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Centrilobular emphysema

MedGen UID:
65133
Concept ID:
C0221227
Disease or Syndrome
Synonyms: Centriacinar Emphysema; Centriacinar Emphysemas; Centrilobular Emphysema; Centrilobular Emphysemas; Emphysema, Centriacinar; Emphysema, Centrilobular; Emphysemas, Centriacinar; Emphysemas, Centrilobular
SNOMED CT: Centriacinar emphysema (68328006); Centrilobular emphysema (68328006)
 
HPO: HP:0032966

Definition

A type of emphysema characterized by destroyed centrilobular alveolar walls and enlargement of respiratory bronchioles and associated alveoli. This is the commonest form of emphysema in cigarette smokers. CT findings are centrilobular areas of decreased attenuation, usually without visible walls, of nonuniform distribution and predominantly located in upper lung zones. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCentrilobular emphysema

Professional guidelines

PubMed

Wick MR
Semin Diagn Pathol 2018 Sep;35(5):315-323. Epub 2018 Aug 10 doi: 10.1053/j.semdp.2018.08.002. PMID: 30154023

Recent clinical studies

Etiology

Crapo JD, Gupta A, Lynch DA, Turner AM, Mroz RM, Janssens W, Ludwig-Sengpiel A, Koegler H, Eleftheraki A, Risse F, Diefenbach C
Respir Res 2023 Nov 17;24(1):290. doi: 10.1186/s12931-023-02584-2. PMID: 37978492Free PMC Article
Wisselink HJ, Yang X, Rook M, Heuvelmans MA, Jiang W, Zhang J, Du Y, Vonder M, Dorrius MD, Ye Z, de Bock GH, Vliegenthart R
Eur J Radiol 2023 Mar;160:110709. Epub 2023 Jan 26 doi: 10.1016/j.ejrad.2023.110709. PMID: 36731401
Maetani T, Tanabe N, Shiraishi Y, Shimada T, Terada S, Shima H, Mochizuki F, Sakamoto R, Kaji S, Oguma T, Sato S, Iijima H, Masuda I, Hirai T
Respiration 2023;102(3):194-202. Epub 2023 Jan 23 doi: 10.1159/000529031. PMID: 36689922Free PMC Article
Janssen R, Piscaer I, Franssen FME, Wouters EFM
Expert Rev Respir Med 2019 Apr;13(4):381-397. Epub 2019 Feb 22 doi: 10.1080/17476348.2019.1580575. PMID: 30761929
Bhatt SP, Nath HP, Kim YI, Ramachandran R, Watts JR, Terry NLJ, Sonavane S, Deshmane SP, Woodruff PG, Oelsner EC, Bodduluri S, Han MK, Labaki WW, Michael Wells J, Martinez FJ, Barr RG, Dransfield MT; SPIROMICS investigators
Respir Res 2018 Dec 18;19(1):257. doi: 10.1186/s12931-018-0946-1. PMID: 30563576Free PMC Article

Diagnosis

Booth S, Hsieh A, Mostaco-Guidolin L, Koo HK, Wu K, Aminazadeh F, Yang CX, Quail D, Wei Y, Cooper JD, Paré PD, Hogg JC, Vasilescu DM, Hackett TL
Am J Respir Crit Care Med 2023 Aug 15;208(4):472-486. doi: 10.1164/rccm.202303-0534OC. PMID: 37406359
Klont F, Horvatovich P, Bowler RP, van Rikxoort E, Charbonnier JP, Kwiatkowski M, Lynch DA, Humphries S, Bischoff R, Ten Hacken NHT, Pouwels SD
Respir Res 2022 Jan 24;23(1):15. doi: 10.1186/s12931-022-01934-w. PMID: 35073932Free PMC Article
Janssen R, Piscaer I, Franssen FME, Wouters EFM
Expert Rev Respir Med 2019 Apr;13(4):381-397. Epub 2019 Feb 22 doi: 10.1080/17476348.2019.1580575. PMID: 30761929
Sieminska A, Kuziemski K
Orphanet J Rare Dis 2014 Jul 11;9:106. doi: 10.1186/s13023-014-0106-8. PMID: 25011486Free PMC Article
Foster WL Jr, Gimenez EI, Roubidoux MA, Sherrier RH, Shannon RH, Roggli VL, Pratt PC
Radiographics 1993 Mar;13(2):311-28. doi: 10.1148/radiographics.13.2.8460222. PMID: 8460222

Therapy

Yang X, Wisselink HJ, Vliegenthart R, Heuvelmans MA, Groen HJM, Vonder M, Dorrius MD, de Bock GH
Radiology 2022 Aug;304(2):322-330. Epub 2022 May 3 doi: 10.1148/radiol.212904. PMID: 35503012
Janssen R, Piscaer I, Franssen FME, Wouters EFM
Expert Rev Respir Med 2019 Apr;13(4):381-397. Epub 2019 Feb 22 doi: 10.1080/17476348.2019.1580575. PMID: 30761929
Jin J, Li S, Yu W, Liu X, Sun Y
Int J Chron Obstruct Pulmon Dis 2018;13:375-384. Epub 2018 Jan 24 doi: 10.2147/COPD.S152447. PMID: 29416328Free PMC Article
Cosio Piqueras MG, Cosio MG
Eur Respir J Suppl 2001 Dec;34:41s-49s. doi: 10.1183/09031936.01.00234601. PMID: 12392034
Saetta M, Finkelstein R, Cosio MG
Eur Respir J 1994 Aug;7(8):1505-15. doi: 10.1183/09031936.94.07081505. PMID: 7957838

Prognosis

Xie W, Jacobs C, Charbonnier JP, Slebos DJ, van Ginneken B
Sci Rep 2023 Aug 29;13(1):14147. doi: 10.1038/s41598-023-40116-6. PMID: 37644032Free PMC Article
Maetani T, Tanabe N, Shiraishi Y, Shimada T, Terada S, Shima H, Mochizuki F, Sakamoto R, Kaji S, Oguma T, Sato S, Iijima H, Masuda I, Hirai T
Respiration 2023;102(3):194-202. Epub 2023 Jan 23 doi: 10.1159/000529031. PMID: 36689922Free PMC Article
Klont F, Horvatovich P, Bowler RP, van Rikxoort E, Charbonnier JP, Kwiatkowski M, Lynch DA, Humphries S, Bischoff R, Ten Hacken NHT, Pouwels SD
Respir Res 2022 Jan 24;23(1):15. doi: 10.1186/s12931-022-01934-w. PMID: 35073932Free PMC Article
Sieminska A, Kuziemski K
Orphanet J Rare Dis 2014 Jul 11;9:106. doi: 10.1186/s13023-014-0106-8. PMID: 25011486Free PMC Article
Cosio Piqueras MG, Cosio MG
Eur Respir J Suppl 2001 Dec;34:41s-49s. doi: 10.1183/09031936.01.00234601. PMID: 12392034

Clinical prediction guides

Booth S, Hsieh A, Mostaco-Guidolin L, Koo HK, Wu K, Aminazadeh F, Yang CX, Quail D, Wei Y, Cooper JD, Paré PD, Hogg JC, Vasilescu DM, Hackett TL
Am J Respir Crit Care Med 2023 Aug 15;208(4):472-486. doi: 10.1164/rccm.202303-0534OC. PMID: 37406359
Maetani T, Tanabe N, Shiraishi Y, Shimada T, Terada S, Shima H, Mochizuki F, Sakamoto R, Kaji S, Oguma T, Sato S, Iijima H, Masuda I, Hirai T
Respiration 2023;102(3):194-202. Epub 2023 Jan 23 doi: 10.1159/000529031. PMID: 36689922Free PMC Article
Klont F, Horvatovich P, Bowler RP, van Rikxoort E, Charbonnier JP, Kwiatkowski M, Lynch DA, Humphries S, Bischoff R, Ten Hacken NHT, Pouwels SD
Respir Res 2022 Jan 24;23(1):15. doi: 10.1186/s12931-022-01934-w. PMID: 35073932Free PMC Article
Bhatt SP, Nath HP, Kim YI, Ramachandran R, Watts JR, Terry NLJ, Sonavane S, Deshmane SP, Woodruff PG, Oelsner EC, Bodduluri S, Han MK, Labaki WW, Michael Wells J, Martinez FJ, Barr RG, Dransfield MT; SPIROMICS investigators
Respir Res 2018 Dec 18;19(1):257. doi: 10.1186/s12931-018-0946-1. PMID: 30563576Free PMC Article
Gelb AF, Christenson SA, Nadel JA
Curr Opin Pulm Med 2016 Mar;22(2):100-5. doi: 10.1097/MCP.0000000000000236. PMID: 26717511

Recent systematic reviews

Yang X, Wisselink HJ, Vliegenthart R, Heuvelmans MA, Groen HJM, Vonder M, Dorrius MD, de Bock GH
Radiology 2022 Aug;304(2):322-330. Epub 2022 May 3 doi: 10.1148/radiol.212904. PMID: 35503012

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