U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Symmetric proximal motor neuropathy due to diabetes mellitus

MedGen UID:
82884
•Concept ID:
C0271673
•
Disease or Syndrome
Synonym: Symmetric Diabetic Proximal Motor Neuropathy
SNOMED CT: Symmetric proximal motor neuropathy with diabetes mellitus (39127005); Symmetric proximal motor neuropathy due to diabetes mellitus (39127005); Symmetric diabetic proximal motor neuropathy (39127005)

Professional guidelines

PubMed

American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update.
Blonde L, Umpierrez GE, Reddy SS, McGill JB, Berga SL, Bush M, Chandrasekaran S, DeFronzo RA, Einhorn D, Galindo RJ, Gardner TW, Garg R, Garvey WT, Hirsch IB, Hurley DL, Izuora K, Kosiborod M, Olson D, Patel SB, Pop-Busui R, Sadhu AR, Samson SL, Stec C, Tamborlane WV Jr, Tuttle KR, Twining C, Vella A, Vellanki P, Weber SL
Endocr Pract 2022 Oct;28(10):923-1049. Epub 2022 Aug 11 doi: 10.1016/j.eprac.2022.08.002. PMID: 35963508Free PMC Article
Peripheral Neuropathy: Evaluation and Differential Diagnosis.
Castelli G, Desai KM, Cantone RE
Am Fam Physician 2020 Dec 15;102(12):732-739. PMID: 33320513
Diabetic peripheral neuropathy: advances in diagnosis and strategies for screening and early intervention.
Selvarajah D, Kar D, Khunti K, Davies MJ, Scott AR, Walker J, Tesfaye S
Lancet Diabetes Endocrinol 2019 Dec;7(12):938-948. Epub 2019 Oct 14 doi: 10.1016/S2213-8587(19)30081-6. PMID: 31624024

Recent clinical studies

Etiology

Towards prevention of diabetic peripheral neuropathy: clinical presentation, pathogenesis, and new treatments.
Elafros MA, Andersen H, Bennett DL, Savelieff MG, Viswanathan V, Callaghan BC, Feldman EL
Lancet Neurol 2022 Oct;21(10):922-936. doi: 10.1016/S1474-4422(22)00188-0. PMID: 36115364Free PMC Article
Progress in the treatment of diabetic peripheral neuropathy.
Yang K, Wang Y, Li YW, Chen YG, Xing N, Lin HB, Zhou P, Yu XP
Biomed Pharmacother 2022 Apr;148:112717. Epub 2022 Feb 19 doi: 10.1016/j.biopha.2022.112717. PMID: 35193039
Diabetic peripheral neuropathy: advances in diagnosis and strategies for screening and early intervention.
Selvarajah D, Kar D, Khunti K, Davies MJ, Scott AR, Walker J, Tesfaye S
Lancet Diabetes Endocrinol 2019 Dec;7(12):938-948. Epub 2019 Oct 14 doi: 10.1016/S2213-8587(19)30081-6. PMID: 31624024
Diabetic neuropathy.
Feldman EL, Callaghan BC, Pop-Busui R, Zochodne DW, Wright DE, Bennett DL, Bril V, Russell JW, Viswanathan V
Nat Rev Dis Primers 2019 Jun 13;5(1):42. doi: 10.1038/s41572-019-0097-9. PMID: 31197183Free PMC Article
Diabetic neuropathy: clinical manifestations and current treatments.
Callaghan BC, Cheng HT, Stables CL, Smith AL, Feldman EL
Lancet Neurol 2012 Jun;11(6):521-34. Epub 2012 May 16 doi: 10.1016/S1474-4422(12)70065-0. PMID: 22608666Free PMC Article

Diagnosis

Gastrointestinal motility disorders in neurologic disease.
Camilleri M
J Clin Invest 2021 Feb 15;131(4) doi: 10.1172/JCI143771. PMID: 33586685Free PMC Article
Diabetic peripheral neuropathy: advances in diagnosis and strategies for screening and early intervention.
Selvarajah D, Kar D, Khunti K, Davies MJ, Scott AR, Walker J, Tesfaye S
Lancet Diabetes Endocrinol 2019 Dec;7(12):938-948. Epub 2019 Oct 14 doi: 10.1016/S2213-8587(19)30081-6. PMID: 31624024
Diabetic neuropathy.
Feldman EL, Callaghan BC, Pop-Busui R, Zochodne DW, Wright DE, Bennett DL, Bril V, Russell JW, Viswanathan V
Nat Rev Dis Primers 2019 Jun 13;5(1):42. doi: 10.1038/s41572-019-0097-9. PMID: 31197183Free PMC Article
Diabetic Gastroparesis.
Bharucha AE, Kudva YC, Prichard DO
Endocr Rev 2019 Oct 1;40(5):1318-1352. doi: 10.1210/er.2018-00161. PMID: 31081877Free PMC Article
Neuropathy and Diabetic Foot Syndrome.
Volmer-Thole M, Lobmann R
Int J Mol Sci 2016 Jun 10;17(6) doi: 10.3390/ijms17060917. PMID: 27294922Free PMC Article

Therapy

Pathogenetic treatments for diabetic peripheral neuropathy.
Ziegler D
Diabetes Res Clin Pract 2023 Dec;206 Suppl 1:110764. doi: 10.1016/j.diabres.2023.110764. PMID: 38245327
Gut microbiota modulate distal symmetric polyneuropathy in patients with diabetes.
Yang J, Yang X, Wu G, Huang F, Shi X, Wei W, Zhang Y, Zhang H, Cheng L, Yu L, Shang J, Lv Y, Wang X, Zhai R, Li P, Cui B, Fang Y, Deng X, Tang S, Wang L, Yuan Q, Zhao L, Zhang F, Zhang C, Yuan H
Cell Metab 2023 Sep 5;35(9):1548-1562.e7. Epub 2023 Jul 13 doi: 10.1016/j.cmet.2023.06.010. PMID: 37451270
Small Fiber Neuropathy.
Strand N, Wie C, Peck J, Maita M, Singh N, Dumbroff J, Tieppo Francio V, Murphy M, Chang K, Dickerson DM, Maloney J
Curr Pain Headache Rep 2022 Jun;26(6):429-438. Epub 2022 Apr 6 doi: 10.1007/s11916-022-01044-8. PMID: 35384587
Diabetic Peripheral Neuropathy: Diagnosis and Treatment.
Røikjer J, Mørch CD, Ejskjaer N
Curr Drug Saf 2021;16(1):2-16. doi: 10.2174/1574886315666200731173113. PMID: 32735526
Cardiac Autonomic Neuropathy in Diabetes Mellitus.
Agashe S, Petak S
Methodist Debakey Cardiovasc J 2018 Oct-Dec;14(4):251-256. doi: 10.14797/mdcj-14-4-251. PMID: 30788010Free PMC Article

Prognosis

Management of diabetic neuropathy.
Cernea S, Raz I
Metabolism 2021 Oct;123:154867. Epub 2021 Aug 17 doi: 10.1016/j.metabol.2021.154867. PMID: 34411554
Study on Risk Factors of Peripheral Neuropathy in Type 2 Diabetes Mellitus and Establishment of Prediction Model.
Wu B, Niu Z, Hu F
Diabetes Metab J 2021 Jul;45(4):526-538. Epub 2021 Jul 30 doi: 10.4093/dmj.2020.0100. PMID: 34352988Free PMC Article
Molecular mechanism of diabetic neuropathy and its pharmacotherapeutic targets.
Dewanjee S, Das S, Das AK, Bhattacharjee N, Dihingia A, Dua TK, Kalita J, Manna P
Eur J Pharmacol 2018 Aug 15;833:472-523. Epub 2018 Jun 30 doi: 10.1016/j.ejphar.2018.06.034. PMID: 29966615
Diabetic neuropathy: mechanisms, emerging treatments, and subtypes.
Albers JW, Pop-Busui R
Curr Neurol Neurosci Rep 2014 Aug;14(8):473. doi: 10.1007/s11910-014-0473-5. PMID: 24954624Free PMC Article
Vasculitic neuropathies.
Gwathmey KG, Burns TM, Collins MP, Dyck PJ
Lancet Neurol 2014 Jan;13(1):67-82. doi: 10.1016/S1474-4422(13)70236-9. PMID: 24331794

Clinical prediction guides

Prevalence and risk factors of diabetic peripheral neuropathy: A population-based cross-sectional study in China.
Wang W, Ji Q, Ran X, Li C, Kuang H, Yu X, Fang H, Yang J, Liu J, Xue Y, Feng B, Lei M, Zhu D
Diabetes Metab Res Rev 2023 Nov;39(8):e3702. Epub 2023 Jul 25 doi: 10.1002/dmrr.3702. PMID: 37490047
Gut microbiota modulate distal symmetric polyneuropathy in patients with diabetes.
Yang J, Yang X, Wu G, Huang F, Shi X, Wei W, Zhang Y, Zhang H, Cheng L, Yu L, Shang J, Lv Y, Wang X, Zhai R, Li P, Cui B, Fang Y, Deng X, Tang S, Wang L, Yuan Q, Zhao L, Zhang F, Zhang C, Yuan H
Cell Metab 2023 Sep 5;35(9):1548-1562.e7. Epub 2023 Jul 13 doi: 10.1016/j.cmet.2023.06.010. PMID: 37451270
Study on Risk Factors of Peripheral Neuropathy in Type 2 Diabetes Mellitus and Establishment of Prediction Model.
Wu B, Niu Z, Hu F
Diabetes Metab J 2021 Jul;45(4):526-538. Epub 2021 Jul 30 doi: 10.4093/dmj.2020.0100. PMID: 34352988Free PMC Article
Cardiac Autonomic Neuropathy in Diabetes Mellitus.
Agashe S, Petak S
Methodist Debakey Cardiovasc J 2018 Oct-Dec;14(4):251-256. doi: 10.14797/mdcj-14-4-251. PMID: 30788010Free PMC Article
Diabetic neuropathy.
Said G
Handb Clin Neurol 2013;115:579-89. doi: 10.1016/B978-0-444-52902-2.00033-3. PMID: 23931803

Recent systematic reviews

Exercise and Neuropathy: Systematic Review with Meta-Analysis.
Streckmann F, Balke M, Cavaletti G, Toscanelli A, Bloch W, Décard BF, Lehmann HC, Faude O
Sports Med 2022 May;52(5):1043-1065. Epub 2021 Dec 29 doi: 10.1007/s40279-021-01596-6. PMID: 34964950
Efficacy of hyperbaric oxygen therapy for diabetic foot ulcers: An updated systematic review and meta-analysis.
Zhang Z, Zhang W, Xu Y, Liu D
Asian J Surg 2022 Jan;45(1):68-78. Epub 2021 Aug 8 doi: 10.1016/j.asjsur.2021.07.047. PMID: 34376365
A systematic review and meta-analysis of efficacy and safety of negative pressure wound therapy in the treatment of diabetic foot ulcer.
Chen L, Zhang S, Da J, Wu W, Ma F, Tang C, Li G, Zhong D, Liao B
Ann Palliat Med 2021 Oct;10(10):10830-10839. doi: 10.21037/apm-21-2476. PMID: 34763444
Impact of age at type 2 diabetes mellitus diagnosis on mortality and vascular complications: systematic review and meta-analyses.
Nanayakkara N, Curtis AJ, Heritier S, Gadowski AM, Pavkov ME, Kenealy T, Owens DR, Thomas RL, Song S, Wong J, Chan JC, Luk AO, Penno G, Ji L, Mohan V, Amutha A, Romero-Aroca P, Gasevic D, Magliano DJ, Teede HJ, Chalmers J, Zoungas S
Diabetologia 2021 Feb;64(2):275-287. Epub 2020 Dec 14 doi: 10.1007/s00125-020-05319-w. PMID: 33313987Free PMC Article
Prevention of foot ulcers in the at-risk patient with diabetes: a systematic review.
van Netten JJ, Price PE, Lavery LA, Monteiro-Soares M, Rasmussen A, Jubiz Y, Bus SA; International Working Group on the Diabetic Foot
Diabetes Metab Res Rev 2016 Jan;32 Suppl 1:84-98. doi: 10.1002/dmrr.2701. PMID: 26340966

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...