U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pestivirus infectious disease

MedGen UID:
60191
•Concept ID:
C0206611
•
Disease or Syndrome
Synonyms: Infection, Pestivirus; Infections, Pestivirus; Pestivirus Infection; Pestivirus Infections
 
Monarch Initiative: MONDO:0005909

Definition

Infections with viruses of the genus pestivirus, family flaviviridae. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPestivirus infectious disease

Professional guidelines

PubMed

Action of celgosivir (6 O-butanoyl castanospermine) against the pestivirus BVDV: implications for the treatment of hepatitis C.
Whitby K, Taylor D, Patel D, Ahmed P, Tyms AS
Antivir Chem Chemother 2004 May;15(3):141-51. doi: 10.1177/095632020401500304. PMID: 15266896

Recent clinical studies

Etiology

Pseudotyped Virus for Flaviviridae.
Zhang L, Wang X, Ming A, Tan W
Adv Exp Med Biol 2023;1407:313-327. doi: 10.1007/978-981-99-0113-5_17. PMID: 36920705
Virome in healthy pangolins reveals compatibility with multiple potentially zoonotic viruses.
Tian FJ, Li J, Liu WL, Liu YJ, Hu YJ, Tu QH, Li Y, Bai Y, Shi M, Que TC, Hu YL, Tong YG
Zool Res 2022 Nov 18;43(6):977-988. doi: 10.24272/j.issn.2095-8137.2022.246. PMID: 36257829Free PMC Article
Prospective cohort study reveals unexpected aetiologies of livestock abortion in northern Tanzania.
Thomas KM, Kibona T, Claxton JR, de Glanville WA, Lankester F, Amani N, Buza JJ, Carter RW, Chapman GE, Crump JA, Dagleish MP, Halliday JEB, Hamilton CM, Innes EA, Katzer F, Livingstone M, Longbottom D, Millins C, Mmbaga BT, Mosha V, Nyarobi J, Nyasebwa OM, Russell GC, Sanka PN, Semango G, Wheelhouse N, Willett BJ, Cleaveland S, Allan KJ
Sci Rep 2022 Jul 8;12(1):11669. doi: 10.1038/s41598-022-15517-8. PMID: 35803982Free PMC Article
Risk factors for Neospora caninum, bovine viral diarrhoea virus, and Leptospira interrogans serovar Hardjo infection in smallholder cattle and buffalo in Lao PDR.
Olmo L, Reichel MP, Nampanya S, Khounsy S, Wahl LC, Clark BA, Thomson PC, Windsor PA, Bush RD
PLoS One 2019;14(8):e0220335. Epub 2019 Aug 8 doi: 10.1371/journal.pone.0220335. PMID: 31393897Free PMC Article
Sequence variability of hepatitis C virus and its clinical relevance.
Dusheiko G, Simmonds P
J Viral Hepat 1994;1(1):3-15. doi: 10.1111/j.1365-2893.1994.tb00057.x. PMID: 8790555

Diagnosis

A Polyuridine Insertion in the 3' Untranslated Region of Classical Swine Fever Virus Activates Immunity and Reduces Viral Virulence in Piglets.
Wang M, Liniger M, Muñoz-González S, Bohórquez JA, Hinojosa Y, Gerber M, López-Soria S, Rosell R, Ruggli N, Ganges L
J Virol 2020 Jan 6;94(2) doi: 10.1128/JVI.01214-19. PMID: 31645448Free PMC Article
When can a veterinarian be expected to detect classical swine fever virus among breeding sows in a herd during an outbreak?
Engel B, Bouma A, Stegeman A, Buist W, Elbers A, Kogut J, Döpfer D, de Jong MC
Prev Vet Med 2005 Feb;67(2-3):195-212. Epub 2004 Dec 19 doi: 10.1016/j.prevetmed.2004.10.010. PMID: 15737431
Genetic heterogeneity of the hepatitis C virus.
Bukh J, Miller RH, Purcell RH
Princess Takamatsu Symp 1995;25:75-91. PMID: 8875612
Sequence variability of hepatitis C virus and its clinical relevance.
Dusheiko G, Simmonds P
J Viral Hepat 1994;1(1):3-15. doi: 10.1111/j.1365-2893.1994.tb00057.x. PMID: 8790555
Hepatitis C virus.
Plagemann PG
Arch Virol 1991;120(3-4):165-80. doi: 10.1007/BF01310473. PMID: 1659796Free PMC Article

Therapy

Discovery and synthesis of 1,2,4-oxadiazole derivatives as novel inhibitors of Zika, dengue, Japanese encephalitis, and classical swine fever virus infections.
Nam S, Na HG, Oh EH, Jung E, Lee YH, Jeong EJ, Ou YD, Zhou B, Ahn S, Shin JS, Han SB, Go YY
Arch Pharm Res 2022 Apr;45(4):280-293. Epub 2022 Apr 20 doi: 10.1007/s12272-022-01380-8. PMID: 35441964
Comparison of the protective efficacy of recombinant adenoviruses against classical swine fever.
Sun Y, Li HY, Zhang XJ, Chang TM, He F, Wang XP, Liu DF, Qiu HJ
Immunol Lett 2011 Mar 30;135(1-2):43-9. Epub 2010 Oct 12 doi: 10.1016/j.imlet.2010.09.010. PMID: 20923683
New drug targets for hepatitis C and other Flaviviridae viruses.
Paula T, Pablo R, Eugenia V, Pablo B, Sabino P, José M, Antonio M, Dolores HM, Pablo L, Javier GS, Vincente S
Infect Disord Drug Targets 2009 Apr;9(2):133-47. doi: 10.2174/187152609787847749. PMID: 19275702
The combination of interferon alpha-2b and n-butyl deoxynojirimycin has a greater than additive antiviral effect upon production of infectious bovine viral diarrhea virus (BVDV) in vitro: implications for hepatitis C virus (HCV) therapy.
Ouzounov S, Mehta A, Dwek RA, Block TM, Jordan R
Antiviral Res 2002 Sep;55(3):425-35. doi: 10.1016/s0166-3542(02)00075-x. PMID: 12206880
Sequence variability of hepatitis C virus and its clinical relevance.
Dusheiko G, Simmonds P
J Viral Hepat 1994;1(1):3-15. doi: 10.1111/j.1365-2893.1994.tb00057.x. PMID: 8790555

Prognosis

A Polyuridine Insertion in the 3' Untranslated Region of Classical Swine Fever Virus Activates Immunity and Reduces Viral Virulence in Piglets.
Wang M, Liniger M, Muñoz-González S, Bohórquez JA, Hinojosa Y, Gerber M, López-Soria S, Rosell R, Ruggli N, Ganges L
J Virol 2020 Jan 6;94(2) doi: 10.1128/JVI.01214-19. PMID: 31645448Free PMC Article
Risk factors for Neospora caninum, bovine viral diarrhoea virus, and Leptospira interrogans serovar Hardjo infection in smallholder cattle and buffalo in Lao PDR.
Olmo L, Reichel MP, Nampanya S, Khounsy S, Wahl LC, Clark BA, Thomson PC, Windsor PA, Bush RD
PLoS One 2019;14(8):e0220335. Epub 2019 Aug 8 doi: 10.1371/journal.pone.0220335. PMID: 31393897Free PMC Article
The NS5A protein of hepatitis C virus is a zinc metalloprotein.
Tellinghuisen TL, Marcotrigiano J, Gorbalenya AE, Rice CM
J Biol Chem 2004 Nov 19;279(47):48576-87. Epub 2004 Aug 31 doi: 10.1074/jbc.M407787200. PMID: 15339921
Genetic heterogeneity of the hepatitis C virus.
Bukh J, Miller RH, Purcell RH
Princess Takamatsu Symp 1995;25:75-91. PMID: 8875612
Hepatitis C virus.
Plagemann PG
Arch Virol 1991;120(3-4):165-80. doi: 10.1007/BF01310473. PMID: 1659796Free PMC Article

Clinical prediction guides

Cattle farmer psychosocial profiles and their association with control strategies for bovine viral diarrhea.
Prosser NS, Green MJ, Ferguson E, Tildesley MJ, Hill EM, Keeling MJ, Kaler J
J Dairy Sci 2022 Apr;105(4):3559-3573. Epub 2022 Jan 28 doi: 10.3168/jds.2021-21386. PMID: 35094853Free PMC Article
CRISPR/Cas9-Mediated Knockout of DNAJC14 Verifies This Chaperone as a Pivotal Host Factor for RNA Replication of Pestiviruses.
Isken O, Postel A, Bruhn B, Lattwein E, Becher P, Tautz N
J Virol 2019 Mar 1;93(5) Epub 2019 Feb 19 doi: 10.1128/JVI.01714-18. PMID: 30518653Free PMC Article
Sequence variability of hepatitis C virus and its clinical relevance.
Dusheiko G, Simmonds P
J Viral Hepat 1994;1(1):3-15. doi: 10.1111/j.1365-2893.1994.tb00057.x. PMID: 8790555
Hepatitis C virus.
Plagemann PG
Arch Virol 1991;120(3-4):165-80. doi: 10.1007/BF01310473. PMID: 1659796Free PMC Article
Studies with an unclassified virus isolated from diarrheic calves.
Woode GN, Reed DE, Runnels PL, Herrig MA, Hill HT
Vet Microbiol 1982 Jul;7(3):221-40. doi: 10.1016/0378-1135(82)90036-0. PMID: 7051518Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...