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Hibernoma

MedGen UID:
61456
•Concept ID:
C0205822
•
Neoplastic Process
Synonym: Hibernomas
SNOMED CT: Hibernoma (77027006); Fetal fat cell lipoma (77027006); Brown fat tumor (77027006); Hibernoma (404064001); Granular cell lipoma (404064001)
 
Monarch Initiative: MONDO:0021168

Definition

A rare benign slow growing adipose tissue tumor, characterized by the presence of polygonal brown fat cells with multivacuolated and/or granular cytoplasm. The tumor is usually painless and is most often seen in young adults. [from NCI]

Professional guidelines

PubMed

Comparative pathophysiology, toxicology, and human cancer risk assessment of pharmaceutical-induced hibernoma.
Radi Z, Bartholomew P, Elwell M, Vogel WM
Toxicol Appl Pharmacol 2013 Dec 15;273(3):456-63. Epub 2013 Oct 18 doi: 10.1016/j.taap.2013.10.011. PMID: 24141031
Deep-seated huge hibernoma of soft tissue: a rare differential diagnosis of atypical lipomatous tumor/well differentiated liposarcoma.
Vassos N, Lell M, Hohenberger W, Croner RS, Agaimy A
Int J Clin Exp Pathol 2013;6(10):2178-84. Epub 2013 Sep 15 PMID: 24133596Free PMC Article
Rhabdomyoma of the head and neck: morphology and differential diagnosis.
Hansen T, Katenkamp D
Virchows Arch 2005 Nov;447(5):849-54. Epub 2005 Aug 18 doi: 10.1007/s00428-005-0038-8. PMID: 16133368

Recent clinical studies

Etiology

Lipomas of the Brachial Plexus: A Case Series and Review of the Literature.
Graf A, Yang K, King D, Dzwierzynski W, Sanger J, Hettinger P
Hand (N Y) 2019 May;14(3):333-338. Epub 2017 Oct 23 doi: 10.1177/1558944717735946. PMID: 29058949Free PMC Article
Temperatures rising: brown fat and bone.
Motyl KJ, Rosen CJ
Discov Med 2011 Mar;11(58):179-85. PMID: 21447277Free PMC Article
MR imaging evaluation of disorders of the chest wall.
Lee TJ, Collins J
Magn Reson Imaging Clin N Am 2008 May;16(2):355-79, x. doi: 10.1016/j.mric.2008.03.001. PMID: 18474337
Subpleural hibernoma.
Ugalde PA, Guilbault F, Vaillancourt R, Couture C
Ann Thorac Surg 2007 Oct;84(4):1376-8. doi: 10.1016/j.athoracsur.2007.05.044. PMID: 17889004
Hibernoma of the neck.
Carinci F, Carls FP, Pelucchi S, Grandi E, Hassanipour A, Pastore A
J Craniofac Surg 2001 May;12(3):284-6. doi: 10.1097/00001665-200105000-00015. PMID: 11358103

Diagnosis

Lipomatoses.
Dupuis H, Lemaitre M, Jannin A, Douillard C, Espiard S, Vantyghem MC
Ann Endocrinol (Paris) 2024 Jun;85(3):231-247. Epub 2024 Jun 12 doi: 10.1016/j.ando.2024.05.003. PMID: 38871514
Hibernoma.
Klevos G, Jose J, Pretell-Mazzini J, Conway S
Am J Orthop (Belle Mead NJ) 2015 Jun;44(6):284-7. PMID: 26046999
Hibernoma.
Alves GR, Antunes MS, Bellenzier L, Haygert CJ
QJM 2013 Aug;106(8):773. Epub 2012 Aug 26 doi: 10.1093/qjmed/hcs157. PMID: 22927539
Mammary hibernoma.
Colville J, Feigin K, Tang L, Keating D, Cohen MA
Breast J 2006 Nov-Dec;12(6):563-5. doi: 10.1111/j.1524-4741.2006.00346.x. PMID: 17238987
Hibernoma of the neck.
Carinci F, Carls FP, Pelucchi S, Grandi E, Hassanipour A, Pastore A
J Craniofac Surg 2001 May;12(3):284-6. doi: 10.1097/00001665-200105000-00015. PMID: 11358103

Therapy

Histopathological Changes in Liver and Heart Tissue Associated with Experimental Ultraviolet Radiation A and B Exposure on Wistar Albino Rats.
Keskin S, Acikgoz E, Ertürk FY, Ragbetli MC, Ozkol H
Photochem Photobiol 2023 Jan;99(1):132-136. Epub 2022 Jun 28 doi: 10.1111/php.13664. PMID: 35702999
Hibernoma as an incidental finding in the 18F-FDG PET/CT of a patient with melanoma.
Marcoval J, Sabaté-Llobera A, Bermejo J, Fornons-Servent R
Melanoma Res 2020 Aug;30(4):420-422. doi: 10.1097/CMR.0000000000000530. PMID: 30358644
Propranolol 18F-FDG PET/CT: A Noninvasive Approach for Differential Diagnosis of Hibernoma and Liposarcoma.
Ciappuccini R, Bardet S, Aide N
Clin Nucl Med 2017 Nov;42(11):879-880. doi: 10.1097/RLU.0000000000001830. PMID: 28902737
Sonographic findings of hibernoma. A report of two cases.
Hardes J, Scheil-Bertram S, Hartwig E, Gebert C, Gosheger G, Schulte M
J Clin Ultrasound 2005 Jul-Aug;33(6):298-301. doi: 10.1002/jcu.20126. PMID: 16134158
Epidural hibernoma as a complication of corticosteroid treatment. Case report.
Perling LH, Laurent JP, Cheek WR
J Neurosurg 1988 Oct;69(4):613-6. doi: 10.3171/jns.1988.69.4.0613. PMID: 3047343

Prognosis

Retroperitoneal hibernoma resected via laparoscopic surgery.
Sujino H, Kasahara K, Tanigawa M, Enomoto M, Udo R, Tago T, Okazaki N, Mazaki J, Ishizaki T, Nagao T, Katsumata K, Tsuchida A, Nagakawa Y
Asian J Endosc Surg 2023 Jul;16(3):528-532. Epub 2023 Jan 2 doi: 10.1111/ases.13160. PMID: 36592950
Lipomas of the Brachial Plexus: A Case Series and Review of the Literature.
Graf A, Yang K, King D, Dzwierzynski W, Sanger J, Hettinger P
Hand (N Y) 2019 May;14(3):333-338. Epub 2017 Oct 23 doi: 10.1177/1558944717735946. PMID: 29058949Free PMC Article
Temperatures rising: brown fat and bone.
Motyl KJ, Rosen CJ
Discov Med 2011 Mar;11(58):179-85. PMID: 21447277Free PMC Article
Subpleural hibernoma.
Ugalde PA, Guilbault F, Vaillancourt R, Couture C
Ann Thorac Surg 2007 Oct;84(4):1376-8. doi: 10.1016/j.athoracsur.2007.05.044. PMID: 17889004
Hibernoma of the neck.
Carinci F, Carls FP, Pelucchi S, Grandi E, Hassanipour A, Pastore A
J Craniofac Surg 2001 May;12(3):284-6. doi: 10.1097/00001665-200105000-00015. PMID: 11358103

Clinical prediction guides

Foamy cell (hibernoma-like) change is a rare histopathological feature in renal cell carcinoma.
Petersson F, Sperga M, Bulimbasic S, Martinek P, Svajdler M, Kuroda N, Hora M, Simpson R, Tichy T, Peckova K, Branzovsky J, Pivovarcikova K, Rotterova P, Kokoskova B, Bauleth K, Martincok D, Nagy V, Michal M, Hes O
Virchows Arch 2014 Aug;465(2):215-24. Epub 2014 Jun 6 doi: 10.1007/s00428-014-1600-z. PMID: 24903672
Hibernoma with metabolic impact?
Vijgen GH, Bouvy ND, Smidt M, Kooreman L, Schaart G, van Marken Lichtenbelt W
BMJ Case Rep 2012 Aug 21;2012 doi: 10.1136/bcr-2012-006325. PMID: 22914232Free PMC Article
Temperatures rising: brown fat and bone.
Motyl KJ, Rosen CJ
Discov Med 2011 Mar;11(58):179-85. PMID: 21447277Free PMC Article
p16 immunohistochemistry as an alternative marker to distinguish atypical lipomatous tumor from deep-seated lipoma.
He M, Aisner S, Benevenia J, Patterson F, Aviv H, Hameed M
Appl Immunohistochem Mol Morphol 2009 Jan;17(1):51-6. doi: 10.1097/PAI.0b013e3181719223. PMID: 18779733
Hibernoma: a possible model of brown fat histogenesis.
Dardick I
Hum Pathol 1978 May;9(3):321-9. doi: 10.1016/s0046-8177(78)80089-6. PMID: 658965

Recent systematic reviews

Brachial plexus neuropathy by hibernoma compression: An unusual presentation of peripheral non-neural sheath nerve tumor and a systematic review of literature.
Sousa LHA, Chaves JPG, Marques RAM, Silva LLG
Neurol India 2019 Mar-Apr;67(2):481-484. doi: 10.4103/0028-3886.258049. PMID: 31085864

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