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Secondary acquired sideroblastic anemia

MedGen UID:
82894
•Concept ID:
C0272024
•
Disease or Syndrome
Synonyms: Acquired sideroblastic anemia; Secondary sideroblastic anemia
SNOMED CT: Secondary acquired sideroblastic anemia (90175006); Secondary sideroblastic anemia (90175006); Acquired sideroblastic anemia (90175006)

Recent clinical studies

Etiology

Ineffective erythropoiesis and regulation of iron status in iron loading anaemias.
Camaschella C, Nai A
Br J Haematol 2016 Feb;172(4):512-23. Epub 2015 Oct 22 doi: 10.1111/bjh.13820. PMID: 26491866
Mitochondrial iron metabolism and sideroblastic anemia.
Sheftel AD, Richardson DR, Prchal J, Ponka P
Acta Haematol 2009;122(2-3):120-33. Epub 2009 Nov 10 doi: 10.1159/000243796. PMID: 19907149
Increased apoptosis in acquired sideroblastic anaemia.
Matthes TW, Meyer G, Samii K, Beris P
Br J Haematol 2000 Dec;111(3):843-52. PMID: 11122146
Myelodysplastic syndromes.
Sultan C, Imbert M, Jouault H, Scoazec JY
Acta Haematol 1987;78 Suppl 1:91-3. doi: 10.1159/000205910. PMID: 3124454
Haem synthesis in sideroblastic anaemia.
Konopka L, Hoffbrand AV
Br J Haematol 1979 May;42(1):73-83. doi: 10.1111/j.1365-2141.1979.tb03699.x. PMID: 465361

Diagnosis

Detection of major and minor bcr/abl fusion gene transcripts in a patient with acute undifferentiated leukemia secondary to treatment with an alkylating agent.
Hattori M, Tanaka M, Yamazaki Y, Nakahara Y, Tsushita K, Utumi M
Leuk Res 1995 Jun;19(6):389-96. doi: 10.1016/0145-2126(95)00004-8. PMID: 7596151
French registry of acute leukemia and myelodysplastic syndromes. Age distribution and hemogram analysis of the 4496 cases recorded during 1982-1983 and classified according to FAB criteria. Groupe Francais de Morphologie Hematologique.
Cancer 1987 Sep 15;60(6):1385-94. PMID: 3476180
Myelodysplastic syndromes.
Sultan C, Imbert M, Jouault H, Scoazec JY
Acta Haematol 1987;78 Suppl 1:91-3. doi: 10.1159/000205910. PMID: 3124454
Iron overload disorders: natural history, pathogenesis, diagnosis, and therapy.
McLaren GD, Muir WA, Kellermeyer RW
Crit Rev Clin Lab Sci 1983;19(3):205-66. doi: 10.3109/10408368309165764. PMID: 6373141
Deoxyuridine-suppression test and bone marrow culture for the diagnosis of macrocytic refractory anaemias.
Garand R, Zittoun J, Marquet J, Mouraud E, Grolleau JY, Le Mevel A, Zittoun R
Scand J Haematol 1980 Sep;25(3):231-6. doi: 10.1111/j.1600-0609.1981.tb01394.x. PMID: 7466311

Therapy

Glycine and Folate Ameliorate Models of Congenital Sideroblastic Anemia.
Fernández-Murray JP, Prykhozhij SV, Dufay JN, Steele SL, Gaston D, Nasrallah GK, Coombs AJ, Liwski RS, Fernandez CV, Berman JN, McMaster CR
PLoS Genet 2016 Jan;12(1):e1005783. Epub 2016 Jan 28 doi: 10.1371/journal.pgen.1005783. PMID: 26821380Free PMC Article
Acquired sideroblastic anaemia induced by a copper-chelating agent.
Perry AR, Pagliuca A, Fitzsimons EJ, Mufti GJ, Williams R
Int J Hematol 1996 Jul;64(1):69-72. doi: 10.1016/0925-5710(96)00457-4. PMID: 8757970
Acquired sideroblastic anaemia after aplastic anaemia caused by D-penicillamine therapy for rheumatoid arthritis.
Ramselaar AC, Dekker AW, Huber-Bruning O, Bijlsma JW
Ann Rheum Dis 1987 Feb;46(2):156-8. doi: 10.1136/ard.46.2.156. PMID: 3827338Free PMC Article
Iron overload disorders: natural history, pathogenesis, diagnosis, and therapy.
McLaren GD, Muir WA, Kellermeyer RW
Crit Rev Clin Lab Sci 1983;19(3):205-66. doi: 10.3109/10408368309165764. PMID: 6373141
Haem synthesis in sideroblastic anaemia.
Konopka L, Hoffbrand AV
Br J Haematol 1979 May;42(1):73-83. doi: 10.1111/j.1365-2141.1979.tb03699.x. PMID: 465361

Prognosis

Different pathophysiological mechanisms of intramitochondrial iron accumulation in acquired and congenital sideroblastic anemia caused by mitochondrial DNA deletion.
Matthes T, Rustin P, Trachsel H, Darbellay R, Costaridou S, Xaidara A, Rideau A, Beris P
Eur J Haematol 2006 Aug;77(2):169-74. doi: 10.1111/j.1600-0609.2006.00674.x. PMID: 16856911
Detection of major and minor bcr/abl fusion gene transcripts in a patient with acute undifferentiated leukemia secondary to treatment with an alkylating agent.
Hattori M, Tanaka M, Yamazaki Y, Nakahara Y, Tsushita K, Utumi M
Leuk Res 1995 Jun;19(6):389-96. doi: 10.1016/0145-2126(95)00004-8. PMID: 7596151
Myelodysplastic syndromes.
Sultan C, Imbert M, Jouault H, Scoazec JY
Acta Haematol 1987;78 Suppl 1:91-3. doi: 10.1159/000205910. PMID: 3124454
Iron overload disorders: natural history, pathogenesis, diagnosis, and therapy.
McLaren GD, Muir WA, Kellermeyer RW
Crit Rev Clin Lab Sci 1983;19(3):205-66. doi: 10.3109/10408368309165764. PMID: 6373141

Clinical prediction guides

Glycine and Folate Ameliorate Models of Congenital Sideroblastic Anemia.
Fernández-Murray JP, Prykhozhij SV, Dufay JN, Steele SL, Gaston D, Nasrallah GK, Coombs AJ, Liwski RS, Fernandez CV, Berman JN, McMaster CR
PLoS Genet 2016 Jan;12(1):e1005783. Epub 2016 Jan 28 doi: 10.1371/journal.pgen.1005783. PMID: 26821380Free PMC Article
Erythroid precursor cells in primary acquired and secondary sideroblastic anemia.
Takaku F, Mizoguchi H, Suda T, Kubota K, Miura Y
Exp Hematol 1980;8 Suppl 8:225-34. PMID: 6962069

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