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Yellow nail syndrome(YNS)

MedGen UID:
113164
•Concept ID:
C0221348
•
Disease or Syndrome
Synonyms: LYMPHEDEMA AND YELLOW NAILS; Lymphedema with yellow nails; YNS
SNOMED CT: Hereditary lymphedema and yellow nails (400211001); Yellow nail syndrome (400211001)
 
Monarch Initiative: MONDO:0007921
OMIM®: 153300
Orphanet: ORPHA662

Definition

Yellow nail syndrome (YNS) is classically considered to comprise a clinical triad of yellow nails, lymphedema, and respiratory tract involvement. Two of these symptoms are required for the diagnosis, since the complete triad is only observed in about one-third of patients. Onset is usually after puberty (Hoque et al., 2007). [from OMIM]

Clinical features

From HPO
Hypoplasia of lymphatic vessels
MedGen UID:
871105
•Concept ID:
C4025570
•
Congenital Abnormality
Congenital underdevelopment of lymph vessels.
See: Feature record | Search on this feature
Lymphedema
MedGen UID:
6155
•Concept ID:
C0024236
•
Disease or Syndrome
Localized fluid retention and tissue swelling caused by a compromised lymphatic system.
See: Feature record | Search on this feature
Predominantly lower limb lymphedema
MedGen UID:
320552
•Concept ID:
C1835228
•
Finding
Localized fluid retention and tissue swelling caused by a compromised lymphatic system, affecting mainly the legs.
See: Feature record | Search on this feature
Yellow nails
MedGen UID:
369197
•Concept ID:
C1768507
•
Sign or Symptom
Yellowish discoloration of the nails.
See: Feature record | Search on this feature
Slow-growing nails
MedGen UID:
331935
•Concept ID:
C1835238
•
Finding
Nails whose growth is slower than normal.
See: Feature record | Search on this feature
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Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVYellow nail syndrome
Follow this link to review classifications for Yellow nail syndrome in Orphanet.

Professional guidelines

PubMed

Yellow Nail Syndrome: Analysis of 23 Consecutive Patients and Effect of Combined Fluconazole-Vitamin-E Treatment.
Benassaia E, Abba S, Fourgeaud C, Mihoubi A, Vignes S
Dermatology 2024;240(2):343-351. Epub 2023 Dec 9 doi: 10.1159/000535577. PMID: 38071959
Transient yellow discoloration of the nails for differential diagnosis with yellow nail syndrome.
Chiriac A, Naznean A, Podoleanu C, Stolnicu S
Orphanet J Rare Dis 2017 Oct 2;12(1):159. doi: 10.1186/s13023-017-0711-4. PMID: 28969652Free PMC Article
Diagnosis and treatment of cutaneous paraneoplastic disorders.
Abreu Velez AM, Howard MS
Dermatol Ther 2010 Nov-Dec;23(6):662-75. doi: 10.1111/j.1529-8019.2010.01371.x. PMID: 21054710

Recent clinical studies

Etiology

Yellow Nail Syndrome: Analysis of 23 Consecutive Patients and Effect of Combined Fluconazole-Vitamin-E Treatment.
Benassaia E, Abba S, Fourgeaud C, Mihoubi A, Vignes S
Dermatology 2024;240(2):343-351. Epub 2023 Dec 9 doi: 10.1159/000535577. PMID: 38071959
Unusual presentation of a man with recurrent chylous ascites.
Joshi AN, Valliani T, Przemioslo R
BMJ Case Rep 2021 Mar 5;14(3) doi: 10.1136/bcr-2020-235273. PMID: 33674287Free PMC Article
Nonmalignant Adult Thoracic Lymphatic Disorders.
Itkin M, McCormack FX
Clin Chest Med 2016 Sep;37(3):409-20. doi: 10.1016/j.ccm.2016.04.004. PMID: 27514588
Fifty shades of yellow: a review of the xanthodermatoses.
Frew JW, Murrell DF, Haber RM
Int J Dermatol 2015 Oct;54(10):1109-23. Epub 2015 Jul 30 doi: 10.1111/ijd.12945. PMID: 26227781
Yellow nail syndrome.
Dhillon SS
Am J Respir Crit Care Med 2012 Sep 15;186(6):e10. doi: 10.1164/rccm.201109-1750IM. PMID: 22984032

Diagnosis

Nail disorders to be kept in mind.
Arnal C, Richert B
Hand Surg Rehabil 2024 Apr;43S:101640. Epub 2024 Jan 10 doi: 10.1016/j.hansur.2024.101640. PMID: 38215878
Chylothorax and Pseudochylothorax.
Braun CM, Ryu JH
Clin Chest Med 2021 Dec;42(4):667-675. doi: 10.1016/j.ccm.2021.08.003. PMID: 34774173
Nail is Systemic Disorders: Main Signs and Clues.
Dehavay F, Richert B
Dermatol Clin 2021 Apr;39(2):153-173. doi: 10.1016/j.det.2020.12.013. PMID: 33745630
Yellow Nails.
Shakshouk H, Lehman JS
Mayo Clin Proc 2020 May;95(5):966-967. doi: 10.1016/j.mayocp.2020.01.037. PMID: 32370857
Orphan Lung Diseases.
Ali MS, Ghori UK, Musani AI
Med Clin North Am 2019 May;103(3):503-515. doi: 10.1016/j.mcna.2018.12.009. PMID: 30955517

Therapy

Yellow Nail Syndrome: Analysis of 23 Consecutive Patients and Effect of Combined Fluconazole-Vitamin-E Treatment.
Benassaia E, Abba S, Fourgeaud C, Mihoubi A, Vignes S
Dermatology 2024;240(2):343-351. Epub 2023 Dec 9 doi: 10.1159/000535577. PMID: 38071959
Bronchiectasis in yellow nail syndrome.
Woodfield G, Nisbet M, Jacob J, Mok W, Loebinger MR, Hansell DM, Wells AU, Wilson R
Respirology 2017 Jan;22(1):101-107. Epub 2016 Aug 23 doi: 10.1111/resp.12866. PMID: 27551950
Yellow nail syndrome.
Dhillon SS
Am J Respir Crit Care Med 2012 Sep 15;186(6):e10. doi: 10.1164/rccm.201109-1750IM. PMID: 22984032
Yellow nail syndrome.
Al Hawsawi K, Pope E
Pediatr Dermatol 2010 Nov-Dec;27(6):675-6. doi: 10.1111/j.1525-1470.2010.01338.x. PMID: 21510012
Yellow nail syndrome.
Maldonado F, Ryu JH
Curr Opin Pulm Med 2009 Jul;15(4):371-5. doi: 10.1097/MCP.0b013e32832ad45a. PMID: 19373089

Prognosis

Nail disorders to be kept in mind.
Arnal C, Richert B
Hand Surg Rehabil 2024 Apr;43S:101640. Epub 2024 Jan 10 doi: 10.1016/j.hansur.2024.101640. PMID: 38215878
Unusual presentation of a man with recurrent chylous ascites.
Joshi AN, Valliani T, Przemioslo R
BMJ Case Rep 2021 Mar 5;14(3) doi: 10.1136/bcr-2020-235273. PMID: 33674287Free PMC Article
Pulmonary Manifestations of Skin Disorders in Children.
Cohen BA, Turcios NL
Pediatr Clin North Am 2021 Feb;68(1):261-276. doi: 10.1016/j.pcl.2020.09.009. PMID: 33228937
Orphan Lung Diseases.
Ali MS, Ghori UK, Musani AI
Med Clin North Am 2019 May;103(3):503-515. doi: 10.1016/j.mcna.2018.12.009. PMID: 30955517
Yellow nail syndrome.
Maldonado F, Ryu JH
Curr Opin Pulm Med 2009 Jul;15(4):371-5. doi: 10.1097/MCP.0b013e32832ad45a. PMID: 19373089

Clinical prediction guides

Yellow nail syndrome: a genetic Disorder?
Abid N, Loukil M, Mahmoud N, Badri I, Bouzaidi K, Ghrairi H
Tunis Med 2021 Avril;99(4):475-477. PMID: 35244933Free PMC Article
Effectiveness of clarithromycin in patients with yellow nail syndrome.
Matsubayashi S, Suzuki M, Suzuki T, Shiozawa A, Kobayashi K, Ishii S, Iikura M, Izumi S, Kudo K, Sugiyama H
BMC Pulm Med 2018 Aug 15;18(1):138. doi: 10.1186/s12890-018-0707-4. PMID: 30111321Free PMC Article
Yellow nail syndrome: a review.
Vignes S, Baran R
Orphanet J Rare Dis 2017 Feb 27;12(1):42. doi: 10.1186/s13023-017-0594-4. PMID: 28241848Free PMC Article
Bronchiectasis in yellow nail syndrome.
Woodfield G, Nisbet M, Jacob J, Mok W, Loebinger MR, Hansell DM, Wells AU, Wilson R
Respirology 2017 Jan;22(1):101-107. Epub 2016 Aug 23 doi: 10.1111/resp.12866. PMID: 27551950
Yellow nail syndrome.
DeCoste SD, Imber MJ, Baden HP
J Am Acad Dermatol 1990 Apr;22(4):608-11. doi: 10.1016/0190-9622(90)70081-r. PMID: 2319021

Recent systematic reviews

Characteristics of patients with yellow nail syndrome and pleural effusion.
Valdés L, Huggins JT, Gude F, Ferreiro L, Alvarez-Dobaño JM, Golpe A, Toubes ME, González-Barcala FJ, José ES, Sahn SA
Respirology 2014 Oct;19(7):985-92. Epub 2014 Aug 14 doi: 10.1111/resp.12357. PMID: 25123563

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