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Gastric intestinal metaplasia

MedGen UID:
75629
•Concept ID:
C0267187
•
Neoplastic Process
Synonyms: Gastric Intestinal Metaplasia; gastric intestinal metaplasia; GIM; intestinal metaplasia; Intestinal metaplasia of gastric mucosa; Intestinal Metaplasia of Gastric Mucosa
SNOMED CT: Intestinal metaplasia of gastric mucosa (72519002)
 
Monarch Initiative: MONDO:0100190

Definition

A morphologic finding indicating the replacement of part of the gastric mucosal epithelium with intestinal-type epithelium. Using immunohistochemical staining, gastric intestinal metaplasia is classified as complete or incomplete. Complete intestinal metaplasia is defined by the decreased expression of gastric mucins and expression of the intestinal mucin MUC2. Incomplete intestinal metaplasia is defined by the co-expression of both gastric mucins and MUC2. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGastric intestinal metaplasia

Professional guidelines

PubMed

Evolving Concepts in Helicobacter pylori Management.
Moss SF, Shah SC, Tan MC, El-Serag HB
Gastroenterology 2024 Feb;166(2):267-283. Epub 2023 Oct 6 doi: 10.1053/j.gastro.2023.09.047. PMID: 37806461Free PMC Article
AGA Clinical Practice Update on the Diagnosis and Management of Atrophic Gastritis: Expert Review.
Shah SC, Piazuelo MB, Kuipers EJ, Li D
Gastroenterology 2021 Oct;161(4):1325-1332.e7. Epub 2021 Aug 26 doi: 10.1053/j.gastro.2021.06.078. PMID: 34454714Free PMC Article
AGA Clinical Practice Guidelines on Management of Gastric Intestinal Metaplasia.
Gupta S, Li D, El Serag HB, Davitkov P, Altayar O, Sultan S, Falck-Ytter Y, Mustafa RA
Gastroenterology 2020 Feb;158(3):693-702. Epub 2019 Dec 6 doi: 10.1053/j.gastro.2019.12.003. PMID: 31816298Free PMC Article

Recent clinical studies

Therapy

Evolving Concepts in Helicobacter pylori Management.
Moss SF, Shah SC, Tan MC, El-Serag HB
Gastroenterology 2024 Feb;166(2):267-283. Epub 2023 Oct 6 doi: 10.1053/j.gastro.2023.09.047. PMID: 37806461Free PMC Article
Gastric intestinal metaplasia: when to treat? How to treat?
Abdelfattah T, Shahab O, Shah TU
Curr Opin Gastroenterol 2021 Nov 1;37(6):602-608. doi: 10.1097/MOG.0000000000000784. PMID: 34432654
Endoscopic grading of gastric intestinal metaplasia (EGGIM): a multicenter validation study.
Esposito G, Pimentel-Nunes P, Angeletti S, Castro R, Libânio D, Galli G, Lahner E, Di Giulio E, Annibale B, Dinis-Ribeiro M
Endoscopy 2019 Jun;51(6):515-521. Epub 2018 Dec 21 doi: 10.1055/a-0808-3186. PMID: 30577062
Helicobacter pylori associated gastric intestinal metaplasia: Treatment and surveillance.
Liu KS, Wong IO, Leung WK
World J Gastroenterol 2016 Jan 21;22(3):1311-20. doi: 10.3748/wjg.v22.i3.1311. PMID: 26811668Free PMC Article
Helicobacter pylori associated chronic gastritis, clinical syndromes, precancerous lesions, and pathogenesis of gastric cancer development.
Watari J, Chen N, Amenta PS, Fukui H, Oshima T, Tomita T, Miwa H, Lim KJ, Das KM
World J Gastroenterol 2014 May 14;20(18):5461-73. doi: 10.3748/wjg.v20.i18.5461. PMID: 24833876Free PMC Article

Prognosis

Gastric intestinal metaplasia: Long-term follow-up results.
Rakici H, Uyanik E, Rakici IM, Polat HB, Akdogan RA, Aydin G, Ayvaz MA, Bedir R
Niger J Clin Pract 2022 Mar;25(3):315-324. doi: 10.4103/njcp.njcp_1548_21. PMID: 35295055
Severity of gastric intestinal metaplasia predicts the risk of gastric cancer: a prospective multicentre cohort study (GCEP).
Lee JWJ, Zhu F, Srivastava S, Tsao SK, Khor C, Ho KY, Fock KM, Lim WC, Ang TL, Chow WC, So JBY, Koh CJ, Chua SJ, Wong ASY, Rao J, Lim LG, Ling KL, Chia CK, Ooi CJ, Rajnakova A, Yap WM, Salto-Tellez M, Ho B, Soong R, Chia KS, Teo YY, Teh M, Yeoh KG
Gut 2022 May;71(5):854-863. Epub 2021 May 11 doi: 10.1136/gutjnl-2021-324057. PMID: 33975867Free PMC Article
AGA Clinical Practice Update on the Diagnosis and Management of Atrophic Gastritis: Expert Review.
Shah SC, Piazuelo MB, Kuipers EJ, Li D
Gastroenterology 2021 Oct;161(4):1325-1332.e7. Epub 2021 Aug 26 doi: 10.1053/j.gastro.2021.06.078. PMID: 34454714Free PMC Article
Surveillance of Gastric Intestinal Metaplasia.
Shah SC, Gawron AJ, Li D
Am J Gastroenterol 2020 May;115(5):641-644. doi: 10.14309/ajg.0000000000000540. PMID: 32058339Free PMC Article
British Society of Gastroenterology guidelines on the diagnosis and management of patients at risk of gastric adenocarcinoma.
Banks M, Graham D, Jansen M, Gotoda T, Coda S, di Pietro M, Uedo N, Bhandari P, Pritchard DM, Kuipers EJ, Rodriguez-Justo M, Novelli MR, Ragunath K, Shepherd N, Dinis-Ribeiro M
Gut 2019 Sep;68(9):1545-1575. Epub 2019 Jul 5 doi: 10.1136/gutjnl-2018-318126. PMID: 31278206Free PMC Article

Clinical prediction guides

Helicobacter pylori promotes gastric intestinal metaplasia through activation of IRF3-mediated kynurenine pathway.
Liang X, Du W, Huang L, Xiang L, Pan W, Yang F, Zheng F, Xie Y, Geng L, Gong S, Xu W
Cell Commun Signal 2023 Jun 16;21(1):141. doi: 10.1186/s12964-023-01162-9. PMID: 37328804Free PMC Article
Severity of gastric intestinal metaplasia predicts the risk of gastric cancer: a prospective multicentre cohort study (GCEP).
Lee JWJ, Zhu F, Srivastava S, Tsao SK, Khor C, Ho KY, Fock KM, Lim WC, Ang TL, Chow WC, So JBY, Koh CJ, Chua SJ, Wong ASY, Rao J, Lim LG, Ling KL, Chia CK, Ooi CJ, Rajnakova A, Yap WM, Salto-Tellez M, Ho B, Soong R, Chia KS, Teo YY, Teh M, Yeoh KG
Gut 2022 May;71(5):854-863. Epub 2021 May 11 doi: 10.1136/gutjnl-2021-324057. PMID: 33975867Free PMC Article
AGA Clinical Practice Update on the Diagnosis and Management of Atrophic Gastritis: Expert Review.
Shah SC, Piazuelo MB, Kuipers EJ, Li D
Gastroenterology 2021 Oct;161(4):1325-1332.e7. Epub 2021 Aug 26 doi: 10.1053/j.gastro.2021.06.078. PMID: 34454714Free PMC Article
Endoscopic grading of gastric intestinal metaplasia (EGGIM): a multicenter validation study.
Esposito G, Pimentel-Nunes P, Angeletti S, Castro R, Libânio D, Galli G, Lahner E, Di Giulio E, Annibale B, Dinis-Ribeiro M
Endoscopy 2019 Jun;51(6):515-521. Epub 2018 Dec 21 doi: 10.1055/a-0808-3186. PMID: 30577062
Helicobacter pylori associated gastric intestinal metaplasia: Treatment and surveillance.
Liu KS, Wong IO, Leung WK
World J Gastroenterol 2016 Jan 21;22(3):1311-20. doi: 10.3748/wjg.v22.i3.1311. PMID: 26811668Free PMC Article

Recent systematic reviews

Global prevalence of gastric intestinal metaplasia: a systematic review and meta-analysis.
Soroorikia S, Kazeminia M, Qaderi K, Ziapour A, Hodhodi T, Javanbakht Z
Syst Rev 2024 Sep 28;13(1):247. doi: 10.1186/s13643-024-02633-x. PMID: 39342409Free PMC Article
Markers of gastric intestinal metaplasia under digital chromoendoscopy: systematic review and meta-analysis.
Wei N, Mulmi Shrestha S, Shi RH
Eur J Gastroenterol Hepatol 2021 Apr 1;33(4):470-478. doi: 10.1097/MEG.0000000000001834. PMID: 32675780
AGA Technical Review on Gastric Intestinal Metaplasia-Epidemiology and Risk Factors.
Altayar O, Davitkov P, Shah SC, Gawron AJ, Morgan DR, Turner K, Mustafa RA
Gastroenterology 2020 Feb;158(3):732-744.e16. Epub 2019 Dec 6 doi: 10.1053/j.gastro.2019.12.002. PMID: 31816301Free PMC Article
Surveillance of gastric intestinal metaplasia for the prevention of gastric cancer.
O'Connor A, McNamara D, O'Moráin CA
Cochrane Database Syst Rev 2013 Sep 23;(9):CD009322. doi: 10.1002/14651858.CD009322.pub2. PMID: 24062262
Salt intake and risk of gastric intestinal metaplasia: systematic review and meta-analysis.
Dias-Neto M, Pintalhao M, Ferreira M, Lunet N
Nutr Cancer 2010;62(2):133-47. doi: 10.1080/01635580903305391. PMID: 20099187

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