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Eales disease

MedGen UID:
75733
•Concept ID:
C0271073
•
Disease or Syndrome
Synonyms: Idiopathic obliterative vasculopathy; Idiopathic recurrent vitreal hemorrhage
SNOMED CT: Eales' disease (54122009)
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
•Concept ID:
C0600599
•
Genetic Function
Source: Orphanet
A mode of inheritance that depends on genetic determinants in more than one gene.
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Non-Mendelian inheritance (Orphanet)
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0018460
Orphanet: ORPHA40923

Definition

A rare ophthalmic disorder characterized by 3 stages: vasculitis, occlusion, and retinal neovascularization, leading to recurrent vitreous hemorrhages and vision loss. [from ORDO]

Professional guidelines

PubMed

Nd:YAG laser hyaloidotomy in the management of Premacular Subhyaloid Hemorrhage.
Khadka D, Bhandari S, Bajimaya S, Thapa R, Paudyal G, Pradhan E
BMC Ophthalmol 2016 Apr 18;16:41. doi: 10.1186/s12886-016-0218-0. PMID: 27090882Free PMC Article
Eales' disease: diagnosis and management.
Das T, Pathengay A, Hussain N, Biswas J
Eye (Lond) 2010 Mar;24(3):472-82. Epub 2010 Jan 15 doi: 10.1038/eye.2009.315. PMID: 20075970
Diagnosis and treatment of Eales' disease.
Walsh AW, Magargal LE, Robb-Doyle E
Trans Pa Acad Ophthalmol Otolaryngol 1986;38(2):511-4. PMID: 3824461

Recent clinical studies

Etiology

Vitrectomy Due to Vitreous Hemorrhage and Tractional Retinal Detachment Secondary to Eales' Disease.
Ersöz MG, Hocaoğlu M, Sayman Muslubaş IB, Arf S, Karaçorlu M
Turk J Ophthalmol 2021 Apr 29;51(2):102-106. doi: 10.4274/tjo.galenos.2020.43709. PMID: 33951898Free PMC Article
Pediatric Eales Disease: An Indian Tertiary Eye Center Experience.
Majumder PD, Sitaula RK, Biswas J
J Pediatr Ophthalmol Strabismus 2018 Jul 1;55(4):270-274. Epub 2018 May 1 doi: 10.3928/01913913-20180213-01. PMID: 29709043
Sickle cell retinopathy: diagnosis and treatment.
Bonanomi MT, Lavezzo MM
Arq Bras Oftalmol 2013 Oct;76(5):320-7. doi: 10.1590/s0004-27492013000500016. PMID: 24232951
Profiling of human leukocyte antigens in Eales disease and tuberculosis.
Cai SJ, Su G, Li H, Xie B, Luo JM
Int Ophthalmol 2013 Oct;33(5):475-9. Epub 2013 Feb 6 doi: 10.1007/s10792-013-9718-6. PMID: 23386050
Ocular tuberculosis.
Helm CJ, Holland GN
Surv Ophthalmol 1993 Nov-Dec;38(3):229-56. doi: 10.1016/0039-6257(93)90076-j. PMID: 8310395

Diagnosis

Eales Disease.
Khan MN, Raza SS, Qadir S, Rehman H, Hussain AK, Nadeem MD, Ullah F
J Ayub Med Coll Abbottabad 2016 Oct-Dec;28(4):816-817. PMID: 28586583
Retinal vasculitis.
Shrestha JK, Khadka D, Lamichhane G, Khanal S
Nepal J Ophthalmol 2009 Jan-Jun;1(1):66-71. doi: 10.3126/nepjoph.v1i1.3675. PMID: 21141023
Eales' disease: oxidant stress and weak antioxidant defence.
Ramakrishnan S, Rajesh M, Sulochana KN
Indian J Ophthalmol 2007 Mar-Apr;55(2):95-102. doi: 10.4103/0301-4738.30701. PMID: 17322597
Eales disease--an update.
Biswas J, Sharma T, Gopal L, Madhavan HN, Sulochana KN, Ramakrishnan S
Surv Ophthalmol 2002 May-Jun;47(3):197-214. doi: 10.1016/s0039-6257(02)00288-6. PMID: 12052408
Ocular tuberculosis.
Helm CJ, Holland GN
Surv Ophthalmol 1993 Nov-Dec;38(3):229-56. doi: 10.1016/0039-6257(93)90076-j. PMID: 8310395

Therapy

Diagnostic and Therapeutic Challenge.
Wilkins CS, Goduni L, Dedania VS, Modi YS, Johnson B, Mehta N, Weng CY
Retina 2021 Jul 1;41(7):1570-1576. doi: 10.1097/IAE.0000000000002820. PMID: 32332425
Intravitreal Bevacizumab: Indications And Complications.
Jan S, Nazim M, Karim S, Hussain Z
J Ayub Med Coll Abbottabad 2016 Apr-Jun;28(2):364-368. PMID: 28718542
Eales Disease.
Khan MN, Raza SS, Qadir S, Rehman H, Hussain AK, Nadeem MD, Ullah F
J Ayub Med Coll Abbottabad 2016 Oct-Dec;28(4):816-817. PMID: 28586583
Eales' disease: diagnosis and management.
Das T, Pathengay A, Hussain N, Biswas J
Eye (Lond) 2010 Mar;24(3):472-82. Epub 2010 Jan 15 doi: 10.1038/eye.2009.315. PMID: 20075970
Ocular tuberculosis.
Helm CJ, Holland GN
Surv Ophthalmol 1993 Nov-Dec;38(3):229-56. doi: 10.1016/0039-6257(93)90076-j. PMID: 8310395

Prognosis

Vitrectomy Due to Vitreous Hemorrhage and Tractional Retinal Detachment Secondary to Eales' Disease.
Ersöz MG, Hocaoğlu M, Sayman Muslubaş IB, Arf S, Karaçorlu M
Turk J Ophthalmol 2021 Apr 29;51(2):102-106. doi: 10.4274/tjo.galenos.2020.43709. PMID: 33951898Free PMC Article
Eales' disease: diagnosis and management.
Das T, Pathengay A, Hussain N, Biswas J
Eye (Lond) 2010 Mar;24(3):472-82. Epub 2010 Jan 15 doi: 10.1038/eye.2009.315. PMID: 20075970
Retinal vasculitis.
Shrestha JK, Khadka D, Lamichhane G, Khanal S
Nepal J Ophthalmol 2009 Jan-Jun;1(1):66-71. doi: 10.3126/nepjoph.v1i1.3675. PMID: 21141023
Eales' disease: oxidant stress and weak antioxidant defence.
Ramakrishnan S, Rajesh M, Sulochana KN
Indian J Ophthalmol 2007 Mar-Apr;55(2):95-102. doi: 10.4103/0301-4738.30701. PMID: 17322597
Retinal vaso-occlusion in sickling hemoglobinopathies.
Goldberg MF
Birth Defects Orig Artic Ser 1976;12(3):475-515. PMID: 782601

Clinical prediction guides

Clinical Features, Long-Term Outcomes, and Prognostic Factors of Eales' Disease in Korean Patients.
Lee SM, Jung JH, Lee J, Choi EY, Shin JY, Kim M
Ocul Immunol Inflamm 2024 Jul;32(5):621-627. Epub 2023 Mar 10 doi: 10.1080/09273948.2023.2183870. PMID: 36897992
Role of Ultra-widefield Imaging in Eales' Disease: A Case Series.
Agarwal AAK, Sharma R, Biswas J
Ocul Immunol Inflamm 2020 Nov 16;28(8):1187-1191. Epub 2020 May 28 doi: 10.1080/09273948.2020.1754432. PMID: 32463328
A New Insight of Herbal Promises Against Ocular Disorders: An Occuloinformatics Approach.
Srivastava P, Tiwari A
Curr Top Med Chem 2016;16(6):634-54. doi: 10.2174/1568026615666150819105716. PMID: 26286213
Eales disease--an update.
Biswas J, Sharma T, Gopal L, Madhavan HN, Sulochana KN, Ramakrishnan S
Surv Ophthalmol 2002 May-Jun;47(3):197-214. doi: 10.1016/s0039-6257(02)00288-6. PMID: 12052408
Retinal vaso-occlusion in sickling hemoglobinopathies.
Goldberg MF
Birth Defects Orig Artic Ser 1976;12(3):475-515. PMID: 782601

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