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Solar urticaria

MedGen UID:
538004
•Concept ID:
C0263610
•
Disease or Syndrome
Synonyms: Solar Urticaria; Urticaria, Solar
SNOMED CT: Solar urticaria (10347006); Sunlight-induced angioedema-urticaria (10347006)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
HPO: HP:0410137
Monarch Initiative: MONDO:0019945
Orphanet: ORPHA97230

Definition

Urticaria in response to exposure to ultraviolet-A (UVA), ultraviolet-B (UVB), visible and rarely infrared light. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSolar urticaria
Follow this link to review classifications for Solar urticaria in Orphanet.

Professional guidelines

PubMed

Successful ligelizumab treatment of severe refractory solar urticaria.
Hershkovitz Y, Khanimov I, Rubin L, Dranitzki Z, Talmon A, Ribak Y, Shamriz O, Levi A, Tal Y
J Allergy Clin Immunol Pract 2023 Aug;11(8):2576-2577. Epub 2023 Feb 15 doi: 10.1016/j.jaip.2023.01.052. PMID: 36796509
Phototherapy in the Evaluation and Management of Photodermatoses.
Jiang AJ, Lim HW
Dermatol Clin 2020 Jan;38(1):71-77. Epub 2019 Oct 18 doi: 10.1016/j.det.2019.08.007. PMID: 31753194
Omalizumab in the Treatment of Chronic Inducible Urticaria.
Chicharro P, Rodríguez P, de Argila D
Actas Dermosifiliogr 2017 Jun;108(5):423-431. Epub 2016 Oct 5 doi: 10.1016/j.ad.2016.07.018. PMID: 27717421

Recent clinical studies

Etiology

How to Approach Chronic Inducible Urticaria.
Maurer M, Fluhr JW, Khan DA
J Allergy Clin Immunol Pract 2018 Jul-Aug;6(4):1119-1130. doi: 10.1016/j.jaip.2018.03.007. PMID: 30033913
Photodermatoses in pigmented skin.
Sharma VK, Sahni K, Wadhwani AR
Photochem Photobiol Sci 2013 Jan;12(1):65-77. doi: 10.1039/c2pp25182e. PMID: 23123922
Xeroderma pigmentosum.
Lehmann AR, McGibbon D, Stefanini M
Orphanet J Rare Dis 2011 Nov 1;6:70. doi: 10.1186/1750-1172-6-70. PMID: 22044607Free PMC Article
Erythropoietic protoporphyria.
Lecha M, Puy H, Deybach JC
Orphanet J Rare Dis 2009 Sep 10;4:19. doi: 10.1186/1750-1172-4-19. PMID: 19744342Free PMC Article
Photosensitivity in lupus.
Millard TP, Hawk JL, McGregor JM
Lupus 2000;9(1):3-10. doi: 10.1177/096120330000900103. PMID: 10713641

Diagnosis

Chronic Inducible Urticaria.
Ritzel D, Altrichter S
Immunol Allergy Clin North Am 2024 Aug;44(3):439-452. Epub 2024 May 18 doi: 10.1016/j.iac.2024.03.003. PMID: 38937008
Chronic inducible urticaria: classification and prominent features of physical and non-physical types.
Pozderac I, Lugović-Mihić L, Artuković M, Stipić-Marković A, Kuna M, Ferček I
Acta Dermatovenerol Alp Pannonica Adriat 2020 Sep;29(3):141-148. PMID: 32975301
How to Approach Chronic Inducible Urticaria.
Maurer M, Fluhr JW, Khan DA
J Allergy Clin Immunol Pract 2018 Jul-Aug;6(4):1119-1130. doi: 10.1016/j.jaip.2018.03.007. PMID: 30033913
Solar urticaria.
Goetze S, Elsner P
J Dtsch Dermatol Ges 2015 Dec;13(12):1250-3. doi: 10.1111/ddg.12809. PMID: 26612794
Solar Urticaria.
Komarow HD, Eisch AR, Young M, Nelson C, Metcalfe DD
J Allergy Clin Immunol Pract 2015 Sep-Oct;3(5):789-90. Epub 2015 May 13 doi: 10.1016/j.jaip.2015.04.006. PMID: 25982230Free PMC Article

Therapy

Review on photoprotection: a clinician's guide to the ingredients, characteristics, adverse effects, and disease-specific benefits of chemical and physical sunscreen compounds.
McDonald KA, Lytvyn Y, Mufti A, Chan AW, Rosen CF
Arch Dermatol Res 2023 May;315(4):735-749. Epub 2022 Nov 28 doi: 10.1007/s00403-022-02483-4. PMID: 36443500
Solar urticaria.
Goetze S, Elsner P
J Dtsch Dermatol Ges 2015 Dec;13(12):1250-3. doi: 10.1111/ddg.12809. PMID: 26612794
Solar Urticaria.
Komarow HD, Eisch AR, Young M, Nelson C, Metcalfe DD
J Allergy Clin Immunol Pract 2015 Sep-Oct;3(5):789-90. Epub 2015 May 13 doi: 10.1016/j.jaip.2015.04.006. PMID: 25982230Free PMC Article
Physical urticaria.
Dice JP
Immunol Allergy Clin North Am 2004 May;24(2):225-46, vi. doi: 10.1016/j.iac.2004.01.005. PMID: 15120149
Solar urticaria-idiopathic?
Horio T
Photodermatol Photoimmunol Photomed 2003 Jun;19(3):147-54. doi: 10.1034/j.1600-0781.2003.00035.x. PMID: 12914600

Prognosis

Solar Urticaria: An Ambispective Study in a Long-term Follow-up Cohort with Emphasis on Therapeutic Predictors and Outcomes.
Pesqué D, Ciudad A, Andrades E, Soto D, Gimeno R, Pujol RM, Giménez-Arnau AM
Acta Derm Venereol 2024 Jan 8;104:adv25576. doi: 10.2340/actadv.v104.25576. PMID: 38189220Free PMC Article
Clinical and photobiological response in eight patients with solar urticaria under treatment with omalizumab, and review of the literature.
Morgado-Carrasco D, Fustà-Novell X, Podlipnik S, Combalia A, Aguilera P
Photodermatol Photoimmunol Photomed 2018 May;34(3):194-199. Epub 2018 Jan 4 doi: 10.1111/phpp.12370. PMID: 29171925
Xeroderma pigmentosum.
Lehmann AR, McGibbon D, Stefanini M
Orphanet J Rare Dis 2011 Nov 1;6:70. doi: 10.1186/1750-1172-6-70. PMID: 22044607Free PMC Article
Erythropoietic protoporphyria.
Lecha M, Puy H, Deybach JC
Orphanet J Rare Dis 2009 Sep 10;4:19. doi: 10.1186/1750-1172-4-19. PMID: 19744342Free PMC Article
Solar urticaria.
Botto NC, Warshaw EM
J Am Acad Dermatol 2008 Dec;59(6):909-20; quiz 921-2. doi: 10.1016/j.jaad.2008.08.020. PMID: 19022098

Clinical prediction guides

Solar urticaria involves rapid mast cell STAT3 activation and neutrophil recruitment, with FcεRI as an upstream regulator.
Rutter KJ, Peake M, Hawkshaw NJ, Scholey R, Bulfone-Paus S, Friedmann PS, Farrar MD, Rhodes LE
J Allergy Clin Immunol 2024 May;153(5):1369-1380.e15. Epub 2024 Jan 4 doi: 10.1016/j.jaci.2023.12.021. PMID: 38184075
Pathogenesis of solar urticaria: Classic perspectives and emerging concepts.
McSweeney SM, Sarkany R, Fassihi H, Tziotzios C, McGrath JA
Exp Dermatol 2022 Apr;31(4):586-593. Epub 2021 Nov 12 doi: 10.1111/exd.14493. PMID: 34726314
Characteristics and clinical significance of augmentation spectra in solar urticaria.
Uetsu N, Nomura Y, Matsuyama Y, Okamoto H
J Dermatol 2020 Apr;47(4):369-377. Epub 2020 Jan 21 doi: 10.1111/1346-8138.15234. PMID: 31960491
Solar urticaria: a time-extended retrospective series of 61 patients and review of literature.
Du-Thanh A, Debu A, Lalheve P, Guillot B, Dereure O, Peyron JL
Eur J Dermatol 2013 Apr 1;23(2):202-7. doi: 10.1684/ejd.2013.1933. PMID: 23587746
Porphyria: genetic and acquired.
Cripps DJ
IARC Sci Publ 1986;(77):549-66. PMID: 3298037

Recent systematic reviews

Systematic review of the clinical characteristics and natural history of solar urticaria.
McSweeney SM, Kloczko E, Chadha M, Sarkany R, Fassihi H, Tziotzios C, McGrath JA
J Am Acad Dermatol 2023 Jul;89(1):138-140. Epub 2023 Feb 15 doi: 10.1016/j.jaad.2023.01.039. PMID: 36796725
Evidence for histamine release in chronic inducible urticaria - A systematic review.
Kulthanan K, Church MK, Grekowitz EM, Hawro T, Kiefer LA, Munprom K, Nanchaipruek Y, Rujitharanawong C, Terhorst-Molawi D, Maurer M
Front Immunol 2022;13:901851. Epub 2022 Jul 28 doi: 10.3389/fimmu.2022.901851. PMID: 35967442Free PMC Article
Isolated solar angioedema: A systematic review of the literature.
Aronovich A, Snast I, Lapidoth M, Leshem YA, Enk CD, Tal Y, Mimouni D, Hodak E, Levi A
Photodermatol Photoimmunol Photomed 2021 Sep;37(5):431-438. Epub 2021 Mar 27 doi: 10.1111/phpp.12677. PMID: 33738834
Omalizumab for the Treatment of Solar Urticaria: Case Series and Systematic Review of the Literature.
Snast I, Kremer N, Lapidoth M, Enk CD, Tal Y, Rosman Y, Confino-Cohen R, Hodak E, Levi A
J Allergy Clin Immunol Pract 2018 Jul-Aug;6(4):1198-1204.e3. Epub 2018 Mar 20 doi: 10.1016/j.jaip.2018.02.032. PMID: 29572192
Omalizumab treatment in patients with chronic inducible urticaria: A systematic review of published evidence.
Maurer M, Metz M, Brehler R, Hillen U, Jakob T, Mahler V, Pföhler C, Staubach P, Treudler R, Wedi B, Magerl M
J Allergy Clin Immunol 2018 Feb;141(2):638-649. Epub 2017 Jul 24 doi: 10.1016/j.jaci.2017.06.032. PMID: 28751232

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