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Acquired factor XIII deficiency

MedGen UID:
1393253
•Concept ID:
C0238120
•
Disease or Syndrome
Synonyms: Acquired Factor XIII Deficiency; acquired factor XIII deficiency; aFXIII
 
Monarch Initiative: MONDO:0021133
Orphanet: ORPHA599513

Definition

An acquired coagulation disorder characterized by the partial or complete absence of factor XIII activity in the blood. [from NCI]

Professional guidelines

PubMed

Coagulation management in patients undergoing mechanical circulatory support.
Görlinger K, Bergmann L, Dirkmann D
Best Pract Res Clin Anaesthesiol 2012 Jun;26(2):179-98. doi: 10.1016/j.bpa.2012.04.003. PMID: 22910089

Recent clinical studies

Therapy

Acquired Factor XIII Deficiency in Patients with Multiple Trauma.
Hetz M, Juratli T, Tiebel O, Giesecke MT, Tsitsilonis S, Held HC, Beyer F, Kleber C
Injury 2023 May;54(5):1257-1264. Epub 2022 Dec 22 doi: 10.1016/j.injury.2022.12.021. PMID: 36577625
Acquired Factor XIII Deficiency in a 19-year-Old Male Following Ballistic Injury.
Rodgers SC, Carter KT, Kutcher ME, Iwuchukwu CO
Am Surg 2022 Sep;88(9):2225-2226. Epub 2022 Apr 27 doi: 10.1177/00031348221091970. PMID: 35476509
Acquired factor XIII deficiency in patients under therapeutic plasma exchange: A poorly explored etiology.
Chuliber FA, Penchasky D, Santoro DM, Viñuales S, Otero V, Villagra Iturre M, Privitera V, Mezzarobba D, Burgos Pratx L, López MS, Barrera L, Schutz N, Arbelbide J, Martinuzzo M
J Clin Apher 2021 Feb;36(1):59-66. Epub 2020 Sep 17 doi: 10.1002/jca.21840. PMID: 32942343
A child with acquired factor XIII deficiency: case report and literature review.
Kessel R, Hu C, Shore-Lesserson L, Rand J, Manwani D
Haemophilia 2013 Nov;19(6):814-26. Epub 2013 Apr 22 doi: 10.1111/hae.12145. PMID: 23607876
Factor XIII deficiency: pathogenic mechanisms and clinical significance.
Egbring R, Kröniger A, Seitz R
Semin Thromb Hemost 1996;22(5):419-25. doi: 10.1055/s-2007-999041. PMID: 8989826

Prognosis

Acquired Factor XIII Deficiency in Patients with Multiple Trauma.
Hetz M, Juratli T, Tiebel O, Giesecke MT, Tsitsilonis S, Held HC, Beyer F, Kleber C
Injury 2023 May;54(5):1257-1264. Epub 2022 Dec 22 doi: 10.1016/j.injury.2022.12.021. PMID: 36577625
Acquired Factor XIII Deficiency in a 19-year-Old Male Following Ballistic Injury.
Rodgers SC, Carter KT, Kutcher ME, Iwuchukwu CO
Am Surg 2022 Sep;88(9):2225-2226. Epub 2022 Apr 27 doi: 10.1177/00031348221091970. PMID: 35476509
Acquired factor XIII deficiency in patients under therapeutic plasma exchange: A poorly explored etiology.
Chuliber FA, Penchasky D, Santoro DM, Viñuales S, Otero V, Villagra Iturre M, Privitera V, Mezzarobba D, Burgos Pratx L, López MS, Barrera L, Schutz N, Arbelbide J, Martinuzzo M
J Clin Apher 2021 Feb;36(1):59-66. Epub 2020 Sep 17 doi: 10.1002/jca.21840. PMID: 32942343
Autoimmune acquired factor XIII deficiency due to anti-factor XIII/13 antibodies: A summary of 93 patients.
Ichinose A; Japanese Collaborative Research Group on AH13
Blood Rev 2017 Jan;31(1):37-45. Epub 2016 Aug 11 doi: 10.1016/j.blre.2016.08.002. PMID: 27542511
A child with acquired factor XIII deficiency: case report and literature review.
Kessel R, Hu C, Shore-Lesserson L, Rand J, Manwani D
Haemophilia 2013 Nov;19(6):814-26. Epub 2013 Apr 22 doi: 10.1111/hae.12145. PMID: 23607876

Clinical prediction guides

Acquired Factor XIII Deficiency in Patients with Multiple Trauma.
Hetz M, Juratli T, Tiebel O, Giesecke MT, Tsitsilonis S, Held HC, Beyer F, Kleber C
Injury 2023 May;54(5):1257-1264. Epub 2022 Dec 22 doi: 10.1016/j.injury.2022.12.021. PMID: 36577625
Tocilizumab induced acquired factor XIII deficiency in patients with rheumatoid arthritis.
Mokuda S, Murata Y, Sawada N, Matoba K, Yamada A, Onishi M, Okuda Y, Jouyama K, Sugiyama E, Takasugi K
PLoS One 2013;8(8):e69944. Epub 2013 Aug 1 doi: 10.1371/journal.pone.0069944. PMID: 23936360Free PMC Article

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