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Essential tremor

MedGen UID:
78725
•Concept ID:
C0270736
•
Disease or Syndrome
Synonyms: Benign essential tremor syndrome; Presenile tremor syndrome
SNOMED CT: Essential tremor (609558009)
 
Related gene: DRD3
 
Monarch Initiative: MONDO:0003233
OMIM® Phenotypic series: PS190300
Orphanet: ORPHA862

Definition

A movement disorder characterized by involuntary and rhythmic shaking of parts of the body, most often the hands or arms, that can be triggered or worsened by physical or environmental stressors. Essential tremor may be progressive and can be inherited in an autosomal dominant manner. [from NCI]

Professional guidelines

PubMed

Diagnosis and Treatment of Essential Tremor.
Wagle Shukla A
Continuum (Minneap Minn) 2022 Oct 1;28(5):1333-1349. doi: 10.1212/CON.0000000000001181. PMID: 36222768
Essential tremor: diagnosis and management.
Shanker V
BMJ 2019 Aug 5;366:l4485. doi: 10.1136/bmj.l4485. PMID: 31383632
Consensus Statement on the classification of tremors. from the task force on tremor of the International Parkinson and Movement Disorder Society.
Bhatia KP, Bain P, Bajaj N, Elble RJ, Hallett M, Louis ED, Raethjen J, Stamelou M, Testa CM, Deuschl G; Tremor Task Force of the International Parkinson and Movement Disorder Society
Mov Disord 2018 Jan;33(1):75-87. Epub 2017 Nov 30 doi: 10.1002/mds.27121. PMID: 29193359Free PMC Article

Recent clinical studies

Etiology

Essential tremor.
Louis ED
Handb Clin Neurol 2023;196:389-401. doi: 10.1016/B978-0-323-98817-9.00012-0. PMID: 37620080
Essential Tremor - Deep Brain Stimulation vs. Focused Ultrasound.
Ferreira Felloni Borges Y, Cheyuo C, Lozano AM, Fasano A
Expert Rev Neurother 2023 Jul-Dec;23(7):603-619. Epub 2023 Jun 8 doi: 10.1080/14737175.2023.2221789. PMID: 37288812
Essential tremor.
Welton T, Cardoso F, Carr JA, Chan LL, Deuschl G, Jankovic J, Tan EK
Nat Rev Dis Primers 2021 Nov 11;7(1):83. doi: 10.1038/s41572-021-00314-w. PMID: 34764294
Essential tremor: genetic update.
Deng H, Wu S, Jankovic J
Expert Rev Mol Med 2019 Dec 10;21:e8. doi: 10.1017/erm.2019.7. PMID: 31818346
Clinical approach to tremor in children.
Torres-Russotto D
Parkinsonism Relat Disord 2019 Feb;59:111-116. Epub 2019 Mar 23 doi: 10.1016/j.parkreldis.2019.03.015. PMID: 30952437

Diagnosis

Diagnosis and Treatment of Essential Tremor.
Wagle Shukla A
Continuum (Minneap Minn) 2022 Oct 1;28(5):1333-1349. doi: 10.1212/CON.0000000000001181. PMID: 36222768
Essential tremor.
Welton T, Cardoso F, Carr JA, Chan LL, Deuschl G, Jankovic J, Tan EK
Nat Rev Dis Primers 2021 Nov 11;7(1):83. doi: 10.1038/s41572-021-00314-w. PMID: 34764294
Managing Essential Tremor.
Hopfner F, Deuschl G
Neurotherapeutics 2020 Oct;17(4):1603-1621. doi: 10.1007/s13311-020-00899-2. PMID: 32915385Free PMC Article
Essential tremor: diagnosis and management.
Shanker V
BMJ 2019 Aug 5;366:l4485. doi: 10.1136/bmj.l4485. PMID: 31383632
Tremor.
Louis ED
Continuum (Minneap Minn) 2019 Aug;25(4):959-975. doi: 10.1212/CON.0000000000000748. PMID: 31356289

Therapy

Medications used to treat tremors.
Frei K, Truong DD
J Neurol Sci 2022 Apr 15;435:120194. Epub 2022 Feb 19 doi: 10.1016/j.jns.2022.120194. PMID: 35279634
Managing Essential Tremor.
Hopfner F, Deuschl G
Neurotherapeutics 2020 Oct;17(4):1603-1621. doi: 10.1007/s13311-020-00899-2. PMID: 32915385Free PMC Article
Essential tremor: diagnosis and management.
Shanker V
BMJ 2019 Aug 5;366:l4485. doi: 10.1136/bmj.l4485. PMID: 31383632
Tremor.
Louis ED
Continuum (Minneap Minn) 2019 Aug;25(4):959-975. doi: 10.1212/CON.0000000000000748. PMID: 31356289
Essential Tremor.
Haubenberger D, Hallett M
N Engl J Med 2018 May 10;378(19):1802-1810. doi: 10.1056/NEJMcp1707928. PMID: 29742376

Prognosis

Technology of deep brain stimulation: current status and future directions.
Krauss JK, Lipsman N, Aziz T, Boutet A, Brown P, Chang JW, Davidson B, Grill WM, Hariz MI, Horn A, Schulder M, Mammis A, Tass PA, Volkmann J, Lozano AM
Nat Rev Neurol 2021 Feb;17(2):75-87. Epub 2020 Nov 26 doi: 10.1038/s41582-020-00426-z. PMID: 33244188Free PMC Article
Essential tremor-plus: a controversial new concept.
Louis ED, Bares M, Benito-Leon J, Fahn S, Frucht SJ, Jankovic J, Ondo WG, Pal PK, Tan EK
Lancet Neurol 2020 Mar;19(3):266-270. Epub 2019 Nov 22 doi: 10.1016/S1474-4422(19)30398-9. PMID: 31767343Free PMC Article
Neurodegeneration and the Cerebellum.
Samson M, Claassen DO
Neurodegener Dis 2017;17(4-5):155-165. Epub 2017 May 3 doi: 10.1159/000460818. PMID: 28463835
Surgery for Dystonia and Tremor.
Crowell JL, Shah BB
Curr Neurol Neurosci Rep 2016 Mar;16(3):22. doi: 10.1007/s11910-016-0627-8. PMID: 26838349
Essential tremor.
Murray TJ
Can Med Assoc J 1981 Jun 15;124(12):1559-65, 1570. PMID: 7018658Free PMC Article

Clinical prediction guides

Cortical involvement in essential tremor with and without rest tremor: a machine learning study.
Bianco MG, Quattrone A, Sarica A, Aracri F, Calomino C, Caligiuri ME, Novellino F, Nisticò R, Buonocore J, Crasà M, Vaccaro MG, Quattrone A
J Neurol 2023 Aug;270(8):4004-4012. Epub 2023 May 5 doi: 10.1007/s00415-023-11747-6. PMID: 37145157Free PMC Article
Rationale and Evidence for Peripheral Nerve Stimulation for Treating Essential Tremor.
Wagle Shukla A
Tremor Other Hyperkinet Mov (N Y) 2022;12:20. Epub 2022 Jun 14 doi: 10.5334/tohm.685. PMID: 35949227Free PMC Article
Essential tremor.
Welton T, Cardoso F, Carr JA, Chan LL, Deuschl G, Jankovic J, Tan EK
Nat Rev Dis Primers 2021 Nov 11;7(1):83. doi: 10.1038/s41572-021-00314-w. PMID: 34764294
The Roles of Age and Aging in Essential Tremor: An Epidemiological Perspective.
Louis ED
Neuroepidemiology 2019;52(1-2):111-118. Epub 2019 Jan 9 doi: 10.1159/000492831. PMID: 30625472
A Randomized Trial of Focused Ultrasound Thalamotomy for Essential Tremor.
Elias WJ, Lipsman N, Ondo WG, Ghanouni P, Kim YG, Lee W, Schwartz M, Hynynen K, Lozano AM, Shah BB, Huss D, Dallapiazza RF, Gwinn R, Witt J, Ro S, Eisenberg HM, Fishman PS, Gandhi D, Halpern CH, Chuang R, Butts Pauly K, Tierney TS, Hayes MT, Cosgrove GR, Yamaguchi T, Abe K, Taira T, Chang JW
N Engl J Med 2016 Aug 25;375(8):730-9. doi: 10.1056/NEJMoa1600159. PMID: 27557301

Recent systematic reviews

Tremor and Parkinsonism in Chromosomopathies - A Systematic Review.
Carvalho V, Ferreira JJ, Correia Guedes L
Mov Disord 2021 Sep;36(9):2017-2025. Epub 2021 May 31 doi: 10.1002/mds.28663. PMID: 34056754
Sleep disorders in essential tremor: systematic review and meta-analysis.
Jiménez-Jiménez FJ, Alonso-Navarro H, García-Martín E, Agúndez JAG
Sleep 2020 Sep 14;43(9) doi: 10.1093/sleep/zsaa039. PMID: 32163585
A Review of the Current Therapies, Challenges, and Future Directions of Transcranial Focused Ultrasound Technology: Advances in Diagnosis and Treatment.
Krishna V, Sammartino F, Rezai A
JAMA Neurol 2018 Feb 1;75(2):246-254. doi: 10.1001/jamaneurol.2017.3129. PMID: 29228074
Topiramate for essential tremor.
Bruno E, Nicoletti A, Quattrocchi G, Allegra R, Filippini G, Colosimo C, Zappia M
Cochrane Database Syst Rev 2017 Apr 14;4(4):CD009683. doi: 10.1002/14651858.CD009683.pub2. PMID: 28409827Free PMC Article
Essential tremor.
Ferreira JJ, Sampaio C
BMJ Clin Evid 2007 May 1;2007 PMID: 19454072Free PMC Article

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