 2022 Oct;24(10):1150-1163. Epub 2022 May 26 doi: 10.1111/codi.16169. PMID: 35505622
Definitive chemoradiotherapy for anal canal cancer: single-center experience.
Tachibana I, Nishimura Y, Inada M, Fukuda K, Ishikawa K, Nishikawa T, Yokokawa M, Nakamatsu K, Kanamori S, Hida JI
Int J Clin Oncol 2018 Dec;23(6):1121-1126. Epub 2018 Jul 10 doi: 10.1007/s10147-018-1316-1. PMID: 29992389
Sentinel node mapping in anal canal cancer: systematic review and meta-analysis.
Tehranian S, Treglia G, Krag DN, Dabbagh Kakhki VR, Zakavi SR, Sadeghi R, Keshtgar M
J Gastrointestin Liver Dis 2013 Sep;22(3):321-8. PMID: 24078990

Recent systematic reviews

Management of persistent anal canal carcinoma after combined-modality therapy: a clinical review.
Musio D, De Felice F, Raffetto N, Tombolini V
Radiat Oncol 2014 Jan 28;9:39. doi: 10.1186/1748-717X-9-39. PMID: 24472223Free PMC Article
Sentinel node mapping in anal canal cancer: systematic review and meta-analysis.
Tehranian S, Treglia G, Krag DN, Dabbagh Kakhki VR, Zakavi SR, Sadeghi R, Keshtgar M
J Gastrointestin Liver Dis 2013 Sep;22(3):321-8. PMID: 24078990

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