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Bing-Neel syndrome

MedGen UID:
542943
•Concept ID:
C0270710
•
Disease or Syndrome
Synonym: Macroglobulinemic brain syndrome
SNOMED CT: Bing-Neel syndrome (77600008); Macroglobulinemic brain syndrome (77600008)

Professional guidelines

PubMed

Bing-Neel Syndrome: Update on the Diagnosis and Treatment.
Nanah A, Al Hadidi S
Clin Lymphoma Myeloma Leuk 2022 Mar;22(3):e213-e219. Epub 2021 Sep 24 doi: 10.1016/j.clml.2021.09.014. PMID: 34674984
Ibrutinib for the treatment of Bing-Neel syndrome: a multicenter study.
Castillo JJ, Itchaki G, Paludo J, Varettoni M, Buske C, Eyre TA, Chavez JC, Shain KH, Issa S, Palomba ML, Pasvolsky O, Simpson D, Talaulikar D, Tam CS, Tedeschi A, Ansell SM, Nayak L, Treon SP
Blood 2019 Jan 24;133(4):299-305. Epub 2018 Dec 6 doi: 10.1182/blood-2018-10-879593. PMID: 30523119
Guideline for the diagnosis, treatment and response criteria for Bing-Neel syndrome.
Minnema MC, Kimby E, D'Sa S, Fornecker LM, Poulain S, Snijders TJ, Kastritis E, Kremer S, Fitsiori A, Simon L, Davi F, Lunn M, Castillo JJ, Patterson CJ, Le Garff-Tavernier M, Costopoulos M, Leblond V, Kersten MJ, Dimopoulos MA, Treon SP
Haematologica 2017 Jan;102(1):43-51. Epub 2016 Oct 6 doi: 10.3324/haematol.2016.147728. PMID: 27758817Free PMC Article

Recent clinical studies

Etiology

Evaluation and Management of Bing-Neel Syndrome.
Schep SJ, Vos JMI, Minnema MC
Hematol Oncol Clin North Am 2023 Aug;37(4):777-786. Epub 2023 May 29 doi: 10.1016/j.hoc.2023.04.008. PMID: 37258354
Report of consensus panel 1 from the 11(th) International Workshop on Waldenstrom's Macroglobulinemia on management of symptomatic, treatment-naïve patients.
Buske C, Castillo JJ, Abeykoon JP, Advani R, Arulogun SO, Branagan AR, Cao X, D'Sa S, Hou J, Kapoor P, Kastritis E, Kersten MJ, LeBlond V, Leiba M, Matous JV, Paludo J, Qiu L, Tam CS, Tedeschi A, Thomas SK, Tohidi-Esfahani I, Varettoni M, Vos JM, Garcia-Sanz R, San-Miguel J, Dimopoulos MA, Treon SP, Trotman J
Semin Hematol 2023 Mar;60(2):73-79. Epub 2023 Mar 29 doi: 10.1053/j.seminhematol.2023.03.005. PMID: 37099027
Bing Neel Syndrome: A Rare Contributing Factor of Psychosis and Suicidality.
Alexander AL, Jackson D, Donahue JE, Chirkov A, Banerjee P
Am J Forensic Med Pathol 2023 Jun 1;44(2):136-139. Epub 2023 Mar 22 doi: 10.1097/PAF.0000000000000824. PMID: 36989081
Are you sure this is Waldenstrom macroglobulinemia?
Ghobrial IM
Hematology Am Soc Hematol Educ Program 2012;2012:586-94. doi: 10.1182/asheducation-2012.1.586. PMID: 23233639
Bing-Neel Syndrome revisited.
Fintelmann F, Forghani R, Schaefer PW, Hochberg EP, Hochberg FH
Clin Lymphoma Myeloma 2009 Mar;9(1):104-6. doi: 10.3816/CLM.2009.n.028. PMID: 19362988

Diagnosis

Evaluation and Management of Bing-Neel Syndrome.
Schep SJ, Vos JMI, Minnema MC
Hematol Oncol Clin North Am 2023 Aug;37(4):777-786. Epub 2023 May 29 doi: 10.1016/j.hoc.2023.04.008. PMID: 37258354
Report of consensus panel 1 from the 11(th) International Workshop on Waldenstrom's Macroglobulinemia on management of symptomatic, treatment-naïve patients.
Buske C, Castillo JJ, Abeykoon JP, Advani R, Arulogun SO, Branagan AR, Cao X, D'Sa S, Hou J, Kapoor P, Kastritis E, Kersten MJ, LeBlond V, Leiba M, Matous JV, Paludo J, Qiu L, Tam CS, Tedeschi A, Thomas SK, Tohidi-Esfahani I, Varettoni M, Vos JM, Garcia-Sanz R, San-Miguel J, Dimopoulos MA, Treon SP, Trotman J
Semin Hematol 2023 Mar;60(2):73-79. Epub 2023 Mar 29 doi: 10.1053/j.seminhematol.2023.03.005. PMID: 37099027
Bing-Neel Syndrome: Update on the Diagnosis and Treatment.
Nanah A, Al Hadidi S
Clin Lymphoma Myeloma Leuk 2022 Mar;22(3):e213-e219. Epub 2021 Sep 24 doi: 10.1016/j.clml.2021.09.014. PMID: 34674984
How we manage Bing-Neel syndrome.
Castillo JJ, Treon SP
Br J Haematol 2019 Nov;187(3):277-285. Epub 2019 Aug 20 doi: 10.1111/bjh.16167. PMID: 31430829
Initial Evaluation of the Patient with Waldenström Macroglobulinemia.
Castillo JJ, Treon SP
Hematol Oncol Clin North Am 2018 Oct;32(5):811-820. Epub 2018 Jul 23 doi: 10.1016/j.hoc.2018.05.008. PMID: 30190019

Therapy

Bing-Neel syndrome with a paravertebral mass.
Suzuki D, Sato D, Kikuchi K, Suzuki T, Sugasawa K, Saito S, Uchimura F, Suzuki Y
Am J Med Sci 2023 Oct;366(4):316-320. Epub 2023 Jul 18 doi: 10.1016/j.amjms.2023.07.004. PMID: 37473959
Report of consensus panel 1 from the 11(th) International Workshop on Waldenstrom's Macroglobulinemia on management of symptomatic, treatment-naïve patients.
Buske C, Castillo JJ, Abeykoon JP, Advani R, Arulogun SO, Branagan AR, Cao X, D'Sa S, Hou J, Kapoor P, Kastritis E, Kersten MJ, LeBlond V, Leiba M, Matous JV, Paludo J, Qiu L, Tam CS, Tedeschi A, Thomas SK, Tohidi-Esfahani I, Varettoni M, Vos JM, Garcia-Sanz R, San-Miguel J, Dimopoulos MA, Treon SP, Trotman J
Semin Hematol 2023 Mar;60(2):73-79. Epub 2023 Mar 29 doi: 10.1053/j.seminhematol.2023.03.005. PMID: 37099027
Bing-Neel Syndrome Successfully Treated with Tirabrutinib.
Oyama T, Taoka K, Chiba A, Matsuda K, Maki H, Masamoto Y, Kurokawa M
Intern Med 2022 Dec 1;61(23):3575-3579. Epub 2022 May 14 doi: 10.2169/internalmedicine.9545-22. PMID: 35569989Free PMC Article
Managing complications secondary to Waldenström's macroglobulinemia.
Pessach I, Dimopoulos MA, Kastritis E
Expert Rev Hematol 2021 Jul;14(7):621-632. Epub 2021 Jul 2 doi: 10.1080/17474086.2021.1947236. PMID: 34170207
How we manage Bing-Neel syndrome.
Castillo JJ, Treon SP
Br J Haematol 2019 Nov;187(3):277-285. Epub 2019 Aug 20 doi: 10.1111/bjh.16167. PMID: 31430829

Prognosis

Evaluation and Management of Bing-Neel Syndrome.
Schep SJ, Vos JMI, Minnema MC
Hematol Oncol Clin North Am 2023 Aug;37(4):777-786. Epub 2023 May 29 doi: 10.1016/j.hoc.2023.04.008. PMID: 37258354
Report of consensus panel 1 from the 11(th) International Workshop on Waldenstrom's Macroglobulinemia on management of symptomatic, treatment-naïve patients.
Buske C, Castillo JJ, Abeykoon JP, Advani R, Arulogun SO, Branagan AR, Cao X, D'Sa S, Hou J, Kapoor P, Kastritis E, Kersten MJ, LeBlond V, Leiba M, Matous JV, Paludo J, Qiu L, Tam CS, Tedeschi A, Thomas SK, Tohidi-Esfahani I, Varettoni M, Vos JM, Garcia-Sanz R, San-Miguel J, Dimopoulos MA, Treon SP, Trotman J
Semin Hematol 2023 Mar;60(2):73-79. Epub 2023 Mar 29 doi: 10.1053/j.seminhematol.2023.03.005. PMID: 37099027
How we manage Bing-Neel syndrome.
Castillo JJ, Treon SP
Br J Haematol 2019 Nov;187(3):277-285. Epub 2019 Aug 20 doi: 10.1111/bjh.16167. PMID: 31430829
Lymphoplasmacytic lymphoma-Waldenstrom's macroglobulinemia.
Vitolo U, Ferreri AJ, Montoto S
Crit Rev Oncol Hematol 2008 Aug;67(2):172-85. Epub 2008 May 21 doi: 10.1016/j.critrevonc.2008.03.008. PMID: 18499469
'Indolent' Waldenstrom's macroglobulinemia and a cerebrospinal fluid protein level of 16 g/L.
Garderet L, Baudel JL, Cervera P, Azizi L, Maury E, Guidet B, Gorin NC, Offenstadt G
Eur J Haematol 2006 Jul;77(1):80-2. doi: 10.1111/j.0902-4441.2006.t01-1-EJH2654.x. PMID: 16827886

Clinical prediction guides

Report of consensus panel 1 from the 11(th) International Workshop on Waldenstrom's Macroglobulinemia on management of symptomatic, treatment-naïve patients.
Buske C, Castillo JJ, Abeykoon JP, Advani R, Arulogun SO, Branagan AR, Cao X, D'Sa S, Hou J, Kapoor P, Kastritis E, Kersten MJ, LeBlond V, Leiba M, Matous JV, Paludo J, Qiu L, Tam CS, Tedeschi A, Thomas SK, Tohidi-Esfahani I, Varettoni M, Vos JM, Garcia-Sanz R, San-Miguel J, Dimopoulos MA, Treon SP, Trotman J
Semin Hematol 2023 Mar;60(2):73-79. Epub 2023 Mar 29 doi: 10.1053/j.seminhematol.2023.03.005. PMID: 37099027
Successful treatment with tirabrutinib for relapsed Bing-Neel syndrome following high-dose methotrexate and craniospinal irradiation.
Saburi M, Sakata M, Okuhiro K, Kawano K, Uesugi S, Wada J, Urabe S, Saburi Y, Ohtsuka E
J Clin Exp Hematop 2022;62(3):181-186. doi: 10.3960/jslrt.22018. PMID: 36171098Free PMC Article
Successful treatment with tirabrutinib for relapsed lymphoplasmacytic lymphoma complicated by Bing-Neel syndrome.
Saburi M, Saburi Y, Kawano K, Sato R, Urabe S, Ohtsuka E
Int J Hematol 2022 Apr;115(4):585-589. Epub 2021 Oct 26 doi: 10.1007/s12185-021-03246-z. PMID: 34699012
Bing-Neel syndrome, a rare complication of Waldenström macroglobulinemia: analysis of 44 cases and review of the literature. A study on behalf of the French Innovative Leukemia Organization (FILO).
Simon L, Fitsiori A, Lemal R, Dupuis J, Carpentier B, Boudin L, Corby A, Aurran-Schleinitz T, Gastaud L, Talbot A, Leprêtre S, Mahe B, Payet C, Soussain C, Bonnet C, Vincent L, Lissandre S, Herbrecht R, Kremer S, Leblond V, Fornecker LM
Haematologica 2015 Dec;100(12):1587-94. Epub 2015 Sep 18 doi: 10.3324/haematol.2015.133744. PMID: 26385211Free PMC Article
Lymphoplasmacytic lymphoma-Waldenstrom's macroglobulinemia.
Vitolo U, Ferreri AJ, Montoto S
Crit Rev Oncol Hematol 2008 Aug;67(2):172-85. Epub 2008 May 21 doi: 10.1016/j.critrevonc.2008.03.008. PMID: 18499469

Recent systematic reviews

Bing-Neel syndrome: a case report and systematic review of clinical manifestations, diagnosis, and treatment options.
Grewal JS, Brar PK, Sahijdak WM, Tworek JA, Chottiner EG
Clin Lymphoma Myeloma 2009 Dec;9(6):462-6. doi: 10.3816/CLM.2009.n.091. PMID: 19951888

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