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Hantavirus hemorrhagic fever with renal syndrome, Puumala virus type

MedGen UID:
69308
•Concept ID:
C0242993
•
Disease or Syndrome
Synonym: Nephropathia Epidemica
 
Monarch Initiative: MONDO:0000284

Definition

Mild form of HFRS rarely hemorrhagic and seldom fatal. Caused by the PUUMALA VIRUS. [from MeSH]

Professional guidelines

PubMed

Serological analysis of hemorrhagic fever with renal syndrome (HFRS) patients in Far Eastern Russia and identification of the causative hantavirus genotype.
Miyamoto H, Kariwa H, Araki K, Lokugamage K, Hayasaka D, Cui BZ, Lokugamage N, Ivanov LI, Mizutani T, Iwasa MA, Yoshimatsu K, Arikawa J, Takashima I
Arch Virol 2003 Aug;148(8):1543-56. doi: 10.1007/s00705-003-0113-x. PMID: 12898330

Recent clinical studies

Etiology

Hantavirus infections.
Avšič-Županc T, Saksida A, Korva M
Clin Microbiol Infect 2019 Apr;21S:e6-e16. Epub 2015 Jun 22 doi: 10.1111/1469-0691.12291. PMID: 24750436
Kidney disease in Puumala hantavirus infection.
Mustonen J, Outinen T, Laine O, Pörsti I, Vaheri A, Mäkelä S
Infect Dis (Lond) 2017 May;49(5):321-332. Epub 2017 Jan 3 doi: 10.1080/23744235.2016.1274421. PMID: 28049381
Urine soluble urokinase-type plasminogen activator receptor levels correlate with proteinuria in Puumala hantavirus infection.
Outinen TK, Mäkelä S, Huttunen R, Mäenpää N, Libraty D, Vaheri A, Mustonen J, Aittoniemi J
J Intern Med 2014 Oct;276(4):387-95. Epub 2014 May 14 doi: 10.1111/joim.12257. PMID: 24717117Free PMC Article
Plasma B-type natriuretic peptide (BNP) in acute Puumala hantavirus infection.
Rajaniemi SM, Hautala N, Sironen T, Vainio O, Vapalahti O, Vaheri A, Vuolteenaho O, Ruskoaho H, Kauma H, Hautala T
Ann Med 2014 Feb;46(1):38-43. Epub 2014 Jan 6 doi: 10.3109/07853890.2013.862960. PMID: 24393073
Elevated levels of total and Puumala virus-specific immunoglobulin E in the Scandinavian type of hemorrhagic fever with renal syndrome.
Alexeyev OA, Ahlm C, Billheden J, Settergren B, Wadell G, Juto P
Clin Diagn Lab Immunol 1994 May;1(3):269-72. doi: 10.1128/cdli.1.3.269-272.1994. PMID: 7496961Free PMC Article

Diagnosis

Dynamics of Puumala hantavirus outbreak in Black Sea Region, Turkey.
Çelebi G, Öztoprak N, Öktem İMA, Heyman P, Lundkvist Å, Wahlström M, Köktürk F, Pişkin N
Zoonoses Public Health 2019 Nov;66(7):783-797. Epub 2019 Jul 11 doi: 10.1111/zph.12625. PMID: 31293096
Hantavirus infections.
Avšič-Županc T, Saksida A, Korva M
Clin Microbiol Infect 2019 Apr;21S:e6-e16. Epub 2015 Jun 22 doi: 10.1111/1469-0691.12291. PMID: 24750436
Kidney disease in Puumala hantavirus infection.
Mustonen J, Outinen T, Laine O, Pörsti I, Vaheri A, Mäkelä S
Infect Dis (Lond) 2017 May;49(5):321-332. Epub 2017 Jan 3 doi: 10.1080/23744235.2016.1274421. PMID: 28049381
The pathogenesis of nephropathia epidemica: new knowledge and unanswered questions.
Mustonen J, Mäkelä S, Outinen T, Laine O, Jylhävä J, Arstila PT, Hurme M, Vaheri A
Antiviral Res 2013 Dec;100(3):589-604. Epub 2013 Oct 12 doi: 10.1016/j.antiviral.2013.10.001. PMID: 24126075
Platelet ligands and ADAMTS13 during Puumala hantavirus infection and associated thrombocytopenia.
Laine O, Mäkelä S, Mustonen J, Helminen M, Vaheri A, Lassila R, Joutsi-Korhonen L
Blood Coagul Fibrinolysis 2011 Sep;22(6):468-72. doi: 10.1097/MBC.0b013e328346a420. PMID: 21508829

Therapy

Plasma B-type natriuretic peptide (BNP) in acute Puumala hantavirus infection.
Rajaniemi SM, Hautala N, Sironen T, Vainio O, Vapalahti O, Vaheri A, Vuolteenaho O, Ruskoaho H, Kauma H, Hautala T
Ann Med 2014 Feb;46(1):38-43. Epub 2014 Jan 6 doi: 10.3109/07853890.2013.862960. PMID: 24393073
The pathogenesis of nephropathia epidemica: new knowledge and unanswered questions.
Mustonen J, Mäkelä S, Outinen T, Laine O, Jylhävä J, Arstila PT, Hurme M, Vaheri A
Antiviral Res 2013 Dec;100(3):589-604. Epub 2013 Oct 12 doi: 10.1016/j.antiviral.2013.10.001. PMID: 24126075
Puumala virus infections in Finland: increased occupational risk for farmers.
Vapalahti K, Paunio M, Brummer-Korvenkontio M, Vaheri A, Vapalahti O
Am J Epidemiol 1999 Jun 15;149(12):1142-51. doi: 10.1093/oxfordjournals.aje.a009769. PMID: 10369509

Prognosis

Kidney disease in Puumala hantavirus infection.
Mustonen J, Outinen T, Laine O, Pörsti I, Vaheri A, Mäkelä S
Infect Dis (Lond) 2017 May;49(5):321-332. Epub 2017 Jan 3 doi: 10.1080/23744235.2016.1274421. PMID: 28049381
Spatial and Temporal Epidemiology of Nephropathia Epidemica Incidence and Hantavirus Seroprevalence in Rodent Hosts: Identification of the Main Environmental Factors in Europe.
Monchatre-Leroy E, Crespin L, Boué F, Marianneau P, Calavas D, Hénaux V
Transbound Emerg Dis 2017 Aug;64(4):1210-1228. Epub 2016 Mar 20 doi: 10.1111/tbed.12494. PMID: 26996739
Plasma pentraxin-3 and coagulation and fibrinolysis variables during acute Puumala hantavirus infection and associated thrombocytopenia.
Laine OK, Koskela SM, Outinen TK, Joutsi-Korhonen L, Huhtala H, Vaheri A, Hurme MA, Jylhävä J, Mäkelä SM, Mustonen JT
Blood Coagul Fibrinolysis 2014 Sep;25(6):612-7. doi: 10.1097/MBC.0000000000000117. PMID: 24751477
Radiological findings and their clinical correlations in nephropathia epidemica.
Paakkala A, Mustonen J
Acta Radiol 2007 Apr;48(3):345-50. doi: 10.1080/02841850701199629. PMID: 17453509
Elevated levels of total and Puumala virus-specific immunoglobulin E in the Scandinavian type of hemorrhagic fever with renal syndrome.
Alexeyev OA, Ahlm C, Billheden J, Settergren B, Wadell G, Juto P
Clin Diagn Lab Immunol 1994 May;1(3):269-72. doi: 10.1128/cdli.1.3.269-272.1994. PMID: 7496961Free PMC Article

Clinical prediction guides

Innate lymphoid cells are activated in HFRS, and their function can be modulated by hantavirus-induced type I interferons.
García M, Carrasco García A, Weigel W, Christ W, Lira-Junior R, Wirth L, Tauriainen J, Maleki K, Vanoni G, Vaheri A, Mäkelä S, Mustonen J, Nordgren J, Smed-Sörensen A, Strandin T, Mjösberg J, Klingström J
PLoS Pathog 2024 Jul;20(7):e1012390. Epub 2024 Jul 22 doi: 10.1371/journal.ppat.1012390. PMID: 39038044Free PMC Article
Virus- and cell type-specific effects in orthohantavirus infection.
Hägele S, Müller A, Nusshag C, Reiser J, Zeier M, Krautkrämer E
Virus Res 2019 Jan 15;260:102-113. Epub 2018 Nov 30 doi: 10.1016/j.virusres.2018.11.015. PMID: 30508604
Neutrophil Activation in Acute Hemorrhagic Fever With Renal Syndrome Is Mediated by Hantavirus-Infected Microvascular Endothelial Cells.
Strandin T, Mäkelä S, Mustonen J, Vaheri A
Front Immunol 2018;9:2098. Epub 2018 Sep 18 doi: 10.3389/fimmu.2018.02098. PMID: 30283445Free PMC Article
Kidney disease in Puumala hantavirus infection.
Mustonen J, Outinen T, Laine O, Pörsti I, Vaheri A, Mäkelä S
Infect Dis (Lond) 2017 May;49(5):321-332. Epub 2017 Jan 3 doi: 10.1080/23744235.2016.1274421. PMID: 28049381
Platelet ligands and ADAMTS13 during Puumala hantavirus infection and associated thrombocytopenia.
Laine O, Mäkelä S, Mustonen J, Helminen M, Vaheri A, Lassila R, Joutsi-Korhonen L
Blood Coagul Fibrinolysis 2011 Sep;22(6):468-72. doi: 10.1097/MBC.0b013e328346a420. PMID: 21508829

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