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Disuse muscle atrophy

MedGen UID:
75533
•Concept ID:
C0264122
•
Disease or Syndrome
Synonyms: Atrophies, Disuse; Atrophy, Disuse; Disuse Atrophies; Disuse Atrophy
SNOMED CT: Disuse atrophy (240129002); Atrophy of muscle due to disuse (240129002); Disuse muscle atrophy (240129002)

Professional guidelines

PubMed

Mitochondrial dysfunction and skeletal muscle atrophy: Causes, mechanisms, and treatment strategies.
Kubat GB, Bouhamida E, Ulger O, Turkel I, Pedriali G, Ramaccini D, Ekinci O, Ozerklig B, Atalay O, Patergnani S, Nur Sahin B, Morciano G, Tuncer M, Tremoli E, Pinton P
Mitochondrion 2023 Sep;72:33-58. Epub 2023 Jul 13 doi: 10.1016/j.mito.2023.07.003. PMID: 37451353
Nitric oxide treatment attenuates muscle atrophy during hind limb suspension in mice.
Anderson JE, Zhu A, Mizuno TM
Free Radic Biol Med 2018 Feb 1;115:458-470. Epub 2017 Dec 19 doi: 10.1016/j.freeradbiomed.2017.12.021. PMID: 29277394

Recent clinical studies

Etiology

Resistance exercise preconditioning prevents disuse muscle atrophy by inhibiting apoptosis and protein degradation via SESN2 in C57BL/6J mice.
Huang Y, Jiang C, Li X, Liu S, Niu Y, Fu L
Biochim Biophys Acta Mol Basis Dis 2024 Apr;1870(4):167111. Epub 2024 Mar 2 doi: 10.1016/j.bbadis.2024.167111. PMID: 38432454
The time course of disuse muscle atrophy of the lower limb in health and disease.
Hardy EJO, Inns TB, Hatt J, Doleman B, Bass JJ, Atherton PJ, Lund JN, Phillips BE
J Cachexia Sarcopenia Muscle 2022 Dec;13(6):2616-2629. Epub 2022 Sep 14 doi: 10.1002/jcsm.13067. PMID: 36104842Free PMC Article
Redox modulation of muscle mass and function.
Gomez-Cabrera MC, Arc-Chagnaud C, Salvador-Pascual A, Brioche T, Chopard A, Olaso-Gonzalez G, Viña J
Redox Biol 2020 Aug;35:101531. Epub 2020 Apr 18 doi: 10.1016/j.redox.2020.101531. PMID: 32371010Free PMC Article
Mitochondrial dysfunction induces muscle atrophy during prolonged inactivity: A review of the causes and effects.
Hyatt H, Deminice R, Yoshihara T, Powers SK
Arch Biochem Biophys 2019 Feb 15;662:49-60. Epub 2018 Nov 16 doi: 10.1016/j.abb.2018.11.005. PMID: 30452895Free PMC Article
Prevention of post-stroke disuse muscle atrophy with a free radical scavenger.
Naritomi H, Moriwaki H
Front Neurol Neurosci 2013;32:139-47. Epub 2013 Jul 8 doi: 10.1159/000346424. PMID: 23859973

Diagnosis

Type 2 diabetes mellitus related sarcopenia: a type of muscle loss distinct from sarcopenia and disuse muscle atrophy.
Liu Z, Guo Y, Zheng C
Front Endocrinol (Lausanne) 2024;15:1375610. Epub 2024 May 24 doi: 10.3389/fendo.2024.1375610. PMID: 38854688Free PMC Article
Nemaline myopathy in a six-month-old Pomeranian dog.
Bester EG, Kitshoff AM, Botha WJ, Van Wilpe E, Du Plessis L, Williams J
J S Afr Vet Assoc 2022 Jun;93(1):38a-38h. PMID: 35950808
Intensive care unit-acquired weakness and the COVID-19 pandemic: A clinical review.
Qin ES, Hough CL, Andrews J, Bunnell AE
PM R 2022 Feb;14(2):227-238. Epub 2022 Jan 31 doi: 10.1002/pmrj.12757. PMID: 35014183
Can antioxidants protect against disuse muscle atrophy?
Powers SK
Sports Med 2014 Nov;44 Suppl 2(Suppl 2):S155-65. doi: 10.1007/s40279-014-0255-x. PMID: 25355189Free PMC Article
Neuromuscular disorders in critical illness.
Pandit L, Agrawal A
Clin Neurol Neurosurg 2006 Oct;108(7):621-7. Epub 2006 May 30 doi: 10.1016/j.clineuro.2006.04.003. PMID: 16730883

Therapy

Resistance exercise preconditioning prevents disuse muscle atrophy by inhibiting apoptosis and protein degradation via SESN2 in C57BL/6J mice.
Huang Y, Jiang C, Li X, Liu S, Niu Y, Fu L
Biochim Biophys Acta Mol Basis Dis 2024 Apr;1870(4):167111. Epub 2024 Mar 2 doi: 10.1016/j.bbadis.2024.167111. PMID: 38432454
The time course of disuse muscle atrophy of the lower limb in health and disease.
Hardy EJO, Inns TB, Hatt J, Doleman B, Bass JJ, Atherton PJ, Lund JN, Phillips BE
J Cachexia Sarcopenia Muscle 2022 Dec;13(6):2616-2629. Epub 2022 Sep 14 doi: 10.1002/jcsm.13067. PMID: 36104842Free PMC Article
Endurance exercise protects skeletal muscle against both doxorubicin-induced and inactivity-induced muscle wasting.
Powers SK, Duarte JA, Le Nguyen B, Hyatt H
Pflugers Arch 2019 Mar;471(3):441-453. Epub 2018 Nov 13 doi: 10.1007/s00424-018-2227-8. PMID: 30426248Free PMC Article
Can antioxidants protect against disuse muscle atrophy?
Powers SK
Sports Med 2014 Nov;44 Suppl 2(Suppl 2):S155-65. doi: 10.1007/s40279-014-0255-x. PMID: 25355189Free PMC Article
Consequences of bed rest.
Brower RG
Crit Care Med 2009 Oct;37(10 Suppl):S422-8. doi: 10.1097/CCM.0b013e3181b6e30a. PMID: 20046130

Prognosis

Type 2 diabetes mellitus related sarcopenia: a type of muscle loss distinct from sarcopenia and disuse muscle atrophy.
Liu Z, Guo Y, Zheng C
Front Endocrinol (Lausanne) 2024;15:1375610. Epub 2024 May 24 doi: 10.3389/fendo.2024.1375610. PMID: 38854688Free PMC Article
The time course of disuse muscle atrophy of the lower limb in health and disease.
Hardy EJO, Inns TB, Hatt J, Doleman B, Bass JJ, Atherton PJ, Lund JN, Phillips BE
J Cachexia Sarcopenia Muscle 2022 Dec;13(6):2616-2629. Epub 2022 Sep 14 doi: 10.1002/jcsm.13067. PMID: 36104842Free PMC Article
Identification of potential microRNAs and KEGG pathways in denervation muscle atrophy based on meta-analysis.
Gu X, Jin B, Qi Z, Yin X
Sci Rep 2021 Jun 30;11(1):13560. doi: 10.1038/s41598-021-92489-1. PMID: 34193880Free PMC Article
Prevention of post-stroke disuse muscle atrophy with a free radical scavenger.
Naritomi H, Moriwaki H
Front Neurol Neurosci 2013;32:139-47. Epub 2013 Jul 8 doi: 10.1159/000346424. PMID: 23859973
Redox homeostasis, oxidative stress and disuse muscle atrophy.
Pellegrino MA, Desaphy JF, Brocca L, Pierno S, Camerino DC, Bottinelli R
J Physiol 2011 May 1;589(Pt 9):2147-60. Epub 2011 Feb 14 doi: 10.1113/jphysiol.2010.203232. PMID: 21320887Free PMC Article

Clinical prediction guides

Intensive care unit-acquired weakness and the COVID-19 pandemic: A clinical review.
Qin ES, Hough CL, Andrews J, Bunnell AE
PM R 2022 Feb;14(2):227-238. Epub 2022 Jan 31 doi: 10.1002/pmrj.12757. PMID: 35014183
Identification of potential microRNAs and KEGG pathways in denervation muscle atrophy based on meta-analysis.
Gu X, Jin B, Qi Z, Yin X
Sci Rep 2021 Jun 30;11(1):13560. doi: 10.1038/s41598-021-92489-1. PMID: 34193880Free PMC Article
Mechanisms responsible for disuse muscle atrophy: potential role of protein provision and exercise as countermeasures.
Mallinson JE, Murton AJ
Nutrition 2013 Jan;29(1):22-8. Epub 2012 Aug 28 doi: 10.1016/j.nut.2012.04.012. PMID: 22951156
Aging affects the transcriptional regulation of human skeletal muscle disuse atrophy.
Suetta C, Frandsen U, Jensen L, Jensen MM, Jespersen JG, Hvid LG, Bayer M, Petersson SJ, Schrøder HD, Andersen JL, Heinemeier KM, Aagaard P, Schjerling P, Kjaer M
PLoS One 2012;7(12):e51238. Epub 2012 Dec 19 doi: 10.1371/journal.pone.0051238. PMID: 23284670Free PMC Article
Benefits of aerobic exercise after stroke.
Potempa K, Braun LT, Tinknell T, Popovich J
Sports Med 1996 May;21(5):337-46. doi: 10.2165/00007256-199621050-00003. PMID: 8724202

Recent systematic reviews

Identification of potential microRNAs and KEGG pathways in denervation muscle atrophy based on meta-analysis.
Gu X, Jin B, Qi Z, Yin X
Sci Rep 2021 Jun 30;11(1):13560. doi: 10.1038/s41598-021-92489-1. PMID: 34193880Free PMC Article
The mechanisms and treatments of muscular pathological changes in immobilization-induced joint contracture: A literature review.
Wang F, Zhang QB, Zhou Y, Chen S, Huang PP, Liu Y, Xu YH
Chin J Traumatol 2019 Apr;22(2):93-98. Epub 2019 Mar 11 doi: 10.1016/j.cjtee.2019.02.001. PMID: 30928194Free PMC Article

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