U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Erythrocytosis due to tissue hypoxemia

MedGen UID:
543844
•Concept ID:
C0272144
•
Disease or Syndrome
SNOMED CT: Erythrocytosis due to tissue hypoxemia (19588001)

Professional guidelines

PubMed

Childhood polycythemias/erythrocytoses: classification, diagnosis, clinical presentation, and treatment.
Cario H
Ann Hematol 2005 Mar;84(3):137-45. Epub 2004 Dec 15 doi: 10.1007/s00277-004-0985-1. PMID: 15599750

Recent clinical studies

Etiology

Critical examination of mechanisms underlying the reduction in heart failure events with SGLT2 inhibitors: identification of a molecular link between their actions to stimulate erythrocytosis and to alleviate cellular stress.
Packer M
Cardiovasc Res 2021 Jan 1;117(1):74-84. doi: 10.1093/cvr/cvaa064. PMID: 32243505
Cyanotic congenital heart disease (CCHD): focus on hypoxemia, secondary erythrocytosis, and coagulation alterations.
Zabala LM, Guzzetta NA
Paediatr Anaesth 2015 Oct;25(10):981-9. Epub 2015 Jul 17 doi: 10.1111/pan.12705. PMID: 26184479
Hypoxemia in patients with COPD: cause, effects, and disease progression.
Kent BD, Mitchell PD, McNicholas WT
Int J Chron Obstruct Pulmon Dis 2011;6:199-208. Epub 2011 Mar 14 doi: 10.2147/COPD.S10611. PMID: 21660297Free PMC Article
Congenital polycythemias/erythrocytoses.
Gordeuk VR, Stockton DW, Prchal JT
Haematologica 2005 Jan;90(1):109-16. PMID: 15642677
Effects of long-term oxygen therapy on mortality and morbidity.
Criner GJ
Respir Care 2000 Jan;45(1):105-18. PMID: 10771786

Diagnosis

A case of congenital methaemoglobinaemia with secondary polycythemia.
Kanwal S, Aamir M, Irum S, Haroon Z, Munir MU, Bibi A
J Pak Med Assoc 2022 Jun;72(6):1218-1221. doi: 10.47391/JPMA.2129. PMID: 35751341
Clinicopathological characteristics of high-altitude polycythemia-related kidney disease in Tibetan inhabitants.
Wang H, Tang C, Dang Z, Yong A, Liu L, Wang S, Zhao M
Kidney Int 2022 Jul;102(1):196-206. Epub 2022 May 2 doi: 10.1016/j.kint.2022.03.027. PMID: 35513124
Ethiopian Native Highlander's Adaptation to Chronic High-Altitude Hypoxia.
Getu A
Biomed Res Int 2022;2022:5749382. Epub 2022 Apr 15 doi: 10.1155/2022/5749382. PMID: 35463974Free PMC Article
Genetic basis of congenital erythrocytosis.
Bento C
Int J Lab Hematol 2018 May;40 Suppl 1:62-67. doi: 10.1111/ijlh.12828. PMID: 29741264
Polycythemia vera.
Murphy S
Dis Mon 1992 Mar;38(3):153-212. doi: 10.1016/0011-5029(92)90002-7. PMID: 1587207

Therapy

Regulation of Erythropoiesis by the Hypoxia-Inducible Factor Pathway: Effects of Genetic and Pharmacological Perturbations.
Semenza GL
Annu Rev Med 2023 Jan 27;74:307-319. Epub 2022 Jun 30 doi: 10.1146/annurev-med-042921-102602. PMID: 35773226
Critical examination of mechanisms underlying the reduction in heart failure events with SGLT2 inhibitors: identification of a molecular link between their actions to stimulate erythrocytosis and to alleviate cellular stress.
Packer M
Cardiovasc Res 2021 Jan 1;117(1):74-84. doi: 10.1093/cvr/cvaa064. PMID: 32243505
Regulated oxygen sensing by protein hydroxylation in renal erythropoietin-producing cells.
Wenger RH, Hoogewijs D
Am J Physiol Renal Physiol 2010 Jun;298(6):F1287-96. Epub 2010 Mar 10 doi: 10.1152/ajprenal.00736.2009. PMID: 20219824
The heart and pulmonary circulation at high altitudes: healthy highlanders and chronic mountain sickness.
Penaloza D, Arias-Stella J
Circulation 2007 Mar 6;115(9):1132-46. doi: 10.1161/CIRCULATIONAHA.106.624544. PMID: 17339571
Recombinant erythropoietin.
Spivak JL
Annu Rev Med 1993;44:243-53. doi: 10.1146/annurev.me.44.020193.001331. PMID: 8476246

Prognosis

Critical examination of mechanisms underlying the reduction in heart failure events with SGLT2 inhibitors: identification of a molecular link between their actions to stimulate erythrocytosis and to alleviate cellular stress.
Packer M
Cardiovasc Res 2021 Jan 1;117(1):74-84. doi: 10.1093/cvr/cvaa064. PMID: 32243505
Genetic basis of congenital erythrocytosis.
Bento C
Int J Lab Hematol 2018 May;40 Suppl 1:62-67. doi: 10.1111/ijlh.12828. PMID: 29741264
HIF signaling pathway in pheochromocytoma and other neuroendocrine tumors.
Jochmanová I, Zelinka T, Widimský J Jr, Pacak K
Physiol Res 2014;63(Suppl 2):S251-62. doi: 10.33549/physiolres.932789. PMID: 24908231
Nitric oxide derivatives and soluble plasma selectins in patients with myeloproliferative neoplasms.
Cella G, Marchetti M, Vianello F, Panova-Noeva M, Vignoli A, Russo L, Barbui T, Falanga A
Thromb Haemost 2010 Jul;104(1):151-6. Epub 2010 Apr 29 doi: 10.1160/TH09-09-0663. PMID: 20431848
Chronic oxygen therapy.
Flick MR, Block AJ
Med Clin North Am 1977 Nov;61(6):1397-406. doi: 10.1016/s0025-7125(16)31268-8. PMID: 412017

Clinical prediction guides

High-altitude hypoxia exposure inhibits erythrophagocytosis by inducing macrophage ferroptosis in the spleen.
Yang WP, Li MQ, Ding J, Li JY, Wu G, Liu B, Gao YQ, Wang GH, Luo QQ
Elife 2024 Apr 17;12 doi: 10.7554/eLife.87496. PMID: 38629942Free PMC Article
Clinicopathological characteristics of high-altitude polycythemia-related kidney disease in Tibetan inhabitants.
Wang H, Tang C, Dang Z, Yong A, Liu L, Wang S, Zhao M
Kidney Int 2022 Jul;102(1):196-206. Epub 2022 May 2 doi: 10.1016/j.kint.2022.03.027. PMID: 35513124
Genetic basis of congenital erythrocytosis.
Bento C
Int J Lab Hematol 2018 May;40 Suppl 1:62-67. doi: 10.1111/ijlh.12828. PMID: 29741264
Carbon monoxide poisoning: systemic manifestations and complications.
Choi IS
J Korean Med Sci 2001 Jun;16(3):253-61. doi: 10.3346/jkms.2001.16.3.253. PMID: 11410684Free PMC Article
Hemorheology in the erythrocytoses.
Pearson TC
Mt Sinai J Med 2001 May;68(3):182-91. PMID: 11373690

Recent systematic reviews

The heart and pulmonary circulation at high altitudes: healthy highlanders and chronic mountain sickness.
Penaloza D, Arias-Stella J
Circulation 2007 Mar 6;115(9):1132-46. doi: 10.1161/CIRCULATIONAHA.106.624544. PMID: 17339571

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...