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Nevus Phakomatoses, Organoid

MedGen UID:
75564
•Concept ID:
C0265329
•
Disease or Syndrome
Synonyms: Feuerstein Mims Syndrome; Feuerstein-Mims Syndrome; Nevus Phakomatosis, Organoid; Organoid Nevus Phakomatoses; Organoid Nevus Phakomatosis; Phakomatoses, Organoid Nevus; Phakomatosis, Organoid Nevus; Schimmelpenning Feuerstein Mims Syndrome; Schimmelpenning Syndrome; Schimmelpenning-Feuerstein-Mims Syndrome; Syndrome, Feuerstein-Mims; Syndrome, Schimmelpenning; Syndrome, Schimmelpenning-Feuerstein-Mims

Professional guidelines

PubMed

An update on Becker's nevus: Pathogenesis and treatment.
Zhou YJ, Zheng DL, Hamblin MR, Xu YD, Wen X
Dermatol Ther 2022 Jul;35(7):e15548. Epub 2022 May 12 doi: 10.1111/dth.15548. PMID: 35502558
Phenotype/genotype correlations in epidermal nevus syndrome as a neurocristopathy.
Flores-Sarnat L, Sarnat HB
Handb Clin Neurol 2015;132:9-25. doi: 10.1016/B978-0-444-62702-5.00002-0. PMID: 26564069
Sebaceus and Becker's Nevus: Overview of Their Presentation, Pathogenesis, Associations, and Treatment.
Patel P, Malik K, Khachemoune A
Am J Clin Dermatol 2015 Jun;16(3):197-204. doi: 10.1007/s40257-015-0123-y. PMID: 25782676

Recent clinical studies

Etiology

Inflammatory linear verrucous epidermal nevus (ILVEN) encompasses a spectrum of inflammatory mosaic disorders.
Atzmony L, Ugwu N, Hamilton C, Paller AS, Zech L, Antaya RJ, Choate KA
Pediatr Dermatol 2022 Nov;39(6):903-907. Epub 2022 Jul 19 doi: 10.1111/pde.15094. PMID: 35853659Free PMC Article
Cd34+ Stromal Cells/Telocytes in Normal and Pathological Skin.
Díaz-Flores L, Gutiérrez R, García MP, González-Gómez M, Rodríguez-Rodriguez R, Hernández-León N, Díaz-Flores L Jr, Carrasco JL
Int J Mol Sci 2021 Jul 8;22(14) doi: 10.3390/ijms22147342. PMID: 34298962Free PMC Article
Phenotype/genotype correlations in epidermal nevus syndrome as a neurocristopathy.
Flores-Sarnat L, Sarnat HB
Handb Clin Neurol 2015;132:9-25. doi: 10.1016/B978-0-444-62702-5.00002-0. PMID: 26564069
The group of epidermal nevus syndromes Part I. Well defined phenotypes.
Happle R
J Am Acad Dermatol 2010 Jul;63(1):1-22; quiz 23-4. doi: 10.1016/j.jaad.2010.01.017. PMID: 20542174
Linear nevus sebaceous syndrome: case reports and review of the literature.
Menascu S, Donner EJ
Pediatr Neurol 2008 Mar;38(3):207-10. doi: 10.1016/j.pediatrneurol.2007.10.012. PMID: 18279757

Diagnosis

Verrucous epidermal nevus.
Rivera-Silva G, Moreno-Treviño MG
Pan Afr Med J 2023;45:146. Epub 2023 Aug 2 doi: 10.11604/pamj.2023.45.146.40966. PMID: 37808438Free PMC Article
Inflammatory linear verrucous epidermal nevus (ILVEN) encompasses a spectrum of inflammatory mosaic disorders.
Atzmony L, Ugwu N, Hamilton C, Paller AS, Zech L, Antaya RJ, Choate KA
Pediatr Dermatol 2022 Nov;39(6):903-907. Epub 2022 Jul 19 doi: 10.1111/pde.15094. PMID: 35853659Free PMC Article
Becker's nevus.
Baalann KP, Krishnan M
Pan Afr Med J 2022;41:142. Epub 2022 Feb 17 doi: 10.11604/pamj.2022.41.142.33417. PMID: 35519166Free PMC Article
Schimmelpenning Syndrome.
Sarswat S, Dixit N
Indian Pediatr 2018 Nov 15;55(11):1014. PMID: 30587664
Syringocystadenoma.
Mundi JP, Rose AE, Boyd KP, Patel RR, Lipkin G
Dermatol Online J 2013 Dec 16;19(12):20722. PMID: 24365013

Therapy

Rate of Benign and Malignant Secondary Tumors Associated With Nevus Sebaceous: A Systematic Review and Meta-Analysis.
Pang S, Cevik J, Sreedharan S, Wilks DJ
Ann Plast Surg 2024 Jun 1;92(6):711-719. Epub 2024 May 9 doi: 10.1097/SAP.0000000000003879. PMID: 38725109
Inflammatory linear verrucous epidermal nevus (ILVEN) encompasses a spectrum of inflammatory mosaic disorders.
Atzmony L, Ugwu N, Hamilton C, Paller AS, Zech L, Antaya RJ, Choate KA
Pediatr Dermatol 2022 Nov;39(6):903-907. Epub 2022 Jul 19 doi: 10.1111/pde.15094. PMID: 35853659Free PMC Article
Safety and effectiveness of 5-aminolevulinic acid photodynamic therapy combined with fractional micro-plasma radio-frequency treatment for verrucous epidermal nevus: A retrospective study with long-term follow-up.
Dai S, He S, Huang X, Chen P, Li Q, Guo J, Zhu M, Shen J, Zeng K
J Dermatol 2021 Aug;48(8):1229-1235. Epub 2021 Apr 25 doi: 10.1111/1346-8138.15923. PMID: 33896053
Verrucous epidermal nevus.
Kim R, Marmon S, Kaplan J, Kamino H, Pomeranz MK
Dermatol Online J 2013 Dec 16;19(12):20707. PMID: 24364998
Difficult-to-control bleeding.
Bellet JS, Wagner AM
Pediatr Dermatol 2009 Sep-Oct;26(5):559-62. doi: 10.1111/j.1525-1470.2009.00985.x. PMID: 19840310

Prognosis

Sebaceous Nevus of the Scalp.
Goel P, Wolfswinkel EM, Fahradyan A, Tsuha M, Hough M, Magee W 3rd, Hammoudeh JA, Urata MM, Howell LK
J Craniofac Surg 2020 Jan/Feb;31(1):257-260. doi: 10.1097/SCS.0000000000006007. PMID: 31725502
Syndromic sebaceous nevus: current findings.
El Ezzi O, de Buys Roessingh AS, Bigorre M, Captier G
Int J Dermatol 2018 May;57(5):599-604. Epub 2018 Feb 16 doi: 10.1111/ijd.13942. PMID: 29453776
Phenotype/genotype correlations in epidermal nevus syndrome as a neurocristopathy.
Flores-Sarnat L, Sarnat HB
Handb Clin Neurol 2015;132:9-25. doi: 10.1016/B978-0-444-62702-5.00002-0. PMID: 26564069
Linear nevus sebaceous syndrome: case reports and review of the literature.
Menascu S, Donner EJ
Pediatr Neurol 2008 Mar;38(3):207-10. doi: 10.1016/j.pediatrneurol.2007.10.012. PMID: 18279757
The Muir-Torre syndrome: a 25-year retrospect.
Schwartz RA, Torre DP
J Am Acad Dermatol 1995 Jul;33(1):90-104. doi: 10.1016/0190-9622(95)90017-9. PMID: 7601953

Clinical prediction guides

Differences in clinical characteristics and lesion proteomics between inflammatory linear verrucous epidermal nevus and local verrucous epidermal nevus.
Yuan T, Lu XH, Tang B Mr, Chang XL, He CF, Wang J, Ci C
J Proteomics 2022 May 30;260:104554. Epub 2022 Mar 11 doi: 10.1016/j.jprot.2022.104554. PMID: 35283356
Sebaceous Nevus of the Scalp.
Goel P, Wolfswinkel EM, Fahradyan A, Tsuha M, Hough M, Magee W 3rd, Hammoudeh JA, Urata MM, Howell LK
J Craniofac Surg 2020 Jan/Feb;31(1):257-260. doi: 10.1097/SCS.0000000000006007. PMID: 31725502
Dermoscopic aspect of verrucous epidermal nevi: new findings.
Elmas ÖF, Akdeniz N
Turk J Med Sci 2019 Jun 18;49(3):710-714. doi: 10.3906/sag-1811-27. PMID: 31203591Free PMC Article
Dermoscopy of Adnexal Tumors.
Zaballos P, Gómez-Martín I, Martin JM, Bañuls J
Dermatol Clin 2018 Oct;36(4):397-412. Epub 2018 Aug 16 doi: 10.1016/j.det.2018.05.007. PMID: 30201149
Phenotype/genotype correlations in epidermal nevus syndrome as a neurocristopathy.
Flores-Sarnat L, Sarnat HB
Handb Clin Neurol 2015;132:9-25. doi: 10.1016/B978-0-444-62702-5.00002-0. PMID: 26564069

Recent systematic reviews

Syringocystadenocarcinoma papilliferum: a systematic review of clinical characteristics, reappraisal of associations, diagnostic pitfalls and management challenges.
Wan L, Park A, Khachemoune A
Arch Dermatol Res 2024 Jun 21;316(7):421. doi: 10.1007/s00403-024-03176-w. PMID: 38904691
Rate of Benign and Malignant Secondary Tumors Associated With Nevus Sebaceous: A Systematic Review and Meta-Analysis.
Pang S, Cevik J, Sreedharan S, Wilks DJ
Ann Plast Surg 2024 Jun 1;92(6):711-719. Epub 2024 May 9 doi: 10.1097/SAP.0000000000003879. PMID: 38725109
Dermoscopy of cutaneous adnexal tumours: a systematic review of the literature.
Lai M, Muscianese M, Piana S, Chester J, Borsari S, Paolino G, Pellacani G, Longo C, Pampena R
J Eur Acad Dermatol Venereol 2022 Sep;36(9):1524-1540. Epub 2022 May 25 doi: 10.1111/jdv.18210. PMID: 35536546Free PMC Article

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