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Type 2 diabetes mellitus in obese

MedGen UID:
543463
•Concept ID:
C0271638
•
Disease or Syndrome
Synonym: Diabetes mellitus type 2 in obese
SNOMED CT: Diabetes mellitus type 2 in obese (81531005); Type 2 diabetes mellitus in obese (81531005)

Professional guidelines

PubMed

Roux-en-Y Gastric Bypass Versus Medical Treatment for Type 2 Diabetes Mellitus in Obese Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Yan Y, Sha Y, Yao G, Wang S, Kong F, Liu H, Zhang G, Zhang H, Hu C, Zhang X
Medicine (Baltimore) 2016 Apr;95(17):e3462. doi: 10.1097/MD.0000000000003462. PMID: 27124041Free PMC Article
Efficacy of laparoscopic sleeve gastrectomy and intensive medical management in obese patients with type 2 diabetes mellitus.
Palikhe G, Gupta R, Behera BN, Sachdeva N, Gangadhar P, Bhansali A
Obes Surg 2014 Apr;24(4):529-35. doi: 10.1007/s11695-013-1114-9. PMID: 24272885

Recent clinical studies

Etiology

Relating Lipoprotein(a) Concentrations to Cardiovascular Event Risk After Acute Coronary Syndrome: A Comparison of 3 Tests.
Szarek M, Reijnders E, Jukema JW, Bhatt DL, Bittner VA, Diaz R, Fazio S, Garon G, Goodman SG, Harrington RA, Ruhaak LR, Schwertfeger M, Tsimikas S, White HD, Steg PG, Cobbaert C, Schwartz GG; ODYSSEY OUTCOMES Investigators
Circulation 2024 Jan 16;149(3):192-203. Epub 2023 Aug 26 doi: 10.1161/CIRCULATIONAHA.123.066398. PMID: 37632469Free PMC Article
Telemedicine management of type 2 diabetes mellitus in obese and overweight young and middle-aged patients during COVID-19 outbreak: A single-center, prospective, randomized control study.
Yin W, Liu Y, Hu H, Sun J, Liu Y, Wang Z
PLoS One 2022;17(9):e0275251. Epub 2022 Sep 29 doi: 10.1371/journal.pone.0275251. PMID: 36174028Free PMC Article
Myocardial Infarction in the ISCHEMIA Trial: Impact of Different Definitions on Incidence, Prognosis, and Treatment Comparisons.
Chaitman BR, Alexander KP, Cyr DD, Berger JS, Reynolds HR, Bangalore S, Boden WE, Lopes RD, Demkow M, Piero Perna G, Riezebos RK, McFalls EO, Banerjee S, Bagai A, Gosselin G, O'Brien SM, Rockhold FW, Waters DD, Thygesen KA, Stone GW, White HD, Maron DJ, Hochman JS; ISCHEMIA Research Group
Circulation 2021 Feb 23;143(8):790-804. Epub 2020 Dec 3 doi: 10.1161/CIRCULATIONAHA.120.047987. PMID: 33267610Free PMC Article
Roux-en-Y Gastric Bypass Versus Medical Treatment for Type 2 Diabetes Mellitus in Obese Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Yan Y, Sha Y, Yao G, Wang S, Kong F, Liu H, Zhang G, Zhang H, Hu C, Zhang X
Medicine (Baltimore) 2016 Apr;95(17):e3462. doi: 10.1097/MD.0000000000003462. PMID: 27124041Free PMC Article
Surgery in the treatment of type 2 diabetes mellitus.
Maleckas A, Venclauskas L, Wallenius V, Lönroth H, Fändriks L
Scand J Surg 2015 Mar;104(1):40-7. Epub 2015 Jan 26 doi: 10.1177/1457496914561140. PMID: 25623915

Diagnosis

Relating Lipoprotein(a) Concentrations to Cardiovascular Event Risk After Acute Coronary Syndrome: A Comparison of 3 Tests.
Szarek M, Reijnders E, Jukema JW, Bhatt DL, Bittner VA, Diaz R, Fazio S, Garon G, Goodman SG, Harrington RA, Ruhaak LR, Schwertfeger M, Tsimikas S, White HD, Steg PG, Cobbaert C, Schwartz GG; ODYSSEY OUTCOMES Investigators
Circulation 2024 Jan 16;149(3):192-203. Epub 2023 Aug 26 doi: 10.1161/CIRCULATIONAHA.123.066398. PMID: 37632469Free PMC Article
Potential biomarker in serum for predicting susceptibility to type 2 diabetes mellitus: Free fatty acid 22:6.
Ma Y, Xiong J, Zhang X, Qiu T, Pang H, Li X, Zhu J, Wang J, Pan C, Yang X, Chu X, Yang B, Wang C, Zhang J
J Diabetes Investig 2021 Jun;12(6):950-962. Epub 2020 Dec 4 doi: 10.1111/jdi.13443. PMID: 33068491Free PMC Article
Glycated hemoglobin A1c as a screening test for detecting type 2 diabetes mellitus in obese children and adolescents.
Yoon JS, So CH, Lee HS, Hwang JS
J Pediatr Endocrinol Metab 2018 Apr 25;31(5):503-506. doi: 10.1515/jpem-2017-0463. PMID: 29652667
Lipocalin-2 expression and serum levels as early predictors of type 2 diabetes mellitus in obese women.
Rashad NM, El-Shal AS, Etewa RL, Wadea FM
IUBMB Life 2017 Feb;69(2):88-97. Epub 2017 Jan 24 doi: 10.1002/iub.1594. PMID: 28116808
Associations among Insulin Resistance, Triacylglycerol/High Density Lipoprotein (TAG/HDL ratio) and Thyroid hormone levels-A study on Type 2 diabetes mellitus in obese and overweight subjects.
Jayanthi R, Srinivasan AR, Hanifah M, Maran AL
Diabetes Metab Syndr 2017 Nov;11 Suppl 1:S121-S126. Epub 2016 Dec 23 doi: 10.1016/j.dsx.2016.12.020. PMID: 28043815

Therapy

Relating Lipoprotein(a) Concentrations to Cardiovascular Event Risk After Acute Coronary Syndrome: A Comparison of 3 Tests.
Szarek M, Reijnders E, Jukema JW, Bhatt DL, Bittner VA, Diaz R, Fazio S, Garon G, Goodman SG, Harrington RA, Ruhaak LR, Schwertfeger M, Tsimikas S, White HD, Steg PG, Cobbaert C, Schwartz GG; ODYSSEY OUTCOMES Investigators
Circulation 2024 Jan 16;149(3):192-203. Epub 2023 Aug 26 doi: 10.1161/CIRCULATIONAHA.123.066398. PMID: 37632469Free PMC Article
Telemedicine management of type 2 diabetes mellitus in obese and overweight young and middle-aged patients during COVID-19 outbreak: A single-center, prospective, randomized control study.
Yin W, Liu Y, Hu H, Sun J, Liu Y, Wang Z
PLoS One 2022;17(9):e0275251. Epub 2022 Sep 29 doi: 10.1371/journal.pone.0275251. PMID: 36174028Free PMC Article
Myocardial Infarction in the ISCHEMIA Trial: Impact of Different Definitions on Incidence, Prognosis, and Treatment Comparisons.
Chaitman BR, Alexander KP, Cyr DD, Berger JS, Reynolds HR, Bangalore S, Boden WE, Lopes RD, Demkow M, Piero Perna G, Riezebos RK, McFalls EO, Banerjee S, Bagai A, Gosselin G, O'Brien SM, Rockhold FW, Waters DD, Thygesen KA, Stone GW, White HD, Maron DJ, Hochman JS; ISCHEMIA Research Group
Circulation 2021 Feb 23;143(8):790-804. Epub 2020 Dec 3 doi: 10.1161/CIRCULATIONAHA.120.047987. PMID: 33267610Free PMC Article
Roux-en-Y Gastric Bypass Versus Medical Treatment for Type 2 Diabetes Mellitus in Obese Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Yan Y, Sha Y, Yao G, Wang S, Kong F, Liu H, Zhang G, Zhang H, Hu C, Zhang X
Medicine (Baltimore) 2016 Apr;95(17):e3462. doi: 10.1097/MD.0000000000003462. PMID: 27124041Free PMC Article
Surgery in the treatment of type 2 diabetes mellitus.
Maleckas A, Venclauskas L, Wallenius V, Lönroth H, Fändriks L
Scand J Surg 2015 Mar;104(1):40-7. Epub 2015 Jan 26 doi: 10.1177/1457496914561140. PMID: 25623915

Prognosis

Relating Lipoprotein(a) Concentrations to Cardiovascular Event Risk After Acute Coronary Syndrome: A Comparison of 3 Tests.
Szarek M, Reijnders E, Jukema JW, Bhatt DL, Bittner VA, Diaz R, Fazio S, Garon G, Goodman SG, Harrington RA, Ruhaak LR, Schwertfeger M, Tsimikas S, White HD, Steg PG, Cobbaert C, Schwartz GG; ODYSSEY OUTCOMES Investigators
Circulation 2024 Jan 16;149(3):192-203. Epub 2023 Aug 26 doi: 10.1161/CIRCULATIONAHA.123.066398. PMID: 37632469Free PMC Article
Myocardial Infarction in the ISCHEMIA Trial: Impact of Different Definitions on Incidence, Prognosis, and Treatment Comparisons.
Chaitman BR, Alexander KP, Cyr DD, Berger JS, Reynolds HR, Bangalore S, Boden WE, Lopes RD, Demkow M, Piero Perna G, Riezebos RK, McFalls EO, Banerjee S, Bagai A, Gosselin G, O'Brien SM, Rockhold FW, Waters DD, Thygesen KA, Stone GW, White HD, Maron DJ, Hochman JS; ISCHEMIA Research Group
Circulation 2021 Feb 23;143(8):790-804. Epub 2020 Dec 3 doi: 10.1161/CIRCULATIONAHA.120.047987. PMID: 33267610Free PMC Article
Potential biomarker in serum for predicting susceptibility to type 2 diabetes mellitus: Free fatty acid 22:6.
Ma Y, Xiong J, Zhang X, Qiu T, Pang H, Li X, Zhu J, Wang J, Pan C, Yang X, Chu X, Yang B, Wang C, Zhang J
J Diabetes Investig 2021 Jun;12(6):950-962. Epub 2020 Dec 4 doi: 10.1111/jdi.13443. PMID: 33068491Free PMC Article
Glycated hemoglobin A1c as a screening test for detecting type 2 diabetes mellitus in obese children and adolescents.
Yoon JS, So CH, Lee HS, Hwang JS
J Pediatr Endocrinol Metab 2018 Apr 25;31(5):503-506. doi: 10.1515/jpem-2017-0463. PMID: 29652667
Roux-en-Y Gastric Bypass Versus Medical Treatment for Type 2 Diabetes Mellitus in Obese Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Yan Y, Sha Y, Yao G, Wang S, Kong F, Liu H, Zhang G, Zhang H, Hu C, Zhang X
Medicine (Baltimore) 2016 Apr;95(17):e3462. doi: 10.1097/MD.0000000000003462. PMID: 27124041Free PMC Article

Clinical prediction guides

Relating Lipoprotein(a) Concentrations to Cardiovascular Event Risk After Acute Coronary Syndrome: A Comparison of 3 Tests.
Szarek M, Reijnders E, Jukema JW, Bhatt DL, Bittner VA, Diaz R, Fazio S, Garon G, Goodman SG, Harrington RA, Ruhaak LR, Schwertfeger M, Tsimikas S, White HD, Steg PG, Cobbaert C, Schwartz GG; ODYSSEY OUTCOMES Investigators
Circulation 2024 Jan 16;149(3):192-203. Epub 2023 Aug 26 doi: 10.1161/CIRCULATIONAHA.123.066398. PMID: 37632469Free PMC Article
Telemedicine management of type 2 diabetes mellitus in obese and overweight young and middle-aged patients during COVID-19 outbreak: A single-center, prospective, randomized control study.
Yin W, Liu Y, Hu H, Sun J, Liu Y, Wang Z
PLoS One 2022;17(9):e0275251. Epub 2022 Sep 29 doi: 10.1371/journal.pone.0275251. PMID: 36174028Free PMC Article
Leptin but not adiponectin is related to type 2 diabetes mellitus in obese adolescents.
Reinehr T, Woelfle J, Wiegand S, Karges B, Meissner T, Nagl K, Holl RW
Pediatr Diabetes 2016 Jun;17(4):281-8. Epub 2015 Apr 16 doi: 10.1111/pedi.12276. PMID: 25882767
Surgery in the treatment of type 2 diabetes mellitus.
Maleckas A, Venclauskas L, Wallenius V, Lönroth H, Fändriks L
Scand J Surg 2015 Mar;104(1):40-7. Epub 2015 Jan 26 doi: 10.1177/1457496914561140. PMID: 25623915
Dysfunctional adiposity and the risk of prediabetes and type 2 diabetes in obese adults.
Neeland IJ, Turer AT, Ayers CR, Powell-Wiley TM, Vega GL, Farzaneh-Far R, Grundy SM, Khera A, McGuire DK, de Lemos JA
JAMA 2012 Sep 19;308(11):1150-9. doi: 10.1001/2012.jama.11132. PMID: 22990274Free PMC Article

Recent systematic reviews

Roux-en-Y Gastric Bypass Versus Medical Treatment for Type 2 Diabetes Mellitus in Obese Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Yan Y, Sha Y, Yao G, Wang S, Kong F, Liu H, Zhang G, Zhang H, Hu C, Zhang X
Medicine (Baltimore) 2016 Apr;95(17):e3462. doi: 10.1097/MD.0000000000003462. PMID: 27124041Free PMC Article

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