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Sclerosing mesenteritis

MedGen UID:
75639
•Concept ID:
C0267770
•
Disease or Syndrome
Synonyms: Idiopathic sclerosing mesenteritis; IgG4-related mesenteritis; Liposclerotic mesenteritis; Mesenteric fibromatosis; Mesenteric lipodystrophy; Mesenteric lipogranuloma; Mesenteric panniculitis; Peritoneal retractile mesenteritis; Retractile mesenteritis
SNOMED CT: Retractile mesenteritis (86422009); Sclerosing mesenteritis (1092381000119100)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0016544
Orphanet: ORPHA238593

Definition

Sclerosing mesenteritis (SM) is a rare pathological disease causing inflammation of the adipose tissue of the small bowel mesentery and is commonly associated with abdominal pain, diarrhea, nausea, weight loss, bloating and loss of appetite. The two subforms include mesenteric panniculitis (where inflammation and fatty necrosis are dominant features) and retractile mesenteritis (where fibrosis and retraction dominate). [from ORDO]

Professional guidelines

PubMed

Colchicine as an Alternative First-Line Treatment of Sclerosing Mesenteritis: A Retrospective Study.
Cortés P, Ghoz HM, Mzaik O, Alhaj Moustafa M, Bi Y, Brahmbhatt B, Daoud N, Pang M
Dig Dis Sci 2022 Jun;67(6):2403-2412. Epub 2021 Jun 4 doi: 10.1007/s10620-021-07081-4. PMID: 34086165
Mesenteric masses: approach to differential diagnosis at MRI with histopathologic correlation.
Ezhapilli SR, Moreno CC, Small WC, Hanley K, Kitajima HD, Mittal PK
J Magn Reson Imaging 2014 Oct;40(4):753-69. Epub 2014 Jul 26 doi: 10.1002/jmri.24690. PMID: 25066410
Sclerosing mesenteritis: clinical features, treatment, and outcome in ninety-two patients.
Akram S, Pardi DS, Schaffner JA, Smyrk TC
Clin Gastroenterol Hepatol 2007 May;5(5):589-96; quiz 523-4. doi: 10.1016/j.cgh.2007.02.032. PMID: 17478346

Recent clinical studies

Etiology

Sclerosing Mesenteritis: A Concise Clinical Review for Clinicians.
Saha B, Tome J, Wang XJ
Mayo Clin Proc 2024 May;99(5):812-820. doi: 10.1016/j.mayocp.2024.01.019. PMID: 38702129
Peritoneal or mesenteric tumours revealing histiocytosis.
Cohen-Aubart F, Ungureanu I, Razanamahery J, Charlotte F, Valmary-Degano S, Hélias-Rodzewicz Z, Cazals-Hatem D, Dartigues P, Delage-Corre M, Selves J, Tas P, Humbert S, Malakhia A, Kunnamo M, Veresezan L, Prokopiou C, Seeber A, Tazi A, Donadieu J, Lucidarme O, Haroche J, Emile JF
BMJ Open Gastroenterol 2021 May;8(1) doi: 10.1136/bmjgast-2021-000622. PMID: 34020934Free PMC Article
Diagnoses and Difficulties in Mesenteric Pathology.
Dashti NK, Shi C
Surg Pathol Clin 2020 Sep;13(3):521-556. Epub 2020 Jul 15 doi: 10.1016/j.path.2020.06.001. PMID: 32773198
Sclerosing mesenteritis: a systematic review of 192 cases.
Sharma P, Yadav S, Needham CM, Feuerstadt P
Clin J Gastroenterol 2017 Apr;10(2):103-111. Epub 2017 Feb 14 doi: 10.1007/s12328-017-0716-5. PMID: 28197781
Sclerosing mesenteritis: imaging findings in 17 patients.
Sabaté JM, Torrubia S, Maideu J, Franquet T, Monill JM, Pérez C
AJR Am J Roentgenol 1999 Mar;172(3):625-9. doi: 10.2214/ajr.172.3.10063848. PMID: 10063848

Diagnosis

Diagnoses and Difficulties in Mesenteric Pathology.
Dashti NK, Shi C
Surg Pathol Clin 2020 Sep;13(3):521-556. Epub 2020 Jul 15 doi: 10.1016/j.path.2020.06.001. PMID: 32773198
Sclerosing Mesenteritis Mimicking IgG4-related Disease.
Fukuda M, Miyake T, Matsubara A, Ikai N, Tanaka E, Namura T, Wada Y, Noujima M, Moritani S, Murakami K, Andoh A, Tani M, Kushima R
Intern Med 2020 Feb 15;59(4):513-518. Epub 2019 Nov 8 doi: 10.2169/internalmedicine.3221-19. PMID: 31708540Free PMC Article
IgG4-Related Sclerosing Mesenteritis.
Kitagawa S, Okamura K
Am J Gastroenterol 2017 Jun;112(6):834. doi: 10.1038/ajg.2017.17. PMID: 28572659
IgG4-associated sclerosing mesenteritis.
Salvarani C, Valli R, Boiardi L, Pipitone N, Nicoli F, Muratore F
Clin Exp Rheumatol 2011 Jan-Feb;29(1 Suppl 64):S79-80. Epub 2011 May 11 PMID: 21586200
Sclerosing mesenteritis.
Cuff R, Landercasper J, Schlack S
Surgery 2001 Apr;129(4):509-10. doi: 10.1067/msy.2001.106425. PMID: 11283546

Therapy

A Rare Cause of Abdominal Pain: IgG4-Related Sclerosing Mesenteritis.
Archer S, Pereira-Guedes T, Fonseca T, Carvalho Sá D, Pedroto I
J Gastrointestin Liver Dis 2023 Jun 22;32(2):141. doi: 10.15403/jgld-4921. PMID: 37345601
A severe case of sclerosing mesenteritis.
Corado SC, Almeida H, Baltazar JR
BMJ Case Rep 2019 Jul 8;12(7) doi: 10.1136/bcr-2018-229035. PMID: 31289157Free PMC Article
IgG4-Related Sclerosing Mesenteritis.
Kitagawa S, Okamura K
Am J Gastroenterol 2017 Jun;112(6):834. doi: 10.1038/ajg.2017.17. PMID: 28572659
A case of IgG4-related mesenteritis.
Mori E, Kamisawa T, Tabata T, Shibata S, Chiba K, Kuruma S, Kuwata G, Onishi T, Fujiwara T, Fujiwara J, Arakawa T, Momma K, Koizumi K, Matsumoto H, Horiguchi S
Clin J Gastroenterol 2015 Dec;8(6):400-5. Epub 2015 Nov 18 doi: 10.1007/s12328-015-0617-4. PMID: 26581887
Sclerosing mesenteritis.
Cuff R, Landercasper J, Schlack S
Surgery 2001 Apr;129(4):509-10. doi: 10.1067/msy.2001.106425. PMID: 11283546

Prognosis

Sclerosing Mesenteritis: A Concise Clinical Review for Clinicians.
Saha B, Tome J, Wang XJ
Mayo Clin Proc 2024 May;99(5):812-820. doi: 10.1016/j.mayocp.2024.01.019. PMID: 38702129
Sclerosing Mesenteritis.
Danford CJ, Lin SC, Wolf JL
Am J Gastroenterol 2019 Jun;114(6):867-873. doi: 10.14309/ajg.0000000000000167. PMID: 30829677
Sclerosing mesenteritis: a systematic review of 192 cases.
Sharma P, Yadav S, Needham CM, Feuerstadt P
Clin J Gastroenterol 2017 Apr;10(2):103-111. Epub 2017 Feb 14 doi: 10.1007/s12328-017-0716-5. PMID: 28197781
A fatal case of sclerosing mesenteritis.
Katsanos KH, Ioachim E, Michail M, Price AC, Agnantis N, Kappas A, Tsianos EV
Dig Liver Dis 2004 Feb;36(2):153-6. doi: 10.1016/j.dld.2003.07.009. PMID: 15002825
Sclerosing mesenteritis. Response to cyclophosphamide.
Bush RW, Hammar SP Jr, Rudolph RH
Arch Intern Med 1986 Mar;146(3):503-5. PMID: 3954521

Clinical prediction guides

Sclerosing mesenteritis due to Mycobacterium genavense infection: A case report.
Artigues Serra F, García-Gasalla M, Campins A, González de Cabo M, Morales R, Peña RR, Gallegos MC, Riera M
Medicine (Baltimore) 2022 Sep 9;101(36):e30351. doi: 10.1097/MD.0000000000030351. PMID: 36086677Free PMC Article
Sclerosing mesenteritis and mesenteric panniculitis - clinical experience and radiological features.
Nyberg L, Björk J, Björkdahl P, Ekberg O, Sjöberg K, Vigren L
BMC Gastroenterol 2017 Jun 13;17(1):75. doi: 10.1186/s12876-017-0632-7. PMID: 28610559Free PMC Article
Anastomosis Between Thoracic Duct and Azygos Vein During Esophagectomy: A Novel Technique with 3-year Follow-up.
Yuan Y, Chen LQ, Zhao Y
World J Surg 2016 Dec;40(12):2984-2987. doi: 10.1007/s00268-016-3666-z. PMID: 27460138
Extraintestinal manifestations of autoimmune pancreatitis.
Milosavljevic T, Kostic-Milosavljevic M, Jovanovic I, Krstic M
Dig Dis 2012;30(2):220-3. Epub 2012 Jun 20 doi: 10.1159/000336708. PMID: 22722443
Misty mesentery: a pictorial review of multidetector-row CT findings.
Filippone A, Cianci R, Di Fabio F, Storto ML
Radiol Med 2011 Apr;116(3):351-65. Epub 2010 Dec 3 doi: 10.1007/s11547-010-0610-4. PMID: 21311992

Recent systematic reviews

Sclerosing mesenteritis: a systematic review of 192 cases.
Sharma P, Yadav S, Needham CM, Feuerstadt P
Clin J Gastroenterol 2017 Apr;10(2):103-111. Epub 2017 Feb 14 doi: 10.1007/s12328-017-0716-5. PMID: 28197781
Mesenteric panniculitis: systematic review of cross-sectional imaging findings and risk of subsequent malignancy.
Halligan S, Plumb A, Taylor S
Eur Radiol 2016 Dec;26(12):4531-4537. Epub 2016 Apr 5 doi: 10.1007/s00330-016-4298-2. PMID: 27048526Free PMC Article

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