U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cholestasis of pregnancy(RICP)

MedGen UID:
82788
Concept ID:
C0268318
Disease or Syndrome
Synonyms: Cholestasis intrahepatic of pregnancy ICP; Cholestasis, intrahepatic of pregnancy; Pregnancy related cholestasis; Recurrent intrahepatic cholestasis of pregnancy; RICP
SNOMED CT: Intrahepatic cholestasis of pregnancy (235888006); Recurrent jaundice of pregnancy (235888006); Recurrent intrahepatic cholestasis of pregnancy (235888006); Cholestasis of pregnancy (235888006); RICP - recurrent intrahepatic cholestasis of pregnancy (235888006)
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
Concept ID:
C0600599
Genetic Function
Source: Orphanet
A mode of inheritance that depends on genetic determinants in more than one gene.
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0100429
Orphanet: ORPHA69665

Definition

Intrahepatic cholestasis of pregnancy (ICP) is a cholestatic disorder characterized by (i) pruritus with onset in the second or third trimester of pregnancy, (ii) elevated serum aminotransferases and bile acid levels, and (iii) spontaneous relief of signs and symptoms within two to three weeks after delivery. [from ORDO]

Professional guidelines

PubMed

Society for Maternal-Fetal Medicine (SMFM). Electronic address: pubs@smfm.org, Lee RH, Mara Greenberg, Metz TD, Pettker CM
Am J Obstet Gynecol 2021 Feb;224(2):B2-B9. Epub 2020 Nov 13 doi: 10.1016/j.ajog.2020.11.002. PMID: 33197417
Bechtel MA
Dermatol Clin 2018 Jul;36(3):259-265. Epub 2018 Apr 26 doi: 10.1016/j.det.2018.02.012. PMID: 29929597
Mittal A
Curr Probl Dermatol 2016;50:142-8. Epub 2016 Aug 23 doi: 10.1159/000446057. PMID: 27578083

Recent clinical studies

Therapy

Karjalainen MK, Karthikeyan S, Oliver-Williams C, Sliz E, Allara E, Fung WT, Surendran P, Zhang W, Jousilahti P, Kristiansson K, Salomaa V, Goodwin M, Hughes DA, Boehnke M, Fernandes Silva L, Yin X, Mahajan A, Neville MJ, van Zuydam NR, de Mutsert R, Li-Gao R, Mook-Kanamori DO, Demirkan A, Liu J, Noordam R, Trompet S, Chen Z, Kartsonaki C, Li L, Lin K, Hagenbeek FA, Hottenga JJ, Pool R, Ikram MA, van Meurs J, Haller T, Milaneschi Y, Kähönen M, Mishra PP, Joshi PK, Macdonald-Dunlop E, Mangino M, Zierer J, Acar IE, Hoyng CB, Lechanteur YTE, Franke L, Kurilshikov A, Zhernakova A, Beekman M, van den Akker EB, Kolcic I, Polasek O, Rudan I, Gieger C, Waldenberger M, Asselbergs FW; China Kadoorie Biobank Collaborative Group; Estonian Biobank Research Team; FinnGen, Hayward C, Fu J, den Hollander AI, Menni C, Spector TD, Wilson JF, Lehtimäki T, Raitakari OT, Penninx BWJH, Esko T, Walters RG, Jukema JW, Sattar N, Ghanbari M, Willems van Dijk K, Karpe F, McCarthy MI, Laakso M, Järvelin MR, Timpson NJ, Perola M, Kooner JS, Chambers JC, van Duijn C, Slagboom PE, Boomsma DI, Danesh J, Ala-Korpela M, Butterworth AS, Kettunen J
Nature 2024 Apr;628(8006):130-138. Epub 2024 Mar 6 doi: 10.1038/s41586-024-07148-y. PMID: 38448586Free PMC Article
Beuers U, Wolters F, Oude Elferink RPJ
Nat Rev Gastroenterol Hepatol 2023 Jan;20(1):26-36. Epub 2022 Oct 28 doi: 10.1038/s41575-022-00687-7. PMID: 36307649
Ovadia C, Sajous J, Seed PT, Patel K, Williamson NJ, Attilakos G, Azzaroli F, Bacq Y, Batsry L, Broom K, Brun-Furrer R, Bull L, Chambers J, Cui Y, Ding M, Dixon PH, Estiú MC, Gardiner FW, Geenes V, Grymowicz M, Günaydin B, Hague WM, Haslinger C, Hu Y, Indraccolo U, Juusela A, Kane SC, Kebapcilar A, Kebapcilar L, Kohari K, Kondrackienė J, Koster MPH, Lee RH, Liu X, Locatelli A, Macias RIR, Madazli R, Majewska A, Maksym K, Marathe JA, Morton A, Oudijk MA, Öztekin D, Peek MJ, Shennan AH, Tribe RM, Tripodi V, Türk Özterlemez N, Vasavan T, Wong LFA, Yinon Y, Zhang Q, Zloto K, Marschall HU, Thornton J, Chappell LC, Williamson C
Lancet Gastroenterol Hepatol 2021 Jul;6(7):547-558. Epub 2021 Apr 27 doi: 10.1016/S2468-1253(21)00074-1. PMID: 33915090Free PMC Article
Walker KF, Chappell LC, Hague WM, Middleton P, Thornton JG
Cochrane Database Syst Rev 2020 Jul 27;7(7):CD000493. doi: 10.1002/14651858.CD000493.pub3. PMID: 32716060Free PMC Article
Ovadia C, Seed PT, Sklavounos A, Geenes V, Di Ilio C, Chambers J, Kohari K, Bacq Y, Bozkurt N, Brun-Furrer R, Bull L, Estiú MC, Grymowicz M, Gunaydin B, Hague WM, Haslinger C, Hu Y, Kawakita T, Kebapcilar AG, Kebapcilar L, Kondrackienė J, Koster MPH, Kowalska-Kańka A, Kupčinskas L, Lee RH, Locatelli A, Macias RIR, Marschall HU, Oudijk MA, Raz Y, Rimon E, Shan D, Shao Y, Tribe R, Tripodi V, Yayla Abide C, Yenidede I, Thornton JG, Chappell LC, Williamson C
Lancet 2019 Mar 2;393(10174):899-909. Epub 2019 Feb 14 doi: 10.1016/S0140-6736(18)31877-4. PMID: 30773280Free PMC Article

Prognosis

Jiang M, Mishu MM, Lu D, Yin X
Taiwan J Obstet Gynecol 2018 Dec;57(6):814-818. doi: 10.1016/j.tjog.2018.10.008. PMID: 30545533
Pataia V, Dixon PH, Williamson C
Am J Physiol Gastrointest Liver Physiol 2017 Jul 1;313(1):G1-G6. Epub 2017 Apr 27 doi: 10.1152/ajpgi.00028.2017. PMID: 28450276
Marinkin IO, Sokolova TM, Kiseleva TV, Kuleshov VM, Makarov KY, Yakimova AV
Eksp Klin Gastroenterol 2016;(9):81-85. PMID: 29889402
Nguyen KD, Sundaram V, Ayoub WS
World J Gastroenterol 2014 Jul 28;20(28):9418-26. doi: 10.3748/wjg.v20.i28.9418. PMID: 25071336Free PMC Article
McDonald JA
J Gastroenterol Hepatol 1999 Jun;14(6):515-8. doi: 10.1046/j.1440-1746.1999.01907.x. PMID: 10385057

Clinical prediction guides

Karjalainen MK, Karthikeyan S, Oliver-Williams C, Sliz E, Allara E, Fung WT, Surendran P, Zhang W, Jousilahti P, Kristiansson K, Salomaa V, Goodwin M, Hughes DA, Boehnke M, Fernandes Silva L, Yin X, Mahajan A, Neville MJ, van Zuydam NR, de Mutsert R, Li-Gao R, Mook-Kanamori DO, Demirkan A, Liu J, Noordam R, Trompet S, Chen Z, Kartsonaki C, Li L, Lin K, Hagenbeek FA, Hottenga JJ, Pool R, Ikram MA, van Meurs J, Haller T, Milaneschi Y, Kähönen M, Mishra PP, Joshi PK, Macdonald-Dunlop E, Mangino M, Zierer J, Acar IE, Hoyng CB, Lechanteur YTE, Franke L, Kurilshikov A, Zhernakova A, Beekman M, van den Akker EB, Kolcic I, Polasek O, Rudan I, Gieger C, Waldenberger M, Asselbergs FW; China Kadoorie Biobank Collaborative Group; Estonian Biobank Research Team; FinnGen, Hayward C, Fu J, den Hollander AI, Menni C, Spector TD, Wilson JF, Lehtimäki T, Raitakari OT, Penninx BWJH, Esko T, Walters RG, Jukema JW, Sattar N, Ghanbari M, Willems van Dijk K, Karpe F, McCarthy MI, Laakso M, Järvelin MR, Timpson NJ, Perola M, Kooner JS, Chambers JC, van Duijn C, Slagboom PE, Boomsma DI, Danesh J, Ala-Korpela M, Butterworth AS, Kettunen J
Nature 2024 Apr;628(8006):130-138. Epub 2024 Mar 6 doi: 10.1038/s41586-024-07148-y. PMID: 38448586Free PMC Article
Walker KF, Chappell LC, Hague WM, Middleton P, Thornton JG
Cochrane Database Syst Rev 2020 Jul 27;7(7):CD000493. doi: 10.1002/14651858.CD000493.pub3. PMID: 32716060Free PMC Article
Alghamdi S, Fleckenstein J
Curr Gastroenterol Rep 2019 Jul 25;21(9):43. doi: 10.1007/s11894-019-0711-8. PMID: 31346820
Jiang M, Mishu MM, Lu D, Yin X
Taiwan J Obstet Gynecol 2018 Dec;57(6):814-818. doi: 10.1016/j.tjog.2018.10.008. PMID: 30545533
McDonald JA
J Gastroenterol Hepatol 1999 Jun;14(6):515-8. doi: 10.1046/j.1440-1746.1999.01907.x. PMID: 10385057

Recent systematic reviews

Yang Z, Yao M, Zhang C, Hu X, Zhong Y, Xu X, Yin J
Eur J Med Res 2022 Sep 14;27(1):178. doi: 10.1186/s40001-022-00802-z. PMID: 36104763Free PMC Article
Zhan Y, Xu T, Chen T, Wang X
Acta Obstet Gynecol Scand 2022 Jul;101(7):719-727. Epub 2022 May 22 doi: 10.1111/aogs.14380. PMID: 35599353Free PMC Article
Ovadia C, Sajous J, Seed PT, Patel K, Williamson NJ, Attilakos G, Azzaroli F, Bacq Y, Batsry L, Broom K, Brun-Furrer R, Bull L, Chambers J, Cui Y, Ding M, Dixon PH, Estiú MC, Gardiner FW, Geenes V, Grymowicz M, Günaydin B, Hague WM, Haslinger C, Hu Y, Indraccolo U, Juusela A, Kane SC, Kebapcilar A, Kebapcilar L, Kohari K, Kondrackienė J, Koster MPH, Lee RH, Liu X, Locatelli A, Macias RIR, Madazli R, Majewska A, Maksym K, Marathe JA, Morton A, Oudijk MA, Öztekin D, Peek MJ, Shennan AH, Tribe RM, Tripodi V, Türk Özterlemez N, Vasavan T, Wong LFA, Yinon Y, Zhang Q, Zloto K, Marschall HU, Thornton J, Chappell LC, Williamson C
Lancet Gastroenterol Hepatol 2021 Jul;6(7):547-558. Epub 2021 Apr 27 doi: 10.1016/S2468-1253(21)00074-1. PMID: 33915090Free PMC Article
Walker KF, Chappell LC, Hague WM, Middleton P, Thornton JG
Cochrane Database Syst Rev 2020 Jul 27;7(7):CD000493. doi: 10.1002/14651858.CD000493.pub3. PMID: 32716060Free PMC Article
Ovadia C, Seed PT, Sklavounos A, Geenes V, Di Ilio C, Chambers J, Kohari K, Bacq Y, Bozkurt N, Brun-Furrer R, Bull L, Estiú MC, Grymowicz M, Gunaydin B, Hague WM, Haslinger C, Hu Y, Kawakita T, Kebapcilar AG, Kebapcilar L, Kondrackienė J, Koster MPH, Kowalska-Kańka A, Kupčinskas L, Lee RH, Locatelli A, Macias RIR, Marschall HU, Oudijk MA, Raz Y, Rimon E, Shan D, Shao Y, Tribe R, Tripodi V, Yayla Abide C, Yenidede I, Thornton JG, Chappell LC, Williamson C
Lancet 2019 Mar 2;393(10174):899-909. Epub 2019 Feb 14 doi: 10.1016/S0140-6736(18)31877-4. PMID: 30773280Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...