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Respiratory syncytial virus bronchiolitis

MedGen UID:
547277
•Concept ID:
C0276340
•
Disease or Syndrome
Synonyms: respiratory syncytial virus bronchiolitis; RSV bronchiolitis
SNOMED CT: Respiratory syncytial virus bronchiolitis (57089007)
 
Monarch Initiative: MONDO:0100286

Definition

Bronciolitis caused by infection with respiratory syncytial virus. [from MONDO]

Professional guidelines

PubMed

Management of Hospitalized Respiratory Syncytial Virus Bronchiolitis in the Pediatric Ward in Spain: Assessing the Impact of a New Clinical Practice Protocol.
Vila J, Lera E, Peremiquel-Trillas P, Martínez L, Barceló I, Andrés C, Rodrigo-Pendás JÁ, Antón A, Rodrigo C
Paediatr Drugs 2022 Jan;24(1):63-71. Epub 2021 Dec 22 doi: 10.1007/s40272-021-00488-6. PMID: 34936054
Respiratory syncytial virus bronchiolitis: prevention and treatment.
Faber TE, Kimpen JL, Bont LJ
Expert Opin Pharmacother 2008 Oct;9(14):2451-8. doi: 10.1517/14656566.9.14.2451. PMID: 18778183
Prevention and treatment of respiratory syncytial virus bronchiolitis and postbronchiolitic wheezing.
Kimpen JL
Respir Res 2002;3 Suppl 1(Suppl 1):S40-5. doi: 10.1186/rr183. PMID: 12119057Free PMC Article

Curated

UK NICE Guideline NG9, Bronchiolitis in children: diagnosis and management, 2021

Recent clinical studies

Etiology

Vosoritide therapy in children with achondroplasia aged 3-59 months: a multinational, randomised, double-blind, placebo-controlled, phase 2 trial.
Savarirayan R, Wilcox WR, Harmatz P, Phillips J 3rd, Polgreen LE, Tofts L, Ozono K, Arundel P, Irving M, Bacino CA, Basel D, Bober MB, Charrow J, Mochizuki H, Kotani Y, Saal HM, Army C, Jeha G, Qi Y, Han L, Fisheleva E, Huntsman-Labed A, Day J
Lancet Child Adolesc Health 2024 Jan;8(1):40-50. Epub 2023 Nov 18 doi: 10.1016/S2352-4642(23)00265-1. PMID: 37984383
Respiratory Syncytial Virus Bronchiolitis: Rapid Evidence Review.
Oppenlander KE, Chung AA, Clabaugh D
Am Fam Physician 2023 Jul;108(1):52-57. PMID: 37440737
Onasemnogene abeparvovec gene therapy for symptomatic infantile-onset spinal muscular atrophy in patients with two copies of SMN2 (STR1VE): an open-label, single-arm, multicentre, phase 3 trial.
Day JW, Finkel RS, Chiriboga CA, Connolly AM, Crawford TO, Darras BT, Iannaccone ST, Kuntz NL, Peña LDM, Shieh PB, Smith EC, Kwon JM, Zaidman CM, Schultz M, Feltner DE, Tauscher-Wisniewski S, Ouyang H, Chand DH, Sproule DM, Macek TA, Mendell JR
Lancet Neurol 2021 Apr;20(4):284-293. Epub 2021 Mar 17 doi: 10.1016/S1474-4422(21)00001-6. PMID: 33743238
Pharmacological targets and emerging treatments for respiratory syncytial virus bronchiolitis.
Elawar F, Oraby AK, Kieser Q, Jensen LD, Culp T, West FG, Marchant DJ
Pharmacol Ther 2021 Apr;220:107712. Epub 2020 Oct 27 doi: 10.1016/j.pharmthera.2020.107712. PMID: 33121940
Respiratory Syncytial Virus Bronchiolitis in Children.
Smith DK, Seales S, Budzik C
Am Fam Physician 2017 Jan 15;95(2):94-99. PMID: 28084708

Diagnosis

Vosoritide therapy in children with achondroplasia aged 3-59 months: a multinational, randomised, double-blind, placebo-controlled, phase 2 trial.
Savarirayan R, Wilcox WR, Harmatz P, Phillips J 3rd, Polgreen LE, Tofts L, Ozono K, Arundel P, Irving M, Bacino CA, Basel D, Bober MB, Charrow J, Mochizuki H, Kotani Y, Saal HM, Army C, Jeha G, Qi Y, Han L, Fisheleva E, Huntsman-Labed A, Day J
Lancet Child Adolesc Health 2024 Jan;8(1):40-50. Epub 2023 Nov 18 doi: 10.1016/S2352-4642(23)00265-1. PMID: 37984383
Respiratory Syncytial Virus Bronchiolitis: Rapid Evidence Review.
Oppenlander KE, Chung AA, Clabaugh D
Am Fam Physician 2023 Jul;108(1):52-57. PMID: 37440737
Respiratory syncytial virus bronchiolitis among refugees and asylum seekers from war-torn countries.
Lavie M, Maymon D, Diamant N, Cahal M, Be'er M, Besor O, Lahat S, Amirav I
Pediatr Pulmonol 2021 Sep;56(9):2888-2892. Epub 2021 Jul 15 doi: 10.1002/ppul.25562. PMID: 34265189
Respiratory Syncytial Virus Bronchiolitis in Children.
Smith DK, Seales S, Budzik C
Am Fam Physician 2017 Jan 15;95(2):94-99. PMID: 28084708
Respiratory syncytial virus bronchiolitis.
Leung AK, Kellner JD, Davies HD
J Natl Med Assoc 2005 Dec;97(12):1708-13. PMID: 16396064Free PMC Article

Therapy

Vosoritide therapy in children with achondroplasia aged 3-59 months: a multinational, randomised, double-blind, placebo-controlled, phase 2 trial.
Savarirayan R, Wilcox WR, Harmatz P, Phillips J 3rd, Polgreen LE, Tofts L, Ozono K, Arundel P, Irving M, Bacino CA, Basel D, Bober MB, Charrow J, Mochizuki H, Kotani Y, Saal HM, Army C, Jeha G, Qi Y, Han L, Fisheleva E, Huntsman-Labed A, Day J
Lancet Child Adolesc Health 2024 Jan;8(1):40-50. Epub 2023 Nov 18 doi: 10.1016/S2352-4642(23)00265-1. PMID: 37984383
Respiratory Syncytial Virus Bronchiolitis: Rapid Evidence Review.
Oppenlander KE, Chung AA, Clabaugh D
Am Fam Physician 2023 Jul;108(1):52-57. PMID: 37440737
Onasemnogene abeparvovec gene therapy for symptomatic infantile-onset spinal muscular atrophy in patients with two copies of SMN2 (STR1VE): an open-label, single-arm, multicentre, phase 3 trial.
Day JW, Finkel RS, Chiriboga CA, Connolly AM, Crawford TO, Darras BT, Iannaccone ST, Kuntz NL, Peña LDM, Shieh PB, Smith EC, Kwon JM, Zaidman CM, Schultz M, Feltner DE, Tauscher-Wisniewski S, Ouyang H, Chand DH, Sproule DM, Macek TA, Mendell JR
Lancet Neurol 2021 Apr;20(4):284-293. Epub 2021 Mar 17 doi: 10.1016/S1474-4422(21)00001-6. PMID: 33743238
Pharmacological targets and emerging treatments for respiratory syncytial virus bronchiolitis.
Elawar F, Oraby AK, Kieser Q, Jensen LD, Culp T, West FG, Marchant DJ
Pharmacol Ther 2021 Apr;220:107712. Epub 2020 Oct 27 doi: 10.1016/j.pharmthera.2020.107712. PMID: 33121940
Respiratory Syncytial Virus Bronchiolitis in Children.
Smith DK, Seales S, Budzik C
Am Fam Physician 2017 Jan 15;95(2):94-99. PMID: 28084708

Prognosis

Respiratory Syncytial Virus Bronchiolitis Before and After COVID-19 Pandemic: Has the Immunity Debt Been Paid Off?
Nenna R, Pierangeli A, Matera L, Petrarca L, Conti MG, Mancino E, di Mattia G, La Regina DP, Virgili F, Papoff P, Bonci E, Midulla F
Pediatr Infect Dis J 2024 Jul 1;43(7):635-639. Epub 2024 Feb 28 doi: 10.1097/INF.0000000000004314. PMID: 38451927
Respiratory syncytial virus bronchiolitis among refugees and asylum seekers from war-torn countries.
Lavie M, Maymon D, Diamant N, Cahal M, Be'er M, Besor O, Lahat S, Amirav I
Pediatr Pulmonol 2021 Sep;56(9):2888-2892. Epub 2021 Jul 15 doi: 10.1002/ppul.25562. PMID: 34265189
Onasemnogene abeparvovec gene therapy for symptomatic infantile-onset spinal muscular atrophy in patients with two copies of SMN2 (STR1VE): an open-label, single-arm, multicentre, phase 3 trial.
Day JW, Finkel RS, Chiriboga CA, Connolly AM, Crawford TO, Darras BT, Iannaccone ST, Kuntz NL, Peña LDM, Shieh PB, Smith EC, Kwon JM, Zaidman CM, Schultz M, Feltner DE, Tauscher-Wisniewski S, Ouyang H, Chand DH, Sproule DM, Macek TA, Mendell JR
Lancet Neurol 2021 Apr;20(4):284-293. Epub 2021 Mar 17 doi: 10.1016/S1474-4422(21)00001-6. PMID: 33743238
Respiratory syncytial virus bronchiolitis.
Leung AK, Kellner JD, Davies HD
J Natl Med Assoc 2005 Dec;97(12):1708-13. PMID: 16396064Free PMC Article
Respiratory syncytial virus bronchiolitis.
Jeng MJ, Lemen RJ
Am Fam Physician 1997 Mar;55(4):1139-46, 1149-50. PMID: 9092277

Clinical prediction guides

Respiratory Syncytial Virus Bronchiolitis Before and After COVID-19 Pandemic: Has the Immunity Debt Been Paid Off?
Nenna R, Pierangeli A, Matera L, Petrarca L, Conti MG, Mancino E, di Mattia G, La Regina DP, Virgili F, Papoff P, Bonci E, Midulla F
Pediatr Infect Dis J 2024 Jul 1;43(7):635-639. Epub 2024 Feb 28 doi: 10.1097/INF.0000000000004314. PMID: 38451927
Vosoritide therapy in children with achondroplasia aged 3-59 months: a multinational, randomised, double-blind, placebo-controlled, phase 2 trial.
Savarirayan R, Wilcox WR, Harmatz P, Phillips J 3rd, Polgreen LE, Tofts L, Ozono K, Arundel P, Irving M, Bacino CA, Basel D, Bober MB, Charrow J, Mochizuki H, Kotani Y, Saal HM, Army C, Jeha G, Qi Y, Han L, Fisheleva E, Huntsman-Labed A, Day J
Lancet Child Adolesc Health 2024 Jan;8(1):40-50. Epub 2023 Nov 18 doi: 10.1016/S2352-4642(23)00265-1. PMID: 37984383
Onasemnogene abeparvovec gene therapy for symptomatic infantile-onset spinal muscular atrophy in patients with two copies of SMN2 (STR1VE): an open-label, single-arm, multicentre, phase 3 trial.
Day JW, Finkel RS, Chiriboga CA, Connolly AM, Crawford TO, Darras BT, Iannaccone ST, Kuntz NL, Peña LDM, Shieh PB, Smith EC, Kwon JM, Zaidman CM, Schultz M, Feltner DE, Tauscher-Wisniewski S, Ouyang H, Chand DH, Sproule DM, Macek TA, Mendell JR
Lancet Neurol 2021 Apr;20(4):284-293. Epub 2021 Mar 17 doi: 10.1016/S1474-4422(21)00001-6. PMID: 33743238
Risk Factors for Respiratory Syncytial Virus Bronchiolitis Admissions.
Meenaghan S, Breatnach C, Smith H
Ir Med J 2020 Jan 16;113(1):9. PMID: 32298565
Neutrophil-endothelial interactions in respiratory syncytial virus bronchiolitis: An understudied aspect with a potential for prediction of severity of disease.
Juliana A, Zonneveld R, Plötz FB, van Meurs M, Wilschut J
J Clin Virol 2020 Feb;123:104258. Epub 2019 Dec 31 doi: 10.1016/j.jcv.2019.104258. PMID: 31931445

Recent systematic reviews

Impact of breastfeeding on the incidence and severity of respiratory syncytial virus bronchiolitis in infants: systematic review.
Mineva G, Philip R
Rural Remote Health 2023 Jan;23(1):8088. Epub 2023 Jan 10 doi: 10.22605/RRH8088. PMID: 36802679
Respiratory syncytial virus bronchiolitis in congenital diaphragmatic hernia: A systematic review of prevalence rates and palivizumab prophylaxis.
Lewis L, Sinha I, Losty PD
Pediatr Pulmonol 2022 Jan;57(1):239-244. Epub 2021 Oct 12 doi: 10.1002/ppul.25717. PMID: 34617409
Interleukin 8 Association with respiratory syncytial virus bronchiolitis: a systematic review and meta-analysis.
Peng L, Meng F, Liu Y, Zhang L
Cell Mol Biol (Noisy-le-grand) 2020 May 15;66(2):74-77. PMID: 32415951
Incidence of apnea in infants hospitalized with respiratory syncytial virus bronchiolitis: a systematic review.
Ralston S, Hill V
J Pediatr 2009 Nov;155(5):728-33. Epub 2009 Aug 3 doi: 10.1016/j.jpeds.2009.04.063. PMID: 19647839

Supplemental Content

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    Clinical resources

    Practice guidelines

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    Curated

    • NICE, 2021
      UK NICE Guideline NG9, Bronchiolitis in children: diagnosis and management, 2021

    Consumer resources

    Reviews

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      Related information in PubMed Central Links
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