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La Crosse encephalitis

MedGen UID:
547309
•Concept ID:
C0276379
•
Disease or Syndrome
Synonyms: Encephalitis, La Crosse; La Crosse Encephalitis; La Crosse Encephalitis Virus Infection
SNOMED CT: La Crosse encephalitis (61094002); LAC - La Crosse encephalitis (61094002); La Crosse virus encephalitis (61094002)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0019378
Orphanet: ORPHA83483

Definition

An acute arboviral infection caused by the <i>La Crosse bunyavirus</i> transmitted by an infected mosquito, usually observed in infants, children or adolescents (6 months to 16 years), and characterized by the onset of flulike symptoms such as fever, chills, nausea, vomiting, headache, and abdominal pain, followed by the onset of encephalitis characterized by somnolence, obtundation, and even seizures, focal neurologic signs (asymmetrical reflexes or Babinski signs), paralysis or even coma. CE can leave sequelae such as residual epilepsy and neurocognitive deficits. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLa Crosse encephalitis

Professional guidelines

PubMed

Neurologic aspects and treatment of La Crosse encephalitis.
Deering WM
Prog Clin Biol Res 1983;123:187-91. PMID: 6867034

Recent clinical studies

Etiology

Current Status of La Crosse Virus in North America and Potential for Future Spread.
Goldman T, Hamer DH
Am J Trop Med Hyg 2024 May 1;110(5):850-855. Epub 2024 Mar 26 doi: 10.4269/ajtmh.23-0160. PMID: 38531108Free PMC Article
La Crosse Encephalitis: A Persistent Arboviral Threat in North Carolina.
Byrd BD
N C Med J 2016 Sep-Oct;77(5):330-3. doi: 10.18043/ncm.77.5.330. PMID: 27621342
La Crosse Encephalitis: An Adult Case Series.
Teleron AL, Rose BK, Williams DM, Kemper SE, McJunkin JE
Am J Med 2016 Aug;129(8):881-4. Epub 2016 Apr 15 doi: 10.1016/j.amjmed.2016.03.021. PMID: 27086496
La Crosse encephalitis in Eastern Tennessee: clinical, environmental, and entomological characteristics from a blinded cohort study.
Erwin PC, Jones TF, Gerhardt RR, Halford SK, Smith AB, Patterson LE, Gottfried KL, Burkhalter KL, Nasci RS, Schaffner W
Am J Epidemiol 2002 Jun 1;155(11):1060-5. doi: 10.1093/aje/155.11.1060. PMID: 12034585
La Crosse encephalitis in children.
McJunkin JE, de los Reyes EC, Irazuzta JE, Caceres MJ, Khan RR, Minnich LL, Fu KD, Lovett GD, Tsai T, Thompson A
N Engl J Med 2001 Mar 15;344(11):801-7. doi: 10.1056/NEJM200103153441103. PMID: 11248155

Diagnosis

Double Crossed: A Case of La Crosse Encephalitis.
Ding A, Shen B, Elliott S, Joshi K, Coghlin D, McLaughlin S
R I Med J (2013) 2020 Apr 1;103(3):59-62. PMID: 32236166
La Crosse encephalitis surveillance using single versus paired serologic testing.
Murphree R, Dunn JR, Schaffner W, Jones TF
Zoonoses Public Health 2012 May;59(3):181-3. Epub 2011 Aug 18 doi: 10.1111/j.1863-2378.2011.01433.x. PMID: 21848528
Clinical comparisons of La Crosse encephalitis and enteroviral central nervous system infections in a pediatric population: 2001 surveillance in East Tennessee.
Hardin SG, Erwin PC, Patterson L, New D, Graber C, Halford SK
Am J Infect Control 2003 Dec;31(8):508-10. doi: 10.1016/s0196-6553(03)00084-1. PMID: 14647115
La Crosse encephalitis in children.
McJunkin JE, de los Reyes EC, Irazuzta JE, Caceres MJ, Khan RR, Minnich LL, Fu KD, Lovett GD, Tsai T, Thompson A
N Engl J Med 2001 Mar 15;344(11):801-7. doi: 10.1056/NEJM200103153441103. PMID: 11248155
California-La Crosse encephalitis.
McJunkin JE, Khan RR, Tsai TF
Infect Dis Clin North Am 1998 Mar;12(1):83-93. doi: 10.1016/s0891-5520(05)70410-4. PMID: 9494831

Therapy

Double Crossed: A Case of La Crosse Encephalitis.
Ding A, Shen B, Elliott S, Joshi K, Coghlin D, McLaughlin S
R I Med J (2013) 2020 Apr 1;103(3):59-62. PMID: 32236166
Safety and pharmacokinetics of ribavirin for the treatment of la crosse encephalitis.
McJunkin JE, Nahata MC, De Los Reyes EC, Hunt WG, Caceres M, Khan RR, Chebib MG, Taravath S, Minnich LL, Carr R, Welch CA, Whitley RJ
Pediatr Infect Dis J 2011 Oct;30(10):860-5. doi: 10.1097/INF.0b013e31821c922c. PMID: 21544005
Severe La Crosse encephalitis with significant neurologic sequelae.
Balkhy HH, Schreiber JR
Pediatr Infect Dis J 2000 Jan;19(1):77-80. doi: 10.1097/00006454-200001000-00016. PMID: 10643856
La Crosse and other forms of California encephalitis.
Rust RS, Thompson WH, Matthews CG, Beaty BJ, Chun RW
J Child Neurol 1999 Jan;14(1):1-14. doi: 10.1177/088307389901400101. PMID: 10025535
California-La Crosse encephalitis.
McJunkin JE, Khan RR, Tsai TF
Infect Dis Clin North Am 1998 Mar;12(1):83-93. doi: 10.1016/s0891-5520(05)70410-4. PMID: 9494831

Prognosis

Double Crossed: A Case of La Crosse Encephalitis.
Ding A, Shen B, Elliott S, Joshi K, Coghlin D, McLaughlin S
R I Med J (2013) 2020 Apr 1;103(3):59-62. PMID: 32236166
La Crosse Encephalitis: An Adult Case Series.
Teleron AL, Rose BK, Williams DM, Kemper SE, McJunkin JE
Am J Med 2016 Aug;129(8):881-4. Epub 2016 Apr 15 doi: 10.1016/j.amjmed.2016.03.021. PMID: 27086496
La Crosse encephalitis surveillance using single versus paired serologic testing.
Murphree R, Dunn JR, Schaffner W, Jones TF
Zoonoses Public Health 2012 May;59(3):181-3. Epub 2011 Aug 18 doi: 10.1111/j.1863-2378.2011.01433.x. PMID: 21848528
Periodic lateralized epileptiform discharges in La Crosse encephalitis, a worrisome subgroup: clinical presentation, electroencephalogram (EEG) patterns, and long-term neurologic outcome.
de los Reyes EC, McJunkin JE, Glauser TA, Tomsho M, O'Neal J
J Child Neurol 2008 Feb;23(2):167-72. Epub 2007 Dec 26 doi: 10.1177/0883073807307984. PMID: 18160548
La Crosse encephalitis in children.
McJunkin JE, de los Reyes EC, Irazuzta JE, Caceres MJ, Khan RR, Minnich LL, Fu KD, Lovett GD, Tsai T, Thompson A
N Engl J Med 2001 Mar 15;344(11):801-7. doi: 10.1056/NEJM200103153441103. PMID: 11248155

Clinical prediction guides

Identification of Host Factors for Rift Valley Fever Phlebovirus.
Balaraman V, Indran SV, Li Y, Meekins DA, Jakkula LUMR, Liu H, Hays MP, Souza-Neto JA, Gaudreault NN, Hardwidge PR, Wilson WC, Weber F, Richt JA
Viruses 2023 Nov 13;15(11) doi: 10.3390/v15112251. PMID: 38005928Free PMC Article
Epidemiology of La Crosse Virus Emergence, Appalachia Region, United States.
Bewick S, Agusto F, Calabrese JM, Muturi EJ, Fagan WF
Emerg Infect Dis 2016 Nov;22(11):1921-1929. doi: 10.3201/eid2211.160308. PMID: 27767009Free PMC Article
La Crosse encephalitis surveillance using single versus paired serologic testing.
Murphree R, Dunn JR, Schaffner W, Jones TF
Zoonoses Public Health 2012 May;59(3):181-3. Epub 2011 Aug 18 doi: 10.1111/j.1863-2378.2011.01433.x. PMID: 21848528
Economic and social impacts of La Crosse encephalitis in western North Carolina.
Utz JT, Apperson CS, MacCormack JN, Salyers M, Dietz EJ, McPherson JT
Am J Trop Med Hyg 2003 Nov;69(5):509-18. PMID: 14695088
La Crosse encephalitis in children.
McJunkin JE, de los Reyes EC, Irazuzta JE, Caceres MJ, Khan RR, Minnich LL, Fu KD, Lovett GD, Tsai T, Thompson A
N Engl J Med 2001 Mar 15;344(11):801-7. doi: 10.1056/NEJM200103153441103. PMID: 11248155

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