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infant of diabetic mother

MedGen UID:
542608
•Concept ID:
C0270221
•
Disease or Syndrome
Synonyms: Infant of a diabetic mother syndrome; Infant of Diabetic Mother; Maternal diabetes syndrome; Syndrome of infant of diabetic mother
SNOMED CT: Syndrome of infant of diabetic mother (21584002); Infant of a diabetic mother syndrome (21584002); Maternal diabetes syndrome (21584002)

Definition

An infant that was born to a mother who persistently had high glucose blood levels during pregnancy. The infants of diabetic mothers are large for their gestational age and may develop hypoglycemic episodes soon after birth. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVinfant of diabetic mother

Professional guidelines

PubMed

Infants Eligible for Neonatal Hypoglycemia Screening: A Systematic Review.
O'Brien M, Gilchrist C, Sadler L, Hegarty JE, Alsweiler JM
JAMA Pediatr 2023 Nov 1;177(11):1187-1196. doi: 10.1001/jamapediatrics.2023.3957. PMID: 37782488Free PMC Article
Etiology and therapeutic management of neonatal jaundice in Iran: a systematic review and meta-analysis.
Zahed Pasha Y, Alizadeh-Tabari S, Zahed Pasha E, Zamani M
World J Pediatr 2020 Oct;16(5):480-493. Epub 2020 Feb 12 doi: 10.1007/s12519-020-00339-3. PMID: 32052364
An emerging evidence base for the management of neonatal hypoglycaemia.
Harding JE, Harris DL, Hegarty JE, Alsweiler JM, McKinlay CJ
Early Hum Dev 2017 Jan;104:51-56. Epub 2016 Dec 15 doi: 10.1016/j.earlhumdev.2016.12.009. PMID: 27989586Free PMC Article

Recent clinical studies

Etiology

Infants Eligible for Neonatal Hypoglycemia Screening: A Systematic Review.
O'Brien M, Gilchrist C, Sadler L, Hegarty JE, Alsweiler JM
JAMA Pediatr 2023 Nov 1;177(11):1187-1196. doi: 10.1001/jamapediatrics.2023.3957. PMID: 37782488Free PMC Article
The Term Newborn: Hypoglycemia.
Hubbard EM, Hay WW Jr
Clin Perinatol 2021 Aug;48(3):665-679. doi: 10.1016/j.clp.2021.05.013. PMID: 34353586
Etiology and therapeutic management of neonatal jaundice in Iran: a systematic review and meta-analysis.
Zahed Pasha Y, Alizadeh-Tabari S, Zahed Pasha E, Zamani M
World J Pediatr 2020 Oct;16(5):480-493. Epub 2020 Feb 12 doi: 10.1007/s12519-020-00339-3. PMID: 32052364
An emerging evidence base for the management of neonatal hypoglycaemia.
Harding JE, Harris DL, Hegarty JE, Alsweiler JM, McKinlay CJ
Early Hum Dev 2017 Jan;104:51-56. Epub 2016 Dec 15 doi: 10.1016/j.earlhumdev.2016.12.009. PMID: 27989586Free PMC Article
Perspective on the Genetics and Diagnosis of Congenital Hyperinsulinism Disorders.
Stanley CA
J Clin Endocrinol Metab 2016 Mar;101(3):815-26. Epub 2016 Feb 23 doi: 10.1210/jc.2015-3651. PMID: 26908106Free PMC Article

Diagnosis

Infants Eligible for Neonatal Hypoglycemia Screening: A Systematic Review.
O'Brien M, Gilchrist C, Sadler L, Hegarty JE, Alsweiler JM
JAMA Pediatr 2023 Nov 1;177(11):1187-1196. doi: 10.1001/jamapediatrics.2023.3957. PMID: 37782488Free PMC Article
The Term Newborn: Hypoglycemia.
Hubbard EM, Hay WW Jr
Clin Perinatol 2021 Aug;48(3):665-679. doi: 10.1016/j.clp.2021.05.013. PMID: 34353586
Infant of diabetic mother: what one needs to know?
Kallem VR, Pandita A, Pillai A
J Matern Fetal Neonatal Med 2020 Feb;33(3):482-492. Epub 2018 Sep 9 doi: 10.1080/14767058.2018.1494710. PMID: 29947269
An emerging evidence base for the management of neonatal hypoglycaemia.
Harding JE, Harris DL, Hegarty JE, Alsweiler JM, McKinlay CJ
Early Hum Dev 2017 Jan;104:51-56. Epub 2016 Dec 15 doi: 10.1016/j.earlhumdev.2016.12.009. PMID: 27989586Free PMC Article
Perspective on the Genetics and Diagnosis of Congenital Hyperinsulinism Disorders.
Stanley CA
J Clin Endocrinol Metab 2016 Mar;101(3):815-26. Epub 2016 Feb 23 doi: 10.1210/jc.2015-3651. PMID: 26908106Free PMC Article

Therapy

Is Routine Monitoring for Hypoglycemia Required in Intramural Asymptomatic Infant of Diabetic Mother? An Audit in a Tertiary Care Hospital.
Khandare J, Ds M, Ananthan A, Nanavati R
J Trop Pediatr 2020 Apr 1;66(2):194-200. doi: 10.1093/tropej/fmz051. PMID: 31340046
An emerging evidence base for the management of neonatal hypoglycaemia.
Harding JE, Harris DL, Hegarty JE, Alsweiler JM, McKinlay CJ
Early Hum Dev 2017 Jan;104:51-56. Epub 2016 Dec 15 doi: 10.1016/j.earlhumdev.2016.12.009. PMID: 27989586Free PMC Article
Evaluation of simple hematological screen for early diagnosis of neonatal sepsis.
Waliullah SM, Islam MN, Siddika M, Hossain MA, Jahan I, Chowdhury AK
Mymensingh Med J 2010 Jan;19(1):41-7. PMID: 20046170
Insulin-like growth factor-1 receptor expression in the placentae of diabetic and normal pregnancies.
Hayati AR, Cheah FC, Tan AE, Tan GC
Early Hum Dev 2007 Jan;83(1):41-6. Epub 2006 Jun 5 doi: 10.1016/j.earlhumdev.2006.04.002. PMID: 16750336
Oversized infant of diabetic mother: its cause and prevention.
Grasso S, Roversi GD
J Perinat Med 1987;15(1):73-82. doi: 10.1515/jpme.1987.15.1.73. PMID: 3295177

Prognosis

Role of cord blood IGF-1 and maternal HbA1c levels to predict interventricular septal hypertrophy among infants of diabetic mothers: A case-control study.
Chandra T, Tripathi S, Tiwari A, Sonkar G, Agarwal S, Kumar M, Singh SN
Early Hum Dev 2023 Apr;179:105751. Epub 2023 Mar 15 doi: 10.1016/j.earlhumdev.2023.105751. PMID: 36933439
Clinical usefulness of glycated albumin and glycated albumin-to-glycated hemoglobin ratio of gestational diabetes mellitus in late pregnancy for predicting infant complications.
Sugawara D, Sato H, Makita E, Kuwata T, Takagi K, Ichihashi K
Pediatr Neonatol 2022 May;63(3):239-246. Epub 2022 Feb 5 doi: 10.1016/j.pedneo.2021.10.007. PMID: 35185003
Incidence of hypoglycemia in newborns at risk and an audit of the 2011 American academy of pediatrics guideline for hypoglycemia.
Hosagasi NH, Aydin M, Zenciroglu A, Ustun N, Beken S
Pediatr Neonatol 2018 Aug;59(4):368-374. Epub 2017 Nov 15 doi: 10.1016/j.pedneo.2017.11.009. PMID: 29198616
Perspective on the Genetics and Diagnosis of Congenital Hyperinsulinism Disorders.
Stanley CA
J Clin Endocrinol Metab 2016 Mar;101(3):815-26. Epub 2016 Feb 23 doi: 10.1210/jc.2015-3651. PMID: 26908106Free PMC Article
A survey of the management of neonatal hypoglycaemia within the Australian and New Zealand Neonatal Network.
Harris DL, Weston PJ, Battin MR, Harding JE
J Paediatr Child Health 2014 Oct;50(10):E55-62. Epub 2009 Oct 26 doi: 10.1111/j.1440-1754.2009.01599.x. PMID: 19863712

Clinical prediction guides

Infants Eligible for Neonatal Hypoglycemia Screening: A Systematic Review.
O'Brien M, Gilchrist C, Sadler L, Hegarty JE, Alsweiler JM
JAMA Pediatr 2023 Nov 1;177(11):1187-1196. doi: 10.1001/jamapediatrics.2023.3957. PMID: 37782488Free PMC Article
Clinical usefulness of glycated albumin and glycated albumin-to-glycated hemoglobin ratio of gestational diabetes mellitus in late pregnancy for predicting infant complications.
Sugawara D, Sato H, Makita E, Kuwata T, Takagi K, Ichihashi K
Pediatr Neonatol 2022 May;63(3):239-246. Epub 2022 Feb 5 doi: 10.1016/j.pedneo.2021.10.007. PMID: 35185003
Hypoglycemia screening of asymptomatic newborns on the 2nd day of life.
Karbalivand H, Iyare A, Aponte A, Xianhong X, Kim M, Havranek T
J Neonatal Perinatal Med 2022;15(2):311-316. doi: 10.3233/NPM-210861. PMID: 34974442
Maternal and neonatal outcomes in mothers with diabetes mellitus in qatari population.
Bayoumi MAA, Masri RM, Matani NYS, Hendaus MA, Masri MM, Chandra P, Langtree LJ, D'Souza S, Olayiwola NO, Shahbal S, Elmalik EE, Bakry MS, Gad AI, Agarwal R
BMC Pregnancy Childbirth 2021 Sep 24;21(1):651. doi: 10.1186/s12884-021-04124-6. PMID: 34560839Free PMC Article
Socioeconomic and racial disparities in the prevalence of congenital heart disease in infants of diabetic mothers.
Chou FS, Chakradhar R, Ghimire LV
J Matern Fetal Neonatal Med 2021 Dec;34(24):4167-4170. Epub 2019 Dec 16 doi: 10.1080/14767058.2019.1702955. PMID: 31842654

Recent systematic reviews

Infants Eligible for Neonatal Hypoglycemia Screening: A Systematic Review.
O'Brien M, Gilchrist C, Sadler L, Hegarty JE, Alsweiler JM
JAMA Pediatr 2023 Nov 1;177(11):1187-1196. doi: 10.1001/jamapediatrics.2023.3957. PMID: 37782488Free PMC Article
Etiology and therapeutic management of neonatal jaundice in Iran: a systematic review and meta-analysis.
Zahed Pasha Y, Alizadeh-Tabari S, Zahed Pasha E, Zamani M
World J Pediatr 2020 Oct;16(5):480-493. Epub 2020 Feb 12 doi: 10.1007/s12519-020-00339-3. PMID: 32052364

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