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Oral lichen planus

MedGen UID:
60084
•Concept ID:
C0206139
•
Disease or Syndrome
Synonym: Oral lichenoid lesions
SNOMED CT: OLP - Oral lichen planus (235049008); Oral lichen planus (235049008)
 
Monarch Initiative: MONDO:0043923

Definition

A chronic, autoimmune inflammatory condition of the mucous membranes in the oral cavity that affects approximately two percent of the population and is most often seen in middle aged women. It is characterized by white, lacy patches; red, swollen tissue; papules and plaques; or open sores. The lesions are typically bilateral. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOral lichen planus

Professional guidelines

PubMed

Oral Lichen Planus: An Update on Diagnosis and Management.
Louisy A, Humbert E, Samimi M
Am J Clin Dermatol 2024 Jan;25(1):35-53. Epub 2023 Sep 15 doi: 10.1007/s40257-023-00814-3. PMID: 37713153
Oral lichen planus - Differential diagnoses, serum autoantibodies, hematinic deficiencies, and management.
Chiang CP, Yu-Fong Chang J, Wang YP, Wu YH, Lu SY, Sun A
J Formos Med Assoc 2018 Sep;117(9):756-765. Epub 2018 Feb 19 doi: 10.1016/j.jfma.2018.01.021. PMID: 29472048
Treatment of oral lichen planus. Systematic review and therapeutic guide.
García-Pola MJ, González-Álvarez L, Garcia-Martin JM
Med Clin (Barc) 2017 Oct 23;149(8):351-362. Epub 2017 Jul 28 doi: 10.1016/j.medcli.2017.06.024. PMID: 28756997

Recent clinical studies

Etiology

Association of serum and salivary dipeptidyl peptidase-4 (DPP-4) with oral cancerous and precancerous lesions; an observational diagnostic accuracy study.
Abdel Fattah Tarrad N, Gamil Shaker O, Abdelkawy M, Hassan S
BMC Oral Health 2024 Oct 10;24(1):1206. doi: 10.1186/s12903-024-04939-7. PMID: 39390508Free PMC Article
Oral and non-oral lichen planus show genetic heterogeneity and differential risk for autoimmune disease and oral cancer.
Reeve MP, Vehviläinen M, Luo S, Ritari J, Karjalainen J, Gracia-Tabuenca J, Mehtonen J, Padmanabhuni SS, Kolosov N, Artomov M, Siirtola H, Olilla HM; FinnGen, Graham D, Partanen J, Xavier RJ, Daly MJ, Ripatti S, Salo T, Siponen M
Am J Hum Genet 2024 Jun 6;111(6):1047-1060. Epub 2024 May 21 doi: 10.1016/j.ajhg.2024.04.020. PMID: 38776927Free PMC Article

Diagnosis

Association of serum and salivary dipeptidyl peptidase-4 (DPP-4) with oral cancerous and precancerous lesions; an observational diagnostic accuracy study.
Abdel Fattah Tarrad N, Gamil Shaker O, Abdelkawy M, Hassan S
BMC Oral Health 2024 Oct 10;24(1):1206. doi: 10.1186/s12903-024-04939-7. PMID: 39390508Free PMC Article
Oral lichen planus and lichenoid lesions: etiopathogenesis, diagnosis and treatment.
Whitehouse P
Br Dent J 2024 Sep;237(5):314. doi: 10.1038/s41415-024-7848-z. PMID: 39271865
Oral and non-oral lichen planus show genetic heterogeneity and differential risk for autoimmune disease and oral cancer.
Reeve MP, Vehviläinen M, Luo S, Ritari J, Karjalainen J, Gracia-Tabuenca J, Mehtonen J, Padmanabhuni SS, Kolosov N, Artomov M, Siirtola H, Olilla HM; FinnGen, Graham D, Partanen J, Xavier RJ, Daly MJ, Ripatti S, Salo T, Siponen M
Am J Hum Genet 2024 Jun 6;111(6):1047-1060. Epub 2024 May 21 doi: 10.1016/j.ajhg.2024.04.020. PMID: 38776927Free PMC Article

Therapy

Oral Lichen Planus: An Update on Diagnosis and Management.
Louisy A, Humbert E, Samimi M
Am J Clin Dermatol 2024 Jan;25(1):35-53. Epub 2023 Sep 15 doi: 10.1007/s40257-023-00814-3. PMID: 37713153
Treatment of oral lichen planus. Systematic review and therapeutic guide.
García-Pola MJ, González-Álvarez L, Garcia-Martin JM
Med Clin (Barc) 2017 Oct 23;149(8):351-362. Epub 2017 Jul 28 doi: 10.1016/j.medcli.2017.06.024. PMID: 28756997
Therapeutic roles of curcumin: lessons learned from clinical trials.
Gupta SC, Patchva S, Aggarwal BB
AAPS J 2013 Jan;15(1):195-218. Epub 2012 Nov 10 doi: 10.1208/s12248-012-9432-8. PMID: 23143785Free PMC Article
Oral lichen planus and lichenoid reactions: etiopathogenesis, diagnosis, management and malignant transformation.
Ismail SB, Kumar SK, Zain RB
J Oral Sci 2007 Jun;49(2):89-106. doi: 10.2334/josnusd.49.89. PMID: 17634721
Oral lichen planus and oral lichenoid lesions: diagnostic and therapeutic considerations.
Al-Hashimi I, Schifter M, Lockhart PB, Wray D, Brennan M, Migliorati CA, Axéll T, Bruce AJ, Carpenter W, Eisenberg E, Epstein JB, Holmstrup P, Jontell M, Lozada-Nur F, Nair R, Silverman B, Thongprasom K, Thornhill M, Warnakulasuriya S, van der Waal I
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007 Mar;103 Suppl:S25.e1-12. Epub 2007 Jan 29 doi: 10.1016/j.tripleo.2006.11.001. PMID: 17261375

Prognosis

Management of oral potentially malignant disorders.
Kerr AR, Lodi G
Oral Dis 2021 Nov;27(8):2008-2025. Epub 2021 Oct 9 doi: 10.1111/odi.13980. PMID: 34324758
Premalignant and malignant oral mucosal lesions: Clinical and pathological findings.
Maymone MBC, Greer RO, Kesecker J, Sahitya PC, Burdine LK, Cheng AD, Maymone AC, Vashi NA
J Am Acad Dermatol 2019 Jul;81(1):59-71. Epub 2018 Nov 14 doi: 10.1016/j.jaad.2018.09.060. PMID: 30447325
Lichen planus and lichenoid dermatoses: Clinical overview and molecular basis.
Tziotzios C, Lee JYW, Brier T, Saito R, Hsu CK, Bhargava K, Stefanato CM, Fenton DA, McGrath JA
J Am Acad Dermatol 2018 Nov;79(5):789-804. doi: 10.1016/j.jaad.2018.02.010. PMID: 30318136
Oral Lichen Planus: an Overview of Potential Risk Factors, Biomarkers and Treatments.
Nosratzehi T
Asian Pac J Cancer Prev 2018 May 26;19(5):1161-1167. doi: 10.22034/APJCP.2018.19.5.1161. PMID: 29801395Free PMC Article
Clinical features and presentation of oral potentially malignant disorders.
Warnakulasuriya S
Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Jun;125(6):582-590. Epub 2018 Apr 4 doi: 10.1016/j.oooo.2018.03.011. PMID: 29673799

Clinical prediction guides

Hydroxychloroquine is effective in oral lichen planus: A multicenter, randomized, controlled trial.
Xie Y, Xu H, Li C, Wang Y, Lu R, Hua H, Tang G, Zhou G, Jin X, Shang Q, Dan P, Zhang C, Luo X, Dan H, Zeng X, Zhou Y, Chen Q
Oral Dis 2024 Jul;30(5):3126-3135. Epub 2023 Oct 4 doi: 10.1111/odi.14746. PMID: 37794749
Single-cell immune profiling reveals immune responses in oral lichen planus.
Li Q, Wang F, Shi Y, Zhong L, Duan S, Kuang W, Liu N, Luo E, Zhou Y, Jiang L, Dan H, Luo X, Zhang D, Chen Q, Zeng X, Li T
Front Immunol 2023;14:1182732. Epub 2023 Apr 6 doi: 10.3389/fimmu.2023.1182732. PMID: 37090715Free PMC Article
Diabetes mellitus and oral lichen planus: A systematic review and meta-analysis.
Mallah N, Ignacio Varela-Centelles P, Seoane-Romero J, Takkouche B
Oral Dis 2022 Nov;28(8):2100-2109. Epub 2021 Jun 11 doi: 10.1111/odi.13927. PMID: 34051029
Anxiety and oral lichen planus.
Liao H, Luo Y, Long L, Peng J, Qiu X, Yuan P, Xu H, Jiang L
Oral Dis 2021 Apr;27(3):506-514. Epub 2020 Aug 11 doi: 10.1111/odi.13569. PMID: 32697012
Oral Lichen Planus: an Overview of Potential Risk Factors, Biomarkers and Treatments.
Nosratzehi T
Asian Pac J Cancer Prev 2018 May 26;19(5):1161-1167. doi: 10.22034/APJCP.2018.19.5.1161. PMID: 29801395Free PMC Article

Recent systematic reviews

Curcumin and Curcuma longa Extract in the Treatment of 10 Types of Autoimmune Diseases: A Systematic Review and Meta-Analysis of 31 Randomized Controlled Trials.
Zeng L, Yang T, Yang K, Yu G, Li J, Xiang W, Chen H
Front Immunol 2022;13:896476. Epub 2022 Aug 1 doi: 10.3389/fimmu.2022.896476. PMID: 35979355Free PMC Article
Worldwide prevalence of oral lichen planus: A systematic review and meta-analysis.
González-Moles MÁ, Warnakulasuriya S, González-Ruiz I, González-Ruiz L, Ayén Á, Lenouvel D, Ruiz-Ávila I, Ramos-García P
Oral Dis 2021 May;27(4):813-828. Epub 2020 Apr 2 doi: 10.1111/odi.13323. PMID: 32144836
Treatment of oral lichen planus. Systematic review and therapeutic guide.
García-Pola MJ, González-Álvarez L, Garcia-Martin JM
Med Clin (Barc) 2017 Oct 23;149(8):351-362. Epub 2017 Jul 28 doi: 10.1016/j.medcli.2017.06.024. PMID: 28756997
Effects of Turmeric (Curcuma longa) on Skin Health: A Systematic Review of the Clinical Evidence.
Vaughn AR, Branum A, Sivamani RK
Phytother Res 2016 Aug;30(8):1243-64. Epub 2016 May 23 doi: 10.1002/ptr.5640. PMID: 27213821
Oral lichen planus and oral lichenoid lesions: diagnostic and therapeutic considerations.
Al-Hashimi I, Schifter M, Lockhart PB, Wray D, Brennan M, Migliorati CA, Axéll T, Bruce AJ, Carpenter W, Eisenberg E, Epstein JB, Holmstrup P, Jontell M, Lozada-Nur F, Nair R, Silverman B, Thongprasom K, Thornhill M, Warnakulasuriya S, van der Waal I
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007 Mar;103 Suppl:S25.e1-12. Epub 2007 Jan 29 doi: 10.1016/j.tripleo.2006.11.001. PMID: 17261375

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