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Auditory hallucination

MedGen UID:
115932
Concept ID:
C0233762
Sign or Symptom
Synonym: Auditory hallucinations
SNOMED CT: Auditory hallucinations (45150006)
 
HPO: HP:0008765

Definition

Perception of sounds without auditory stimulus. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAuditory hallucination

Conditions with this feature

Migraine, familial hemiplegic, 1
MedGen UID:
331388
Concept ID:
C1832884
Disease or Syndrome
Familial hemiplegic migraine (FHM) falls within the category of migraine with aura. In migraine with aura (including FHM) the neurologic symptoms of aura are unequivocally localizable to the cerebral cortex or brain stem and include visual disturbance (most common), sensory loss (e.g., numbness or paresthesias of the face or an extremity), and dysphasia (difficulty with speech). FHM must include motor involvement, such as hemiparesis (weakness of an extremity). Hemiparesis occurs with at least one other symptom during FHM aura. Neurologic deficits with FHM attacks can be prolonged for hours to days and may outlast the associated migrainous headache. FHM is often earlier in onset than typical migraine, frequently beginning in the first or second decade; the frequency of attacks tends to decrease with age. Approximately 40%-50% of families with CACNA1A-FHM have cerebellar signs ranging from nystagmus to progressive, usually late-onset mild ataxia.
Ceroid lipofuscinosis, neuronal, 4 (Kufs type)
MedGen UID:
320287
Concept ID:
C1834207
Disease or Syndrome
Neuronal ceroid lipofuscinosis-4 (CLN4) is an autosomal dominant neurodegenerative disorder characterized by onset of symptoms in adulthood. It belongs to a group of progressive neurodegenerative diseases characterized by accumulation of intracellular autofluorescent lipopigment storage material in the brain and other tissues. Several different forms have been described according to age of onset (see, e.g., CLN3, 204200). Individuals with the adult form, sometimes referred to as Kufs disease, develop psychiatric manifestations, seizures, cerebellar ataxia, and cognitive decline. Retinal degeneration is usually not present (summary by Benitez et al., 2011 and Velinov et al., 2012). For a general phenotypic description and a discussion of genetic heterogeneity of CLN, see CLN1 (256730).
Familial temporal lobe epilepsy 4
MedGen UID:
368897
Concept ID:
C1968847
Disease or Syndrome
A temporal lobe epilepsy characterized by autosomal dominant inheritance of occipitotemporal lobe epilepsy and migraine with visual aura and that has material basis in variation in the chromosome region 9q21-q22.
Amyloidosis, hereditary systemic 1
MedGen UID:
414031
Concept ID:
C2751492
Disease or Syndrome
Hereditary transthyretin (ATTR) amyloidosis is characterized by a slowly progressive peripheral sensorimotor and/or autonomic neuropathy as well as non-neuropathic changes of cardiomyopathy, nephropathy, vitreous opacities, and CNS amyloidosis. The disease usually begins in the third to fifth decade in persons from endemic foci in Portugal and Japan; onset is later in persons from other areas. Typically, sensory neuropathy starts in the lower extremities with paresthesias and hypesthesias of the feet, followed within a few years by motor neuropathy. In some persons, particularly those with early-onset disease, autonomic neuropathy is the first manifestation of the condition; findings can include: orthostatic hypotension, constipation alternating with diarrhea, attacks of nausea and vomiting, delayed gastric emptying, sexual impotence, anhidrosis, and urinary retention or incontinence. Cardiac amyloidosis is mainly characterized by progressive cardiomyopathy. Individuals with leptomeningeal amyloidosis may have the following CNS findings: dementia, psychosis, visual impairment, headache, seizures, motor paresis, ataxia, myelopathy, hydrocephalus, or intracranial hemorrhage.
Skeletal overgrowth-craniofacial dysmorphism-hyperelastic skin-white matter lesions syndrome
MedGen UID:
896409
Concept ID:
C4225270
Disease or Syndrome
Kosaki overgrowth syndrome (KOGS) is characterized by a facial gestalt involving prominent forehead, proptosis, downslanting palpebral fissures, broad nasal bridge, thin upper lip, and pointed chin. Affected individuals are tall, with an elongated lower segment, and have large hands and feet. Skin is hyperelastic and fragile. Patients exhibit progressive dilatory and vascular changes in basilar/vertebral and coronary arteries starting in the teenage years (Takenouchi et al., 2015; Takenouchi et al., 2021).
Lissencephaly 10
MedGen UID:
1719546
Concept ID:
C5394354
Disease or Syndrome
Lissencephaly-10 (LIS10) is a neurologic disorder characterized by variably delayed development with mildly to moderately impaired intellectual development and language delay, as well as seizures, which are often intractable. There is a spectrum of severity, with some patients having normal early development and only borderline to mild cognitive impairment. Brain imaging shows features consistent with neuronal migration defects, including posterior-predominant lissencephaly, pachygyria, agyria, and subcortical band heterotopia (summary by Tsai et al., 2020). For a general description and a discussion of genetic heterogeneity of lissencephaly, see LIS1 (607432).
Agenesis of corpus callosum, cardiac, ocular, and genital syndrome
MedGen UID:
1718475
Concept ID:
C5394523
Disease or Syndrome
Agenesis of corpus callosum, cardiac, ocular, and genital syndrome (ACOGS) is a syndromic neurodevelopmental disorder characterized by global developmental delay and/or intellectual disability, corpus callosum agenesis or hypoplasia, craniofacial dysmorphisms, and ocular, cardiac, and genital anomalies (Accogli et al., 2019).
Ceroid lipofuscinosis, neuronal, 6B (Kufs type)
MedGen UID:
1794137
Concept ID:
C5561927
Disease or Syndrome
Neuronal ceroid lipofuscinosis-6B (CLN6B) is an autosomal recessive form of 'Kufs disease,' which refers in general to adult-onset neuronal ceroid lipofuscinosis without retinal involvement. CLN6B is a neurodegenerative disorder with a mean onset of symptoms at around age 28 years, although onset in the teens and later adulthood may also occur. Patients typically present with progressive myoclonus epilepsy, ataxia, loss of motor function, dysarthria, progressive dementia, and progressive cerebral and cerebellar atrophy on brain imaging. Ultrastructural examination typically shows fingerprint profiles and granular osmiophilic deposits in some tissues, including brain samples (summary by Arsov et al., 2011 and Berkovic et al., 2019). However, pathologic findings in peripheral tissues in adults is not as accurate for diagnosis as it is in children with the disease (Cherian et al., 2021). For a general phenotypic description and a discussion of genetic heterogeneity of CLN, see CLN1 (256730).
Leukoencephalopathy, diffuse hereditary, with spheroids 1
MedGen UID:
1794139
Concept ID:
C5561929
Disease or Syndrome
CSF1R-related adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is characterized by executive dysfunction, memory decline, personality changes, motor impairments, and seizures. A frontal lobe syndrome (e.g., loss of judgment, lack of social inhibitors, lack of insight, and motor persistence) usually appears early in the disease course. The mean age of onset is usually in the fourth decade. Affected individuals eventually become bedridden with spasticity and rigidity. The disease course ranges from two to 30 or more years (mean: 8 years).

Professional guidelines

PubMed

Dumrikarnlert C, Thakolwiboon S, Senanarong V
BMC Neurol 2023 Sep 22;23(1):334. doi: 10.1186/s12883-023-03305-4. PMID: 37737161Free PMC Article
Jiang WL, Cai DB, Sun CH, Yin F, Goerigk S, Brunoni AR, Zhao XW, Mayes TL, Zheng W, Xiang YT
Asian J Psychiatr 2022 Jul;73:103100. Epub 2022 Apr 6 doi: 10.1016/j.ajp.2022.103100. PMID: 35430496
Zarrabi H, Khalkhali M, Hamidi A, Ahmadi R, Zavarmousavi M
BMC Psychiatry 2016 Feb 25;16:44. doi: 10.1186/s12888-016-0745-5. PMID: 26911516Free PMC Article

Recent clinical studies

Etiology

Li X, Yang C, Liang X, Li D, Zhou Z, Xiao H, Liu X, Li J, Yang D, Li M
Clin Invest Med 2022 Jun 26;45(2):E39-48. doi: 10.25011/cim.v45i2.38096. PMID: 35752981
Fernyhough C
Psychol Med 2019 Dec;49(16):2639-2645. Epub 2019 Sep 18 doi: 10.1017/S0033291719002496. PMID: 31530334Free PMC Article
Kim J, Iwata Y, Plitman E, Caravaggio F, Chung JK, Shah P, Blumberger DM, Pollock BG, Remington G, Graff-Guerrero A, Gerretsen P
J Psychiatr Res 2019 Mar;110:117-126. Epub 2018 Dec 10 doi: 10.1016/j.jpsychires.2018.12.009. PMID: 30639917
Ertekin Pinar S RN, PhD, Tel H RN, PhD
Issues Ment Health Nurs 2019 Jan;40(1):50-57. Epub 2018 Aug 15 doi: 10.1080/01612840.2018.1463324. PMID: 30111213
Blom JD
Handb Clin Neurol 2015;129:433-55. doi: 10.1016/B978-0-444-62630-1.00024-X. PMID: 25726283

Diagnosis

Fernyhough C
Psychol Med 2019 Dec;49(16):2639-2645. Epub 2019 Sep 18 doi: 10.1017/S0033291719002496. PMID: 31530334Free PMC Article
Ertekin Pinar S RN, PhD, Tel H RN, PhD
Issues Ment Health Nurs 2019 Jan;40(1):50-57. Epub 2018 Aug 15 doi: 10.1080/01612840.2018.1463324. PMID: 30111213
Powers AR 3rd, Gancsos MG, Finn ES, Morgan PT, Corlett PR
Psychopathology 2015;48(6):376-85. Epub 2015 Sep 12 doi: 10.1159/000438675. PMID: 26361209Free PMC Article
Blom JD
Handb Clin Neurol 2015;129:433-55. doi: 10.1016/B978-0-444-62630-1.00024-X. PMID: 25726283
Sanjuan J, Gonzalez JC, Aguilar EJ, Leal C, van Os J
Acta Psychiatr Scand 2004 Oct;110(4):273-8. doi: 10.1111/j.1600-0447.2004.00336.x. PMID: 15352928

Therapy

El Ashry AMN, Abd El Dayem SM, Ramadan FH
Arch Psychiatr Nurs 2021 Apr;35(2):141-152. Epub 2021 Jan 29 doi: 10.1016/j.apnu.2021.01.003. PMID: 33781392
Kim J, Iwata Y, Plitman E, Caravaggio F, Chung JK, Shah P, Blumberger DM, Pollock BG, Remington G, Graff-Guerrero A, Gerretsen P
J Psychiatr Res 2019 Mar;110:117-126. Epub 2018 Dec 10 doi: 10.1016/j.jpsychires.2018.12.009. PMID: 30639917
Lindenmayer JP, Kulsa MKC, Sultana T, Kaur A, Yang R, Ljuri I, Parker B, Khan A
Brain Stimul 2019 Jan-Feb;12(1):54-61. Epub 2018 Oct 2 doi: 10.1016/j.brs.2018.10.002. PMID: 30316742
Ertekin Pinar S RN, PhD, Tel H RN, PhD
Issues Ment Health Nurs 2019 Jan;40(1):50-57. Epub 2018 Aug 15 doi: 10.1080/01612840.2018.1463324. PMID: 30111213
Powers AR 3rd, Gancsos MG, Finn ES, Morgan PT, Corlett PR
Psychopathology 2015;48(6):376-85. Epub 2015 Sep 12 doi: 10.1159/000438675. PMID: 26361209Free PMC Article

Prognosis

Bell A, Toh WL, Allen P, Cella M, Jardri R, Larøi F, Moseley P, Rossell SL
Aust N Z J Psychiatry 2024 Jun;58(6):467-497. Epub 2024 Mar 12 doi: 10.1177/00048674241235849. PMID: 38470085Free PMC Article
Ghosh CC, McVicar D, Davidson G, Shannon C, Armour C
BMC Psychiatry 2023 May 2;23(1):307. doi: 10.1186/s12888-023-04780-2. PMID: 37131149Free PMC Article
Kafadar E, Fisher VL, Quagan B, Hammer A, Jaeger H, Mourgues C, Thomas R, Chen L, Imtiaz A, Sibarium E, Negreira AM, Sarisik E, Polisetty V, Benrimoh D, Sheldon AD, Lim C, Mathys C, Powers AR
Biol Psychiatry 2022 Nov 15;92(10):772-780. Epub 2022 May 13 doi: 10.1016/j.biopsych.2022.05.007. PMID: 35843743Free PMC Article
Coebergh JAF, Lauw RF, Sommer IEC, Blom JD
J Neurol 2019 Jun;266(6):1501-1515. Epub 2019 Apr 10 doi: 10.1007/s00415-019-09289-x. PMID: 30972497Free PMC Article
Powers AR 3rd, Gancsos MG, Finn ES, Morgan PT, Corlett PR
Psychopathology 2015;48(6):376-85. Epub 2015 Sep 12 doi: 10.1159/000438675. PMID: 26361209Free PMC Article

Clinical prediction guides

Li X, Yang C, Liang X, Li D, Zhou Z, Xiao H, Liu X, Li J, Yang D, Li M
Clin Invest Med 2022 Jun 26;45(2):E39-48. doi: 10.25011/cim.v45i2.38096. PMID: 35752981
Hamilton LS, Oganian Y, Hall J, Chang EF
Cell 2021 Sep 2;184(18):4626-4639.e13. Epub 2021 Aug 18 doi: 10.1016/j.cell.2021.07.019. PMID: 34411517Free PMC Article
Lindenmayer JP, Kulsa MKC, Sultana T, Kaur A, Yang R, Ljuri I, Parker B, Khan A
Brain Stimul 2019 Jan-Feb;12(1):54-61. Epub 2018 Oct 2 doi: 10.1016/j.brs.2018.10.002. PMID: 30316742
Ertekin Pinar S RN, PhD, Tel H RN, PhD
Issues Ment Health Nurs 2019 Jan;40(1):50-57. Epub 2018 Aug 15 doi: 10.1080/01612840.2018.1463324. PMID: 30111213
Powers AR 3rd, Gancsos MG, Finn ES, Morgan PT, Corlett PR
Psychopathology 2015;48(6):376-85. Epub 2015 Sep 12 doi: 10.1159/000438675. PMID: 26361209Free PMC Article

Recent systematic reviews

Bell A, Toh WL, Allen P, Cella M, Jardri R, Larøi F, Moseley P, Rossell SL
Aust N Z J Psychiatry 2024 Jun;58(6):467-497. Epub 2024 Mar 12 doi: 10.1177/00048674241235849. PMID: 38470085Free PMC Article
Vasilevska V, Guest PC, Bernstein HG, Schroeter ML, Geis C, Steiner J
J Neuroinflammation 2021 Oct 28;18(1):245. doi: 10.1186/s12974-021-02293-x. PMID: 34711233Free PMC Article
Anderson A, Hartley S, Bucci S
J Behav Ther Exp Psychiatry 2021 Jun;71:101635. Epub 2020 Dec 10 doi: 10.1016/j.jbtep.2020.101635. PMID: 33348277
Coebergh JAF, Lauw RF, Sommer IEC, Blom JD
J Neurol 2019 Jun;266(6):1501-1515. Epub 2019 Apr 10 doi: 10.1007/s00415-019-09289-x. PMID: 30972497Free PMC Article
Otani VH, Shiozawa P, Cordeiro Q, Uchida RR
Int J Psychiatry Clin Pract 2015;19(4):228-32. Epub 2014 Nov 20 doi: 10.3109/13651501.2014.980830. PMID: 25356661

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