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Legal blindness

MedGen UID:
78763
•Concept ID:
C0271215
•
Disease or Syndrome
Synonyms: Blindness, Legal; Legal Blindness
SNOMED CT: Legal blindness (65956007)

Professional guidelines

PubMed

Piloting a forced-choice task to elicit treatment preferences in geographic atrophy.
Enoch J, Ghulakhszian A, Sekhon M, Crabb DP, Taylor DJ, Dinah C
BMC Res Notes 2023 Sep 30;16(1):244. doi: 10.1186/s13104-023-06531-8. PMID: 37777762Free PMC Article
Usher Syndrome on the Island of Ireland: A Genotype-Phenotype Review.
Stephenson KAJ, Whelan L, Zhu J, Dockery A, Wynne NC, Cairns RM, Kirk C, Turner J, Duignan ES, O'Byrne JJ, Silvestri G, Kenna PF, Farrar GJ, Keegan DJ
Invest Ophthalmol Vis Sci 2023 Jul 3;64(10):23. doi: 10.1167/iovs.64.10.23. PMID: 37466950Free PMC Article
Intermediate uveitis associated with MS: Diagnosis, clinical features, pathogenic mechanisms, and recommendations for management.
Abraham A, Nicholson L, Dick A, Rice C, Atan D
Neurol Neuroimmunol Neuroinflamm 2021 Jan;8(1) Epub 2020 Oct 30 doi: 10.1212/NXI.0000000000000909. PMID: 33127747Free PMC Article

Recent clinical studies

Therapy

The Benefits of Flavonoids in Diabetic Retinopathy.
Matos AL, Bruno DF, Ambrósio AF, Santos PF
Nutrients 2020 Oct 16;12(10) doi: 10.3390/nu12103169. PMID: 33081260Free PMC Article
Matrix Metalloproteinases in Age-Related Macular Degeneration (AMD).
García-Onrubia L, Valentín-Bravo FJ, Coco-Martin RM, González-Sarmiento R, Pastor JC, Usategui-Martín R, Pastor-Idoate S
Int J Mol Sci 2020 Aug 18;21(16) doi: 10.3390/ijms21165934. PMID: 32824762Free PMC Article
Macular Edema in Childhood Uveitis.
Garweg JG
Klin Monbl Augenheilkd 2018 Apr;235(4):373-376. Epub 2018 Feb 16 doi: 10.1055/s-0043-123650. PMID: 29452454
Age-related macular degeneration (AMD): pathogenesis and therapy.
Nowak JZ
Pharmacol Rep 2006 May-Jun;58(3):353-63. PMID: 16845209
Open-angle glaucoma.
Distelhorst JS, Hughes GM
Am Fam Physician 2003 May 1;67(9):1937-44. PMID: 12751655

Prognosis

Macular Edema in Childhood Uveitis.
Garweg JG
Klin Monbl Augenheilkd 2018 Apr;235(4):373-376. Epub 2018 Feb 16 doi: 10.1055/s-0043-123650. PMID: 29452454
Autoimmunity in uveitis.
Ten Berge JC, Schreurs MWJ, van Daele PLA, Rothova A
Acta Ophthalmol 2018 Aug;96(5):481-485. Epub 2018 Jan 25 doi: 10.1111/aos.13652. PMID: 29369534
Microperimetry in age: related macular degeneration.
Midena E, Pilotto E
Eye (Lond) 2017 Jul;31(7):985-994. Epub 2017 Mar 3 doi: 10.1038/eye.2017.34. PMID: 28257134Free PMC Article
Dominant optic atrophy.
Lenaers G, Hamel C, Delettre C, Amati-Bonneau P, Procaccio V, Bonneau D, Reynier P, Milea D
Orphanet J Rare Dis 2012 Jul 9;7:46. doi: 10.1186/1750-1172-7-46. PMID: 22776096Free PMC Article
Cone rod dystrophies.
Hamel CP
Orphanet J Rare Dis 2007 Feb 1;2:7. doi: 10.1186/1750-1172-2-7. PMID: 17270046Free PMC Article

Clinical prediction guides

Clinical and Genetic Characterization of RDH12-Retinal Dystrophy in a South American Cohort.
Daich Varela M, Moya R, Azevedo Souza Amaral R, Schlottmann PG, Álvarez Mendiara A, Francone A, Guazi Resende R, Capalbo L, Gelvez N, López G, Morales-Acevedo AM, Ossa RH, Arno G, Michaelides M, Tamayo ML, Ferraz Sallum JM
Ophthalmol Retina 2024 Feb;8(2):163-173. Epub 2023 Sep 13 doi: 10.1016/j.oret.2023.09.007. PMID: 37714431
Do Nutrients and Nutraceuticals Play a Role in Diabetic Retinopathy? A Systematic Review.
Milluzzo A, Barchitta M, Maugeri A, Magnano San Lio R, Favara G, Mazzone MG, Sciacca L, Agodi A
Nutrients 2022 Oct 21;14(20) doi: 10.3390/nu14204430. PMID: 36297113Free PMC Article
Blindness and visual impairment in Central Europe.
Glatz M, Riedl R, Glatz W, Schneider M, Wedrich A, Bolz M, Strauss RW
PLoS One 2022;17(1):e0261897. Epub 2022 Jan 13 doi: 10.1371/journal.pone.0261897. PMID: 35025896Free PMC Article
Autoimmunity in uveitis.
Ten Berge JC, Schreurs MWJ, van Daele PLA, Rothova A
Acta Ophthalmol 2018 Aug;96(5):481-485. Epub 2018 Jan 25 doi: 10.1111/aos.13652. PMID: 29369534
Childhood-onset Leber hereditary optic neuropathy.
Majander A, Bowman R, Poulton J, Antcliff RJ, Reddy MA, Michaelides M, Webster AR, Chinnery PF, Votruba M, Moore AT, Yu-Wai-Man P
Br J Ophthalmol 2017 Nov;101(11):1505-1509. Epub 2017 Mar 17 doi: 10.1136/bjophthalmol-2016-310072. PMID: 28314831

Recent systematic reviews

Do Nutrients and Nutraceuticals Play a Role in Diabetic Retinopathy? A Systematic Review.
Milluzzo A, Barchitta M, Maugeri A, Magnano San Lio R, Favara G, Mazzone MG, Sciacca L, Agodi A
Nutrients 2022 Oct 21;14(20) doi: 10.3390/nu14204430. PMID: 36297113Free PMC Article
Visual Deficits and Dysfunctions Associated with Traumatic Brain Injury: A Systematic Review and Meta-analysis.
Merezhinskaya N, Mallia RK, Park D, Bryden DW, Mathur K, Barker FM 2nd
Optom Vis Sci 2019 Aug;96(8):542-555. doi: 10.1097/OPX.0000000000001407. PMID: 31343512
Corticosteroid implants for chronic non-infectious uveitis.
Brady CJ, Villanti AC, Law HA, Rahimy E, Reddy R, Sieving PC, Garg SJ, Tang J
Cochrane Database Syst Rev 2016 Feb 12;2(2):CD010469. doi: 10.1002/14651858.CD010469.pub2. PMID: 26866343Free PMC Article
Systematic review of anti-tumor necrosis factor-alpha therapy for treatment of immune-mediated uveitis.
Cordero-Coma M, Yilmaz T, Onal S
Ocul Immunol Inflamm 2013;21(1):19-27. doi: 10.3109/09273948.2012.723107. PMID: 23323577
Ranibizumab and pegaptanib for the treatment of age-related macular degeneration: a systematic review and economic evaluation.
Colquitt JL, Jones J, Tan SC, Takeda A, Clegg AJ, Price A
Health Technol Assess 2008 May;12(16):iii-iv, ix-201. doi: 10.3310/hta12160. PMID: 18462575

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