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Isolated corticotropin deficiency(IAD)

MedGen UID:
82882
•Concept ID:
C0271583
•
Disease or Syndrome
Synonym: ACTH Deficiency, Isolated
SNOMED CT: Isolated corticotropin deficiency (80599001); Specific corticotropin deficiency (80599001); Isolated ACTH deficiency (80599001)
 
OMIM®: 201400; 604614

Professional guidelines

PubMed

Diagnosis and management of congenital hypopituitarism in children.
Castets S, Thomas-Teinturier C, Villanueva C, Amsellem J, Barat P, Brun G, Quoc EB, Carel JC, De Filippo GP, Kipnis C, Martinerie L, Vergier J, Saveanu A, Teissier N, Coutant R, Léger J, Reynaud R
Arch Pediatr 2024 Apr;31(3):165-171. Epub 2024 Mar 27 doi: 10.1016/j.arcped.2024.01.003. PMID: 38538470
Isolated adrenocorticotropic hormone deficiency following immune checkpoint inhibitors treatment often occurs in polyglandular endocrinopathies.
Chen H, Zhang L, Zhao L, Li X
BMC Endocr Disord 2023 Jul 6;23(1):139. doi: 10.1186/s12902-023-01397-0. PMID: 37415148Free PMC Article
Immune checkpoint inhibitor related hypophysitis: diagnostic criteria and recovery patterns.
Nguyen H, Shah K, Waguespack SG, Hu MI, Habra MA, Cabanillas ME, Busaidy NL, Bassett R, Zhou S, Iyer PC, Simmons G, Kaya D, Pitteloud M, Subudhi SK, Diab A, Dadu R
Endocr Relat Cancer 2021 Jun 2;28(7):419-431. doi: 10.1530/ERC-20-0513. PMID: 33890870Free PMC Article

Recent clinical studies

Etiology

Clinical features and autoimmune associations in patients presenting with Idiopathic Isolated ACTH deficiency.
Hannon AM, Hunter S, Smith D, Sherlock M, O'Halloran D, Thompson CJ; Irish Pituitary Database Group
Clin Endocrinol (Oxf) 2018 Mar;88(3):491-497. Epub 2018 Jan 21 doi: 10.1111/cen.13536. PMID: 29266367

Diagnosis

Clinical features and autoimmune associations in patients presenting with Idiopathic Isolated ACTH deficiency.
Hannon AM, Hunter S, Smith D, Sherlock M, O'Halloran D, Thompson CJ; Irish Pituitary Database Group
Clin Endocrinol (Oxf) 2018 Mar;88(3):491-497. Epub 2018 Jan 21 doi: 10.1111/cen.13536. PMID: 29266367
Silent thyroiditis, isolated corticotropin deficiency, and alopecia universalis in a patient with ulcerative colitis and elevated levels of plasma factor VIII: an unusual case of autoimmune polyglandular syndrome type 3.
Sheehan MT, Islam R
Endocr Pract 2009 Mar;15(2):138-42. doi: 10.4158/EP.15.2.138. PMID: 19289325
Isolated corticotropin deficiency in chronic alcoholism.
Kearney T, Robinson S, Johnston DG
J R Soc Med 2000 Jan;93(1):15-7. doi: 10.1177/014107680009300105. PMID: 10700840Free PMC Article
Isolated corticotropin deficiency in adults. Report of 10 cases and review of literature.
Yamamoto T, Fukuyama J, Hasegawa K, Sugiura M
Arch Intern Med 1992 Aug;152(8):1705-12. PMID: 1323248
Pseudo-Addison's disease. Isolated corticotropin deficiency associated with hyporeninemic hypoaldosteronism.
Manser TJ, Estep H
Arch Intern Med 1986 May;146(5):996-7. doi: 10.1001/archinte.146.5.996. PMID: 3008682

Therapy

Recovery of ovulatory menstrual cycles under hydrocortisone in two amenorrheic women with isolated corticotropin deficiency.
Dewailly D, Bourdelle-Hego MF, Pouplard-Barthelaix A, Fossati P
Horm Res 1988;29(1):14-6. doi: 10.1159/000180958. PMID: 2840382
Abnormal thyrotropin and prolactin levels in untreated corticotropin deficiency.
Gonzalez JJ, Werk EE Jr
Arch Intern Med 1985 Feb;145(2):356-7. PMID: 2983627
Isolated corticotropin deficiency.
Ichiba Y, Goto T
Am J Dis Child 1983 Dec;137(12):1202-3. doi: 10.1001/archpedi.1983.02140380062021. PMID: 6314808

Prognosis

Silent thyroiditis, isolated corticotropin deficiency, and alopecia universalis in a patient with ulcerative colitis and elevated levels of plasma factor VIII: an unusual case of autoimmune polyglandular syndrome type 3.
Sheehan MT, Islam R
Endocr Pract 2009 Mar;15(2):138-42. doi: 10.4158/EP.15.2.138. PMID: 19289325
Isolated corticotropin deficiency in adults. Report of 10 cases and review of literature.
Yamamoto T, Fukuyama J, Hasegawa K, Sugiura M
Arch Intern Med 1992 Aug;152(8):1705-12. PMID: 1323248

Clinical prediction guides

Isolated corticotropin deficiency in adults. Report of 10 cases and review of literature.
Yamamoto T, Fukuyama J, Hasegawa K, Sugiura M
Arch Intern Med 1992 Aug;152(8):1705-12. PMID: 1323248

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