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Autonomic neuropathy

MedGen UID:
82621
Concept ID:
C0259749
Disease or Syndrome
Synonyms: autonomic nervous system peripheral neuropathy; Autonomic Neuropathy; autonomic neuropathy; autonomic peripheral neuropathy; peripheral neuropathy of autonomic nervous system
SNOMED CT: Autonomic neuropathy (277879009)
 
Monarch Initiative: MONDO:0001300

Definition

An inherited or acquired peripheral neuropathy affecting the autonomic nervous system. It results in disruption of the involuntary body functions. Inherited causes include Fabry disease and porphyrias. Acquired causes include diabetes, uremia, hepatic disorders, vitamin deficiencies, toxins, and drug toxicities. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAutonomic neuropathy

Professional guidelines

PubMed

Hovaguimian A
Neurol Clin 2023 Feb;41(1):193-213. Epub 2022 Oct 31 doi: 10.1016/j.ncl.2022.08.002. PMID: 36400555
Cernea S, Raz I
Metabolism 2021 Oct;123:154867. Epub 2021 Aug 17 doi: 10.1016/j.metabol.2021.154867. PMID: 34411554
Jensen TS, Karlsson P, Gylfadottir SS, Andersen ST, Bennett DL, Tankisi H, Finnerup NB, Terkelsen AJ, Khan K, Themistocleous AC, Kristensen AG, Itani M, Sindrup SH, Andersen H, Charles M, Feldman EL, Callaghan BC
Brain 2021 Jul 28;144(6):1632-1645. doi: 10.1093/brain/awab079. PMID: 33711103Free PMC Article

Recent clinical studies

Etiology

Ziegler D, Herder C, Papanas N
Diabetes Metab Res Rev 2023 Nov;39(8):e3693. Epub 2023 Jul 20 doi: 10.1002/dmrr.3693. PMID: 37470302
Hovaguimian A
Neurol Clin 2023 Feb;41(1):193-213. Epub 2022 Oct 31 doi: 10.1016/j.ncl.2022.08.002. PMID: 36400555
Cernea S, Raz I
Metabolism 2021 Oct;123:154867. Epub 2021 Aug 17 doi: 10.1016/j.metabol.2021.154867. PMID: 34411554
Agashe S, Petak S
Methodist Debakey Cardiovasc J 2018 Oct-Dec;14(4):251-256. doi: 10.14797/mdcj-14-4-251. PMID: 30788010Free PMC Article
Charnogursky G, Lee H, Lopez N
Handb Clin Neurol 2014;120:773-85. doi: 10.1016/B978-0-7020-4087-0.00051-6. PMID: 24365351

Diagnosis

Dillon BR, Ang L, Pop-Busui R
Annu Rev Med 2024 Jan 29;75:293-306. doi: 10.1146/annurev-med-043021-033114. PMID: 38285516
Hovaguimian A
Neurol Clin 2023 Feb;41(1):193-213. Epub 2022 Oct 31 doi: 10.1016/j.ncl.2022.08.002. PMID: 36400555
Gandhi Mehta RK, Caress JB, Rudnick SR, Bonkovsky HL
Muscle Nerve 2021 Aug;64(2):140-152. Epub 2021 Mar 31 doi: 10.1002/mus.27232. PMID: 33786855
Patel K, Horak H, Tiryaki E
Muscle Nerve 2021 Jan;63(1):22-30. Epub 2020 Jul 28 doi: 10.1002/mus.27014. PMID: 32589300
Agashe S, Petak S
Methodist Debakey Cardiovasc J 2018 Oct-Dec;14(4):251-256. doi: 10.14797/mdcj-14-4-251. PMID: 30788010Free PMC Article

Therapy

Goldney J, Sargeant JA, Davies MJ
Diabetologia 2023 Oct;66(10):1832-1845. Epub 2023 Aug 19 doi: 10.1007/s00125-023-05988-3. PMID: 37597048Free PMC Article
Su X, He J, Cui J, Li H, Men J
Ann Noninvasive Electrocardiol 2022 Nov;27(6):e12996. Epub 2022 Jul 27 doi: 10.1111/anec.12996. PMID: 35894768Free PMC Article
Cernea S, Raz I
Metabolism 2021 Oct;123:154867. Epub 2021 Aug 17 doi: 10.1016/j.metabol.2021.154867. PMID: 34411554
Kaur D, Tiwana H, Stino A, Sandroni P
Muscle Nerve 2021 Jan;63(1):10-21. Epub 2020 Sep 14 doi: 10.1002/mus.27048. PMID: 32926436
Agashe S, Petak S
Methodist Debakey Cardiovasc J 2018 Oct-Dec;14(4):251-256. doi: 10.14797/mdcj-14-4-251. PMID: 30788010Free PMC Article

Prognosis

Cernea S, Raz I
Metabolism 2021 Oct;123:154867. Epub 2021 Aug 17 doi: 10.1016/j.metabol.2021.154867. PMID: 34411554
Didangelos T, Karlafti E, Kotzakioulafi E, Margariti E, Giannoulaki P, Batanis G, Tesfaye S, Kantartzis K
Nutrients 2021 Jan 27;13(2) doi: 10.3390/nu13020395. PMID: 33513879Free PMC Article
Cheshire WP, Freeman R, Gibbons CH, Cortelli P, Wenning GK, Hilz MJ, Spies JM, Lipp A, Sandroni P, Wada N, Mano A, Ah Kim H, Kimpinski K, Iodice V, Idiáquez J, Thaisetthawatkul P, Coon EA, Low PA, Singer W
Clin Neurophysiol 2021 Feb;132(2):666-682. Epub 2020 Dec 22 doi: 10.1016/j.clinph.2020.11.024. PMID: 33419664
Agashe S, Petak S
Methodist Debakey Cardiovasc J 2018 Oct-Dec;14(4):251-256. doi: 10.14797/mdcj-14-4-251. PMID: 30788010Free PMC Article
Jacoby RM, Nesto RW
J Am Coll Cardiol 1992 Sep;20(3):736-44. doi: 10.1016/0735-1097(92)90033-j. PMID: 1512357

Clinical prediction guides

Ziegler D, Herder C, Papanas N
Diabetes Metab Res Rev 2023 Nov;39(8):e3693. Epub 2023 Jul 20 doi: 10.1002/dmrr.3693. PMID: 37470302
Tezuka T, Okuzumi S, Nakashima C, Ide T, Imai S, Mitsuboshi S, Kuwahara Y, Takizawa T, Seki M, Minematsu N, Aragane N, Nakahara J, Hori S, Nakane S, Suzuki S
J Neurol 2023 Jul;270(7):3413-3423. Epub 2023 Mar 20 doi: 10.1007/s00415-023-11667-5. PMID: 36939931
Cheshire WP, Freeman R, Gibbons CH, Cortelli P, Wenning GK, Hilz MJ, Spies JM, Lipp A, Sandroni P, Wada N, Mano A, Ah Kim H, Kimpinski K, Iodice V, Idiáquez J, Thaisetthawatkul P, Coon EA, Low PA, Singer W
Clin Neurophysiol 2021 Feb;132(2):666-682. Epub 2020 Dec 22 doi: 10.1016/j.clinph.2020.11.024. PMID: 33419664
Agashe S, Petak S
Methodist Debakey Cardiovasc J 2018 Oct-Dec;14(4):251-256. doi: 10.14797/mdcj-14-4-251. PMID: 30788010Free PMC Article
Vinik AI, Erbas T
Handb Clin Neurol 2013;117:279-94. doi: 10.1016/B978-0-444-53491-0.00022-5. PMID: 24095132

Recent systematic reviews

Rasmussen VF, Jensen TS, Tankisi H, Karlsson P, Vestergaard ET, Kristensen K, Nyengaard JR, Terkelsen AJ
J Diabetes Complications 2021 Nov;35(11):108027. Epub 2021 Aug 18 doi: 10.1016/j.jdiacomp.2021.108027. PMID: 34429229
Picard M, Tauveron I, Magdasy S, Benichou T, Bagheri R, Ugbolue UC, Navel V, Dutheil F
PLoS One 2021;16(5):e0251863. Epub 2021 May 17 doi: 10.1371/journal.pone.0251863. PMID: 33999947Free PMC Article
Zilliox LA, Russell JW
Clin Auton Res 2019 Aug;29(4):443-455. Epub 2019 May 10 doi: 10.1007/s10286-019-00607-x. PMID: 31076938Free PMC Article
Benichou T, Pereira B, Mermillod M, Tauveron I, Pfabigan D, Maqdasy S, Dutheil F
PLoS One 2018;13(4):e0195166. Epub 2018 Apr 2 doi: 10.1371/journal.pone.0195166. PMID: 29608603Free PMC Article
Shih KC, Lam KS, Tong L
Nutr Diabetes 2017 Mar 20;7(3):e251. doi: 10.1038/nutd.2017.4. PMID: 28319106Free PMC Article

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