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Central blindness

MedGen UID:
543227
•Concept ID:
C0271214
•
Disease or Syndrome
Synonym: Cerebral blindness
SNOMED CT: Central blindness (39139002); Cerebral blindness (39139002)

Professional guidelines

PubMed

Age-Related Macular Degeneration: Pathophysiology, Management, and Future Perspectives.
Flores R, Carneiro Â, Vieira M, Tenreiro S, Seabra MC
Ophthalmologica 2021;244(6):495-511. Epub 2021 Jun 15 doi: 10.1159/000517520. PMID: 34130290
Glaucoma in Adults-Screening, Diagnosis, and Management: A Review.
Stein JD, Khawaja AP, Weizer JS
JAMA 2021 Jan 12;325(2):164-174. doi: 10.1001/jama.2020.21899. PMID: 33433580
The Diagnosis and Treatment of Age-Related Macular Degeneration.
Stahl A
Dtsch Arztebl Int 2020 Jul 20;117(29-30):513-520. doi: 10.3238/arztebl.2020.0513. PMID: 33087239Free PMC Article

Recent clinical studies

Therapy

Evaluation of vascular endothelial growth factor (VEGF) level in the tears and serum of age-related macular degeneration patients.
Shahidatul-Adha M, Zunaina E, Aini-Amalina MN
Sci Rep 2022 Mar 15;12(1):4423. doi: 10.1038/s41598-022-08492-7. PMID: 35292705Free PMC Article
IL-18 Immunotherapy for Neovascular AMD: Tolerability and Efficacy in Nonhuman Primates.
Doyle SL, López FJ, Celkova L, Brennan K, Mulfaul K, Ozaki E, Kenna PF, Kurali E, Hudson N, Doggett T, Ferguson TA, Humphries P, Adamson P, Campbell M
Invest Ophthalmol Vis Sci 2015 Aug;56(9):5424-30. doi: 10.1167/iovs.15-17264. PMID: 26284546
Advances in pharmacotherapy for wet age-related macular degeneration.
Santarelli M, Diplotti L, Samassa F, Veritti D, Kuppermann BD, Lanzetta P
Expert Opin Pharmacother 2015;16(12):1769-81. Epub 2015 Jul 13 doi: 10.1517/14656566.2015.1067679. PMID: 26165696
Predictive role of C677T MTHFR polymorphism in variable efficacy of photodynamic therapy for neovascular age-related macular degeneration.
Parmeggiani F, Gemmati D, Costagliola C, Sebastiani A, Incorvaia C
Pharmacogenomics 2009 Jan;10(1):81-95. doi: 10.2217/14622416.10.1.81. PMID: 19102718
Trilateral retinoblastoma with pituitary-hypothalamic dysfunction.
Dai S, Dimaras H, Héon E, Budning A, Doyle J, Halliday W, Drake J, Gallie BL, Chan HS
Ophthalmic Genet 2008 Sep;29(3):120-5. doi: 10.1080/13816810802043678. PMID: 18766991

Prognosis

Evaluation of vascular endothelial growth factor (VEGF) level in the tears and serum of age-related macular degeneration patients.
Shahidatul-Adha M, Zunaina E, Aini-Amalina MN
Sci Rep 2022 Mar 15;12(1):4423. doi: 10.1038/s41598-022-08492-7. PMID: 35292705Free PMC Article
Effect of Factor XIII-A G185T Polymorphism on Visual Prognosis after Photodynamic Therapy for Neovascular Macular Degeneration.
Parmeggiani F, Costagliola C, Semeraro F, Romano MR, Rinaldi M, Gallenga CE, Serino ML, Incorvaia C, D'Angelo S, De Nadai K, Dell'Omo R, Russo A, Gemmati D, Perri P
Int J Mol Sci 2015 Aug 20;16(8):19796-811. doi: 10.3390/ijms160819796. PMID: 26307969Free PMC Article
Predictive role of gene polymorphisms affecting thrombin-generation pathway in variable efficacy of photodynamic therapy for neovascular age-related macular degeneration.
Parmeggiani F, Gemmati D, Costagliola C, Sebastiani A, Incorvaia C
Recent Pat DNA Gene Seq 2009;3(2):114-22. doi: 10.2174/187221509788654151. PMID: 19519581
Predictive role of C677T MTHFR polymorphism in variable efficacy of photodynamic therapy for neovascular age-related macular degeneration.
Parmeggiani F, Gemmati D, Costagliola C, Sebastiani A, Incorvaia C
Pharmacogenomics 2009 Jan;10(1):81-95. doi: 10.2217/14622416.10.1.81. PMID: 19102718
Trilateral retinoblastoma with pituitary-hypothalamic dysfunction.
Dai S, Dimaras H, Héon E, Budning A, Doyle J, Halliday W, Drake J, Gallie BL, Chan HS
Ophthalmic Genet 2008 Sep;29(3):120-5. doi: 10.1080/13816810802043678. PMID: 18766991

Clinical prediction guides

Evaluation of vascular endothelial growth factor (VEGF) level in the tears and serum of age-related macular degeneration patients.
Shahidatul-Adha M, Zunaina E, Aini-Amalina MN
Sci Rep 2022 Mar 15;12(1):4423. doi: 10.1038/s41598-022-08492-7. PMID: 35292705Free PMC Article
Effect of Factor XIII-A G185T Polymorphism on Visual Prognosis after Photodynamic Therapy for Neovascular Macular Degeneration.
Parmeggiani F, Costagliola C, Semeraro F, Romano MR, Rinaldi M, Gallenga CE, Serino ML, Incorvaia C, D'Angelo S, De Nadai K, Dell'Omo R, Russo A, Gemmati D, Perri P
Int J Mol Sci 2015 Aug 20;16(8):19796-811. doi: 10.3390/ijms160819796. PMID: 26307969Free PMC Article
Predictive role of gene polymorphisms affecting thrombin-generation pathway in variable efficacy of photodynamic therapy for neovascular age-related macular degeneration.
Parmeggiani F, Gemmati D, Costagliola C, Sebastiani A, Incorvaia C
Recent Pat DNA Gene Seq 2009;3(2):114-22. doi: 10.2174/187221509788654151. PMID: 19519581
Predictive role of C677T MTHFR polymorphism in variable efficacy of photodynamic therapy for neovascular age-related macular degeneration.
Parmeggiani F, Gemmati D, Costagliola C, Sebastiani A, Incorvaia C
Pharmacogenomics 2009 Jan;10(1):81-95. doi: 10.2217/14622416.10.1.81. PMID: 19102718
Trilateral retinoblastoma with pituitary-hypothalamic dysfunction.
Dai S, Dimaras H, Héon E, Budning A, Doyle J, Halliday W, Drake J, Gallie BL, Chan HS
Ophthalmic Genet 2008 Sep;29(3):120-5. doi: 10.1080/13816810802043678. PMID: 18766991

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