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Vaginal clear cell adenocarcinoma

MedGen UID:
66774
•Concept ID:
C0238517
•
Neoplastic Process
Synonyms: Clear cell adenocarcinoma of the vagina; Clear Cell Adenocarcinoma of the Vagina; Clear Cell Adenocarcinoma of Vagina; Vagina Clear Cell Adenocarcinoma; Vaginal Clear Cell Adenocarcinoma
 
HPO: HP:0031521

Definition

A type of adenocarcinoma originating in the vagina and characterized by large cells with moderate to abundant clear cytoplasm. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVaginal clear cell adenocarcinoma

Professional guidelines

PubMed

Expression of Markers of Müllerian Clear Cell Carcinoma in Primary Cervical and Vaginal Gastric-type Adenocarcinomas.
Talia KL, Wong RW, McCluggage WG
Int J Gynecol Pathol 2019 May;38(3):276-282. doi: 10.1097/PGP.0000000000000529. PMID: 29901522
Impact of Chemotherapy and Radiotherapy on Management of Early Stage Clear Cell and Papillary Serous Carcinoma of the Uterus.
Hong JC, Foote J, Broadwater G, Gaillard S, Havrilesky LJ, Chino JP
Int J Gynecol Cancer 2017 May;27(4):720-729. doi: 10.1097/IGC.0000000000000926. PMID: 28375927
Treatment failure in endometrial carcinoma.
Huang HJ, Tang YH, Chou HH, Yang LY, Chao A, Huang YT, Lin G, Liu FY, Chang TC, Lai CH
Int J Gynecol Cancer 2014 Jun;24(5):885-93. doi: 10.1097/IGC.0000000000000131. PMID: 24819657

Recent clinical studies

Etiology

Late cervical and vaginal clear cell adenocarcinoma in women exposed in utero to diethylstilbestrol: Evaluation and screening.
Tournaire M, Gondry J, Mauny L, Devouche E, Morice P
J Gynecol Obstet Hum Reprod 2023 Oct;52(8):102630. Epub 2023 Jul 13 doi: 10.1016/j.jogoh.2023.102630. PMID: 37451413
Diethylstilbestrol: Potential health risks for women exposed in utero and their offspring.
Conlon JL
JAAPA 2017 Feb;30(2):49-52. doi: 10.1097/01.JAA.0000511800.91372.34. PMID: 28098674
Clear cell adenocarcinoma of the female genital tract: long-term outcome and fertility aspects after brachytherapy aimed at a conservative treatment.
Magné N, Chargari C, Levy A, Rodriguez C, De Vos V, Gerbaulet A, Duvillard P, Morice P, Haie-Meder C
Int J Gynecol Cancer 2012 Oct;22(8):1378-82. doi: 10.1097/IGC.0b013e318264a51d. PMID: 22932263
Intrauterine exposure to diethylstilbestrol: long-term effects in humans.
Swan SH
APMIS 2000 Dec;108(12):793-804. doi: 10.1111/j.1600-0463.2000.tb00001.x. PMID: 11252812
An evaluation of stage II vaginal clear cell adenocarcinoma according to substages.
Senekjian EK, Frey KW, Stone C, Herbst AL
Gynecol Oncol 1988 Sep;31(1):56-64. doi: 10.1016/0090-8258(88)90269-7. PMID: 3410356

Diagnosis

Late cervical and vaginal clear cell adenocarcinoma in women exposed in utero to diethylstilbestrol: Evaluation and screening.
Tournaire M, Gondry J, Mauny L, Devouche E, Morice P
J Gynecol Obstet Hum Reprod 2023 Oct;52(8):102630. Epub 2023 Jul 13 doi: 10.1016/j.jogoh.2023.102630. PMID: 37451413
Vaginal clear cell adenocarcinoma with early pulmonary metastasis in a child.
Alipour P, Arjmandi K, Hallaji F
Pediatr Hematol Oncol 2008 Sep;25(7):679-84. doi: 10.1080/08880010802313723. PMID: 18850481
Influence of in utero diethylstilbestrol exposure on the prognosis and biologic behavior of vaginal clear-cell adenocarcinoma.
Waggoner SE, Mittendorf R, Biney N, Anderson D, Herbst AL
Gynecol Oncol 1994 Nov;55(2):238-44. doi: 10.1006/gyno.1994.1284. PMID: 7959291
Diethylstilbestrol-associated vaginal adenosis followed by clear cell adenocarcinoma.
Sander R, Nuss RC, Rhatigan RM
Int J Gynecol Pathol 1986;5(4):362-70. doi: 10.1097/00004347-198612000-00008. PMID: 3643169
Colposcopic and pathologic features in two cases of DES-related vaginal clear-cell adenocarcinoma.
Blythe JG, Michael H, Hodel KA
J Reprod Med 1983 Feb;28(2):137-46. PMID: 6834354

Therapy

Late cervical and vaginal clear cell adenocarcinoma in women exposed in utero to diethylstilbestrol: Evaluation and screening.
Tournaire M, Gondry J, Mauny L, Devouche E, Morice P
J Gynecol Obstet Hum Reprod 2023 Oct;52(8):102630. Epub 2023 Jul 13 doi: 10.1016/j.jogoh.2023.102630. PMID: 37451413
Diethylstilbestrol: Potential health risks for women exposed in utero and their offspring.
Conlon JL
JAAPA 2017 Feb;30(2):49-52. doi: 10.1097/01.JAA.0000511800.91372.34. PMID: 28098674
Diethylstilboestrol--a long-term legacy.
Harris RM, Waring RH
Maturitas 2012 Jun;72(2):108-12. Epub 2012 Mar 29 doi: 10.1016/j.maturitas.2012.03.002. PMID: 22464649
Intrauterine exposure to diethylstilbestrol: long-term effects in humans.
Swan SH
APMIS 2000 Dec;108(12):793-804. doi: 10.1111/j.1600-0463.2000.tb00001.x. PMID: 11252812
Vaginal clear cell adenocarcinoma.
Karnaky KJ
Obstet Gynecol 1973 Sep;42(3):479-80. PMID: 4724419

Prognosis

Clear cell adenocarcinoma of the female genital tract: long-term outcome and fertility aspects after brachytherapy aimed at a conservative treatment.
Magné N, Chargari C, Levy A, Rodriguez C, De Vos V, Gerbaulet A, Duvillard P, Morice P, Haie-Meder C
Int J Gynecol Cancer 2012 Oct;22(8):1378-82. doi: 10.1097/IGC.0b013e318264a51d. PMID: 22932263
Intrauterine exposure to diethylstilbestrol: long-term effects in humans.
Swan SH
APMIS 2000 Dec;108(12):793-804. doi: 10.1111/j.1600-0463.2000.tb00001.x. PMID: 11252812
Influence of in utero diethylstilbestrol exposure on the prognosis and biologic behavior of vaginal clear-cell adenocarcinoma.
Waggoner SE, Mittendorf R, Biney N, Anderson D, Herbst AL
Gynecol Oncol 1994 Nov;55(2):238-44. doi: 10.1006/gyno.1994.1284. PMID: 7959291
Local therapy in stage I clear cell adenocarcinoma of the vagina.
Senekjian EK, Frey KW, Anderson D, Herbst AL
Cancer 1987 Sep 15;60(6):1319-24. doi: 10.1002/1097-0142(19870915)60:6<1319::aid-cncr2820600626>3.0.co;2-h. PMID: 3621114
Colposcopic and pathologic features in two cases of DES-related vaginal clear-cell adenocarcinoma.
Blythe JG, Michael H, Hodel KA
J Reprod Med 1983 Feb;28(2):137-46. PMID: 6834354

Clinical prediction guides

Late cervical and vaginal clear cell adenocarcinoma in women exposed in utero to diethylstilbestrol: Evaluation and screening.
Tournaire M, Gondry J, Mauny L, Devouche E, Morice P
J Gynecol Obstet Hum Reprod 2023 Oct;52(8):102630. Epub 2023 Jul 13 doi: 10.1016/j.jogoh.2023.102630. PMID: 37451413
Clear cell adenocarcinoma of the female genital tract: long-term outcome and fertility aspects after brachytherapy aimed at a conservative treatment.
Magné N, Chargari C, Levy A, Rodriguez C, De Vos V, Gerbaulet A, Duvillard P, Morice P, Haie-Meder C
Int J Gynecol Cancer 2012 Oct;22(8):1378-82. doi: 10.1097/IGC.0b013e318264a51d. PMID: 22932263
Colposcopic and pathologic features in two cases of DES-related vaginal clear-cell adenocarcinoma.
Blythe JG, Michael H, Hodel KA
J Reprod Med 1983 Feb;28(2):137-46. PMID: 6834354
Induction of urogenital neoplasia and abnormalities from prenatal exposure to diethylstilbestrol.
Netzloff ML
Ann Clin Lab Sci 1979 Jul-Aug;9(4):263-7. PMID: 485089

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