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Persistent lymphocytosis

MedGen UID:
543898
•Concept ID:
C0272214
•
Disease or Syndrome
SNOMED CT: Persistent lymphocytosis (24159007)

Professional guidelines

PubMed

Cytogenetics in the management of clonal chromosomal abnormalities of undetermined significance and persistent polyclonal B-cell lymphocytosis: Guidelines from the Groupe Francophone de Cytogénétique Hématologique (GFCH).
Nadal N, Auger N, Bidet A, Nguyen-Khac F
Curr Res Transl Med 2023 Oct-Dec;71(4):103426. Epub 2023 Oct 26 doi: 10.1016/j.retram.2023.103426. PMID: 38016423
HLH and TET2 Mutation Presenting after First Cycle of CLL Treatment.
Geiger AJ, Yasar DG, Sitwala KV
Clin Med Res 2023 Sep;21(3):155-158. doi: 10.3121/cmr.2023.1804. PMID: 37985171Free PMC Article
Three-year follow-up of treatment-naïve and previously treated patients with CLL and SLL receiving single-agent ibrutinib.
Byrd JC, Furman RR, Coutre SE, Burger JA, Blum KA, Coleman M, Wierda WG, Jones JA, Zhao W, Heerema NA, Johnson AJ, Shaw Y, Bilotti E, Zhou C, James DF, O'Brien S
Blood 2015 Apr 16;125(16):2497-506. Epub 2015 Feb 19 doi: 10.1182/blood-2014-10-606038. PMID: 25700432Free PMC Article

Recent clinical studies

Etiology

Manifestations of B-cell expansion with NF-κB and T-cell anergy disease overlapping with hemophagocytic lymphohistiocytosis.
Xiao H, Mou W, Zhang R, Guo X, Chen H, Zhang L, Liu G, Gui J
Scand J Immunol 2023 Apr;97(4):e13256. Epub 2023 Feb 9 doi: 10.1111/sji.13256. PMID: 37401643
Longitudinal Outcomes for Multisystem Inflammatory Syndrome in Children.
Farooqi KM, Chan A, Weller RJ, Mi J, Jiang P, Abrahams E, Ferris A, Krishnan US, Pasumarti N, Suh S, Shah AM, DiLorenzo MP, Zachariah P, Milner JD, Rosenzweig EB, Gorelik M, Anderson BR; Columbia University Interdisciplinary MIS-C Follow-up Program and the CUIMC Pediatric/Adult Congenital Heart Research Collaborative
Pediatrics 2021 Aug;148(2) Epub 2021 Jul 15 doi: 10.1542/peds.2021-051155. PMID: 34266903
IFN-γ mRNA expression is lower in Holstein cows infected with bovine leukemia virus with high proviral load and persistent lymphocytosis.
Úsuga-Monroy C, González Herrera LG, Echeverri Zuluaga JJ, Díaz FJ, López-Herrera A
Acta Virol 2020;64(4):451-456. doi: 10.4149/av_2020_409. PMID: 33151739
Persistent polyclonal B-cell lymphocytosis in chronic smokers: more than meets the eye.
Dasanu CA, Codreanu I
Conn Med 2012 Feb;76(2):69-72. PMID: 22670354
Detection of a novel bovine lymphotropic herpesvirus.
Rovnak J, Quackenbush SL, Reyes RA, Baines JD, Parrish CR, Casey JW
J Virol 1998 May;72(5):4237-42. doi: 10.1128/JVI.72.5.4237-4242.1998. PMID: 9557713Free PMC Article

Diagnosis

Manifestations of B-cell expansion with NF-κB and T-cell anergy disease overlapping with hemophagocytic lymphohistiocytosis.
Xiao H, Mou W, Zhang R, Guo X, Chen H, Zhang L, Liu G, Gui J
Scand J Immunol 2023 Apr;97(4):e13256. Epub 2023 Feb 9 doi: 10.1111/sji.13256. PMID: 37401643
Rheumatoid disease: an unusual cause of relapsing meningoencephalitis.
Alexander SK, Di Cicco M, Pohl U, Cifelli A
BMJ Case Rep 2018 Jan 12;2018 doi: 10.1136/bcr-2017-222587. PMID: 29330273Free PMC Article
Animal immunodeficiency viruses.
Egberink H, Horzinek MC
Vet Microbiol 1992 Nov;33(1-4):311-31. doi: 10.1016/0378-1135(92)90059-3. PMID: 1336243Free PMC Article
Chronic B-cell lymphocytosis.
Perreault C, Boileau J, Gyger M, de Bellefeuille C, D'Angelo G, Belanger R, Lacombe M, Lavallee R, Bonny Y, Paquin M
Eur J Haematol 1989 Apr;42(4):361-7. doi: 10.1111/j.1600-0609.1989.tb01226.x. PMID: 2785931
Granulated T cell lymphocytosis with neutropenia: malignant or benign chronic lymphoproliferative disorder?
McKenna RW, Arthur DC, Gajl-Peczalska KJ, Flynn P, Brunning RD
Blood 1985 Aug;66(2):259-66. PMID: 3874660

Therapy

Rheumatoid disease: an unusual cause of relapsing meningoencephalitis.
Alexander SK, Di Cicco M, Pohl U, Cifelli A
BMJ Case Rep 2018 Jan 12;2018 doi: 10.1136/bcr-2017-222587. PMID: 29330273Free PMC Article
An open-label phase 2 trial of entospletinib (GS-9973), a selective spleen tyrosine kinase inhibitor, in chronic lymphocytic leukemia.
Sharman J, Hawkins M, Kolibaba K, Boxer M, Klein L, Wu M, Hu J, Abella S, Yasenchak C
Blood 2015 Apr 9;125(15):2336-43. Epub 2015 Feb 18 doi: 10.1182/blood-2014-08-595934. PMID: 25696919Free PMC Article
Prolonged lymphocytosis during ibrutinib therapy is associated with distinct molecular characteristics and does not indicate a suboptimal response to therapy.
Woyach JA, Smucker K, Smith LL, Lozanski A, Zhong Y, Ruppert AS, Lucas D, Williams K, Zhao W, Rassenti L, Ghia E, Kipps TJ, Mantel R, Jones J, Flynn J, Maddocks K, O'Brien S, Furman RR, James DF, Clow F, Lozanski G, Johnson AJ, Byrd JC
Blood 2014 Mar 20;123(12):1810-7. Epub 2014 Jan 10 doi: 10.1182/blood-2013-09-527853. PMID: 24415539Free PMC Article
Persistent polyclonal B-cell lymphocytosis in chronic smokers: more than meets the eye.
Dasanu CA, Codreanu I
Conn Med 2012 Feb;76(2):69-72. PMID: 22670354
Leptomeningeal involvement in a patient with splenic lymphoma with villous lymphocytes.
Gotlib V, Singareddy S, Gergis U, Vakios J, Guevara E, Chadburn A, Yavorkovsky LL, Patel A, Butt A, Nayak A
Leuk Lymphoma 2002 Jun;43(6):1337-40. doi: 10.1080/10428190290026411. PMID: 12153005

Prognosis

Longitudinal Outcomes for Multisystem Inflammatory Syndrome in Children.
Farooqi KM, Chan A, Weller RJ, Mi J, Jiang P, Abrahams E, Ferris A, Krishnan US, Pasumarti N, Suh S, Shah AM, DiLorenzo MP, Zachariah P, Milner JD, Rosenzweig EB, Gorelik M, Anderson BR; Columbia University Interdisciplinary MIS-C Follow-up Program and the CUIMC Pediatric/Adult Congenital Heart Research Collaborative
Pediatrics 2021 Aug;148(2) Epub 2021 Jul 15 doi: 10.1542/peds.2021-051155. PMID: 34266903
Prolonged lymphocytosis during ibrutinib therapy is associated with distinct molecular characteristics and does not indicate a suboptimal response to therapy.
Woyach JA, Smucker K, Smith LL, Lozanski A, Zhong Y, Ruppert AS, Lucas D, Williams K, Zhao W, Rassenti L, Ghia E, Kipps TJ, Mantel R, Jones J, Flynn J, Maddocks K, O'Brien S, Furman RR, James DF, Clow F, Lozanski G, Johnson AJ, Byrd JC
Blood 2014 Mar 20;123(12):1810-7. Epub 2014 Jan 10 doi: 10.1182/blood-2013-09-527853. PMID: 24415539Free PMC Article
Blueberry muffin rash as the presenting sign of Aicardi-Goutières syndrome.
Brisman S, Gonzalez M, Morel KD
Pediatr Dermatol 2009 Jul-Aug;26(4):432-5. doi: 10.1111/j.1525-1470.2009.00947.x. PMID: 19689519
Abnormal NK cell lymphocytosis detected after splenectomy: association with repeated infections, relapsing neutropenia, and persistent polyclonal B-cell proliferation.
Granjo E, Lima M, Fraga M, Santos F, Magalhães C, Queirós ML, Moreira I, Rocha S, Silva AS, Rebelo I, Quintanilha A, Ribeiro ML, Candeias J, Orfão A
Int J Hematol 2002 Jun;75(5):484-8. doi: 10.1007/BF02982110. PMID: 12095147
Granulated T cell lymphocytosis with neutropenia: malignant or benign chronic lymphoproliferative disorder?
McKenna RW, Arthur DC, Gajl-Peczalska KJ, Flynn P, Brunning RD
Blood 1985 Aug;66(2):259-66. PMID: 3874660

Clinical prediction guides

Longitudinal Outcomes for Multisystem Inflammatory Syndrome in Children.
Farooqi KM, Chan A, Weller RJ, Mi J, Jiang P, Abrahams E, Ferris A, Krishnan US, Pasumarti N, Suh S, Shah AM, DiLorenzo MP, Zachariah P, Milner JD, Rosenzweig EB, Gorelik M, Anderson BR; Columbia University Interdisciplinary MIS-C Follow-up Program and the CUIMC Pediatric/Adult Congenital Heart Research Collaborative
Pediatrics 2021 Aug;148(2) Epub 2021 Jul 15 doi: 10.1542/peds.2021-051155. PMID: 34266903
Prolonged lymphocytosis during ibrutinib therapy is associated with distinct molecular characteristics and does not indicate a suboptimal response to therapy.
Woyach JA, Smucker K, Smith LL, Lozanski A, Zhong Y, Ruppert AS, Lucas D, Williams K, Zhao W, Rassenti L, Ghia E, Kipps TJ, Mantel R, Jones J, Flynn J, Maddocks K, O'Brien S, Furman RR, James DF, Clow F, Lozanski G, Johnson AJ, Byrd JC
Blood 2014 Mar 20;123(12):1810-7. Epub 2014 Jan 10 doi: 10.1182/blood-2013-09-527853. PMID: 24415539Free PMC Article
Animal immunodeficiency viruses.
Egberink H, Horzinek MC
Vet Microbiol 1992 Nov;33(1-4):311-31. doi: 10.1016/0378-1135(92)90059-3. PMID: 1336243Free PMC Article
Characterization and molecular cloning of a bovine lentivirus related to human immunodeficiency virus.
Gonda MA, Braun MJ, Carter SG, Kost TA, Bess JW Jr, Arthur LO, Van der Maaten MJ
Nature 1987 Nov 26-Dec 2;330(6146):388-91. doi: 10.1038/330388a0. PMID: 3683555
Polymyalgia rheumatica and chronic lymphatic leukaemia.
von Knorring J, Selroos O
Scand J Rheumatol 1977;6(3):145-7. doi: 10.3109/03009747709095438. PMID: 929120

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