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Cow Milk Allergy

MedGen UID:
120589
•Concept ID:
C0266815
•
Pathologic Function
Synonyms: Allergy, Cow's Milk; Cow's Milk Allergies; Cow's Milk Allergy; Cows Milk Allergy; Milk Allergy, Cow's

Professional guidelines

PubMed

Diagnosis and management of food allergy-associated gastroesophageal reflux disease in young children-EAACI position paper.
Meyer R, Vandenplas Y, Lozinsky AC, Vieira MC, Canani RB, Dupont C, Uysal P, Cavkaytar O, Knibb R, Fleischer DM, Nowak-Wegrzyn A, Venter C
Pediatr Allergy Immunol 2022 Oct;33(10):e13856. doi: 10.1111/pai.13856. PMID: 36282131
Strategies and Future Opportunities for the Prevention, Diagnosis, and Management of Cow Milk Allergy.
Zepeda-Ortega B, Goh A, Xepapadaki P, Sprikkelman A, Nicolaou N, Hernandez REH, Latiff AHA, Yat MT, Diab M, Hussaini BA, Setiabudiawan B, Kudla U, van Neerven RJJ, Muhardi L, Warner JO
Front Immunol 2021;12:608372. Epub 2021 Jun 10 doi: 10.3389/fimmu.2021.608372. PMID: 34177882Free PMC Article
Soy protein for the prevention and treatment of children with cow-milk allergy.
Businco L, Bruno G, Giampietro PG
Am J Clin Nutr 1998 Dec;68(6 Suppl):1447S-1452S. doi: 10.1093/ajcn/68.6.1447S. PMID: 9848515

Recent clinical studies

Etiology

Identification of cow milk epitopes to characterize and quantify disease-specific T cells in allergic children.
Lewis SA, Sutherland A, Soldevila F, Westernberg L, Aoki M, Frazier A, Maiche S, Erlewyn-Lajeunesse M, Arshad H, Leonard S, Laubach S, Dantzer JA, Wood RA, Sette A, Seumois G, Vijayanand P, Peters B
J Allergy Clin Immunol 2023 Nov;152(5):1196-1209. Epub 2023 Aug 19 doi: 10.1016/j.jaci.2023.07.020. PMID: 37604312Free PMC Article
Diagnosis and management of food allergy-associated gastroesophageal reflux disease in young children-EAACI position paper.
Meyer R, Vandenplas Y, Lozinsky AC, Vieira MC, Canani RB, Dupont C, Uysal P, Cavkaytar O, Knibb R, Fleischer DM, Nowak-Wegrzyn A, Venter C
Pediatr Allergy Immunol 2022 Oct;33(10):e13856. doi: 10.1111/pai.13856. PMID: 36282131
Strategies and Future Opportunities for the Prevention, Diagnosis, and Management of Cow Milk Allergy.
Zepeda-Ortega B, Goh A, Xepapadaki P, Sprikkelman A, Nicolaou N, Hernandez REH, Latiff AHA, Yat MT, Diab M, Hussaini BA, Setiabudiawan B, Kudla U, van Neerven RJJ, Muhardi L, Warner JO
Front Immunol 2021;12:608372. Epub 2021 Jun 10 doi: 10.3389/fimmu.2021.608372. PMID: 34177882Free PMC Article
Prevention and Management of Cow's Milk Allergy in Non-Exclusively Breastfed Infants.
Vandenplas Y
Nutrients 2017 Jul 10;9(7) doi: 10.3390/nu9070731. PMID: 28698533Free PMC Article
Food Protein-Induced Enterocolitis Syndrome.
Nowak-Węgrzyn A, Jarocka-Cyrta E, Moschione Castro A
J Investig Allergol Clin Immunol 2017;27(1):1-18. doi: 10.18176/jiaci.0135. PMID: 28211341

Diagnosis

Identification of cow milk epitopes to characterize and quantify disease-specific T cells in allergic children.
Lewis SA, Sutherland A, Soldevila F, Westernberg L, Aoki M, Frazier A, Maiche S, Erlewyn-Lajeunesse M, Arshad H, Leonard S, Laubach S, Dantzer JA, Wood RA, Sette A, Seumois G, Vijayanand P, Peters B
J Allergy Clin Immunol 2023 Nov;152(5):1196-1209. Epub 2023 Aug 19 doi: 10.1016/j.jaci.2023.07.020. PMID: 37604312Free PMC Article
Diagnosis and management of food allergy-associated gastroesophageal reflux disease in young children-EAACI position paper.
Meyer R, Vandenplas Y, Lozinsky AC, Vieira MC, Canani RB, Dupont C, Uysal P, Cavkaytar O, Knibb R, Fleischer DM, Nowak-Wegrzyn A, Venter C
Pediatr Allergy Immunol 2022 Oct;33(10):e13856. doi: 10.1111/pai.13856. PMID: 36282131
Strategies and Future Opportunities for the Prevention, Diagnosis, and Management of Cow Milk Allergy.
Zepeda-Ortega B, Goh A, Xepapadaki P, Sprikkelman A, Nicolaou N, Hernandez REH, Latiff AHA, Yat MT, Diab M, Hussaini BA, Setiabudiawan B, Kudla U, van Neerven RJJ, Muhardi L, Warner JO
Front Immunol 2021;12:608372. Epub 2021 Jun 10 doi: 10.3389/fimmu.2021.608372. PMID: 34177882Free PMC Article
Food Protein-Induced Enterocolitis Syndrome.
Nowak-Wegrzyn A, Berin MC, Mehr S
J Allergy Clin Immunol Pract 2020 Jan;8(1):24-35. doi: 10.1016/j.jaip.2019.08.020. PMID: 31950904
Food Protein-Induced Enterocolitis Syndrome.
Nowak-Węgrzyn A, Jarocka-Cyrta E, Moschione Castro A
J Investig Allergol Clin Immunol 2017;27(1):1-18. doi: 10.18176/jiaci.0135. PMID: 28211341

Therapy

Goat Milk Allergy and a Potential Role for Goat Milk in Cow's Milk Allergy.
Benjamin-van Aalst O, Dupont C, van der Zee L, Garssen J, Knipping K
Nutrients 2024 Jul 24;16(15) doi: 10.3390/nu16152402. PMID: 39125282Free PMC Article
Strategies and Future Opportunities for the Prevention, Diagnosis, and Management of Cow Milk Allergy.
Zepeda-Ortega B, Goh A, Xepapadaki P, Sprikkelman A, Nicolaou N, Hernandez REH, Latiff AHA, Yat MT, Diab M, Hussaini BA, Setiabudiawan B, Kudla U, van Neerven RJJ, Muhardi L, Warner JO
Front Immunol 2021;12:608372. Epub 2021 Jun 10 doi: 10.3389/fimmu.2021.608372. PMID: 34177882Free PMC Article
Food Protein-Induced Enterocolitis Syndrome.
Nowak-Węgrzyn A, Jarocka-Cyrta E, Moschione Castro A
J Investig Allergol Clin Immunol 2017;27(1):1-18. doi: 10.18176/jiaci.0135. PMID: 28211341
Oral immunotherapy for cow's milk allergy.
Passalacqua G, Landi M, Pajno GB
Curr Opin Allergy Clin Immunol 2012 Jun;12(3):271-7. doi: 10.1097/ACI.0b013e3283535b93. PMID: 22499143
Soy protein for the prevention and treatment of children with cow-milk allergy.
Businco L, Bruno G, Giampietro PG
Am J Clin Nutr 1998 Dec;68(6 Suppl):1447S-1452S. doi: 10.1093/ajcn/68.6.1447S. PMID: 9848515

Prognosis

Risk factors for discontinuing oral immunotherapy in children with persistent cow milk allergy.
Benelli E, Trombetta A, Badina L, Andrade S, Zamagni G, Prisco A, Traini E, Barbi E, Berti I
Immun Inflamm Dis 2022 Jul;10(7):e668. doi: 10.1002/iid3.668. PMID: 35759227Free PMC Article
Predictive Factors for Oral Immune Modulation in Cow Milk Allergy.
Muntean IA, Bocsan IC, Wiest LK, Pintea I, Dobrican CT, Duca E, Ureche C, Buzoianu AD, Deleanu D
Nutrients 2022 Jan 23;14(3) doi: 10.3390/nu14030494. PMID: 35276853Free PMC Article
Contribution of Molecular Allergen Analysis in Diagnosis of Milk Allergy.
Bartuzi Z, Cocco RR, Muraro A, Nowak-Węgrzyn A
Curr Allergy Asthma Rep 2017 Jul;17(7):46. doi: 10.1007/s11882-017-0716-z. PMID: 28597347
Food Protein-Induced Enterocolitis Syndrome.
Nowak-Węgrzyn A, Jarocka-Cyrta E, Moschione Castro A
J Investig Allergol Clin Immunol 2017;27(1):1-18. doi: 10.18176/jiaci.0135. PMID: 28211341
Matrix effect on baked milk tolerance in children with IgE cow milk allergy.
Miceli Sopo S, Greco M, Monaco S, Bianchi A, Cuomo B, Liotti L, Iacono ID
Allergol Immunopathol (Madr) 2016 Nov-Dec;44(6):517-523. Epub 2016 Jul 30 doi: 10.1016/j.aller.2016.03.005. PMID: 27480790

Clinical prediction guides

Risk factors for discontinuing oral immunotherapy in children with persistent cow milk allergy.
Benelli E, Trombetta A, Badina L, Andrade S, Zamagni G, Prisco A, Traini E, Barbi E, Berti I
Immun Inflamm Dis 2022 Jul;10(7):e668. doi: 10.1002/iid3.668. PMID: 35759227Free PMC Article
Predictive Factors for Oral Immune Modulation in Cow Milk Allergy.
Muntean IA, Bocsan IC, Wiest LK, Pintea I, Dobrican CT, Duca E, Ureche C, Buzoianu AD, Deleanu D
Nutrients 2022 Jan 23;14(3) doi: 10.3390/nu14030494. PMID: 35276853Free PMC Article
Prevention and Management of Cow's Milk Allergy in Non-Exclusively Breastfed Infants.
Vandenplas Y
Nutrients 2017 Jul 10;9(7) doi: 10.3390/nu9070731. PMID: 28698533Free PMC Article
Contribution of Molecular Allergen Analysis in Diagnosis of Milk Allergy.
Bartuzi Z, Cocco RR, Muraro A, Nowak-Węgrzyn A
Curr Allergy Asthma Rep 2017 Jul;17(7):46. doi: 10.1007/s11882-017-0716-z. PMID: 28597347
Gastroesophageal reflux and cow milk allergy: is there a link?
Salvatore S, Vandenplas Y
Pediatrics 2002 Nov;110(5):972-84. doi: 10.1542/peds.110.5.972. PMID: 12415039

Recent systematic reviews

Efficacy and safety of hydrolyzed formulas for cow's milk allergy management: A systematic review of randomized controlled trials.
Stróżyk A, Horvath A, Meyer R, Szajewska H
Clin Exp Allergy 2020 Jul;50(7):766-779. Epub 2020 Jun 11 doi: 10.1111/cea.13669. PMID: 32446273
Oral immunotherapy for milk allergy.
Yeung JP, Kloda LA, McDevitt J, Ben-Shoshan M, Alizadehfar R
Cochrane Database Syst Rev 2012 Nov 14;11(11):CD009542. doi: 10.1002/14651858.CD009542.pub2. PMID: 23152278Free PMC Article

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