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Vulvar vestibulitis

MedGen UID:
124347
•Concept ID:
C0269084
•
Disease or Syndrome
Synonyms: Vestibulitides, Vulvar; Vestibulitis, Vulvar; Vulvar Vestibulitides; Vulvar Vestibulitis; Vulvar Vestibulitis Syndrome
SNOMED CT: Vulval vestibulitis (30833006); Vestibulodynia (30833006); Vulvar vestibulitis (30833006)

Definition

Inflammation of the vulvar vestibular region at the entrance of the VAGINA, generally involving surface mucosa and submucosal vestibular glands. It is characterized by ERYTHEMA and chronic recurrent pain in this area. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVulvar vestibulitis

Professional guidelines

PubMed

To cut or not to cut: treatment of vulvar vestibulitis syndrome.
van der Werf-Eldering MJ, Batstra L
J Psychosom Obstet Gynaecol 2004 Mar;25(1):77-9. doi: 10.1080/01674820410001737450. PMID: 15376407
Evaluation and differential diagnosis of dyspareunia.
Heim LJ
Am Fam Physician 2001 Apr 15;63(8):1535-44. PMID: 11327429
Vulvar vestibulitis: aetiology, diagnosis and treatment.
Rogstad KE
Int J STD AIDS 2000 Sep;11(9):557-62. doi: 10.1258/0956462001916443. PMID: 10997495

Recent clinical studies

Etiology

Effectiveness of Two Transcutaneous Electrical Nerve Stimulation (TENS) Protocols in Women with Provoked Vestibulodynia: A Randomized Controlled Trial.
Murina F, Recalcati D, Di Francesco S, Cetin I
Med Sci (Basel) 2023 Aug 2;11(3) doi: 10.3390/medsci11030048. PMID: 37606427Free PMC Article
Hormonal contraception and pelvic floor function: a systematic review.
Champaneria R, D'Andrea RM, Latthe PM
Int Urogynecol J 2016 May;27(5):709-22. Epub 2015 Sep 25 doi: 10.1007/s00192-015-2833-3. PMID: 26407563
Vulvodynia.
Smart OC, MacLean AB
Curr Opin Obstet Gynecol 2003 Dec;15(6):497-500. doi: 10.1097/00001703-200312000-00007. PMID: 14624216
Vulvar vestibulitis: a reappraisal.
Rosenman SD
Conn Med 2002 Oct;66(10):589-93. PMID: 12448210
Vulvodynia and vulvar vestibulitis: challenges in diagnosis and management.
Metts JF
Am Fam Physician 1999 Mar 15;59(6):1547-56, 1561-2. PMID: 10193596

Diagnosis

Vulvodynia.
Ben-Aroya Z, Edwards L
Semin Cutan Med Surg 2015 Dec;34(4):192-8. doi: 10.12788/j.sder.2015.0181. PMID: 26650698
Chronic pelvic pain.
Stein SL
Gastroenterol Clin North Am 2013 Dec;42(4):785-800. Epub 2013 Oct 23 doi: 10.1016/j.gtc.2013.08.005. PMID: 24280400
Vulvodynia.
Goldstein AT, Burrows L
J Sex Med 2008 Jan;5(1):5-14; quiz 15. doi: 10.1111/j.1743-6109.2007.00679.x. PMID: 18173761
Vulvodynia.
Smart OC, MacLean AB
Curr Opin Obstet Gynecol 2003 Dec;15(6):497-500. doi: 10.1097/00001703-200312000-00007. PMID: 14624216
Vulvar vestibulitis syndrome.
Marinoff SC, Turner ML
Dermatol Clin 1992 Apr;10(2):435-44. PMID: 1606769

Therapy

Effectiveness of Two Transcutaneous Electrical Nerve Stimulation (TENS) Protocols in Women with Provoked Vestibulodynia: A Randomized Controlled Trial.
Murina F, Recalcati D, Di Francesco S, Cetin I
Med Sci (Basel) 2023 Aug 2;11(3) doi: 10.3390/medsci11030048. PMID: 37606427Free PMC Article
Localized Provoked Vulvodynia-An Ignored Vulvar Pain Syndrome.
Paavonen J, Eschenbach DA
Front Cell Infect Microbiol 2021;11:678961. Epub 2021 Jun 17 doi: 10.3389/fcimb.2021.678961. PMID: 34222047Free PMC Article
Surgical treatment of vulvar vestibulitis: a review.
Tommola P, Unkila-Kallio L, Paavonen J
Acta Obstet Gynecol Scand 2010 Nov;89(11):1385-95. doi: 10.3109/00016349.2010.512071. PMID: 20955094
Vulvar vestibulitis: a reappraisal.
Rosenman SD
Conn Med 2002 Oct;66(10):589-93. PMID: 12448210
Vulvar vestibulitis syndrome: an overview.
Marinoff SC, Turner ML
Am J Obstet Gynecol 1991 Oct;165(4 Pt 2):1228-33. doi: 10.1016/s0002-9378(12)90732-2. PMID: 1659198

Prognosis

Vulvodynia.
Ben-Aroya Z, Edwards L
Semin Cutan Med Surg 2015 Dec;34(4):192-8. doi: 10.12788/j.sder.2015.0181. PMID: 26650698
Vulvar vestibulitis: a reappraisal.
Rosenman SD
Conn Med 2002 Oct;66(10):589-93. PMID: 12448210
Interstitial cystitis: urgency and frequency syndrome.
Metts JF
Am Fam Physician 2001 Oct 1;64(7):1199-206. PMID: 11601802
Understanding vulvodynia.
Byth JL
Australas J Dermatol 1998 Aug;39(3):139-48; quiz 149-50. doi: 10.1111/j.1440-0960.1998.tb01270.x. PMID: 9737039
Subsets of vulvodynia.
McKay M
J Reprod Med 1988 Aug;33(8):695-8. PMID: 3050074

Clinical prediction guides

Effectiveness of Two Transcutaneous Electrical Nerve Stimulation (TENS) Protocols in Women with Provoked Vestibulodynia: A Randomized Controlled Trial.
Murina F, Recalcati D, Di Francesco S, Cetin I
Med Sci (Basel) 2023 Aug 2;11(3) doi: 10.3390/medsci11030048. PMID: 37606427Free PMC Article
Vulvar vestibular effects of ospemifene: a pilot study.
Murina F, Di Francesco S, Oneda S
Gynecol Endocrinol 2018 Jul;34(7):631-635. Epub 2018 Jan 15 doi: 10.1080/09513590.2018.1427717. PMID: 29334798
Determining the cause of vulvovaginal symptoms.
Farage MA, Miller KW, Ledger WJ
Obstet Gynecol Surv 2008 Jul;63(7):445-64. doi: 10.1097/OGX.0b013e318172ee25. PMID: 18559121
Overlap between orofacial pain and vulvar vestibulitis syndrome.
Zolnoun DA, Rohl J, Moore CG, Perinetti-Liebert C, Lamvu GM, Maixner W
Clin J Pain 2008 Mar-Apr;24(3):187-91. doi: 10.1097/AJP.0b013e318159f976. PMID: 18287822Free PMC Article
Neurogenic inflammation and chronic pelvic pain.
Wesselmann U
World J Urol 2001 Jun;19(3):180-5. doi: 10.1007/s003450100201. PMID: 11469605

Recent systematic reviews

Is Vulvodynia Associated With an Altered Vaginal Microbiota?: A Systematic Review.
Sacinti KG, Razeghian H, Awad-Igbaria Y, Lima-Silva J, Palzur E, Vieira-Baptista P, Verstraelen H, Bornstein J
J Low Genit Tract Dis 2024 Jan 1;28(1):64-72. Epub 2023 Nov 13 doi: 10.1097/LGT.0000000000000780. PMID: 37963335
Hormonal contraception and pelvic floor function: a systematic review.
Champaneria R, D'Andrea RM, Latthe PM
Int Urogynecol J 2016 May;27(5):709-22. Epub 2015 Sep 25 doi: 10.1007/s00192-015-2833-3. PMID: 26407563

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