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Hand eczema

MedGen UID:
536929
•Concept ID:
C0239816
•
Disease or Syndrome
Synonyms: Dermatitis of hand; Hand dermatitis
SNOMED CT: Dermatitis of hand (238539001); Hand dermatitis (238539001); Hand eczema (238539001)

Professional guidelines

PubMed

A Review of Existing and New Treatments for the Management of Hand Eczema.
Ho JSS, Molin S
J Cutan Med Surg 2023 Sep-Oct;27(5):493-503. Epub 2023 Jul 27 doi: 10.1177/12034754231188325. PMID: 37496489Free PMC Article
Guidelines for diagnosis, prevention, and treatment of hand eczema.
Thyssen JP, Schuttelaar MLA, Alfonso JH, Andersen KE, Angelova-Fischer I, Arents BWM, Bauer A, Brans R, Cannavo A, Christoffers WA, Crépy MN, Elsner P, Fartasch M, Filon FL, Giménez-Arnau AM, Gonçalo M, Guzmán-Perera MG, Hamann CR, Hoetzenecker W, Johansen JD, John SM, Kunkeler ACM, Hadzavdic SL, Molin S, Nixon R, Oosterhaven JAF, Rustemeyer T, Serra-Baldrich E, Shah M, Simon D, Skudlik C, Spiewak R, Valiukevičienė S, Voorberg AN, Weisshaar E, Agner T
Contact Dermatitis 2022 May;86(5):357-378. Epub 2022 Mar 3 doi: 10.1111/cod.14035. PMID: 34971008
Nickel allergy and allergic contact dermatitis: A clinical review of immunology, epidemiology, exposure, and treatment.
Ahlström MG, Thyssen JP, Wennervaldt M, Menné T, Johansen JD
Contact Dermatitis 2019 Oct;81(4):227-241. Epub 2019 Jul 9 doi: 10.1111/cod.13327. PMID: 31140194

Recent clinical studies

Etiology

Efficacy and safety of dupilumab in patients with severe chronic hand eczema with inadequate response or intolerance to alitretinoin: a randomized, double-blind, placebo-controlled phase IIb proof-of-concept study.
Voorberg AN, Kamphuis E, Christoffers WA, Schuttelaar MLA
Br J Dermatol 2023 Sep 15;189(4):400-409. doi: 10.1093/bjd/ljad156. PMID: 37170922
Hand hygiene and hand eczema: A systematic review and meta-analysis.
Loh EW, Yew YW
Contact Dermatitis 2022 Oct;87(4):303-314. Epub 2022 May 2 doi: 10.1111/cod.14133. PMID: 35460528Free PMC Article
Guidelines for diagnosis, prevention, and treatment of hand eczema.
Thyssen JP, Schuttelaar MLA, Alfonso JH, Andersen KE, Angelova-Fischer I, Arents BWM, Bauer A, Brans R, Cannavo A, Christoffers WA, Crépy MN, Elsner P, Fartasch M, Filon FL, Giménez-Arnau AM, Gonçalo M, Guzmán-Perera MG, Hamann CR, Hoetzenecker W, Johansen JD, John SM, Kunkeler ACM, Hadzavdic SL, Molin S, Nixon R, Oosterhaven JAF, Rustemeyer T, Serra-Baldrich E, Shah M, Simon D, Skudlik C, Spiewak R, Valiukevičienė S, Voorberg AN, Weisshaar E, Agner T
Contact Dermatitis 2022 May;86(5):357-378. Epub 2022 Mar 3 doi: 10.1111/cod.14035. PMID: 34971008
Occupational food allergy.
Fukutomi Y
Curr Opin Allergy Clin Immunol 2019 Jun;19(3):243-248. doi: 10.1097/ACI.0000000000000530. PMID: 30883394
Work-related hand eczema.
Kvam MS, Alfonso JH, Berents TL, Randem BG, Stylianou E
Tidsskr Nor Laegeforen 2019 Feb 12;139(3) Epub 2019 Feb 5 doi: 10.4045/tidsskr.18.0213. PMID: 30754949

Diagnosis

Children atopic dermatitis: Diagnosis, mimics, overlaps, and therapeutic implication.
Napolitano M, Fabbrocini G, Martora F, Genco L, Noto M, Patruno C
Dermatol Ther 2022 Dec;35(12):e15901. Epub 2022 Oct 13 doi: 10.1111/dth.15901. PMID: 36200594Free PMC Article
Differences between pediatric and adult atopic dermatitis.
Ramírez-Marín HA, Silverberg JI
Pediatr Dermatol 2022 May;39(3):345-353. Epub 2022 Mar 16 doi: 10.1111/pde.14971. PMID: 35297082
Guidelines for diagnosis, prevention, and treatment of hand eczema.
Thyssen JP, Schuttelaar MLA, Alfonso JH, Andersen KE, Angelova-Fischer I, Arents BWM, Bauer A, Brans R, Cannavo A, Christoffers WA, Crépy MN, Elsner P, Fartasch M, Filon FL, Giménez-Arnau AM, Gonçalo M, Guzmán-Perera MG, Hamann CR, Hoetzenecker W, Johansen JD, John SM, Kunkeler ACM, Hadzavdic SL, Molin S, Nixon R, Oosterhaven JAF, Rustemeyer T, Serra-Baldrich E, Shah M, Simon D, Skudlik C, Spiewak R, Valiukevičienė S, Voorberg AN, Weisshaar E, Agner T
Contact Dermatitis 2022 May;86(5):357-378. Epub 2022 Mar 3 doi: 10.1111/cod.14035. PMID: 34971008
Advances and novel developments in mechanisms of allergic inflammation.
Han X, Krempski JW, Nadeau K
Allergy 2020 Dec;75(12):3100-3111. Epub 2020 Nov 4 doi: 10.1111/all.14632. PMID: 33068299
Hand eczema: treatment.
Elsner P, Agner T
J Eur Acad Dermatol Venereol 2020 Jan;34 Suppl 1:13-21. doi: 10.1111/jdv.16062. PMID: 31860736

Therapy

A Review of Existing and New Treatments for the Management of Hand Eczema.
Ho JSS, Molin S
J Cutan Med Surg 2023 Sep-Oct;27(5):493-503. Epub 2023 Jul 27 doi: 10.1177/12034754231188325. PMID: 37496489Free PMC Article
Hand hygiene and hand eczema: A systematic review and meta-analysis.
Loh EW, Yew YW
Contact Dermatitis 2022 Oct;87(4):303-314. Epub 2022 May 2 doi: 10.1111/cod.14133. PMID: 35460528Free PMC Article
Dupilumab: A Review of Present Indications and Off-Label Uses.
Muñoz-Bellido FJ, Moreno E, Dávila I
J Investig Allergol Clin Immunol 2022 Apr 19;32(2):97-115. Epub 2021 Mar 3 doi: 10.18176/jiaci.0682. PMID: 33661102
Hand eczema: treatment.
Elsner P, Agner T
J Eur Acad Dermatol Venereol 2020 Jan;34 Suppl 1:13-21. doi: 10.1111/jdv.16062. PMID: 31860736
Work-related hand eczema.
Kvam MS, Alfonso JH, Berents TL, Randem BG, Stylianou E
Tidsskr Nor Laegeforen 2019 Feb 12;139(3) Epub 2019 Feb 5 doi: 10.4045/tidsskr.18.0213. PMID: 30754949

Prognosis

Children atopic dermatitis: Diagnosis, mimics, overlaps, and therapeutic implication.
Napolitano M, Fabbrocini G, Martora F, Genco L, Noto M, Patruno C
Dermatol Ther 2022 Dec;35(12):e15901. Epub 2022 Oct 13 doi: 10.1111/dth.15901. PMID: 36200594Free PMC Article
Lifestyle factors and hand eczema: A systematic review and meta-analysis of observational studies.
Loman L, Brands MJ, Massella Patsea AAL, Politiek K, Arents BWM, Schuttelaar MLA
Contact Dermatitis 2022 Sep;87(3):211-232. Epub 2022 Apr 2 doi: 10.1111/cod.14102. PMID: 35277987Free PMC Article
Hand eczema: epidemiology, prognosis and prevention.
Agner T, Elsner P
J Eur Acad Dermatol Venereol 2020 Jan;34 Suppl 1:4-12. doi: 10.1111/jdv.16061. PMID: 31860734
Dupilumab for hand eczema.
Zirwas MJ
J Am Acad Dermatol 2018 Jul;79(1):167-169. Epub 2018 Mar 10 doi: 10.1016/j.jaad.2018.02.073. PMID: 29535032
Management of Chronic Hand Eczema.
de León FJ, Berbegal L, Silvestre JF
Actas Dermosifiliogr 2015 Sep;106(7):533-44. Epub 2015 May 23 doi: 10.1016/j.ad.2015.04.005. PMID: 26005193

Clinical prediction guides

Dupilumab treatment improves signs, symptoms, quality of life, and work productivity in patients with atopic hand and foot dermatitis: Results from a phase 3, randomized, double-blind, placebo-controlled trial.
Simpson EL, Silverberg JI, Worm M, Honari G, Masuda K, Syguła E, Schuttelaar MLA, Mortensen E, Laws E, Akinlade B, Patel N, Maloney J, Paleczny H, Delevry D, Xiao J, Dubost-Brama A, Bansal A
J Am Acad Dermatol 2024 Jun;90(6):1190-1199. Epub 2024 Feb 1 doi: 10.1016/j.jaad.2023.12.066. PMID: 38296199
Efficacy and safety of dupilumab in patients with severe chronic hand eczema with inadequate response or intolerance to alitretinoin: a randomized, double-blind, placebo-controlled phase IIb proof-of-concept study.
Voorberg AN, Kamphuis E, Christoffers WA, Schuttelaar MLA
Br J Dermatol 2023 Sep 15;189(4):400-409. doi: 10.1093/bjd/ljad156. PMID: 37170922
The pan-JAK inhibitor delgocitinib in a cream formulation demonstrates dose response in chronic hand eczema in a 16-week randomized phase IIb trial.
Worm M, Thyssen JP, Schliemann S, Bauer A, Shi VY, Ehst B, Tillmann S, Korn S, Resen K, Agner T
Br J Dermatol 2022 Jul;187(1):42-51. Epub 2022 Apr 19 doi: 10.1111/bjd.21037. PMID: 35084738Free PMC Article
Comparing alternating pressure mattresses and high-specification foam mattresses to prevent pressure ulcers in high-risk patients: the PRESSURE 2 RCT.
Nixon J, Brown S, Smith IL, McGinnis E, Vargas-Palacios A, Nelson EA, Brown J, Coleman S, Collier H, Fernandez C, Gilberts R, Henderson V, McCabe C, Muir D, Rutherford C, Stubbs N, Thorpe B, Wallner K, Walker K, Wilson L, Hulme C
Health Technol Assess 2019 Sep;23(52):1-176. doi: 10.3310/hta23520. PMID: 31559948Free PMC Article
The hand eczema severity index (HECSI): a scoring system for clinical assessment of hand eczema. A study of inter- and intraobserver reliability.
Held E, Skoet R, Johansen JD, Agner T
Br J Dermatol 2005 Feb;152(2):302-7. doi: 10.1111/j.1365-2133.2004.06305.x. PMID: 15727643

Recent systematic reviews

Topical anti-inflammatory treatments for eczema: network meta-analysis.
Lax SJ, Van Vogt E, Candy B, Steele L, Reynolds C, Stuart B, Parker R, Axon E, Roberts A, Doyle M, Chu DK, Futamura M, Santer M, Williams HC, Cro S, Drucker AM, Boyle RJ
Cochrane Database Syst Rev 2024 Aug 6;8(8):CD015064. doi: 10.1002/14651858.CD015064.pub2. PMID: 39105474Free PMC Article
Hand hygiene and hand eczema: A systematic review and meta-analysis.
Loh EW, Yew YW
Contact Dermatitis 2022 Oct;87(4):303-314. Epub 2022 May 2 doi: 10.1111/cod.14133. PMID: 35460528Free PMC Article
Lifestyle factors and hand eczema: A systematic review and meta-analysis of observational studies.
Loman L, Brands MJ, Massella Patsea AAL, Politiek K, Arents BWM, Schuttelaar MLA
Contact Dermatitis 2022 Sep;87(3):211-232. Epub 2022 Apr 2 doi: 10.1111/cod.14102. PMID: 35277987Free PMC Article
Systematic review of cost-of-illness studies in hand eczema.
Politiek K, Oosterhaven JA, Vermeulen KM, Schuttelaar ML
Contact Dermatitis 2016 Aug;75(2):67-76. Epub 2016 May 24 doi: 10.1111/cod.12590. PMID: 27218305
Tobacco smoking and hand eczema - is there an association?
Sørensen JA, Clemmensen KK, Nixon RL, Diepgen TL, Agner T
Contact Dermatitis 2015 Dec;73(6):326-35. Epub 2015 Jul 3 doi: 10.1111/cod.12429. PMID: 26140658

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