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Chronic schizophrenia

MedGen UID:: 66383
•Concept ID:: C0221765
•: Mental or Behavioral Dysfunction

Synonym:	Chronic Schizophrenia
SNOMED CT:	Chronic schizophrenia (83746006)

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVChronic schizophrenia

Abnormality of the nervous system
- Abnormal nervous system physiology
  - Abnormality of mental function
    - Atypical behavior
      - Diagnostic behavioral phenotype
        Schizophrenia
        Chronic schizophrenia
        Chronic latent schizophrenia
        Chronic residual schizophrenia

Professional guidelines

PubMed

Associations of the Gut Microbiome With Treatment Resistance in Schizophrenia.

Vasileva SS, Yang Y, Baker A, Siskind D, Gratten J, Eyles D
JAMA Psychiatry 2024 Mar 1;81(3):292-302. doi: 10.1001/jamapsychiatry.2023.5371. PMID: 38294805 Free PMC Article

Cannabidiol as a treatment option for schizophrenia: recent evidence and current studies.

Schoevers J, Leweke JE, Leweke FM
Curr Opin Psychiatry 2020 May;33(3):185-191. doi: 10.1097/YCO.0000000000000596. PMID: 32073423

Treatment of schizophrenia.

Kane JM
Schizophr Bull 1987;13(1):133-56. doi: 10.1093/schbul/13.1.133. PMID: 2885912

See all (181)

Recent clinical studies

Etiology

Meta-analysis of cortical thickness reduction in adult schizophrenia.

Sun S, Xiao S, Guo Z, Gong J, Tang G, Huang L, Wang Y
J Psychiatry Neurosci 2023 Nov-Dec;48(6):E461-E470. Epub 2023 Dec 20 doi: 10.1503/jpn.230081. PMID: 38123240 Free PMC Article

Autobiographical memory impairment in chronic schizophrenia: Significance and clinical correlates.

Herold CJ, Lässer MM, Schröder J
J Neuropsychol 2023 Mar;17(1):89-107. Epub 2022 Sep 5 doi: 10.1111/jnp.12288. PMID: 36065152

Brain ventricular volume changes in schizophrenia. A narrative review.

Svancer P, Spaniel F
Neurosci Lett 2021 Aug 10;759:136065. Epub 2021 Jun 16 doi: 10.1016/j.neulet.2021.136065. PMID: 34146640

Mismatch Negativity in First-Episode Schizophrenia: A Meta-Analysis.

Haigh SM, Coffman BA, Salisbury DF
Clin EEG Neurosci 2017 Jan;48(1):3-10. Epub 2016 May 11 doi: 10.1177/1550059416645980. PMID: 27170669 Free PMC Article

Anhedonia and schizophrenia.

Harrow M, Grinker RR, Holzman PS, Kayton L
Am J Psychiatry 1977 Jul;134(7):794-7. doi: 10.1176/ajp.134.7.794. PMID: 869058

See all (1600)

Diagnosis

Sensitivity and specificity of hypoactivations and failure of de-activation in schizophrenia.

Salgado-Pineda P, Radua J, Sarró S, Guerrero-Pedraza A, Salvador R, Pomarol-Clotet E, McKenna PJ
Schizophr Res 2018 Nov;201:224-230. Epub 2018 Jun 25 doi: 10.1016/j.schres.2018.06.013. PMID: 29954704

Mismatch Negativity in First-Episode Schizophrenia: A Meta-Analysis.

Haigh SM, Coffman BA, Salisbury DF
Clin EEG Neurosci 2017 Jan;48(1):3-10. Epub 2016 May 11 doi: 10.1177/1550059416645980. PMID: 27170669 Free PMC Article

Sleep-related psychosis.

Frase L, Sixt B, Nissen C
BMJ Case Rep 2013 Jul 8;2013 doi: 10.1136/bcr-2013-009373. PMID: 23839606 Free PMC Article

Schizotypal personality disorder.

Chemerinski E, Triebwasser J, Roussos P, Siever LJ
J Pers Disord 2013 Oct;27(5):652-79. Epub 2012 Aug 28 doi: 10.1521/pedi_2012_26_053. PMID: 22928856

Anhedonia and schizophrenia.

Harrow M, Grinker RR, Holzman PS, Kayton L
Am J Psychiatry 1977 Jul;134(7):794-7. doi: 10.1176/ajp.134.7.794. PMID: 869058

See all (1190)

Therapy

Adjunctive agents to antipsychotics in schizophrenia: a systematic umbrella review and recommendations for amino acids, hormonal therapies and anti-inflammatory drugs.

Fond G, Mallet J, Urbach M, Benros ME, Berk M, Billeci M, Boyer L, Correll CU, Fornaro M, Kulkarni J, Leboyer M, Llorca PM, Misdrahi D, Rey R, Schürhoff F, Solmi M, Sommer IEC, Stahl SM, Pignon B, Berna F
BMJ Ment Health 2023 Oct;26(1) doi: 10.1136/bmjment-2023-300771. PMID: 37852631 Free PMC Article

Clonidine augmentation in patients with schizophrenia: A double-blind, randomized placebo-controlled trial.

Kruiper C, Sommer IEC, Koster M, Bakker PR, Durston S, Oranje B
Schizophr Res 2023 May;255:148-154. Epub 2023 Mar 28 doi: 10.1016/j.schres.2023.03.039. PMID: 36989672

Efficacy and safety of adjunctive therapy with fingolimod in patients with schizophrenia: A randomized, double-blind, placebo-controlled clinical trial.

Karbalaee M, Jameie M, Amanollahi M, TaghaviZanjani F, Parsaei M, Basti FA, Mokhtari S, Moradi K, Ardakani MK, Akhondzadeh S
Schizophr Res 2023 Apr;254:92-98. Epub 2023 Feb 18 doi: 10.1016/j.schres.2023.02.020. PMID: 36805834

The Use of Long-Acting Injectable Antipsychotics in Schizophrenia: Evaluating the Evidence.

Correll CU, Citrome L, Haddad PM, Lauriello J, Olfson M, Calloway SM, Kane JM
J Clin Psychiatry 2016;77(suppl 3):1-24. doi: 10.4088/JCP.15032su1. PMID: 27732772

Aripiprazole.

McGavin JK, Goa KL
CNS Drugs 2002;16(11):779-86; discussion 787-8. doi: 10.2165/00023210-200216110-00008. PMID: 12383035

See all (1447)

Prognosis

Digital Phenotyping in Adults with Schizophrenia: A Narrative Review.

Lane E, D'Arcey J, Kidd S, Onyeaka H, Alon N, Joshi D, Torous J
Curr Psychiatry Rep 2023 Nov;25(11):699-706. Epub 2023 Oct 20 doi: 10.1007/s11920-023-01467-z. PMID: 37861979

Autobiographical memory impairment in chronic schizophrenia: Significance and clinical correlates.

Herold CJ, Lässer MM, Schröder J
J Neuropsychol 2023 Mar;17(1):89-107. Epub 2022 Sep 5 doi: 10.1111/jnp.12288. PMID: 36065152

Brain ventricular volume changes in schizophrenia. A narrative review.

Svancer P, Spaniel F
Neurosci Lett 2021 Aug 10;759:136065. Epub 2021 Jun 16 doi: 10.1016/j.neulet.2021.136065. PMID: 34146640

Ageing with schizophrenia: an update.

Solomon HV, Sinopoli M, DeLisi LE
Curr Opin Psychiatry 2021 May 1;34(3):266-274. doi: 10.1097/YCO.0000000000000694. PMID: 33534420

Mismatch Negativity in First-Episode Schizophrenia: A Meta-Analysis.

Haigh SM, Coffman BA, Salisbury DF
Clin EEG Neurosci 2017 Jan;48(1):3-10. Epub 2016 May 11 doi: 10.1177/1550059416645980. PMID: 27170669 Free PMC Article

See all (681)

Clinical prediction guides

L-Theanine adjunct to risperidone in the treatment of chronic schizophrenia inpatients: a randomized, double-blind, placebo-controlled clinical trial.

Shamabadi A, Fattollahzadeh-Noor S, Fallahpour B, A Basti F, Khodaei Ardakani MR, Akhondzadeh S
Psychopharmacology (Berl) 2023 Dec;240(12):2631-2640. Epub 2023 Sep 12 doi: 10.1007/s00213-023-06458-9. PMID: 37697164

Neurodegenerative model of schizophrenia: Growing evidence to support a revisit.

Stone WS, Phillips MR, Yang LH, Kegeles LS, Susser ES, Lieberman JA
Schizophr Res 2022 May;243:154-162. Epub 2022 Mar 25 doi: 10.1016/j.schres.2022.03.004. PMID: 35344853 Free PMC Article

Color painting predicts clinical symptoms in chronic schizophrenia patients via deep learning.

Shen H, Wang SH, Zhang Y, Wang H, Li F, Lucas MV, Zhang YD, Liu Y, Yuan TF
BMC Psychiatry 2021 Oct 22;21(1):522. doi: 10.1186/s12888-021-03452-3. PMID: 34686178 Free PMC Article

Insomnia, suicidal ideation, and psychopathology in Chinese patients with chronic schizophrenia.

Miller BJ, McCall WV, Xia L, Zhang Y, Li W, Yao X, Liu H
Prog Neuropsychopharmacol Biol Psychiatry 2021 Dec 20;111:110202. Epub 2020 Dec 4 doi: 10.1016/j.pnpbp.2020.110202. PMID: 33285266

Anhedonia and schizophrenia.

Harrow M, Grinker RR, Holzman PS, Kayton L
Am J Psychiatry 1977 Jul;134(7):794-7. doi: 10.1176/ajp.134.7.794. PMID: 869058

See all (1282)

Recent systematic reviews

Meta-analysis of cortical thickness reduction in adult schizophrenia.

Sun S, Xiao S, Guo Z, Gong J, Tang G, Huang L, Wang Y
J Psychiatry Neurosci 2023 Nov-Dec;48(6):E461-E470. Epub 2023 Dec 20 doi: 10.1503/jpn.230081. PMID: 38123240 Free PMC Article

Adjunctive agents to antipsychotics in schizophrenia: a systematic umbrella review and recommendations for amino acids, hormonal therapies and anti-inflammatory drugs.

Antipsychotic-induced akathisia in adults with acute schizophrenia: A systematic review and dose-response meta-analysis.

Wu H, Siafis S, Wang D, Burschinski A, Schneider-Thoma J, Priller J, Davis JM, Leucht S
Eur Neuropsychopharmacol 2023 Jul;72:40-49. Epub 2023 Apr 17 doi: 10.1016/j.euroneuro.2023.03.015. PMID: 37075639

Antipsychotic-induced extrapyramidal side effects: A systematic review and meta-analysis of observational studies.

Ali T, Sisay M, Tariku M, Mekuria AN, Desalew A
PLoS One 2021;16(9):e0257129. Epub 2021 Sep 10 doi: 10.1371/journal.pone.0257129. PMID: 34506552 Free PMC Article

A systematic review and meta-analysis of cognitive remediation in early schizophrenia.

Revell ER, Neill JC, Harte M, Khan Z, Drake RJ
Schizophr Res 2015 Oct;168(1-2):213-22. Epub 2015 Aug 21 doi: 10.1016/j.schres.2015.08.017. PMID: 26305063

See all (38)

MedGen

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Chronic schizophrenia

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

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