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Oral erythroplakia

MedGen UID:
540324
•Concept ID:
C0267008
•
Disease or Syndrome
Synonyms: Erythroplakia of mouth; Erythroplasia of Queyrat of oral mucosa; Oral erythroplasia
SNOMED CT: Erythroplakia of mouth (69299000); Erythroplasia of Queyrat of oral mucosa (69299000); Oral erythroplasia (69299000); Oral erythroplakia (69299000)
 
HPO: HP:0030934

Definition

A velvety red but not ulcerated lesion of the oral mucosa. The texture may be roughened or normal, and the lesion is neither raised nor depressed. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOral erythroplakia

Professional guidelines

PubMed

Oral potentially malignant disorders: clinical diagnosis and current screening aids: a narrative review.
Parakh MK, Ulaganambi S, Ashifa N, Premkumar R, Jain AL
Eur J Cancer Prev 2020 Jan;29(1):65-72. doi: 10.1097/CEJ.0000000000000510. PMID: 30921006
Nano Drug Delivery in Treatment of Oral Cancer, A Review of the Literature.
Kakkar V, Verma MK, Saini K, Kaur IP
Curr Drug Targets 2019;20(10):1008-1017. doi: 10.2174/1389450120666190319125734. PMID: 30892161
A new approach for treatment of precancerous lesions with curcumin solid-lipid nanoparticle-loaded gels: in vitro and clinical evaluation.
Hazzah HA, Farid RM, Nasra MM, Zakaria M, Gawish Y, El-Massik MA, Abdallah OY
Drug Deliv 2016 May;23(4):1409-19. Epub 2015 Jul 6 doi: 10.3109/10717544.2015.1065524. PMID: 26146889

Recent clinical studies

Etiology

Oral erythroplakia and oral erythroplakia-like oral squamous cell carcinoma - what's the difference?
Öhman J, Zlotogorski-Hurvitz A, Dobriyan A, Reiter S, Vered M, Willberg J, Lajolo C, Siponen M
BMC Oral Health 2023 Nov 13;23(1):859. doi: 10.1186/s12903-023-03619-2. PMID: 37957684Free PMC Article
Critical update, systematic review, and meta-analysis of oral erythroplakia as an oral potentially malignant disorder.
Lorenzo-Pouso AI, Lafuente-Ibáñez de Mendoza I, Pérez-Sayáns M, Pérez-Jardón A, Chamorro-Petronacci CM, Blanco-Carrión A, Aguirre-Urízar JM
J Oral Pathol Med 2022 Aug;51(7):585-593. Epub 2022 May 12 doi: 10.1111/jop.13304. PMID: 35488780Free PMC Article
Oral leukoplakia and erythroplakia in young patients: a systematic review.
Roza ALOC, Kowalski LP, William WN Jr, de Castro G Jr, Chaves ALF, Araújo ALD, Ribeiro ACP, Brandão TB, Lopes MA, Vargas PA, Santos-Silva AR; Latin American Cooperative Oncology Group–Brazilian Group of Head and Neck Cancer
Oral Surg Oral Med Oral Pathol Oral Radiol 2021 Jan;131(1):73-84. Epub 2020 Sep 14 doi: 10.1016/j.oooo.2020.09.002. PMID: 33187936
Potentially malignant disorders of the oral cavity and oral dysplasia: A systematic review and meta-analysis of malignant transformation rate by subtype.
Iocca O, Sollecito TP, Alawi F, Weinstein GS, Newman JG, De Virgilio A, Di Maio P, Spriano G, Pardiñas López S, Shanti RM
Head Neck 2020 Mar;42(3):539-555. Epub 2019 Dec 5 doi: 10.1002/hed.26006. PMID: 31803979
Outcome of excision of oral erythroplakia.
Yang SW, Lee YS, Chang LC, Hsieh TY, Chen TA
Br J Oral Maxillofac Surg 2015 Feb;53(2):142-7. Epub 2014 Nov 18 doi: 10.1016/j.bjoms.2014.10.016. PMID: 25467247

Diagnosis

Oral erythroplakia and oral erythroplakia-like oral squamous cell carcinoma - what's the difference?
Öhman J, Zlotogorski-Hurvitz A, Dobriyan A, Reiter S, Vered M, Willberg J, Lajolo C, Siponen M
BMC Oral Health 2023 Nov 13;23(1):859. doi: 10.1186/s12903-023-03619-2. PMID: 37957684Free PMC Article
Critical update, systematic review, and meta-analysis of oral erythroplakia as an oral potentially malignant disorder.
Lorenzo-Pouso AI, Lafuente-Ibáñez de Mendoza I, Pérez-Sayáns M, Pérez-Jardón A, Chamorro-Petronacci CM, Blanco-Carrión A, Aguirre-Urízar JM
J Oral Pathol Med 2022 Aug;51(7):585-593. Epub 2022 May 12 doi: 10.1111/jop.13304. PMID: 35488780Free PMC Article
Oral leukoplakia and erythroplakia in young patients: a systematic review.
Roza ALOC, Kowalski LP, William WN Jr, de Castro G Jr, Chaves ALF, Araújo ALD, Ribeiro ACP, Brandão TB, Lopes MA, Vargas PA, Santos-Silva AR; Latin American Cooperative Oncology Group–Brazilian Group of Head and Neck Cancer
Oral Surg Oral Med Oral Pathol Oral Radiol 2021 Jan;131(1):73-84. Epub 2020 Sep 14 doi: 10.1016/j.oooo.2020.09.002. PMID: 33187936
Oral cancer and oral erythroplakia: an update and implication for clinicians.
Villa A, Villa C, Abati S
Aust Dent J 2011 Sep;56(3):253-6. Epub 2011 Jul 10 doi: 10.1111/j.1834-7819.2011.01337.x. PMID: 21884139
Oral erythroplakia--a review.
Reichart PA, Philipsen HP
Oral Oncol 2005 Jul;41(6):551-61. Epub 2005 Apr 9 doi: 10.1016/j.oraloncology.2004.12.003. PMID: 15975518

Therapy

Critical update, systematic review, and meta-analysis of oral erythroplakia as an oral potentially malignant disorder.
Lorenzo-Pouso AI, Lafuente-Ibáñez de Mendoza I, Pérez-Sayáns M, Pérez-Jardón A, Chamorro-Petronacci CM, Blanco-Carrión A, Aguirre-Urízar JM
J Oral Pathol Med 2022 Aug;51(7):585-593. Epub 2022 May 12 doi: 10.1111/jop.13304. PMID: 35488780Free PMC Article
Cancer stem cell markers ALDH1 and Bmi1 expression in oral erythroplakia revisited: Implication for driving the process of field cancerization.
Feng J, Zhou Z, Shi L, Yang X, Liu W
J Oral Pathol Med 2020 Jan;49(1):96-99. Epub 2019 Sep 5 doi: 10.1111/jop.12955. PMID: 31444928
Outcome of excision of oral erythroplakia.
Yang SW, Lee YS, Chang LC, Hsieh TY, Chen TA
Br J Oral Maxillofac Surg 2015 Feb;53(2):142-7. Epub 2014 Nov 18 doi: 10.1016/j.bjoms.2014.10.016. PMID: 25467247
Oral cancer and oral erythroplakia: an update and implication for clinicians.
Villa A, Villa C, Abati S
Aust Dent J 2011 Sep;56(3):253-6. Epub 2011 Jul 10 doi: 10.1111/j.1834-7819.2011.01337.x. PMID: 21884139
A high prevalence of p53 mutations in pre-malignant oral erythroplakia.
Qin GZ, Park JY, Chen SY, Lazarus P
Int J Cancer 1999 Jan 29;80(3):345-8. doi: 10.1002/(sici)1097-0215(19990129)80:3<345::aid-ijc2>3.0.co;2-n. PMID: 9935172

Prognosis

Critical update, systematic review, and meta-analysis of oral erythroplakia as an oral potentially malignant disorder.
Lorenzo-Pouso AI, Lafuente-Ibáñez de Mendoza I, Pérez-Sayáns M, Pérez-Jardón A, Chamorro-Petronacci CM, Blanco-Carrión A, Aguirre-Urízar JM
J Oral Pathol Med 2022 Aug;51(7):585-593. Epub 2022 May 12 doi: 10.1111/jop.13304. PMID: 35488780Free PMC Article
Oral erythroplakia-What is it?
Holmstrup P
Oral Dis 2018 Mar;24(1-2):138-143. doi: 10.1111/odi.12709. PMID: 29480616
Oral verruciform xanthoma and erythroplakia associated with chronic graft-versus-host disease: a rare case report and review of the literature.
Capocasale G, Panzarella V, Tozzo P, Mauceri R, Rodolico V, Lauritano D, Campisi G
BMC Res Notes 2017 Nov 28;10(1):631. doi: 10.1186/s13104-017-2952-7. PMID: 29183344Free PMC Article
Outcome of excision of oral erythroplakia.
Yang SW, Lee YS, Chang LC, Hsieh TY, Chen TA
Br J Oral Maxillofac Surg 2015 Feb;53(2):142-7. Epub 2014 Nov 18 doi: 10.1016/j.bjoms.2014.10.016. PMID: 25467247
Oral cancer and oral erythroplakia: an update and implication for clinicians.
Villa A, Villa C, Abati S
Aust Dent J 2011 Sep;56(3):253-6. Epub 2011 Jul 10 doi: 10.1111/j.1834-7819.2011.01337.x. PMID: 21884139

Clinical prediction guides

Oral leukoplakia and erythroplakia in young patients: a southern Brazilian multicenter study.
Soares AC, Gomes APN, Calderipe CB, Salum FG, Cherubini K, Martins MD, Schuch LF, Kirschnick LB, Abreu LG, Santos-Silva AR, Vasconcelos ACU
Braz Oral Res 2024;38:e069. Epub 2024 Aug 5 doi: 10.1590/1807-3107bor-2024.vol38.0069. PMID: 39109766Free PMC Article
Critical update, systematic review, and meta-analysis of oral erythroplakia as an oral potentially malignant disorder.
Lorenzo-Pouso AI, Lafuente-Ibáñez de Mendoza I, Pérez-Sayáns M, Pérez-Jardón A, Chamorro-Petronacci CM, Blanco-Carrión A, Aguirre-Urízar JM
J Oral Pathol Med 2022 Aug;51(7):585-593. Epub 2022 May 12 doi: 10.1111/jop.13304. PMID: 35488780Free PMC Article
Oral leukoplakia and erythroplakia in young patients: a systematic review.
Roza ALOC, Kowalski LP, William WN Jr, de Castro G Jr, Chaves ALF, Araújo ALD, Ribeiro ACP, Brandão TB, Lopes MA, Vargas PA, Santos-Silva AR; Latin American Cooperative Oncology Group–Brazilian Group of Head and Neck Cancer
Oral Surg Oral Med Oral Pathol Oral Radiol 2021 Jan;131(1):73-84. Epub 2020 Sep 14 doi: 10.1016/j.oooo.2020.09.002. PMID: 33187936
Oral verruciform xanthoma and erythroplakia associated with chronic graft-versus-host disease: a rare case report and review of the literature.
Capocasale G, Panzarella V, Tozzo P, Mauceri R, Rodolico V, Lauritano D, Campisi G
BMC Res Notes 2017 Nov 28;10(1):631. doi: 10.1186/s13104-017-2952-7. PMID: 29183344Free PMC Article
Outcome of excision of oral erythroplakia.
Yang SW, Lee YS, Chang LC, Hsieh TY, Chen TA
Br J Oral Maxillofac Surg 2015 Feb;53(2):142-7. Epub 2014 Nov 18 doi: 10.1016/j.bjoms.2014.10.016. PMID: 25467247

Recent systematic reviews

Critical update, systematic review, and meta-analysis of oral erythroplakia as an oral potentially malignant disorder.
Lorenzo-Pouso AI, Lafuente-Ibáñez de Mendoza I, Pérez-Sayáns M, Pérez-Jardón A, Chamorro-Petronacci CM, Blanco-Carrión A, Aguirre-Urízar JM
J Oral Pathol Med 2022 Aug;51(7):585-593. Epub 2022 May 12 doi: 10.1111/jop.13304. PMID: 35488780Free PMC Article
Oral leukoplakia and erythroplakia in young patients: a systematic review.
Roza ALOC, Kowalski LP, William WN Jr, de Castro G Jr, Chaves ALF, Araújo ALD, Ribeiro ACP, Brandão TB, Lopes MA, Vargas PA, Santos-Silva AR; Latin American Cooperative Oncology Group–Brazilian Group of Head and Neck Cancer
Oral Surg Oral Med Oral Pathol Oral Radiol 2021 Jan;131(1):73-84. Epub 2020 Sep 14 doi: 10.1016/j.oooo.2020.09.002. PMID: 33187936
Potentially malignant disorders of the oral cavity and oral dysplasia: A systematic review and meta-analysis of malignant transformation rate by subtype.
Iocca O, Sollecito TP, Alawi F, Weinstein GS, Newman JG, De Virgilio A, Di Maio P, Spriano G, Pardiñas López S, Shanti RM
Head Neck 2020 Mar;42(3):539-555. Epub 2019 Dec 5 doi: 10.1002/hed.26006. PMID: 31803979

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