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Acute respiratory failure

MedGen UID:
75540
•Concept ID:
C0264490
•
Disease or Syndrome
Synonyms: Acute Respiratory Failure; acute respiratory failure; ARF - Acute respiratory failure; respiratory failure, acute
SNOMED CT: Acute respiratory failure (65710008); ARF - Acute respiratory failure (65710008)
 
Monarch Initiative: MONDO:0001208

Definition

Life-threatening respiratory failure that develops rapidly. Causes include injury, sepsis, drug overdose, and pancreatitis. It manifests with dyspnea and cyanosis and may lead to cardiovascular shock. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute respiratory failure

Professional guidelines

PubMed

ERS clinical practice guidelines: high-flow nasal cannula in acute respiratory failure.
Oczkowski S, Ergan B, Bos L, Chatwin M, Ferrer M, Gregoretti C, Heunks L, Frat JP, Longhini F, Nava S, Navalesi P, Ozsancak Uğurlu A, Pisani L, Renda T, Thille AW, Winck JC, Windisch W, Tonia T, Boyd J, Sotgiu G, Scala R
Eur Respir J 2022 Apr;59(4) Epub 2022 Apr 14 doi: 10.1183/13993003.01574-2021. PMID: 34649974
Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19): A Review.
Wiersinga WJ, Rhodes A, Cheng AC, Peacock SJ, Prescott HC
JAMA 2020 Aug 25;324(8):782-793. doi: 10.1001/jama.2020.12839. PMID: 32648899
Official ERS/ATS clinical practice guidelines: noninvasive ventilation for acute respiratory failure.
Rochwerg B, Brochard L, Elliott MW, Hess D, Hill NS, Nava S, Navalesi P Members Of The Steering Committee, Antonelli M, Brozek J, Conti G, Ferrer M, Guntupalli K, Jaber S, Keenan S, Mancebo J, Mehta S, Raoof S Members Of The Task Force
Eur Respir J 2017 Aug;50(2) Epub 2017 Aug 31 doi: 10.1183/13993003.02426-2016. PMID: 28860265

Recent clinical studies

Etiology

Use of nasal high flow oxygen during acute respiratory failure.
Ricard JD, Roca O, Lemiale V, Corley A, Braunlich J, Jones P, Kang BJ, Lellouche F, Nava S, Rittayamai N, Spoletini G, Jaber S, Hernandez G
Intensive Care Med 2020 Dec;46(12):2238-2247. Epub 2020 Sep 8 doi: 10.1007/s00134-020-06228-7. PMID: 32901374Free PMC Article
Acute respiratory failure in immunocompromised adults.
Azoulay E, Mokart D, Kouatchet A, Demoule A, Lemiale V
Lancet Respir Med 2019 Feb;7(2):173-186. Epub 2018 Dec 7 doi: 10.1016/S2213-2600(18)30345-X. PMID: 30529232Free PMC Article
Acute Respiratory Failure in Children.
Friedman ML, Nitu ME
Pediatr Ann 2018 Jul 1;47(7):e268-e273. doi: 10.3928/19382359-20180625-01. PMID: 30001440
Noninvasive ventilation for acute respiratory failure.
Hess DR
Respir Care 2013 Jun;58(6):950-72. doi: 10.4187/respcare.02319. PMID: 23709194
Permissive hypercapnia.
Bigatello LM, Patroniti N, Sangalli F
Curr Opin Crit Care 2001 Feb;7(1):34-40. doi: 10.1097/00075198-200102000-00006. PMID: 11373509

Diagnosis

Acute respiratory failure in immunocompromised adults.
Azoulay E, Mokart D, Kouatchet A, Demoule A, Lemiale V
Lancet Respir Med 2019 Feb;7(2):173-186. Epub 2018 Dec 7 doi: 10.1016/S2213-2600(18)30345-X. PMID: 30529232Free PMC Article
Lung Ultrasound for Critically Ill Patients.
Mojoli F, Bouhemad B, Mongodi S, Lichtenstein D
Am J Respir Crit Care Med 2019 Mar 15;199(6):701-714. doi: 10.1164/rccm.201802-0236CI. PMID: 30372119
Acute Respiratory Failure in Children.
Friedman ML, Nitu ME
Pediatr Ann 2018 Jul 1;47(7):e268-e273. doi: 10.3928/19382359-20180625-01. PMID: 30001440
Noninvasive ventilation in acute respiratory failure.
Mas A, Masip J
Int J Chron Obstruct Pulmon Dis 2014;9:837-52. Epub 2014 Aug 11 doi: 10.2147/COPD.S42664. PMID: 25143721Free PMC Article
Relevance of lung ultrasound in the diagnosis of acute respiratory failure: the BLUE protocol.
Lichtenstein DA, Mezière GA
Chest 2008 Jul;134(1):117-25. Epub 2008 Apr 10 doi: 10.1378/chest.07-2800. PMID: 18403664Free PMC Article

Therapy

Extracorporeal Life Support for Adults With Respiratory Failure and Related Indications: A Review.
Brodie D, Slutsky AS, Combes A
JAMA 2019 Aug 13;322(6):557-568. doi: 10.1001/jama.2019.9302. PMID: 31408142
Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness.
Girard TD, Exline MC, Carson SS, Hough CL, Rock P, Gong MN, Douglas IS, Malhotra A, Owens RL, Feinstein DJ, Khan B, Pisani MA, Hyzy RC, Schmidt GA, Schweickert WD, Hite RD, Bowton DL, Masica AL, Thompson JL, Chandrasekhar R, Pun BT, Strength C, Boehm LM, Jackson JC, Pandharipande PP, Brummel NE, Hughes CG, Patel MB, Stollings JL, Bernard GR, Dittus RS, Ely EW; MIND-USA Investigators
N Engl J Med 2018 Dec 27;379(26):2506-2516. Epub 2018 Oct 22 doi: 10.1056/NEJMoa1808217. PMID: 30346242Free PMC Article
The role of high flow oxygen therapy in acute respiratory failure.
Masclans JR, Pérez-Terán P, Roca O
Med Intensiva 2015 Nov;39(8):505-15. Epub 2015 Oct 1 doi: 10.1016/j.medin.2015.05.009. PMID: 26429697
The acute respiratory distress syndrome.
Matthay MA, Ware LB, Zimmerman GA
J Clin Invest 2012 Aug;122(8):2731-40. Epub 2012 Aug 1 doi: 10.1172/JCI60331. PMID: 22850883Free PMC Article
Consequences of bed rest.
Brower RG
Crit Care Med 2009 Oct;37(10 Suppl):S422-8. doi: 10.1097/CCM.0b013e3181b6e30a. PMID: 20046130

Prognosis

Acute respiratory failure in immunocompromised adults.
Azoulay E, Mokart D, Kouatchet A, Demoule A, Lemiale V
Lancet Respir Med 2019 Feb;7(2):173-186. Epub 2018 Dec 7 doi: 10.1016/S2213-2600(18)30345-X. PMID: 30529232Free PMC Article
Acute Respiratory Failure.
Cannon J, Pamplin J, Zonies D, Mason P, Sine C, Cancio L, McNeill J, Colombo C, Osborn E, Ricca R, Allan P, DellaVolpe J, Chung K, Stockinger Z
Mil Med 2018 Sep 1;183(suppl_2):123-129. doi: 10.1093/milmed/usy151. PMID: 30189088
Mechanical Ventilation-induced Diaphragm Atrophy Strongly Impacts Clinical Outcomes.
Goligher EC, Dres M, Fan E, Rubenfeld GD, Scales DC, Herridge MS, Vorona S, Sklar MC, Rittayamai N, Lanys A, Murray A, Brace D, Urrea C, Reid WD, Tomlinson G, Slutsky AS, Kavanagh BP, Brochard LJ, Ferguson ND
Am J Respir Crit Care Med 2018 Jan 15;197(2):204-213. doi: 10.1164/rccm.201703-0536OC. PMID: 28930478
Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries.
Bellani G, Laffey JG, Pham T, Fan E, Brochard L, Esteban A, Gattinoni L, van Haren F, Larsson A, McAuley DF, Ranieri M, Rubenfeld G, Thompson BT, Wrigge H, Slutsky AS, Pesenti A; LUNG SAFE Investigators; ESICM Trials Group
JAMA 2016 Feb 23;315(8):788-800. doi: 10.1001/jama.2016.0291. PMID: 26903337
Early intensive care unit mobility therapy in the treatment of acute respiratory failure.
Morris PE, Goad A, Thompson C, Taylor K, Harry B, Passmore L, Ross A, Anderson L, Baker S, Sanchez M, Penley L, Howard A, Dixon L, Leach S, Small R, Hite RD, Haponik E
Crit Care Med 2008 Aug;36(8):2238-43. doi: 10.1097/CCM.0b013e318180b90e. PMID: 18596631

Clinical prediction guides

Extracorporeal Life Support for Adults With Respiratory Failure and Related Indications: A Review.
Brodie D, Slutsky AS, Combes A
JAMA 2019 Aug 13;322(6):557-568. doi: 10.1001/jama.2019.9302. PMID: 31408142
Acute respiratory failure in immunocompromised adults.
Azoulay E, Mokart D, Kouatchet A, Demoule A, Lemiale V
Lancet Respir Med 2019 Feb;7(2):173-186. Epub 2018 Dec 7 doi: 10.1016/S2213-2600(18)30345-X. PMID: 30529232Free PMC Article
Acute respiratory failure requiring mechanical ventilation in severe chronic obstructive pulmonary disease (COPD).
Gadre SK, Duggal A, Mireles-Cabodevila E, Krishnan S, Wang XF, Zell K, Guzman J
Medicine (Baltimore) 2018 Apr;97(17):e0487. doi: 10.1097/MD.0000000000010487. PMID: 29703009Free PMC Article
Mechanical Ventilation to Minimize Progression of Lung Injury in Acute Respiratory Failure.
Brochard L, Slutsky A, Pesenti A
Am J Respir Crit Care Med 2017 Feb 15;195(4):438-442. doi: 10.1164/rccm.201605-1081CP. PMID: 27626833
Standardized Rehabilitation and Hospital Length of Stay Among Patients With Acute Respiratory Failure: A Randomized Clinical Trial.
Morris PE, Berry MJ, Files DC, Thompson JC, Hauser J, Flores L, Dhar S, Chmelo E, Lovato J, Case LD, Bakhru RN, Sarwal A, Parry SM, Campbell P, Mote A, Winkelman C, Hite RD, Nicklas B, Chatterjee A, Young MP
JAMA 2016 Jun 28;315(24):2694-702. doi: 10.1001/jama.2016.7201. PMID: 27367766Free PMC Article

Recent systematic reviews

Extracorporeal membrane oxygenation for critically ill adults.
Burrell A, Kim J, Alliegro P, Romero L, Serpa Neto A, Mariajoseph F, Hodgson C
Cochrane Database Syst Rev 2023 Sep 26;9(9):CD010381. doi: 10.1002/14651858.CD010381.pub3. PMID: 37750499Free PMC Article
Evidence for Beneficial Effect of Daily Use of Mechanical Insufflation-Exsufflation in Patients With Neuromuscular Diseases.
Veldhoen ES, van der Wal R, Verweij-van den Oudenrijn LP, Wösten-van Asperen RM, Gaytant MA, van der Ent CK, van der Pol WL, Hulzebos EH
Respir Care 2023 Apr;68(4):531-546. doi: 10.4187/respcare.09664. PMID: 36963967Free PMC Article
Association of Positive End-Expiratory Pressure and Lung Recruitment Selection Strategies with Mortality in Acute Respiratory Distress Syndrome: A Systematic Review and Network Meta-analysis.
Dianti J, Tisminetzky M, Ferreyro BL, Englesakis M, Del Sorbo L, Sud S, Talmor D, Ball L, Meade M, Hodgson C, Beitler JR, Sahetya S, Nichol A, Fan E, Rochwerg B, Brochard L, Slutsky AS, Ferguson ND, Serpa Neto A, Adhikari NKJ, Angriman F, Goligher EC
Am J Respir Crit Care Med 2022 Jun 1;205(11):1300-1310. doi: 10.1164/rccm.202108-1972OC. PMID: 35180042
Noninvasive respiratory support following extubation in critically ill adults: a systematic review and network meta-analysis.
Fernando SM, Tran A, Sadeghirad B, Burns KEA, Fan E, Brodie D, Munshi L, Goligher EC, Cook DJ, Fowler RA, Herridge MS, Cardinal P, Jaber S, Møller MH, Thille AW, Ferguson ND, Slutsky AS, Brochard LJ, Seely AJE, Rochwerg B
Intensive Care Med 2022 Feb;48(2):137-147. Epub 2021 Nov 25 doi: 10.1007/s00134-021-06581-1. PMID: 34825256
Evidence-Based Practices for Acute Respiratory Failure and Acute Respiratory Distress Syndrome: A Systematic Review of Reviews.
Ervin JN, Rentes VC, Dibble ER, Sjoding MW, Iwashyna TJ, Hough CL, Ng Gong M, Sales AE
Chest 2020 Dec;158(6):2381-2393. Epub 2020 Jul 16 doi: 10.1016/j.chest.2020.06.080. PMID: 32682771Free PMC Article

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