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Loeffler endocarditis

MedGen UID:
104788
Concept ID:
C0206143
Disease or Syndrome
Synonyms: Endocarditis, Loeffler; Endocarditis, Loeffler's; Endocarditis, Loefflers; Loeffler Endocarditis; Loeffler's Endocarditis; Loefflers Endocarditis
 
Monarch Initiative: MONDO:0019159
Orphanet: ORPHA75566

Definition

A rare restrictive cardiomyopathy characterized by hypereosinophilia and fibrous thickening of the endocardium, with usually large thrombi against the ventricle walls, that can lead to cardiovascular complications such as heart failure and thromboembolism. It manifests with symptoms like edema, fatigue and shortness of breath. It is usually secondary to eosinophil-associated tissue damage and is associated with idiopathic hypereosinophilic syndrome, chronic eosinophilic leukemia, carcinoma, or lymphoma. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLoeffler endocarditis
Follow this link to review classifications for Loeffler endocarditis in Orphanet.

Professional guidelines

PubMed

Valent P, Klion AD, Roufosse F, Simon D, Metzgeroth G, Leiferman KM, Schwaab J, Butterfield JH, Sperr WR, Sotlar K, Vandenberghe P, Hoermann G, Haferlach T, Moriggl R, George TI, Akin C, Bochner BS, Gotlib J, Reiter A, Horny HP, Arock M, Simon HU, Gleich GJ
Allergy 2023 Jan;78(1):47-59. Epub 2022 Oct 19 doi: 10.1111/all.15544. PMID: 36207764Free PMC Article
Requena G, van den Bosch J, Akuthota P, Kovalszki A, Steinfeld J, Kwon N, Van Dyke MK
J Allergy Clin Immunol Pract 2022 Aug;10(8):2125-2134. Epub 2022 Apr 22 doi: 10.1016/j.jaip.2022.03.034. PMID: 35470096
Shomali W, Gotlib J
Am J Hematol 2022 Jan 1;97(1):129-148. Epub 2021 Oct 8 doi: 10.1002/ajh.26352. PMID: 34533850

Recent clinical studies

Etiology

Lou J, Wu W, Chen X, Xie M, Lv Q
Anatol J Cardiol 2023 Jul 3;27(7):E23-E24. Epub 2023 Jun 7 doi: 10.14744/AnatolJCardiol.2023.3231. PMID: 37288846Free PMC Article
Jin X, Ma C, Liu S, Guan Z, Wang Y, Yang J
Echocardiography 2017 Aug;34(8):1242-1246. Epub 2017 Jun 1 doi: 10.1111/echo.13573. PMID: 28573678
Osovska NY, Kuzminova NV, Knyazkova II
Pol Merkur Lekarski 2016 Nov 25;41(245):231-237. PMID: 27883350
Sato T, Matsuyama TA, Seguchi O, Murata Y, Sunami H, Yanase M, Fujita T, Ishibashi-Ueda H, Nakatani T
Cardiovasc Pathol 2015 Jul-Aug;24(4):254-7. Epub 2015 Mar 6 doi: 10.1016/j.carpath.2015.03.001. PMID: 25804825
Lofiego C, Ferlito M, Rocchi G, Biagini E, Perugini E, Branzi A, Rapezzi C
Eur J Heart Fail 2005 Oct;7(6):1023-6. Epub 2005 Sep 26 doi: 10.1016/j.ejheart.2005.06.004. PMID: 16188499

Diagnosis

Caruso S, Marrone G, Gentile G
Radiology 2022 Sep;304(3):736-742. doi: 10.1148/radiol.210453. PMID: 35994399
Zhang Q, Si D, Zhang Z, Zhang W
BMC Cardiovasc Disord 2021 Dec 28;21(1):615. doi: 10.1186/s12872-021-02443-2. PMID: 34961478Free PMC Article
Blagova OV, Aliyeva IN, Nedostup AV, Kogan EA, Komarov RN, Chernyavsky SV, Seslavinskaya VV, Shelukha PA, Sedov VP, Gagarina NV, Mershina EA, Sinitsyn VE, Fomin VV
Ter Arkh 2019 May 16;91(4):99-106. doi: 10.26442/00403660.2019.04.000048. PMID: 31094483
Mactier I, Dalzell JR, Carrick D
Heart 2019 Jun;105(12):960-966. Epub 2019 Feb 14 doi: 10.1136/heartjnl-2018-314114. PMID: 30765423
Çetin S, Heper G, Gökhan Vural M, Hazirolan T
Wien Klin Wochenschr 2016 Jul;128(13-14):513-5. Epub 2016 Mar 15 doi: 10.1007/s00508-016-0981-1. PMID: 26980214

Therapy

Zhang Q, Si D, Zhang Z, Zhang W
BMC Cardiovasc Disord 2021 Dec 28;21(1):615. doi: 10.1186/s12872-021-02443-2. PMID: 34961478Free PMC Article
Blagova OV, Aliyeva IN, Nedostup AV, Kogan EA, Komarov RN, Chernyavsky SV, Seslavinskaya VV, Shelukha PA, Sedov VP, Gagarina NV, Mershina EA, Sinitsyn VE, Fomin VV
Ter Arkh 2019 May 16;91(4):99-106. doi: 10.26442/00403660.2019.04.000048. PMID: 31094483
Gao M, Zhang W, Zhao W, Qin L, Pei F, Zheng Y
Medicine (Baltimore) 2018 Mar;97(11):e0079. doi: 10.1097/MD.0000000000010079. PMID: 29538200Free PMC Article
Osovska NY, Kuzminova NV, Knyazkova II
Pol Merkur Lekarski 2016 Nov 25;41(245):231-237. PMID: 27883350
Inoue T, Watanabe C, Ayukawa H, Nadahama T, Hosokawa A, Beppu K, Oya H, Sasaki Y, Takeda S, Shirasaka A, Doi T, Hashimoto T, Kawai C
Circulation 2015 Feb 24;131(8):e353-4. doi: 10.1161/CIRCULATIONAHA.114.012976. PMID: 25712061

Prognosis

Zhang Q, Si D, Zhang Z, Zhang W
BMC Cardiovasc Disord 2021 Dec 28;21(1):615. doi: 10.1186/s12872-021-02443-2. PMID: 34961478Free PMC Article
Blagova OV, Aliyeva IN, Nedostup AV, Kogan EA, Komarov RN, Chernyavsky SV, Seslavinskaya VV, Shelukha PA, Sedov VP, Gagarina NV, Mershina EA, Sinitsyn VE, Fomin VV
Ter Arkh 2019 May 16;91(4):99-106. doi: 10.26442/00403660.2019.04.000048. PMID: 31094483
Gao M, Zhang W, Zhao W, Qin L, Pei F, Zheng Y
Medicine (Baltimore) 2018 Mar;97(11):e0079. doi: 10.1097/MD.0000000000010079. PMID: 29538200Free PMC Article
Jin X, Ma C, Liu S, Guan Z, Wang Y, Yang J
Echocardiography 2017 Aug;34(8):1242-1246. Epub 2017 Jun 1 doi: 10.1111/echo.13573. PMID: 28573678
Sato T, Matsuyama TA, Seguchi O, Murata Y, Sunami H, Yanase M, Fujita T, Ishibashi-Ueda H, Nakatani T
Cardiovasc Pathol 2015 Jul-Aug;24(4):254-7. Epub 2015 Mar 6 doi: 10.1016/j.carpath.2015.03.001. PMID: 25804825

Clinical prediction guides

Kandels J, Pawluczuk J, Stöbe S, Hagendorff A
Int J Cardiovasc Imaging 2024 Sep;40(9):2007-2013. Epub 2024 May 23 doi: 10.1007/s10554-024-03147-2. PMID: 38780708Free PMC Article
Blagova OV, Aliyeva IN, Nedostup AV, Kogan EA, Komarov RN, Chernyavsky SV, Seslavinskaya VV, Shelukha PA, Sedov VP, Gagarina NV, Mershina EA, Sinitsyn VE, Fomin VV
Ter Arkh 2019 May 16;91(4):99-106. doi: 10.26442/00403660.2019.04.000048. PMID: 31094483
Jin X, Ma C, Liu S, Guan Z, Wang Y, Yang J
Echocardiography 2017 Aug;34(8):1242-1246. Epub 2017 Jun 1 doi: 10.1111/echo.13573. PMID: 28573678
Dedieu N, Giardini A, Khambadkone S, Marek J
Eur J Echocardiogr 2011 Jan;12(1):E3. Epub 2010 Aug 20 doi: 10.1093/ejechocard/jeq098. PMID: 20729294
Lofiego C, Ferlito M, Rocchi G, Biagini E, Perugini E, Branzi A, Rapezzi C
Eur J Heart Fail 2005 Oct;7(6):1023-6. Epub 2005 Sep 26 doi: 10.1016/j.ejheart.2005.06.004. PMID: 16188499

Recent systematic reviews

Zhang Q, Si D, Zhang Z, Zhang W
BMC Cardiovasc Disord 2021 Dec 28;21(1):615. doi: 10.1186/s12872-021-02443-2. PMID: 34961478Free PMC Article

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