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Cyclic thrombocytopenia

MedGen UID:
78799
•Concept ID:
C0272282
•
Disease or Syndrome
Synonym: Thrombocytopenia, cyclic
SNOMED CT: Cyclic thrombocytopenia (48788004); Tidal platelet dysgenesis (48788004)
 
Monarch Initiative: MONDO:0008556
OMIM®: 188020

Professional guidelines

PubMed

Management of menorrhagia associated with chemotherapy-induced thrombocytopenia in women with hematologic malignancy.
Bates JS, Buie LW, Woodis CB
Pharmacotherapy 2011 Nov;31(11):1092-110. doi: 10.1592/phco.31.11.1092. PMID: 22026397
Severe chronic neutropenia: treatment and follow-up of patients in the Severe Chronic Neutropenia International Registry.
Dale DC, Cottle TE, Fier CJ, Bolyard AA, Bonilla MA, Boxer LA, Cham B, Freedman MH, Kannourakis G, Kinsey SE, Davis R, Scarlata D, Schwinzer B, Zeidler C, Welte K
Am J Hematol 2003 Feb;72(2):82-93. doi: 10.1002/ajh.10255. PMID: 12555210
Risk and benefit of treatment of severe chronic neutropenia with granulocyte colony-stimulating factor.
Cottle TE, Fier CJ, Donadieu J, Kinsey SE
Semin Hematol 2002 Apr;39(2):134-40. doi: 10.1053/shem.2002.31914. PMID: 11957197

Recent clinical studies

Etiology

Longitudinal study of 2 patients with cyclic thrombocytopenia, STAT3 and MPL mutations.
Zhang H, Chien M, Hou Y, Shomali W, Brar RS, Ho C, Han P, Xu D, Zhang BM, Guo X, Tolentino LL, Wu NC, Tsai AG, Jin J, Witteles WH, Chen Z, Abidi P, Jangam D, Krieger MS, Craig M, Bussel JB, Gotlib JR, Zehnder JL
Blood Adv 2023 Jan 10;7(1):190-194. doi: 10.1182/bloodadvances.2021006701. PMID: 35381066Free PMC Article
Molecular diagnosis of granulocytic anaplasmosis and infectious cyclic thrombocytopenia by PCR-RFLP.
Alberti A, Sparagano OA
Ann N Y Acad Sci 2006 Oct;1081:371-8. doi: 10.1196/annals.1373.055. PMID: 17135540
Megakaryopoiesis in patients with cyclic thrombocytopenia.
Nagasawa T, Hasegawa Y, Kamoshita M, Ohtani K, Komeno T, Itoh T, Shinagawa A, Kojima H, Ninomiya H, Abe T
Br J Haematol 1995 Sep;91(1):185-90. doi: 10.1111/j.1365-2141.1995.tb05267.x. PMID: 7577630

Diagnosis

Cyclic thrombocytopenia related to erythropoietin-dependent anti-platelet anti-GPIV/IIIb antibody in hemodialysis.
Florens N, Bordet JC, Giannoli C, Le Toriellec E, Guebre-Egziabher F
J Nephrol 2022 Jun;35(5):1525-1529. Epub 2022 May 21 doi: 10.1007/s40620-022-01348-3. PMID: 35596916
gltA typing of Anaplasma strains related to A. platys: Taxonomical and one health implications.
Zobba R, Schianchi E, Ben Said M, Belkahia H, Messadi L, Piredda R, Pittau M, Alberti A
Ticks Tick Borne Dis 2022 Jan;13(1):101850. Epub 2021 Oct 10 doi: 10.1016/j.ttbdis.2021.101850. PMID: 34656046
How I manage cyclic thrombocytopenia.
Kyrle PA, Eichinger S
Blood 2021 Jan 14;137(2):178-184. doi: 10.1182/blood.2020008218. PMID: 33197928
Molecular diagnosis of granulocytic anaplasmosis and infectious cyclic thrombocytopenia by PCR-RFLP.
Alberti A, Sparagano OA
Ann N Y Acad Sci 2006 Oct;1081:371-8. doi: 10.1196/annals.1373.055. PMID: 17135540
Idiopathic cyclic thrombocytopenia.
Go RS
Blood Rev 2005 Jan;19(1):53-9. doi: 10.1016/j.blre.2004.05.001. PMID: 15572217

Therapy

The highs and lows of cyclic thrombocytopenia.
Zhang H, Villar-Prados A, Bussel JB, Zehnder JL
Br J Haematol 2024 Jan;204(1):56-67. Epub 2023 Dec 11 doi: 10.1111/bjh.19239. PMID: 38083878Free PMC Article
Cyclic thrombocytopenia related to erythropoietin-dependent anti-platelet anti-GPIV/IIIb antibody in hemodialysis.
Florens N, Bordet JC, Giannoli C, Le Toriellec E, Guebre-Egziabher F
J Nephrol 2022 Jun;35(5):1525-1529. Epub 2022 May 21 doi: 10.1007/s40620-022-01348-3. PMID: 35596916
Cyclic immune thrombocytopenia responsive to thrombopoietic growth factor therapy.
Rice L, Nichol JL, McMillan R, Roskos LK, Bacile M
Am J Hematol 2001 Nov;68(3):210-4. doi: 10.1002/ajh.1181. PMID: 11754405
Danazol therapy for cyclic thrombocytopenia.
Rocha R, Horstman L, Ahn YS, Mylvaganam R, Harrington WJ
Am J Hematol 1991 Feb;36(2):140-3. doi: 10.1002/ajh.2830360213. PMID: 2012064
Cyclic thrombocytopenia. Case report and review of literature.
Cohen T, Cooney DP
Scand J Haematol 1974;12(1):9-17. doi: 10.1111/j.1600-0609.1974.tb00174.x. PMID: 4598703

Prognosis

Case report: Comprehensive clinical, pathological and genetic investigations to decipher the background of cyclic thrombocytopenia.
Nagy ZF, Árvai K, Lakatos P, Debreceni IB, Szili B, Istenes I, Bödör C, Demeter J
Pathol Oncol Res 2024;30:1611914. Epub 2024 Sep 30 doi: 10.3389/pore.2024.1611914. PMID: 39403403Free PMC Article
Acquired cyclic thrombocytopenia-thrombocytosis with periodic defect of platelet function.
Balduini CL, Stella CC, Rosti V, Bertolino G, Noris P, Ascari E
Br J Haematol 1993 Dec;85(4):718-22. doi: 10.1111/j.1365-2141.1993.tb03214.x. PMID: 7918035
Oscillating platelet counts in healthy individuals: experimental investigation and quantitative evaluation of thrombocytopoietic feedback control.
von Schulthess GK, Gessner U
Scand J Haematol 1986 May;36(5):473-9. doi: 10.1111/j.1600-0609.1986.tb02283.x. PMID: 3738428

Clinical prediction guides

Case report: Comprehensive clinical, pathological and genetic investigations to decipher the background of cyclic thrombocytopenia.
Nagy ZF, Árvai K, Lakatos P, Debreceni IB, Szili B, Istenes I, Bödör C, Demeter J
Pathol Oncol Res 2024;30:1611914. Epub 2024 Sep 30 doi: 10.3389/pore.2024.1611914. PMID: 39403403Free PMC Article
Pleural effusion-related Nocardia otitidiscaviarum, Anaplasma platys and Ehrlichia canis coinfection in a dog.
Garcia Ribeiro M, da Silva CPC, Pchevuzinske LM, Portilho FVR, Siqueira AK, Takahira RK, Paschoal NR, de Souza AAL, Rodrigues CA, de Almeida BO, Bello TS, Filho MFÁ, de Lima Paz PJ, Dutra V, Nakazato L, Pereira NA, de Aguiar DM
Braz J Microbiol 2023 Sep;54(3):2497-2504. Epub 2023 Jun 23 doi: 10.1007/s42770-023-01029-8. PMID: 37351788Free PMC Article
Idiopathic cyclic thrombocytopenia.
Go RS
Blood Rev 2005 Jan;19(1):53-9. doi: 10.1016/j.blre.2004.05.001. PMID: 15572217
Cyclic change of cytokines in a patient with cyclic thrombocytopenia.
Kimura F, Nakamura Y, Sato K, Wakimoto N, Kato T, Tahara T, Yamada M, Nagata N, Motoyoshi K
Br J Haematol 1996 Jul;94(1):171-4. doi: 10.1046/j.1365-2141.1996.d01-1783.x. PMID: 8757531
Acquired cyclic thrombocytopenia-thrombocytosis with periodic defect of platelet function.
Balduini CL, Stella CC, Rosti V, Bertolino G, Noris P, Ascari E
Br J Haematol 1993 Dec;85(4):718-22. doi: 10.1111/j.1365-2141.1993.tb03214.x. PMID: 7918035

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