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Keshan disease

MedGen UID:
78639
•Concept ID:
C0268095
•
Disease or Syndrome
Synonyms: Caused by deficiency of selenium in the diet; Enlarged heart and poor heart function
SNOMED CT: Keshan disease (46939000); Congestive cardiomyopathy due to selenium deficiency (46939000)
 
Monarch Initiative: MONDO:0000241

Definition

A congestive cardiomyopathy caused by a combination of dietary deficiency of selenium and the presence of a mutated strain of Coxsackievirus. [from MONDO]

Professional guidelines

PubMed

Efficacy of Long-term Selenium Supplementation in the Treatment of Chronic Keshan Disease with Congestive Heart Failure.
Zhu YH, Wang XF, Yang G, Wei J, Tan WH, Wang LX, Guo X, Lammi MJ, Xu JH
Curr Med Sci 2019 Apr;39(2):237-242. Epub 2019 Apr 23 doi: 10.1007/s11596-019-2025-3. PMID: 31016516
Health risk assessment of environmental selenium: Emerging evidence and challenges (Review).
Vinceti M, Filippini T, Cilloni S, Bargellini A, Vergoni AV, Tsatsakis A, Ferrante M
Mol Med Rep 2017 May;15(5):3323-3335. Epub 2017 Mar 24 doi: 10.3892/mmr.2017.6377. PMID: 28339083Free PMC Article
Rationale for clinical trials of selenium as an antioxidant for the treatment of the cardiomyopathy of Friedreich's ataxia.
Fryer MJ
Med Hypotheses 2002 Feb;58(2):127-32. doi: 10.1054/mehy.2001.1474. PMID: 11812188

Recent clinical studies

Etiology

Impact of Selenium Deficiency on Clinical Outcomes in Newly Diagnosed Heart Failure Patients in Japan.
Watanabe S, Usui M
J Nutr Sci Vitaminol (Tokyo) 2023;69(6):479-484. doi: 10.3177/jnsv.69.479. PMID: 38171821
Association of Plasma Selenium and Its Untargeted Metabolomic Profiling with Cervical Cancer Prognosis.
Qi L, Wang Y, Wang R, Wang M, Jablonska E, Zhou H, Su S, Jia Y, Zhang Y, Li Q, Wang T
Biol Trace Elem Res 2023 Oct;201(10):4637-4648. Epub 2023 Jan 7 doi: 10.1007/s12011-022-03552-5. PMID: 36609649
Electrophysiological Effect of Citreoviridin on Human InducedPluripotent Stem Cell-derived Cardiomyocytes.
Uchiyama Y, Yamazaki D, Kobayashi N, Kanda Y, Sugita-Konishi Y
Shokuhin Eiseigaku Zasshi 2022;63(6):210-217. doi: 10.3358/shokueishi.63.210. PMID: 36575035
Prevention of Keshan Disease by Selenium Supplementation: a Systematic Review and Meta-analysis.
Zhou H, Wang T, Li Q, Li D
Biol Trace Elem Res 2018 Nov;186(1):98-105. Epub 2018 Apr 7 doi: 10.1007/s12011-018-1302-5. PMID: 29627894
Selenium.
Alexander J
Novartis Found Symp 2007;282:143-9; discussion 149-53, 212-8. PMID: 17913229

Diagnosis

Impact of Selenium Deficiency on Clinical Outcomes in Newly Diagnosed Heart Failure Patients in Japan.
Watanabe S, Usui M
J Nutr Sci Vitaminol (Tokyo) 2023;69(6):479-484. doi: 10.3177/jnsv.69.479. PMID: 38171821
Relationship Between Myocardial Injury and Expression of PGC-1α and Its Coactivators in Chronic Keshan Disease.
Jiang S, Ye QR, Zhen RX, Zhang JN, Zhang YY, Liu X, Hou J
Curr Med Sci 2022 Feb;42(1):85-92. Epub 2021 Oct 27 doi: 10.1007/s11596-021-2454-7. PMID: 34705216
Selenium in Endocrinology-Selenoprotein-Related Diseases, Population Studies, and Epidemiological Evidence.
Köhrle J
Endocrinology 2021 Feb 1;162(2) doi: 10.1210/endocr/bqaa228. PMID: 33382424
Risk factors for Keshan disease: a prospective cohort study protocol of gut flora.
Li Z, Wei J, Zhang Y, Li G, Zhu H, Lei N, He Q, Geng Y, Zhu J
BMC Cardiovasc Disord 2020 Nov 11;20(1):481. doi: 10.1186/s12872-020-01765-x. PMID: 33176699Free PMC Article
M-mode echocardiographic features of children with Keshan disease. A preliminary observation of 106 cases.
Tang SC, Liu YX, Jin ZH, Wang MR, Xia LQ, Zhou TF, Zhang J
Chin Med J (Engl) 1984 Nov;97(11):795-800. PMID: 6242288

Therapy

Association of Plasma Selenium and Its Untargeted Metabolomic Profiling with Cervical Cancer Prognosis.
Qi L, Wang Y, Wang R, Wang M, Jablonska E, Zhou H, Su S, Jia Y, Zhang Y, Li Q, Wang T
Biol Trace Elem Res 2023 Oct;201(10):4637-4648. Epub 2023 Jan 7 doi: 10.1007/s12011-022-03552-5. PMID: 36609649
Selenium.
Prabhu KS, Lei XG
Adv Nutr 2016 Mar;7(2):415-7. Epub 2016 Mar 15 doi: 10.3945/an.115.010785. PMID: 26980826Free PMC Article
The epidemiology of selenium deficiency in the etiological study of endemic diseases in China.
Ge K, Yang G
Am J Clin Nutr 1993 Feb;57(2 Suppl):259S-263S. doi: 10.1093/ajcn/57.2.259S. PMID: 8427200
Pathologic anatomy of the dilated cardiomyopathies.
Ferrans VJ
Am J Cardiol 1989 Aug 2;64(6):9C-11C. doi: 10.1016/0002-9149(89)90677-2. PMID: 2756900
Selenium in total parenteral nutrition.
von Stockhausen HB
Biol Trace Elem Res 1988 Jan-Apr;15:147-55. doi: 10.1007/BF02990133. PMID: 2484513

Prognosis

Recent Advances on Selenium Nutrition and Keshan Disease.
Li SJ, Wang AW, Huang KL, Yang Y
Int Heart J 2024;65(2):173-179. doi: 10.1536/ihj.23-628. PMID: 38556328
Selenium, Selenoproteins, and Heart Failure: Current Knowledge and Future Perspective.
Al-Mubarak AA, van der Meer P, Bomer N
Curr Heart Fail Rep 2021 Jun;18(3):122-131. Epub 2021 Apr 9 doi: 10.1007/s11897-021-00511-4. PMID: 33835398Free PMC Article
Risk factors for Keshan disease: a prospective cohort study protocol of gut flora.
Li Z, Wei J, Zhang Y, Li G, Zhu H, Lei N, He Q, Geng Y, Zhu J
BMC Cardiovasc Disord 2020 Nov 11;20(1):481. doi: 10.1186/s12872-020-01765-x. PMID: 33176699Free PMC Article
Regional ecological risk assessment of selenium in Jilin province, China.
Baoyan M, Xuelin Z
Sci Total Environ 2000 Oct 30;262(1-2):103-10. doi: 10.1016/s0048-9697(00)00588-x. PMID: 11059846
Observations on effect of sodium selenite in prevention of Keshan disease.
Chin Med J (Engl) 1979 Jul;92(7):471-6. PMID: 114371

Clinical prediction guides

Association of Plasma Selenium and Its Untargeted Metabolomic Profiling with Cervical Cancer Prognosis.
Qi L, Wang Y, Wang R, Wang M, Jablonska E, Zhou H, Su S, Jia Y, Zhang Y, Li Q, Wang T
Biol Trace Elem Res 2023 Oct;201(10):4637-4648. Epub 2023 Jan 7 doi: 10.1007/s12011-022-03552-5. PMID: 36609649
Effects of Fusarium mycotoxin butenolide on myocardial mitochondria in vitro.
Wang YM, Liu JB, Peng SQ
Toxicol Mech Methods 2009 Feb;19(2):79-85. doi: 10.1080/15376510802322802. PMID: 19778250
Selenium deficiency and viral infection.
Beck MA, Levander OA, Handy J
J Nutr 2003 May;133(5 Suppl 1):1463S-7S. doi: 10.1093/jn/133.5.1463S. PMID: 12730444
Selenium in total parenteral nutrition.
von Stockhausen HB
Biol Trace Elem Res 1988 Jan-Apr;15:147-55. doi: 10.1007/BF02990133. PMID: 2484513
Keshan disease-an endemic cardiomyopathy in China.
Ge K, Xue A, Bai J, Wang S
Virchows Arch A Pathol Anat Histopathol 1983;401(1):1-15. doi: 10.1007/BF00644785. PMID: 6412443

Recent systematic reviews

Prevention of Keshan Disease by Selenium Supplementation: a Systematic Review and Meta-analysis.
Zhou H, Wang T, Li Q, Li D
Biol Trace Elem Res 2018 Nov;186(1):98-105. Epub 2018 Apr 7 doi: 10.1007/s12011-018-1302-5. PMID: 29627894

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