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Hemiplegic migraine

MedGen UID:
78740
Concept ID:
C0270862
Disease or Syndrome
Synonym: Hemiplegic migraines
SNOMED CT: Hemiplegic migraine (59292006)

Definition

A rare variety of migraine with aura characterized by the presence of a motor weakness during the aura. There are two main forms depending on the familial history: patients with at least one first- or second-degree relative who has aura including motor weakness have familial hemiplegic migraine (FHM); patients without such familial history have sporadic hemiplegic migraine (SHM). [from ORPHANET]

Professional guidelines

PubMed

Indelicato E, Boesch S
Handb Exp Pharmacol 2023;279:227-248. doi: 10.1007/164_2022_625. PMID: 36592223
Le Roux M, Barth M, Gueden S, Desbordes de Cepoy P, Aeby A, Vilain C, Hirsch E, de Saint Martin A, Portes VD, Lesca G, Riquet A, Chaton L, Villeneuve N, Villard L, Cances C, Valton L, Renaldo F, Vermersch AI, Altuzarra C, Nguyen-Morel MA, Van Gils J, Angelini C, Biraben A, Arnaud L, Riant F, Van Bogaert P
Eur J Paediatr Neurol 2021 Jul;33:75-85. Epub 2021 May 26 doi: 10.1016/j.ejpn.2021.05.010. PMID: 34102571
Viana M, Afridi S
Naunyn Schmiedebergs Arch Pharmacol 2018 Jan;391(1):1-7. Epub 2017 Nov 16 doi: 10.1007/s00210-017-1438-4. PMID: 29143861

Recent clinical studies

Etiology

Sanchez Del Rio M, Cutrer FM
Handb Clin Neurol 2023;198:71-83. doi: 10.1016/B978-0-12-823356-6.00016-0. PMID: 38043972
Grangeon L, Lange KS, Waliszewska-Prosół M, Onan D, Marschollek K, Wiels W, Mikulenka P, Farham F, Gollion C, Ducros A; European Headache Federation School of Advanced Studies (EHF-SAS)
J Headache Pain 2023 Feb 20;24(1):12. doi: 10.1186/s10194-023-01547-8. PMID: 36800925Free PMC Article
Ducros A
Rev Neurol (Paris) 2021 Sep;177(7):801-808. Epub 2021 Jul 23 doi: 10.1016/j.neurol.2021.06.002. PMID: 34304862
de Boer I, van den Maagdenberg AMJM, Terwindt GM
Curr Opin Neurol 2019 Jun;32(3):413-421. doi: 10.1097/WCO.0000000000000687. PMID: 30883436Free PMC Article
Anttila V, Wessman M, Kallela M, Palotie A
Handb Clin Neurol 2018;148:493-503. doi: 10.1016/B978-0-444-64076-5.00031-4. PMID: 29478595

Diagnosis

de Boer I, Hansen JM, Terwindt GM
Handb Clin Neurol 2024;199:353-365. doi: 10.1016/B978-0-12-823357-3.00015-X. PMID: 38307656
Nandyala A, Shah T, Ailani J
Curr Neurol Neurosci Rep 2023 Jul;23(7):381-387. Epub 2023 May 29 doi: 10.1007/s11910-023-01277-z. PMID: 37247170
Indelicato E, Boesch S
Handb Exp Pharmacol 2023;279:227-248. doi: 10.1007/164_2022_625. PMID: 36592223
Di Stefano V, Rispoli MG, Pellegrino N, Graziosi A, Rotondo E, Napoli C, Pietrobon D, Brighina F, Parisi P
J Neurol Neurosurg Psychiatry 2020 Jul;91(7):764-771. Epub 2020 May 19 doi: 10.1136/jnnp-2020-322850. PMID: 32430436Free PMC Article
Scheffer IE, Nabbout R
Epilepsia 2019 Dec;60 Suppl 3:S17-S24. doi: 10.1111/epi.16386. PMID: 31904117

Therapy

Paungarttner J, Quartana M, Patti L, Sklenárová B, Farham F, Jiménez IH, Soylu MG, Vlad IM, Tasdelen S, Mateu T, Marsico O, Reina F, Tischler V, Lampl C; European Headache Federation School of Advanced Studies (EHF – SAS)
J Headache Pain 2024 Jan 26;25(1):11. doi: 10.1186/s10194-024-01719-0. PMID: 38273253Free PMC Article
Gotra P, Bhardwaj N, Ludhiadch A, Singh G, Munshi A
Mol Neurobiol 2021 Aug;58(8):3874-3883. Epub 2021 Apr 15 doi: 10.1007/s12035-021-02386-x. PMID: 33856647
Di Stefano V, Rispoli MG, Pellegrino N, Graziosi A, Rotondo E, Napoli C, Pietrobon D, Brighina F, Parisi P
J Neurol Neurosurg Psychiatry 2020 Jul;91(7):764-771. Epub 2020 May 19 doi: 10.1136/jnnp-2020-322850. PMID: 32430436Free PMC Article
Viana M, Afridi S
Naunyn Schmiedebergs Arch Pharmacol 2018 Jan;391(1):1-7. Epub 2017 Nov 16 doi: 10.1007/s00210-017-1438-4. PMID: 29143861
Lewis DW
Neurol Clin 2009 May;27(2):481-501. doi: 10.1016/j.ncl.2008.11.003. PMID: 19289227

Prognosis

de Boer I, Hansen JM, Terwindt GM
Handb Clin Neurol 2024;199:353-365. doi: 10.1016/B978-0-12-823357-3.00015-X. PMID: 38307656
Paungarttner J, Quartana M, Patti L, Sklenárová B, Farham F, Jiménez IH, Soylu MG, Vlad IM, Tasdelen S, Mateu T, Marsico O, Reina F, Tischler V, Lampl C; European Headache Federation School of Advanced Studies (EHF – SAS)
J Headache Pain 2024 Jan 26;25(1):11. doi: 10.1186/s10194-024-01719-0. PMID: 38273253Free PMC Article
Lipman AR, Fan X, Shen Y, Chung WK
Clin Genet 2022 Oct;102(4):288-295. Epub 2022 Jun 26 doi: 10.1111/cge.14180. PMID: 35722745Free PMC Article
Vetro A, Nielsen HN, Holm R, Hevner RF, Parrini E, Powis Z, Møller RS, Bellan C, Simonati A, Lesca G, Helbig KL, Palmer EE, Mei D, Ballardini E, Van Haeringen A, Syrbe S, Leuzzi V, Cioni G, Curry CJ, Costain G, Santucci M, Chong K, Mancini GMS, Clayton-Smith J, Bigoni S, Scheffer IE, Dobyns WB, Vilsen B, Guerrini R; ATP1A2/A3-collaborators
Brain 2021 Jun 22;144(5):1435-1450. doi: 10.1093/brain/awab052. PMID: 33880529
Lewis DW
Neurol Clin 2009 May;27(2):481-501. doi: 10.1016/j.ncl.2008.11.003. PMID: 19289227

Clinical prediction guides

de Boer I, Hansen JM, Terwindt GM
Handb Clin Neurol 2024;199:353-365. doi: 10.1016/B978-0-12-823357-3.00015-X. PMID: 38307656
Lipman AR, Fan X, Shen Y, Chung WK
Clin Genet 2022 Oct;102(4):288-295. Epub 2022 Jun 26 doi: 10.1111/cge.14180. PMID: 35722745Free PMC Article
Vetro A, Nielsen HN, Holm R, Hevner RF, Parrini E, Powis Z, Møller RS, Bellan C, Simonati A, Lesca G, Helbig KL, Palmer EE, Mei D, Ballardini E, Van Haeringen A, Syrbe S, Leuzzi V, Cioni G, Curry CJ, Costain G, Santucci M, Chong K, Mancini GMS, Clayton-Smith J, Bigoni S, Scheffer IE, Dobyns WB, Vilsen B, Guerrini R; ATP1A2/A3-collaborators
Brain 2021 Jun 22;144(5):1435-1450. doi: 10.1093/brain/awab052. PMID: 33880529
Anttila V, Wessman M, Kallela M, Palotie A
Handb Clin Neurol 2018;148:493-503. doi: 10.1016/B978-0-444-64076-5.00031-4. PMID: 29478595
Kowalska M, Prendecki M, Kozubski W, Lianeri M, Dorszewska J
Oncotarget 2016 Aug 2;7(31):50708-50718. doi: 10.18632/oncotarget.9367. PMID: 27191890Free PMC Article

Recent systematic reviews

Christensen RH, Gollion C, Amin FM, Moskowitz MA, Hadjikhani N, Ashina M
J Headache Pain 2022 Jun 1;23(1):60. doi: 10.1186/s10194-022-01430-y. PMID: 35650524Free PMC Article
Evans RW, Burch RC, Frishberg BM, Marmura MJ, Mechtler LL, Silberstein SD, Turner DP
Headache 2020 Feb;60(2):318-336. Epub 2019 Dec 31 doi: 10.1111/head.13720. PMID: 31891197
Wang R, Nie X, Xu S, Zhang M, Dong Z, Yu S
Headache 2020 Feb;60(2):382-395. Epub 2019 Nov 8 doi: 10.1111/head.13687. PMID: 31701545
Prontera P, Sarchielli P, Caproni S, Bedetti C, Cupini LM, Calabresi P, Costa C
Cephalalgia 2018 Feb;38(2):361-373. Epub 2017 Jan 6 doi: 10.1177/0333102416686347. PMID: 28058944
Viana M, Sprenger T, Andelova M, Goadsby PJ
Cephalalgia 2013 May;33(7):483-90. Epub 2013 Mar 8 doi: 10.1177/0333102413479834. PMID: 23475294

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