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Age-related cognitive decline

MedGen UID:
536650
•Concept ID:
C0236848
•
Mental or Behavioral Dysfunction
SNOMED CT: Age-related cognitive decline (102891000)

Professional guidelines

PubMed

A practical approach to the management of cerebral amyloid angiopathy.
Kozberg MG, Perosa V, Gurol ME, van Veluw SJ
Int J Stroke 2021 Jun;16(4):356-369. Epub 2020 Nov 29 doi: 10.1177/1747493020974464. PMID: 33252026Free PMC Article
The cholinergic system in the pathophysiology and treatment of Alzheimer's disease.
Hampel H, Mesulam MM, Cuello AC, Farlow MR, Giacobini E, Grossberg GT, Khachaturian AS, Vergallo A, Cavedo E, Snyder PJ, Khachaturian ZS
Brain 2018 Jul 1;141(7):1917-1933. doi: 10.1093/brain/awy132. PMID: 29850777Free PMC Article
Herbal drug treatment.
Jarema M
Neuro Endocrinol Lett 2008 Nov;29 Suppl 1:93-104. PMID: 19029875

Recent clinical studies

Etiology

Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer's disease.
Inoue Y, Shue F, Bu G, Kanekiyo T
Mol Neurodegener 2023 Jul 11;18(1):46. doi: 10.1186/s13024-023-00640-5. PMID: 37434208Free PMC Article
Nutrition and cognitive health: A life course approach.
Puri S, Shaheen M, Grover B
Front Public Health 2023;11:1023907. Epub 2023 Mar 27 doi: 10.3389/fpubh.2023.1023907. PMID: 37050953Free PMC Article
Nutrition, Physical Activity, and Other Lifestyle Factors in the Prevention of Cognitive Decline and Dementia.
Dominguez LJ, Veronese N, Vernuccio L, Catanese G, Inzerillo F, Salemi G, Barbagallo M
Nutrients 2021 Nov 15;13(11) doi: 10.3390/nu13114080. PMID: 34836334Free PMC Article
Exercise and dementia prevention.
Alty J, Farrow M, Lawler K
Pract Neurol 2020 May;20(3):234-240. Epub 2020 Jan 21 doi: 10.1136/practneurol-2019-002335. PMID: 31964800
Mediterranean Diet and Age-Related Cognitive Decline: A Randomized Clinical Trial.
Valls-Pedret C, Sala-Vila A, Serra-Mir M, Corella D, de la Torre R, Martínez-González MÁ, Martínez-Lapiscina EH, Fitó M, Pérez-Heras A, Salas-Salvadó J, Estruch R, Ros E
JAMA Intern Med 2015 Jul;175(7):1094-1103. doi: 10.1001/jamainternmed.2015.1668. PMID: 25961184

Diagnosis

Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer's disease.
Inoue Y, Shue F, Bu G, Kanekiyo T
Mol Neurodegener 2023 Jul 11;18(1):46. doi: 10.1186/s13024-023-00640-5. PMID: 37434208Free PMC Article
A practical approach to the management of cerebral amyloid angiopathy.
Kozberg MG, Perosa V, Gurol ME, van Veluw SJ
Int J Stroke 2021 Jun;16(4):356-369. Epub 2020 Nov 29 doi: 10.1177/1747493020974464. PMID: 33252026Free PMC Article
Exercise and dementia prevention.
Alty J, Farrow M, Lawler K
Pract Neurol 2020 May;20(3):234-240. Epub 2020 Jan 21 doi: 10.1136/practneurol-2019-002335. PMID: 31964800
Exercise and Hippocampal Memory Systems.
Voss MW, Soto C, Yoo S, Sodoma M, Vivar C, van Praag H
Trends Cogn Sci 2019 Apr;23(4):318-333. Epub 2019 Feb 16 doi: 10.1016/j.tics.2019.01.006. PMID: 30777641Free PMC Article
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy.
Liu CC, Liu CC, Kanekiyo T, Xu H, Bu G
Nat Rev Neurol 2013 Feb;9(2):106-18. Epub 2013 Jan 8 doi: 10.1038/nrneurol.2012.263. PMID: 23296339Free PMC Article

Therapy

Hypertension, Neurodegeneration, and Cognitive Decline.
Pacholko A, Iadecola C
Hypertension 2024 May;81(5):991-1007. Epub 2024 Mar 1 doi: 10.1161/HYPERTENSIONAHA.123.21356. PMID: 38426329Free PMC Article
Plant-Based Dietary Patterns, Plant Foods, and Age-Related Cognitive Decline.
Rajaram S, Jones J, Lee GJ
Adv Nutr 2019 Nov 1;10(Suppl_4):S422-S436. doi: 10.1093/advances/nmz081. PMID: 31728502Free PMC Article
Nutritional prevention of cognitive decline and dementia.
Dominguez LJ, Barbagallo M
Acta Biomed 2018 Jun 7;89(2):276-290. doi: 10.23750/abm.v89i2.7401. PMID: 29957766Free PMC Article
The cholinergic system in the pathophysiology and treatment of Alzheimer's disease.
Hampel H, Mesulam MM, Cuello AC, Farlow MR, Giacobini E, Grossberg GT, Khachaturian AS, Vergallo A, Cavedo E, Snyder PJ, Khachaturian ZS
Brain 2018 Jul 1;141(7):1917-1933. doi: 10.1093/brain/awy132. PMID: 29850777Free PMC Article
Mediterranean Diet and Age-Related Cognitive Decline: A Randomized Clinical Trial.
Valls-Pedret C, Sala-Vila A, Serra-Mir M, Corella D, de la Torre R, Martínez-González MÁ, Martínez-Lapiscina EH, Fitó M, Pérez-Heras A, Salas-Salvadó J, Estruch R, Ros E
JAMA Intern Med 2015 Jul;175(7):1094-1103. doi: 10.1001/jamainternmed.2015.1668. PMID: 25961184

Prognosis

Nutrition and cognitive health: A life course approach.
Puri S, Shaheen M, Grover B
Front Public Health 2023;11:1023907. Epub 2023 Mar 27 doi: 10.3389/fpubh.2023.1023907. PMID: 37050953Free PMC Article
ApoE Cascade Hypothesis in the pathogenesis of Alzheimer's disease and related dementias.
Martens YA, Zhao N, Liu CC, Kanekiyo T, Yang AJ, Goate AM, Holtzman DM, Bu G
Neuron 2022 Apr 20;110(8):1304-1317. Epub 2022 Mar 16 doi: 10.1016/j.neuron.2022.03.004. PMID: 35298921Free PMC Article
Plant-Based Dietary Patterns, Plant Foods, and Age-Related Cognitive Decline.
Rajaram S, Jones J, Lee GJ
Adv Nutr 2019 Nov 1;10(Suppl_4):S422-S436. doi: 10.1093/advances/nmz081. PMID: 31728502Free PMC Article
Nutritional prevention of cognitive decline and dementia.
Dominguez LJ, Barbagallo M
Acta Biomed 2018 Jun 7;89(2):276-290. doi: 10.23750/abm.v89i2.7401. PMID: 29957766Free PMC Article
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy.
Liu CC, Liu CC, Kanekiyo T, Xu H, Bu G
Nat Rev Neurol 2013 Feb;9(2):106-18. Epub 2013 Jan 8 doi: 10.1038/nrneurol.2012.263. PMID: 23296339Free PMC Article

Clinical prediction guides

Aerobic exercise training and neurocognitive function in cognitively normal older adults: A one-year randomized controlled trial.
Tarumi T, Patel NR, Tomoto T, Pasha E, Khan AM, Kostroske K, Riley J, Tinajero CD, Wang C, Hynan LS, Rodrigue KM, Kennedy KM, Park DC, Zhang R
J Intern Med 2022 Nov;292(5):788-803. Epub 2022 Jul 3 doi: 10.1111/joim.13534. PMID: 35713933Free PMC Article
ApoE Cascade Hypothesis in the pathogenesis of Alzheimer's disease and related dementias.
Martens YA, Zhao N, Liu CC, Kanekiyo T, Yang AJ, Goate AM, Holtzman DM, Bu G
Neuron 2022 Apr 20;110(8):1304-1317. Epub 2022 Mar 16 doi: 10.1016/j.neuron.2022.03.004. PMID: 35298921Free PMC Article
Plant-Based Dietary Patterns, Plant Foods, and Age-Related Cognitive Decline.
Rajaram S, Jones J, Lee GJ
Adv Nutr 2019 Nov 1;10(Suppl_4):S422-S436. doi: 10.1093/advances/nmz081. PMID: 31728502Free PMC Article
Mediterranean Diet and Age-Related Cognitive Decline: A Randomized Clinical Trial.
Valls-Pedret C, Sala-Vila A, Serra-Mir M, Corella D, de la Torre R, Martínez-González MÁ, Martínez-Lapiscina EH, Fitó M, Pérez-Heras A, Salas-Salvadó J, Estruch R, Ros E
JAMA Intern Med 2015 Jul;175(7):1094-1103. doi: 10.1001/jamainternmed.2015.1668. PMID: 25961184
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy.
Liu CC, Liu CC, Kanekiyo T, Xu H, Bu G
Nat Rev Neurol 2013 Feb;9(2):106-18. Epub 2013 Jan 8 doi: 10.1038/nrneurol.2012.263. PMID: 23296339Free PMC Article

Recent systematic reviews

Effects of the ketogenic diet on cognition: a systematic review.
Chinna-Meyyappan A, Gomes FA, Koning E, Fabe J, Breda V, Brietzke E
Nutr Neurosci 2023 Dec;26(12):1258-1278. Epub 2022 Nov 10 doi: 10.1080/1028415X.2022.2143609. PMID: 36354157
The effects of aerobic exercise and transcranial direct current stimulation on cognitive function in older adults with and without cognitive impairment: A systematic review and meta-analysis.
Talar K, Vetrovsky T, van Haren M, Négyesi J, Granacher U, Váczi M, Martín-Arévalo E, Del Olmo MF, Kałamacka E, Hortobágyi T
Ageing Res Rev 2022 Nov;81:101738. Epub 2022 Sep 23 doi: 10.1016/j.arr.2022.101738. PMID: 36162707
Nutrition and exercise interventions could ameliorate age-related cognitive decline: a meta-analysis of randomized controlled trials.
Liu T, Li N, Hou Z, Liu L, Gao L, Wang L, Tan J
Aging Clin Exp Res 2021 Jul;33(7):1799-1809. Epub 2020 Oct 14 doi: 10.1007/s40520-020-01730-w. PMID: 33052590
Dietary Patterns and Cognitive Health in Older Adults: A Systematic Review.
Chen X, Maguire B, Brodaty H, O'Leary F
J Alzheimers Dis 2019;67(2):583-619. doi: 10.3233/JAD-180468. PMID: 30689586
The impact of retirement on age related cognitive decline - a systematic review.
Meng A, Nexø MA, Borg V
BMC Geriatr 2017 Jul 21;17(1):160. doi: 10.1186/s12877-017-0556-7. PMID: 28732489Free PMC Article

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